ATE485397T1 - Vorrichtung zur durchführung von pcr unter zeitnaher beobachtung der fluoreszenz - Google Patents

Vorrichtung zur durchführung von pcr unter zeitnaher beobachtung der fluoreszenz

Info

Publication number
ATE485397T1
ATE485397T1 AT06004925T AT06004925T ATE485397T1 AT E485397 T1 ATE485397 T1 AT E485397T1 AT 06004925 T AT06004925 T AT 06004925T AT 06004925 T AT06004925 T AT 06004925T AT E485397 T1 ATE485397 T1 AT E485397T1
Authority
AT
Austria
Prior art keywords
fluorescence
performing pcr
timely monitoring
container
capillary tube
Prior art date
Application number
AT06004925T
Other languages
German (de)
English (en)
Inventor
Carl T Wittwer
Kirk M Ririe
Original Assignee
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24643601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE485397(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found
Application granted granted Critical
Publication of ATE485397T1 publication Critical patent/ATE485397T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Clinical Laboratory Science (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Microscoopes, Condenser (AREA)
  • Control Of Temperature (AREA)
  • Selective Calling Equipment (AREA)
AT06004925T 1996-06-04 1997-06-04 Vorrichtung zur durchführung von pcr unter zeitnaher beobachtung der fluoreszenz ATE485397T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65899396A 1996-06-04 1996-06-04

Publications (1)

Publication Number Publication Date
ATE485397T1 true ATE485397T1 (de) 2010-11-15

Family

ID=24643601

Family Applications (5)

Application Number Title Priority Date Filing Date
AT06004925T ATE485397T1 (de) 1996-06-04 1997-06-04 Vorrichtung zur durchführung von pcr unter zeitnaher beobachtung der fluoreszenz
AT97926890T ATE309388T1 (de) 1996-06-04 1997-06-04 Gerät und verfahren zur fluoreszenzmessung der dna-amplifikation
AT04022352T ATE390491T1 (de) 1996-06-04 1997-06-04 Behälter zum durchführen und beobachten biologischer prozesse
AT03025810T ATE321891T1 (de) 1996-06-04 1997-06-04 Vorrichtung und verfahren zur durchführung und überprüfung von biologischen prozessen
AT97929833T ATE260988T1 (de) 1996-06-04 1997-06-04 Vorrichtung und verfahren zur durchführung und überwachung von polymerase kettenreaktionen

Family Applications After (4)

Application Number Title Priority Date Filing Date
AT97926890T ATE309388T1 (de) 1996-06-04 1997-06-04 Gerät und verfahren zur fluoreszenzmessung der dna-amplifikation
AT04022352T ATE390491T1 (de) 1996-06-04 1997-06-04 Behälter zum durchführen und beobachten biologischer prozesse
AT03025810T ATE321891T1 (de) 1996-06-04 1997-06-04 Vorrichtung und verfahren zur durchführung und überprüfung von biologischen prozessen
AT97929833T ATE260988T1 (de) 1996-06-04 1997-06-04 Vorrichtung und verfahren zur durchführung und überwachung von polymerase kettenreaktionen

Country Status (11)

Country Link
EP (7) EP0912760B1 (enExample)
JP (2) JP4278712B2 (enExample)
AT (5) ATE485397T1 (enExample)
AU (2) AU727296B2 (enExample)
CA (2) CA2256773C (enExample)
DE (5) DE69735563T2 (enExample)
DK (1) DK2298931T3 (enExample)
ES (6) ES2304573T3 (enExample)
NZ (2) NZ333137A (enExample)
PT (1) PT2298931E (enExample)
WO (2) WO1997046707A2 (enExample)

