MXPA05012799A - Compuestos triheterociclicos, composiciones y metodos para tratar cancer o enfermedades virales. - Google Patents

Compuestos triheterociclicos, composiciones y metodos para tratar cancer o enfermedades virales.

Info

Publication number
MXPA05012799A
MXPA05012799A MXPA05012799A MXPA05012799A MXPA05012799A MX PA05012799 A MXPA05012799 A MX PA05012799A MX PA05012799 A MXPA05012799 A MX PA05012799A MX PA05012799 A MXPA05012799 A MX PA05012799A MX PA05012799 A MXPA05012799 A MX PA05012799A
Authority
MX
Mexico
Prior art keywords
compositions
methods
treating cancer
viral diseases
triheterocyclic
Prior art date
Application number
MXPA05012799A
Other languages
English (en)
Inventor
Sasmita Tripathy
Original Assignee
Gemin X Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemin X Biotechnologies Inc filed Critical Gemin X Biotechnologies Inc
Publication of MXPA05012799A publication Critical patent/MXPA05012799A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

La presente invencion se refiere a los compuestos triheterociclicos novedosos, que tienen la formula (I): (ver formula I) y las sales aceptadas para uso farmaceutico de estos, en donde: Q1 es -O-, -S- o -N(R1)-; Q2 es -C(R3)- o -N-; Q3 es -C(R5)-o -N-; Q4 es -C(R9)- o -N-; las composiciones que contienen un compuesto triheterociclico y los metodos utiles para el tratamiento o prevencion de cancer o una alteracion neoplasica, que consisten en administrar un compuesto triheterociclico. Los compuestos, composiciones y metodos de la invencion tambien son utiles para inhibir el crecimiento de una celula cancerosa o celula neoplasica, para el tratamiento o prevencion de una infeccion viral o para inhibir la replicacion y/o infectividad de un virus.
MXPA05012799A 2003-05-30 2004-05-28 Compuestos triheterociclicos, composiciones y metodos para tratar cancer o enfermedades virales. MXPA05012799A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47474103P 2003-05-30 2003-05-30
PCT/CA2004/000793 WO2004106328A1 (en) 2003-05-30 2004-05-28 Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases

Publications (1)

Publication Number Publication Date
MXPA05012799A true MXPA05012799A (es) 2006-02-22

Family

ID=33490730

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05012799A MXPA05012799A (es) 2003-05-30 2004-05-28 Compuestos triheterociclicos, composiciones y metodos para tratar cancer o enfermedades virales.

Country Status (24)