Families Citing this family (244)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2544455T3 (es) * 1997-02-28 2015-08-31 Cepheid Montaje para reacción química con intercambio de calor, ópticamente interrogada
DE19811730A1 (de) * 1998-03-18 1999-09-23 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Identifizieren einer Markierung
EP1614473A3 (en) 1998-05-01 2007-03-14 Gen-Probe Incorporated Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
EP3093649B1 (en) * 1998-05-16 2019-05-08 Life Technologies Corporation A combination of a reaction apparatus and an optical instrument monitoring dna polymerase chain reactions
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
DE19850593A1 (de) * 1998-11-03 2000-05-04 Biochip Technologies Gmbh Verfahren zum Nachweis von Hybridisierungsereignissen bei DNA
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
US6387621B1 (en) 1999-04-27 2002-05-14 University Of Utah Research Foundation Automated analysis of real-time nucleic acid amplification
US7423750B2 (en) 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
ES2367551T3 (es) * 1999-08-13 2011-11-04 Bayer Technology Services Gmbh Dispositivo y procedimiento para la determinación de múltiples analitos.
DE19946296A1 (de) * 1999-09-28 2001-03-29 Roche Diagnostics Gmbh Multiplex-PCR zum Nachweis von EHEC-Infektionen
JP4846152B2 (ja) * 1999-11-12 2011-12-28 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 低発熱光源を有する蛍光測定器
US6691041B2 (en) 2000-03-31 2004-02-10 Roche Molecular Systems, Inc. Method for the efficiency-corrected real-time quantification of nucleic acids
DE10045521A1 (de) * 2000-03-31 2001-10-04 Roche Diagnostics Gmbh Nukleinsäureamplifikationen
US6783934B1 (en) 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
EP2316569A1 (en) * 2000-06-28 2011-05-04 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
US6849407B2 (en) 2000-08-31 2005-02-01 Mayo Foundation For Medical Education And Research Detection of varicella-zoster virus
DE10044373A1 (de) 2000-09-08 2002-03-21 Roche Diagnostics Gmbh Neues Reagenz zur Markierung von Nukleinsäuren
DE60236068D1 (de) 2001-01-31 2010-06-02 Mayo Foundation Nachweis von herpex-simplex-virus
US6830888B2 (en) 2001-05-07 2004-12-14 Mayo Foundation For Medical Education And Research Detection of Legionella
US7226732B2 (en) * 2001-07-16 2007-06-05 Cepheid Methods, apparatus, and computer programs for verifying the integrity of a probe
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7373253B2 (en) 2002-02-12 2008-05-13 Idaho Technology Multi-test analysis of real-time nucleic acid amplification
US6593093B1 (en) 2002-02-20 2003-07-15 Mayo Foundation For Medical Education And Research Detection of group a Streptococcus
US7785776B2 (en) 2002-05-13 2010-08-31 Idaho Technology, Inc. Genotyping by amplicon melting curve analysis
AU2003245302A1 (en) 2002-05-17 2003-12-02 Applera Corporation Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
AUPS267802A0 (en) * 2002-05-30 2002-06-20 Bio-Molecular Holdings Pty Limited Improved dna amplification apparatus and method
CA2433473A1 (en) * 2002-07-23 2004-01-23 F. Hoffmann-La Roche Ag Fluorescent hybridization probes with reduced background
US7074598B2 (en) 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7074599B2 (en) 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
EP2527468B1 (en) 2002-10-23 2014-10-01 University of Utah Research Foundation Amplicon melting analysis with saturation dyes
US9850381B2 (en) * 2002-10-23 2017-12-26 University Of Utah Research Foundation Amplicon melting analysis with saturation dyes
EP1564300A4 (en) * 2002-11-13 2007-09-05 Hitachi High Tech Corp PROCESS FOR NUCLEIC ACID AMPLIFICATION AND DEVICE THEREFOR
EP1570079B1 (en) 2002-12-06 2010-07-21 Roche Diagnostics GmbH Multiplex assay detection of pathogenic organisms
US7718361B2 (en) 2002-12-06 2010-05-18 Roche Molecular Systems, Inc. Quantitative test for bacterial pathogens
GB2399776A (en) * 2003-03-24 2004-09-29 Pa Knowledge Ltd Cyclical heating and cooling device and associated methods
EP2284278A1 (en) 2003-04-04 2011-02-16 Roche Diagnostics GmbH Improved system for multi color real time PCR
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
US7788039B2 (en) 2003-09-25 2010-08-31 Roche Molecular Systems, Inc. Quantitation of nucleic acids using growth curves
CA2494571C (en) 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
EP1709200B1 (en) 2003-12-03 2012-05-09 Abbott Laboratories Double stranded linear nucleic acid probe and uses thereof
US8304192B2 (en) 2004-03-05 2012-11-06 University Of Toledo Methods and compositions for assessing nucleic acids and alleles
JP2005295877A (ja) * 2004-04-09 2005-10-27 Taiyo Yuden Co Ltd 核酸分析方法、分析装置及び分析用ディスク
CA2568238C (en) 2004-04-12 2013-10-15 Medical College Of Ohio Methods and compositions for assaying analytes
US9657347B2 (en) 2004-04-20 2017-05-23 University of Utah Research Foundation and BioFire Defense, LLC Nucleic acid melting analysis with saturation dyes
US7727480B2 (en) 2004-08-05 2010-06-01 Universal Bio Research Co., Ltd. Reaction vessel, reaction vessel liquid introducing device, liquid introducing and reaction measuring device, and liquid introducing device
EP1627921B1 (de) * 2004-08-18 2008-08-27 Roche Diagnostics GmbH Verfahren zur Messung einer Nukleinsäureamplifikation in Real Time beinhaltend die Positionierung eines Reaktionsgefässes relativ zu einer Detektionseinheit
GB0419325D0 (en) * 2004-09-01 2004-09-29 Perkinelmer Ltd A method of analysing a sample including fluorescent labels and apparatus therefor
EP1634965B1 (en) 2004-09-09 2010-01-20 Roche Diagnostics GmbH Real time PCR with the addition of pyrophosphatase
DE102004043909A1 (de) * 2004-09-10 2006-03-30 Kendro Laboratory Products Gmbh Erwärmungsvorrichtung für Proben auf dem Gebiet der Life-Science
US8445265B2 (en) 2004-10-06 2013-05-21 Universal Bio Research Co., Ltd. Reaction vessel and reaction controller
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
ES2284087T3 (es) 2005-01-18 2007-11-01 F. Hoffmann-La Roche Ag Generacion de imagenes de señales de fluorescencia mediante opticas telecentricas de excitacion y de generacion de imagenes.
ES2285578T3 (es) 2005-01-18 2007-11-16 F. Hoffmann-La Roche Ag Visualizacion de señales de fluorescencia utilizando telecentricidad.
US7759469B2 (en) 2005-03-10 2010-07-20 Roche Diagnostics Operations, Inc. Labeling reagent
EP1700922B1 (en) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituted 5-Nitroindole derivatives and labeled oligonucleotide probes containing them
US8008066B2 (en) * 2005-03-10 2011-08-30 Gen-Probe Incorporated System for performing multi-formatted assays
EP1921454B1 (en) * 2005-03-10 2015-08-12 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes
US7680604B2 (en) 2005-03-11 2010-03-16 Roche Molecular Systems, Inc. PCR elbow determination by rotational transform after zero slope alignment
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US20070048877A1 (en) * 2005-08-26 2007-03-01 Karl Skold Method and device for preparing a biological sample for biological analyses
US9017964B2 (en) 2005-08-26 2015-04-28 Denator Aktiebolag Preparing biological samples for analysis
US7569367B2 (en) 2005-09-07 2009-08-04 Roche Diagnostics Operations, Inc. Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy
US7991561B2 (en) 2005-09-29 2011-08-02 Roche Molecular Systems, Inc. Ct determination by cluster analysis with variable cluster endpoint
US7991558B2 (en) 2005-09-29 2011-08-02 Roche Molecular Systems, Inc. Systems and methods for determining real-time PCR cycle thresholds using cluster analysis
US7781165B2 (en) 2005-10-19 2010-08-24 Roche Diagnostics Operations, Inc. Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification
US7875425B2 (en) 2005-11-09 2011-01-25 Applied Biosystems, Llc Methods for monitoring polymerase chain reactions
GB0522972D0 (en) * 2005-11-11 2005-12-21 Integrated Design Ltd Thermal cycler
ES2332139T3 (es) 2005-11-23 2010-01-27 F. Hoffmann-La Roche Ag Polinucleotidos con mimetico de fosfato.
US7844403B2 (en) 2005-12-20 2010-11-30 Roche Molecular Systems, Inc. Temperature step correction with double sigmoid Levenberg-Marquardt and robust linear regression
US7668663B2 (en) 2005-12-20 2010-02-23 Roche Molecular Systems, Inc. Levenberg-Marquardt outlier spike removal method
US7680868B2 (en) 2005-12-20 2010-03-16 Roche Molecular Systems, Inc. PCR elbow determination by use of a double sigmoid function curve fit with the Levenburg-Marquardt algorithm and normalization
US7991562B2 (en) 2005-12-20 2011-08-02 Roche Molecular Systems, Inc. PCR elbow determination using curvature analysis of a double sigmoid
US7981606B2 (en) 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
CN101421417B (zh) 2006-02-27 2013-04-03 霍夫曼-拉罗奇有限公司 经由镁螯合的pcr热启动
CA2648195A1 (en) 2006-04-04 2007-10-11 Labonnet Ltd. Assessment of reaction kinetics compatibility between polymerase chain reactions
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US8119352B2 (en) 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8535888B2 (en) 2006-12-29 2013-09-17 Mayo Foundation For Medical Education And Research Compositions and methods for detecting methicillin-resistant S. aureus
EP1956097A1 (en) 2007-02-06 2008-08-13 bioMerieux B.V. Method for discriminating single nucleotide polymorphisms (SNPs)
WO2008102772A1 (ja) * 2007-02-22 2008-08-28 Toyo Boseki Kabushiki Kaisha 核酸増幅装置
JP4458133B2 (ja) * 2007-02-27 2010-04-28 ソニー株式会社 核酸増幅装置
US9475051B2 (en) 2007-02-27 2016-10-25 Sony Corporation Nucleic acid amplifier
JP5191041B2 (ja) 2007-04-05 2013-04-24 エフ．ホフマン−ラ ロシュ アーゲー 急速ワンステップｒｔ−ｐｃｒ