Country Link
US (4) US7425553B2 (es)
EP (1) EP1644363B1 (es)
JP (1) JP4980715B2 (es)
KR (1) KR101168441B1 (es)
CN (1) CN1832939B (es)
AT (1) ATE546456T1 (es)
AU (1) AU2004242928B2 (es)
BR (1) BRPI0410870A (es)
CA (1) CA2527583C (es)
CY (1) CY1113038T1 (es)
DK (1) DK1644363T3 (es)
ES (1) ES2382377T3 (es)
HK (1) HK1082737A1 (es)
HR (1) HRP20120379T1 (es)
IL (1) IL172189A (es)
MX (1) MXPA05012799A (es)
NO (1) NO333006B1 (es)
NZ (1) NZ543897A (es)
PL (1) PL1644363T3 (es)
PT (1) PT1644363E (es)
RU (1) RU2360913C2 (es)
SI (1) SI1644363T1 (es)
WO (1) WO2004106328A1 (es)
ZA (1) ZA200509718B (es)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200509718B (en) * 2003-05-30 2007-03-28 Gemin X Biotechnologies Inc Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
US20060035945A1 (en) * 2003-05-30 2006-02-16 Giorgio Attardo Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
EP1746888A2 (en) * 2004-05-13 2007-01-31 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
ES2454551T3 (es) * 2004-12-28 2014-04-10 Gemin X Pharmaceuticals Canada Inc. Compuestos dipirrólicos, composiciones, y métodos para el tratamiento del cáncer o enfermedades virales
EP1853255A4 (en) * 2005-02-22 2009-07-08 Gemin X Pharmaceuticals Canada METHODS FOR TREATING ARTHRITIS USING TRIHETEROCYCLIC COMPOUNDS
US7994360B2 (en) 2005-05-16 2011-08-09 Xtl Biopharmaceuticals Ltd. Benzofuran compounds
US20080051400A1 (en) * 2006-07-06 2008-02-28 Gemin X Biotechnologies Inc. Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound
CA2674831A1 (en) 2006-12-22 2008-11-13 Schering Corporation 5,6-ring annulated indole derivatives and methods of use thereof
KR20090094154A (ko) * 2006-12-22 2009-09-03 쉐링 코포레이션 Ｈｃｖ 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
AU2007339386B8 (en) 2006-12-22 2013-12-05 Merck Sharp & Dohme Corp. 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
US9649499B2 (en) 2007-03-28 2017-05-16 Medtronic ATS Medical, Inc. Method for inhibiting platelet interaction with biomaterial surfaces
PE20090630A1 (es) 2007-08-29 2009-05-16 Schering Corp Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion
US8404845B2 (en) 2007-08-29 2013-03-26 Merck Sharp & Dohme Corp. 2,3-substituted azaindole derivatives for treating viral infections
EP2197842B1 (en) 2007-08-29 2012-05-23 Schering Corporation 2, 3-substituted indole derivatives for treating viral infections
CN101130539B (zh) * 2007-09-26 2012-05-30 浙江大学 吲哚取代咪唑啉-2-酮类衍生物及其制备方法和用途
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
MX2010005356A (es) 2007-11-16 2010-05-27 Schering Corp Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
MX2010005355A (es) 2007-11-16 2010-06-02 Schering Corp Derivados de indol sustituidos con 3-aminosulfonilo y metodos de uso de los mismos.
CA2727620A1 (en) 2008-06-13 2009-12-17 Schering Corporation Tricyclic indole derivatives and methods of use thereof
WO2012136851A1 (en) * 2011-04-08 2012-10-11 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for inhibiting influenza viruses replication
US8946445B2 (en) * 2011-10-12 2015-02-03 Nanjing Allgen Pharma Co., Ltd. Heterocyclic molecules as apoptosis inducers
US20150313906A1 (en) * 2012-12-19 2015-11-05 Glaxosmithkline Llc Combination
CN103044311B (zh) * 2012-12-26 2015-04-22 山东大学 一种多取代吲哚类化合物及其制备方法和应用
US20160022708A1 (en) * 2013-03-14 2016-01-28 St. Jude Children's Research Hospital Methods and compositions for the treatment of glutamine-addicted cancers
US9340540B2 (en) 2014-02-28 2016-05-17 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
WO2015171591A1 (en) 2014-05-05 2015-11-12 Board Of Trustees Of The University Of Arkansas COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
WO2016014625A1 (en) 2014-07-22 2016-01-28 Board Of Trustees Of The University Of Arkansas Compositions and methods for selectively depleting senescent cells
WO2016023082A1 (en) 2014-08-12 2016-02-18 Monash University Lymph directing prodrugs
US20160251376A1 (en) 2015-02-27 2016-09-01 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