US8418929B2 (en) 2007-04-06 2013-04-16 Universal Bio Research Co., Ltd. Temperature controlling apparatus and temperature controlling method
WO2008136318A1 (ja) * 2007-04-26 2008-11-13 Toyo Boseki Kabushiki Kaisha 核酸増幅方法およびそれに用いる容器
EP2182049A1 (en) 2007-05-23 2010-05-05 Trust Medical Co., Ltd. Container for liquid reaction mixture, reaction-promoting device using the same and method therefor
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US8386184B2 (en) 2007-08-28 2013-02-26 Becton, Dickinson And Company Systems and methods for determining an amount of starting reagent using the polymerase chain reaction
DE102007041864B4 (de) 2007-09-04 2012-05-03 Sirs-Lab Gmbh Verfahren zum Nachweis von Bakterien und Pilzen
US20090119020A1 (en) 2007-09-25 2009-05-07 Roche Molecular Systems, Inc. Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid
CN101809170B (zh) 2007-09-28 2014-08-20 3M创新有限公司 用于检测核酸的双寡核苷酸方法
KR101844172B1 (ko) 2007-10-02 2018-03-30 테라노스, 인코포레이티드 모듈러 현장 진료 장치 및 이의 용도
JP5178149B2 (ja) * 2007-10-31 2013-04-10 キヤノン株式会社 標的核酸のリアルタイムｐｃｒ方法及びその装置
DE102007063102B4 (de) 2007-12-28 2022-02-10 Robert Bosch Gmbh Verfahren zur Erfassung eines periodisch pulsierenden Betriebsparameters
WO2009092564A2 (en) * 2008-01-23 2009-07-30 Roche Diagnostics Gmbh Integrated instrument performing synthesis and amplification
JP2011510675A (ja) * 2008-02-07 2011-04-07 フォレンシック サイエンシーズ サーヴィス リミテッド 分析の及び分析に関する改善
WO2009100215A2 (en) 2008-02-08 2009-08-13 Mayo Foundation For Medical Education And Research Detection of clostridium difficile
DE102008010436A1 (de) * 2008-02-21 2009-09-03 Berthold Technologies Gmbh & Co. Kg Vorrichtung und Verfahren zur Messung von Lumineszenz und Fluoreszenz von transfizierten Zellen oder Organteilen
JP2009201444A (ja) * 2008-02-29 2009-09-10 Hitachi High-Technologies Corp 核酸分析装置
CA2658520C (en) 2008-03-19 2016-11-08 F. Hoffmann-La Roche Ag Nucleic acid amplification in the presence of modified randomers
GB0806676D0 (en) 2008-04-12 2008-05-14 Environment Agency The Environmental monitoring
EP2130929B1 (en) 2008-06-06 2013-10-09 F. Hoffmann-La Roche AG Internally controlled multiplex detection and quantification of microbial nucleic acids
EP2138588A1 (en) 2008-06-23 2009-12-30 Koninklijke Philips Electronics N.V. Melting curve measurement during amplification
US8097412B2 (en) 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
EP2148187A1 (de) 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
CA2638458A1 (en) 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
WO2010012464A1 (en) 2008-08-01 2010-02-04 Roche Diagnostics Gmbh Improved lysis and reverse transcription for mrna quantification
US7910720B2 (en) 2008-09-09 2011-03-22 Roche Diagnostics Operations, Inc. Polyanion for improved nucleic acid amplification
US8219324B2 (en) 2008-09-12 2012-07-10 Roche Molecular Systems, Inc. Real-time PCR elbow calling by equation-less algorithm
CA2682439A1 (en) 2008-10-17 2010-04-17 F. Hoffmann-La Roche Ag Cell monitoring and molecular analysis
US8346485B2 (en) 2008-11-25 2013-01-01 Quest Diagnostics Investments Incorporated Methods and apparatuses for estimating initial target nucleic acid concentration in a sample by modeling background signal and cycle-dependent amplification efficiency of a polymerase chain reaction
CA2688174C (en) 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
KR101423936B1 (ko) * 2009-03-11 2014-07-29 (주)바이오니아 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법
CN102439130A (zh) * 2009-03-31 2012-05-02 财团法人神奈川科学技术研究院 液体回流型高速基因扩增装置
WO2010146339A1 (en) 2009-06-15 2010-12-23 Bg Research Ltd Nucleic acid detection
US8219366B2 (en) 2009-08-26 2012-07-10 Roche Molecular Sytems, Inc. Determination of elbow values for PCR for parabolic shaped curves
US10288632B2 (en) * 2009-09-21 2019-05-14 Pocared Diagnostics Ltd. System for conducting the identification of bacteria in biological samples
FI20096021A0 (fi) 2009-10-06 2009-10-06 Wallac Oy Optinen mittausinstrumentti
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US20110250598A1 (en) 2010-04-12 2011-10-13 Ulrike Fischer Detergent free polymerases
CN103675303B (zh) 2010-07-23 2016-02-03 贝克曼考尔特公司 传感器系统
CN103069007A (zh) 2010-07-29 2013-04-24 霍夫曼-拉罗奇有限公司 微生物核酸的定性和定量检测
CN103154269A (zh) 2010-07-29 2013-06-12 霍夫曼-拉罗奇有限公司 用于多种参数的对照核酸
ES2644797T3 (es) 2010-07-29 2017-11-30 F. Hoffmann-La Roche Ag PCR genérica
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
ES2617258T5 (es) 2010-07-29 2023-11-15 Hoffmann La Roche Preparación de muestras genéricas
CA2810317A1 (en) 2010-10-04 2012-04-12 F. Hoffmann-La Roche Ag Method for cell lysis in a pcr reaction buffer
CA2810291C (en) 2010-10-04 2016-09-27 F. Hoffmann-La Roche Ag Method for cell lysis and amplification of rna in a rt-pcr reaction buffer
CA2810316A1 (en) 2010-10-04 2012-04-12 F. Hoffmann-La Roche Ag Method for cell lysis and pcr within the same reaction vessel