WO2017021963A1 (en) 2015-08-03 2017-02-09 Biokine Therapeutics Ltd. Cxcr4 binding agents for treatment of diseases
EP4327809A3 (en) 2015-09-02 2024-04-17 Takeda Pharmaceutical Company Limited Tyk2 inhibitors and uses thereof
JP7118888B2 (ja) 2015-09-08 2022-08-16 モナッシュ ユニバーシティ リンパ指向性プロドラッグ
US10683308B2 (en) 2015-09-11 2020-06-16 Navitor Pharmaceuticals, Inc. Rapamycin analogs and uses thereof
US20170087125A1 (en) * 2015-09-30 2017-03-30 Augusta University Research Institute, Inc. Flavonoid compositions for the treatment of cancer
EP4112611A3 (en) 2015-10-23 2023-03-22 Navitor Pharmaceuticals, Inc. Modulators of sestrin-gator2 interaction and uses thereof
US11370792B2 (en) 2015-12-14 2022-06-28 Raze Therapeutics, Inc. Caffeine inhibitors of MTHFD2 and uses thereof
EP4234552A3 (en) 2016-03-09 2023-10-18 Raze Therapeutics, Inc. 3-phosphoglycerate dehydrogenase inhibitors and uses thereof
PL3426243T3 (pl) 2016-03-09 2021-10-04 Raze Therapeutics, Inc. Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania
WO2017157825A1 (en) 2016-03-15 2017-09-21 F. Hoffmann-La Roche Ag Combinations of lsd1 inhibitors for use in the treatment of solid tumors
US11013698B2 (en) 2016-03-15 2021-05-25 Oryzon Genomics S.A. Combinations of LSD1 inhibitors for the treatment of hematological malignancies
WO2017177216A1 (en) * 2016-04-08 2017-10-12 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Prodigiosin analogs
US10870640B2 (en) 2016-04-08 2020-12-22 Institute For Cancer Research Prodigiosin analogs and methods of use
JP2019510785A (ja) 2016-04-08 2019-04-18 エックス４ ファーマシューティカルズ， インコーポレイテッド 癌を処置する方法
WO2017184995A1 (en) 2016-04-21 2017-10-26 Bioventures, Llc Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof
US10988465B2 (en) 2016-06-21 2021-04-27 X4 Pharmaceuticals, Inc. CXCR4 inhibitors and uses thereof
CN116554168A (zh) 2016-06-21 2023-08-08 X4 制药有限公司 Cxcr4抑制剂及其用途
TWI763722B (zh) 2016-10-14 2022-05-11 美商林伯士拉克許米公司 Tyk2抑制劑及其用途
AU2017345736B2 (en) 2016-10-21 2022-04-07 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
EP3538091A4 (en) 2016-11-08 2020-06-10 Navitor Pharmaceuticals, Inc. PHENYL AMINO PIPERIDINE MTORC INHIBITORS AND USES THEREOF
CN110177544A (zh) 2016-11-29 2019-08-27 普尔泰克健康有限公司 用于递送治疗剂的外泌体
US11091451B2 (en) 2016-12-05 2021-08-17 Raze Therapeutics, Inc. SHMT inhibitors and uses thereof
US10624968B2 (en) 2017-01-06 2020-04-21 Bicyclerd Limited Compounds for treating cancer
CA3055209A1 (en) 2017-03-08 2018-09-13 Nimbus Lakshmi, Inc. Tyk2 inhibitors, uses, and methods for production thereof
EP3375778A1 (en) 2017-03-14 2018-09-19 Artax Biopharma Inc. Aryl-piperidine derivatives
EP3375784A1 (en) 2017-03-14 2018-09-19 Artax Biopharma Inc. Aza-dihydro-acridone derivatives
WO2018191146A1 (en) 2017-04-10 2018-10-18 Navitor Pharmaceuticals, Inc. Heteroaryl rheb inhibitors and uses thereof
CN116370448A (zh) 2017-04-26 2023-07-04 纳维托制药有限公司 Sestrin-gator2相互作用的调节剂及其用途
WO2019023468A1 (en) 2017-07-28 2019-01-31 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
US11883497B2 (en) 2017-08-29 2024-01-30 Puretech Lyt, Inc. Lymphatic system-directing lipid prodrugs
WO2019046491A1 (en) 2017-08-29 2019-03-07 Ariya Therapeutics, Inc. LIPIDIC PRODRUGS DIRECTING TO THE LYMPHATIC SYSTEM
US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
IL273432B (en) 2017-09-22 2022-09-01 Kymera Therapeutics Inc Protein compounds and their uses
EP3727362A4 (en) 2017-12-19 2021-10-06 PureTech LYT, Inc. MYCOPHENOLIC ACID LIPID MEDICINAL PRODUCTS AND THEIR USES
US11304954B2 (en) 2017-12-19 2022-04-19 Puretech Lyt, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
US11608345B1 (en) 2017-12-19 2023-03-21 Puretech Lyt, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
AU2018396142A1 (en) 2017-12-26 2020-07-16 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2019140387A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3743069A4 (en) 2018-01-22 2021-06-09 BioVentures, LLC DEGRADER OF BCL-2 PROTEIN FOR CANCER TREATMENT
TWI816742B (zh) 2018-01-29 2023-10-01 美商維泰克斯製藥公司 Gcn2抑制劑及其用途
JP7377207B2 (ja) 2018-01-29 2023-11-09 メルク パテント ゲーエムベーハー Ｇｃｎ２阻害剤およびその使用
KR20200140262A (ko) 2018-02-27 2020-12-15 아텍스 바이오파마 인코포레이티드 Tcr-nck 상호 작용의 억제제로서의 크로멘 유도체
WO2019209759A1 (en) 2018-04-24 2019-10-31 Merck Patent Gmbh Antiproliferation compounds and uses thereof
US11059826B2 (en) 2018-04-24 2021-07-13 Vertex Pharmaceuticals Incorporated Pteridinone compounds and uses thereof
KR20210021534A (ko) 2018-06-15 2021-02-26 나비토르 파마슈티칼스 인코포레이티드 라파마이신 유사체 및 이의 용도
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
EP3817748A4 (en) 2018-07-06 2022-08-24 Kymera Therapeutics, Inc. TRICYCLIC CRBN LIGANDS AND USES THEREOF
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
CN113164419A (zh) 2018-09-07 2021-07-23 皮克医疗公司 Eif4e抑制剂和其用途
AU2019360941A1 (en) 2018-10-15 2021-04-29 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
EP3870158A4 (en) 2018-10-24 2022-08-10 Navitor Pharmaceuticals, Inc. POLYMORPHIC COMPOUNDS AND USES THEREOF
CN113271938A (zh) 2018-11-30 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
JP2022516401A (ja) 2018-11-30 2022-02-28 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
EP3670659A1 (en) 2018-12-20 2020-06-24 Abivax Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
AU2020212001A1 (en) 2019-01-23 2021-07-22 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
WO2020201753A1 (en) 2019-04-02 2020-10-08 Bicycletx Limited Bicycle toxin conjugates and uses thereof
TW202106676A (zh) 2019-04-05 2021-02-16 美商凱麥拉醫療公司 Stat降解劑及其用途
CN114502540A (zh) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 Tead抑制剂和其用途
CN115038688A (zh) 2019-09-11 2022-09-09 文森雷生物科学股份有限公司 Usp30抑制剂及其用途
WO2021050964A1 (en) 2019-09-13 2021-03-18 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
EP4051259A4 (en) 2019-11-01 2023-11-22 Navitor Pharmaceuticals, Inc. TREATMENT METHODS USING AN MTORC1 MODULATOR
US11819476B2 (en) 2019-12-05 2023-11-21 Janssen Pharmaceutica Nv Rapamycin analogs and uses thereof
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
BR112022011651A2 (pt) 2019-12-17 2022-08-23 Kymera Therapeutics Inc Degradadores de irak e usos dos mesmos
MX2022007841A (es) 2019-12-23 2022-07-19 Kymera Therapeutics Inc Degradadores del regulador dependiente de actina asociado a la matriz relacionado con el complejo switch/sacarosa no fermentable de la subfamilia a de la cromatina (smarca)y usos de los mismos.
TW202146393A (zh) 2020-03-03 2021-12-16 美商皮克醫療公司 Eif4e抑制劑及其用途
CA3171258A1 (en) 2020-03-19 2021-09-23 Nan JI Mdm2 degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
BR112023001638A2 (pt) 2020-07-30 2023-02-23 Kymera Therapeutics Inc Métodos de tratamento de linfomas mutantes
CA3186504A1 (en) 2020-08-17 2022-02-24 Stephen J. Blakemore Bicycle conjugates specific for nectin-4 and uses thereof
WO2022120353A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
CN117015531A (zh) 2020-12-02 2023-11-07 医肯纳肿瘤学公司 Tead抑制剂及其用途
EP4008324A1 (en) 2020-12-07 2022-06-08 Cellestia Biotech AG Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer
US20240041884A1 (en) 2020-12-07 2024-02-08 Cellestia Biotech Ag Pharmaceutical Combinations for Treating Cancer
WO2022167457A1 (en) 2021-02-02 2022-08-11 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
WO2022167445A1 (en) 2021-02-02 2022-08-11 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
US11773103B2 (en) 2021-02-15 2023-10-03 Kymera Therapeutics, Inc. IRAK4 degraders and uses thereof
EP4301756A1 (en) 2021-03-05 2024-01-10 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
AU2022258968A1 (en) 2021-04-16 2023-10-19 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023028238A1 (en) 2021-08-25 2023-03-02 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
CA3229560A1 (en) 2021-08-25 2023-03-02 Christopher L. Vandeusen Eif4e inhibitors and uses thereof
WO2023107606A1 (en) 2021-12-09 2023-06-15 University Of Florida Research Foundation, Incorporated Bcl-xl/bcl-2 dual degraders for treatment of cancers