CN103237880B (zh) 2010-10-15 2016-08-03 环球生物研究株式会社 利用多功能分注单元的核酸自动处理装置及其方法
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
EP2465945A1 (en) 2010-12-17 2012-06-20 F. Hoffmann-La Roche AG Generic matrix for control nucleic acids
CN106323876B (zh) 2011-01-21 2020-02-14 西拉诺斯知识产权有限责任公司 样品使用最大化的系统和方法
USD684273S1 (en) 2011-02-22 2013-06-11 Universal Bio Research Co., Ltd. Reaction vessel for amplifying nucleic acid
AU2012222178B2 (en) 2011-02-24 2014-12-18 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
KR102110174B1 (ko) 2011-05-18 2020-05-14 디아소린 에스.피.에이. 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
CN105170203B (zh) 2011-05-18 2017-07-18 3M创新有限公司 检测选定体积的材料在样本处理装置中存在的系统和方法
US9067205B2 (en) 2011-05-18 2015-06-30 3M Innovative Properties Company Systems and methods for valving on a sample processing device
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
SG11201401913YA (en) 2011-09-30 2014-09-26 Life Technologies Corp Systems and methods for biological analysis
US9506943B2 (en) 2011-11-07 2016-11-29 Beckman Coulter, Inc. Aliquotter system and workflow
JP6062449B2 (ja) 2011-11-07 2017-01-18 ベックマン コールター， インコーポレイテッド 標本コンテナ検出
WO2013070748A1 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Magnetic damping for specimen transport system
CN104040352B (zh) 2011-11-07 2016-09-07 贝克曼考尔特公司 机械臂
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
KR20140092378A (ko) 2011-11-07 2014-07-23 베크만 컬터, 인코포레이티드 샘플을 처리하기 위한 시스템 및 방법
US9932633B2 (en) 2012-03-21 2018-04-03 Roche Molecular Systems, Inc. Methods for assessing RNA quality
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
DE102012108158B4 (de) 2012-09-03 2016-03-17 Johann Wolfgang Goethe-Universität Kapillarzelle, Anordnung und Verfahren zur Aufnahme, zur Positionierung und zur Untersuchung einer mikroskopischen Probe
US10176293B2 (en) 2012-10-02 2019-01-08 Roche Molecular Systems, Inc. Universal method to determine real-time PCR cycle threshold values
EP2722399A1 (en) 2012-10-18 2014-04-23 Roche Diagniostics GmbH Method for preventing high molecular weight products during amplification
WO2014113785A1 (en) * 2013-01-18 2014-07-24 Biomeme Incorporated Analytic device
US10399057B2 (en) 2013-02-05 2019-09-03 Phc Holdings Corporation Analysis device, genetic analysis method, analysis receptacle, and control method for fuzzy control
AU2013202788B2 (en) * 2013-03-14 2015-10-01 Gen-Probe Incorporated Indexing signal detection module
US10626440B2 (en) 2013-05-21 2020-04-21 Universal Bio Research Co., Ltd. Sequencer pretreatment device and method thereof
US10072288B2 (en) 2013-11-11 2018-09-11 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using overlapped primer and melting probe
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
FR3035411A1 (fr) * 2015-04-23 2016-10-28 Morpho Procede d'amplification d'acide nucleique a des fins d'analyse, machine d'amplification correspondante et cartouche pour cette machine
US11266730B2 (en) 2015-09-29 2022-03-08 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for BCG therapy
US10391498B2 (en) 2015-12-11 2019-08-27 Spartan Bioscience Inc. Systems and methods for nucleic acid amplification
JP6962927B2 (ja) 2016-03-11 2021-11-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ジカウイルス検出用組成物および方法
EP3458597B1 (en) 2016-05-18 2022-09-07 Roche Diagnostics GmbH Quantitative real time pcr amplification using an electrowetting-based device
ES2874259T3 (es) 2016-05-27 2021-11-04 Roche Diagnostics Gmbh Composiciones y procedimientos para la detección de Trichomonas vaginalis
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
US20170356025A1 (en) 2016-06-14 2017-12-14 Roche Molecular Systems, Inc. Internal control probes for improving pcr assay performance
MX2019001186A (es) 2016-07-29 2019-08-29 Juno Therapeutics Inc Metodos para evaluar la presencia o la ausencia de un virus capaz de replicacion.
EP3494227B1 (en) 2016-08-02 2024-12-11 Roche Diagnostics GmbH Helper oligonucleotide for improving efficiency of amplification and detection/quantitation of nucleic acids
CN107964507B (zh) * 2016-10-18 2022-09-27 财团法人工业技术研究院 热对流聚合酶连锁反应装置及其光学检测方法
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
RU2018134774A (ru) 2016-12-28 2021-01-29 КАБУСИКИ КАЙСЯ Мираи Дженомикс Устройство для анализа
US10793901B2 (en) 2016-12-28 2020-10-06 Roche Molecular Systems, Inc. Reversibly protected nucleotide reagents with high thermal stability
US20180363044A1 (en) 2017-06-14 2018-12-20 Roche Molecular Systems, Inc. Compositions and methods for improving the thermal stability of nucleic acid amplification reagents
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
EP3682024A4 (en) 2017-09-15 2021-05-12 Biomeme, Inc. METHODS AND SYSTEMS FOR AUTOMATIC SAMPLE PROCESSING
WO2019063661A1 (en) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS
US11078534B2 (en) 2017-11-27 2021-08-03 Roche Molecular Systems, Inc. Photocleavable nucleotide reagents with high stability
CN111712581A (zh) 2017-12-15 2020-09-25 生米公司 用于分析样品的便携式装置和方法
US11535903B2 (en) 2018-01-31 2022-12-27 Juno Therapeutics, Inc. Methods and reagents for assessing the presence or absence of replication competent virus
WO2019155488A1 (en) * 2018-02-07 2019-08-15 Jaydeep Bhattacharya A low cost microfluidic device for dna/rna isolation, purification and amplification using chip based pcr/ rt- pcr for biosensing applications
US20190292596A1 (en) 2018-03-21 2019-09-26 Roche Molecular Systems, Inc. Modified nucleoside phosphates with high thermal stability
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
EP3835790A4 (en) 2018-08-10 2022-04-27 Kabushiki Kaisha Mirai Genomics ANALYSIS DEVICE
WO2020114998A1 (en) 2018-12-03 2020-06-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of candida auris
JP7483745B2 (ja) 2019-03-21 2024-05-15 バイオミーム インコーポレイテッド 多機能性分析デバイス
CN116786186A (zh) * 2019-05-01 2023-09-22 卢米耐克斯公司 用于热循环的装置以及样品模块
CN113785073A (zh) 2019-05-02 2021-12-10 豪夫迈·罗氏有限公司 基于链分离温度利用dITP进行RNA靶标相比于DNA靶标的优先性/选择性扩增
US12385101B2 (en) 2019-05-07 2025-08-12 Roche Molecular Systems, Inc. Compositions and methods for detection of neisseria gonorroheae
WO2021013972A1 (en) 2019-07-25 2021-01-28 F. Hoffmann-La Roche Ag Compositions and methods for detection of epstein barr virus (ebv)
WO2021037399A1 (en) 2019-08-27 2021-03-04 F. Hoffmann-La Roche Ag Compositions and methods for amplification and detection of hepatitis b virus rna, including hbv rna transcribed from cccdna
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
EP4073175A1 (en) 2019-12-09 2022-10-19 F. Hoffmann-La Roche AG Dicationic fluorescent dyes
ES2991814T3 (es) 2019-12-27 2024-12-05 Hoffmann La Roche Composiciones y procedimientos para detectar Staphylococcus aureus resistente a la meticilina
CN116171333A (zh) 2020-03-09 2023-05-26 豪夫迈·罗氏有限公司 用于检测严重急性呼吸综合征冠状病毒2(sars-cov-2)、甲型流感和乙型流感的组合物和方法
JP2023545631A (ja) 2020-09-18 2023-10-31 バイオミーム，インコーポレイテッド 試料を分析するための運搬可能デバイスおよび方法
WO2022117784A1 (en) 2020-12-04 2022-06-09 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
JP7209980B2 (ja) 2020-12-11 2023-01-23 東洋紡株式会社 Ｄｎａポリメラーゼの５’→３’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体
JP2022099005A (ja) 2020-12-22 2022-07-04 船井電機株式会社 マイクロ流体デバイスおよび核酸増幅方法
US20220205020A1 (en) 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
JP2024505686A (ja) 2021-02-05 2024-02-07 エフ． ホフマン－ラ ロシュ アーゲー ヒトパラインフルエンザウイルス１－４（ｈｐｉｖ１－４）の検出のための組成物及び方法
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
EP4308296A2 (en) 2021-03-19 2024-01-24 BG Research Ltd An apparatus and associated methods for thermal cycling
US20240240273A1 (en) 2021-05-06 2024-07-18 Roche Molecular Systems, Inc. Compositions and Methods for Detecting Hepatitis Delta Virus by a Dual-Target Assay
CN113355230B (zh) * 2021-07-06 2023-11-24 宁波胤瑞生物医学仪器有限责任公司 芯片锁紧装置
CN117836428A (zh) * 2021-07-08 2024-04-05 安盛生科股份有限公司 进行定量聚合酶链反应的系统及方法
DE202022002981U1 (de) 2021-09-23 2024-05-08 N6 Tec, Inc. Systeme zur Probenanalyse
WO2023079032A1 (en) 2021-11-05 2023-05-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
US20250011882A1 (en) 2021-11-22 2025-01-09 Roche Molecular Systems, Inc. Compositions and Methods for Detecting vanA and/or vanB Genes Associated with Multidrug Resistance
EP4441252A1 (en) 2021-12-03 2024-10-09 Medicinal Genomics Corporation Psilocybe assay
EP4547873A1 (en) 2022-06-30 2025-05-07 F. Hoffmann-La Roche AG Compositions and methods for detecting lymphogranuloma venereum (lgv) serovars of chlamydia trachomatis
WO2024042042A1 (en) 2022-08-24 2024-02-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting monkeypox virus
AU2023343062A1 (en) 2022-09-13 2025-04-03 Medicinal Genomics Corporation Psilocybe assay
CN115555060B (zh) * 2022-09-22 2024-11-05 冰山松洋生物科技(大连)有限公司 一种环境试验箱
WO2024141442A1 (en) 2022-12-25 2024-07-04 F. Hoffmann-La Roche Ag Compositions and methods for detecting carbapenem resistant acinetobacter calcoaceticus-baumannii (crab)
EP4669777A1 (en) 2023-02-25 2025-12-31 F. Hoffmann-La Roche AG COMPOSITIONS AND METHODS FOR DETECTION OF CANDIDA SPECIES
CN120917150A (zh) 2023-03-03 2025-11-07 豪夫迈·罗氏有限公司 用于检测b族链球菌（无乳链球菌）和克林霉素抗性基因决定子的组合物和方法
WO2024235904A1 (en) 2023-05-16 2024-11-21 Roche Molecular Systems, Inc. Detection of target analytes using multimodal signal probes
WO2025027080A1 (en) 2023-08-03 2025-02-06 F. Hoffmann-La Roche Ag Use of 5'-tailed long primers to improve amplification performance when targeting short primer-binding sites
WO2025202488A1 (en) 2024-03-28 2025-10-02 Roche Diagnostics Gmbh Enhancer of nucleic acid amplification
WO2025257247A1 (en) 2024-06-12 2025-12-18 Roche Diagnostics International Ag Automated pcr analyzer