WO2023114984A1 (en) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2023173053A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023173057A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023211889A1 (en) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Polymorphic compounds and uses thereof
WO2023230205A1 (en) 2022-05-25 2023-11-30 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2024028365A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Substituted pyridone gpr84 antagonists and uses thereof
WO2024028364A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Aryl-triazolyl and related gpr84 antagonists and uses thereof
WO2024028363A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Heteroaryl carboxamide and related gpr84 antagonists and uses thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6134403A (ja) 1984-07-26 1986-02-18 Nec Corp 光干渉計
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5338854A (en) 1991-02-13 1994-08-16 Molecular Probes, Inc. Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes
JPH0586374A (ja) 1991-09-26 1993-04-06 Teikoku Sekiyu Kk 炭水化物を可燃性のガスに分解する方法
GB9326284D0 (en) 1993-12-23 1994-02-23 Erba Carlo Spa Pyrrolydenemethyl-derivatives and process for their preparation
JP3357462B2 (ja) 1994-06-21 2002-12-16 協和油化株式会社 立体障害性ニトロキシル化合物の製造方法
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
EP0756200B1 (en) 1995-07-26 1999-11-10 Konica Corporation Silver halide color photographic light-sensitive material
DE69713485T2 (de) 1996-02-01 2003-01-30 Chugai Pharmaceutical Co Ltd Medikamente für die Behandlung oder Vorbeugung von Thrombocytopenie
JP3949198B2 (ja) 1996-10-23 2007-07-25 赤穂化成株式会社 Ｖ−ＡＴＰａｓｅ 脱共役 Ｈ＋ ポンプ阻害剤
JP3949196B2 (ja) 1996-10-23 2007-07-25 赤穂化成株式会社 免疫抑制剤
GB9705035D0 (en) * 1997-03-11 1997-04-30 Pharmacia & Upjohn Spa Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation
US6162520A (en) 1997-09-17 2000-12-19 Mitsui Chemicals, Inc. Optical recording medium and dipyrromethene metal chelate compound for use therein
GB9726130D0 (en) * 1997-12-10 1998-02-11 Pharmacia & Upjohn Spa 2,2'-BI-1H-pyrrole derivatives useful in the treatment of leukemia brought on by HTLV-I
WO1999030709A1 (en) 1997-12-17 1999-06-24 Merck & Co., Inc. Integrin receptor antagonists
HU228492B1 (en) 1998-10-23 2013-03-28 Amgen Inc Methods and compositions for the prevention and treatment of anemia
AU2164300A (en) 1998-12-04 2000-06-26 N.V. Organon Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin
JP2000275435A (ja) 1999-03-25 2000-10-06 Sumitomo Chem Co Ltd 光学異方体フィルムおよび液晶表示装置
JP4085574B2 (ja) 2000-01-06 2008-05-14 東レ株式会社 発光素子
US6407244B1 (en) * 2000-01-26 2002-06-18 Gemin X Biotechnologies Inc. Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
JP2001223081A (ja) 2000-02-08 2001-08-17 Toray Ind Inc 発光素子
JP2001223082A (ja) 2000-02-08 2001-08-17 Toray Ind Inc 発光素子
JP4058881B2 (ja) 2000-04-12 2008-03-12 東レ株式会社 発光素子
JP2001307884A (ja) 2000-04-26 2001-11-02 Toray Ind Inc 発光素子
JP2001330729A (ja) 2000-05-23 2001-11-30 Sumitomo Chem Co Ltd 光学異方体フィルムおよび液晶表示装置
JP2001330730A (ja) 2000-05-23 2001-11-30 Sumitomo Chem Co Ltd 光学異方体フィルムおよび液晶表示装置
US7087224B2 (en) 2000-10-31 2006-08-08 Amgen Inc. Method of treating anemia by administering IL-1ra
US6452014B1 (en) * 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
EP1427722B1 (en) * 2001-07-18 2007-11-14 Gemin X Biotechnologies Inc. Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression
CN1894241A (zh) 2002-08-09 2007-01-10 阿斯利康(瑞典)有限公司 作为代谢型谷氨酸受体－5调节剂的“1,2,4” 噁二唑
US20060035945A1 (en) 2003-05-30 2006-02-16 Giorgio Attardo Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
ZA200509718B (en) 2003-05-30 2007-03-28 Gemin X Biotechnologies Inc Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
WO2005117908A2 (en) 2004-05-28 2005-12-15 Gemin X Biotechnologies, Inc. Triheterocyclic compounds compositions, and methods for treating cancer or viral diseases
EP1853255A4 (en) 2005-02-22 2009-07-08 Gemin X Pharmaceuticals Canada METHODS FOR TREATING ARTHRITIS USING TRIHETEROCYCLIC COMPOUNDS
US20080051400A1 (en) * 2006-07-06 2008-02-28 Gemin X Biotechnologies Inc. Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound

Also Published As

Publication number Publication date
JP4980715B2 (ja) 2012-07-18
NO20056057L (no) 2006-02-28
ZA200509718B (en) 2007-03-28
BRPI0410870A (pt) 2006-07-04
US20080318902A1 (en) 2008-12-25
CN1832939B (zh) 2010-04-28
US7709477B2 (en) 2010-05-04
NO333006B1 (no) 2013-02-18
EP1644363B1 (en) 2012-02-22
IL172189A0 (en) 2011-08-01
NZ543897A (en) 2009-04-30
US20050014802A1 (en) 2005-01-20
DK1644363T3 (da) 2012-05-29
AU2004242928B2 (en) 2011-03-10
PT1644363E (pt) 2012-05-18
CA2527583A1 (en) 2004-12-09
ATE546456T1 (de) 2012-03-15
PL1644363T3 (pl) 2012-07-31
US20080318903A1 (en) 2008-12-25
IL172189A (en) 2014-01-30
ES2382377T3 (es) 2012-06-07
US7425553B2 (en) 2008-09-16
AU2004242928A1 (en) 2004-12-09
US20120004224A1 (en) 2012-01-05
HK1082737A1 (en) 2006-06-16
JP2007502845A (ja) 2007-02-15
US8420638B2 (en) 2013-04-16
CN1832939A (zh) 2006-09-13
CY1113038T1 (el) 2016-04-13
WO2004106328A1 (en) 2004-12-09
KR101168441B1 (ko) 2012-07-25
RU2360913C2 (ru) 2009-07-10
EP1644363A1 (en) 2006-04-12
RU2005141553A (ru) 2006-07-27
SI1644363T1 (sl) 2012-07-31
HRP20120379T1 (hr) 2012-05-31
KR20060036054A (ko) 2006-04-27
CA2527583C (en) 2013-12-17

Similar Documents

Publication Publication Date Title
MXPA05012799A (es) Compuestos triheterociclicos, composiciones y metodos para tratar cancer o enfermedades virales.
GEP20063938B (en) Hepatitis c virus inhibitors
ATE437872T1 (de) Proteinkinaseinhibitoren
GB0413087D0 (en) Therapeutic compounds
WO2001064639A3 (en) Pde iv inhibiting amides, compositions and pharmaceutical use
SG128491A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
GEP20063831B (en) Substituted bicyclic derivatives for treatment of abnormal cell growth
WO2005117908A3 (en) Triheterocyclic compounds compositions, and methods for treating cancer or viral diseases
MY136761A (en) Oxazol derivatives
MX2009009238A (es) Nuevos inhibidores de fosfodiesterasa.
GEP20063751B (en) 2-Acyl Indol Derivatives and Their Use as Anti-Tumour Agents
MXPA04005156A (es) Antagonistas del receptor de adenosina a2a.
DE60305514D1 (de) Neue verwendung von benzothiazolderivaten
SE0301232D0 (sv) Novel use
MXPA02007271A (es) Compuestos de tipo pirrol, composiciones que los contienen, y metodos para el tratamiento de cancer o enfermedades virales.
ATE238981T1 (de) Antitumorwirkstoffe
MXPA04006033A (es) Dicetopiperacinas sustituidas como antagonistas de oxitocina.
MXPA05005790A (es) Aminoalcoxiindoles como ligandos del receptor 5-ht6 para el tratamiento de enfermedades del sistema nervioso central.
DE60031686D1 (de) Pyrazinone, diese verbindungen enthaltende zusammenstellungen
HK1058515A1 (en) Use of pamoic acid for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates.
RS44004A (en) Processes for the preparation of substituted bicyclid derivatives for the treatment of abnormal cell growth
AU2002362008A1 (en) Amine 1,2- and 1,3-diol compounds and their use for treatment of alzheimer's disease
MXPA06001115A (es) Un proceso nuevo para la preparacion de imipenem.
MXPA04000402A (es) Compuestos de tipo pirrol, composiciones que los contienen, y metodos que los emplean para el tratamiento de cancer y enfermedades virales y para causar inmunosupresion.
ATE301997T1 (de) Antivirale therapie

Legal Events

Date Code Title Description
FG Grant or registration