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3219416A (en) * 1962-10-30 1965-11-23 Scientific Industries Apparatus for the automatic chemical sequential treatment and analysis of small quantities of material
US3556659A (en) * 1966-02-03 1971-01-19 Applied Physics Corp Laser-excited raman spectrometer
US3616264A (en) 1969-06-30 1971-10-26 Beckman Instruments Inc Temperature-controlled discrete sample analyzer
US3718133A (en) * 1971-01-12 1973-02-27 Damon Corp Container unit for liquid samples
CH587486A5 (enExample) * 1974-11-29 1977-05-13 Hoffmann La Roche
AU528259B2 (en) * 1978-09-14 1983-04-21 Union Carbide Corp Method and apparatus for assaying liquid materials
IT1101295B (it) 1978-11-22 1985-09-28 Erba Strumentazione Camera gas-cromatografica
US4420679A (en) 1982-02-26 1983-12-13 Delta Associates, Inc. Gas chromatographic oven using symmetrical flow of preheated - premixed ambient air
JPS60241884A (ja) * 1984-05-15 1985-11-30 Tokyo Daigaku 自動サイクリング反応装置およびこれを用いる自動分析装置
US4762413A (en) * 1984-09-07 1988-08-09 Olympus Optical Co., Ltd. Method and apparatus for measuring immunological reaction with the aid of fluctuation in intensity of scattered light
US4740472A (en) * 1985-08-05 1988-04-26 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
EP0404258B1 (en) * 1989-06-20 1994-09-28 Claudio Bonini Test-tube with lenticular outside surface particularly for automatized clinical analysis
US5449621A (en) * 1989-07-31 1995-09-12 Biotope, Inc. Method for measuring specific binding assays
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
WO1992020778A1 (en) * 1991-05-24 1992-11-26 Kindconi Pty Limited Biochemical reaction control
US5340715A (en) * 1991-06-07 1994-08-23 Ciba Corning Diagnostics Corp. Multiple surface evanescent wave sensor with a reference
DE4234086A1 (de) † 1992-02-05 1993-08-12 Diagen Inst Molekularbio Verfahren zur bestimmung von in vitro amplifizierten nukleinsaeuresequenzen
DE69207580T2 (de) * 1992-03-23 1996-08-08 Hoffmann La Roche Verfahren zum DNS-Nachweis
ES2168275T3 (es) * 1992-04-06 2002-06-16 Abbott Lab Metodo y dispositivo de deteccion de acido nucleico o de analito por medio de una tecnica de reflexion interna total.
JPH0634546A (ja) * 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
WO1994021780A1 (en) * 1993-03-18 1994-09-29 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture Apparatus for the quantitative determination of particulate analytes
AU704947B2 (en) * 1993-05-18 1999-05-06 University Of Utah Research Foundation Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
JP3598123B2 (ja) * 1993-07-15 2004-12-08 浜松ホトニクス株式会社 核酸の変性検出装置
ATE208658T1 (de) * 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
DK1921169T3 (da) * 1993-11-12 2012-06-04 Phri Properties Inc Hybridiseringssonder til nukleinsyredetektion, universelle stamceller, fremgangsmåder og kits
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
AU699986B2 (en) * 1994-02-01 1998-12-17 Igene Inc. Molecular analyzer and method of use
CA2143365A1 (en) * 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
WO1995030139A1 (en) * 1994-04-29 1995-11-09 Perkin-Elmer Corporation System for real time detection of nucleic acid amplification products
EP0763133B1 (en) * 1994-05-23 2001-08-01 Biotronics Corporation Method for detecting a target nucleic acid
US5622821A (en) * 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
DE69527125T2 (de) * 1994-11-09 2003-02-27 Hitachi, Ltd. Verfahren und Vorrichtung zur DNS Analyse
US5800996A (en) * 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence

Also Published As

Publication number Publication date
DE69727932D1 (de) 2004-04-08
EP1493826B1 (en) 2008-03-26
EP1442794B1 (en) 2006-03-29
DE69735563T2 (de) 2007-05-16
JP4278712B2 (ja) 2009-06-17
EP1704922A3 (en) 2007-12-12
WO1997046712A2 (en) 1997-12-11
ES2354902T3 (es) 2011-03-21
EP1442794A2 (en) 2004-08-04
WO1997046712A3 (en) 1998-05-07
EP0906449A2 (en) 1999-04-07
ES2304573T3 (es) 2008-10-16
ATE390491T1 (de) 2008-04-15
JP2000512138A (ja) 2000-09-19
PT2298931E (pt) 2013-11-11
EP1704922A2 (en) 2006-09-27
EP0912760A2 (en) 1999-05-06
EP2298931A9 (en) 2011-06-01
AU727296B2 (en) 2000-12-07
DE69740030D1 (de) 2010-12-02
EP1674585B1 (en) 2010-10-20
CA2256612A1 (en) 1997-12-11
AU729644B2 (en) 2001-02-08
ES2253778T3 (es) 2006-06-01
EP2298931B2 (en) 2020-06-24
WO1997046707A2 (en) 1997-12-11
DE69738605D1 (de) 2008-05-08
DE69727932T2 (de) 2005-03-10
ES2260562T3 (es) 2006-11-01
EP2298931B1 (en) 2013-08-07
CA2256773C (en) 2010-01-26
DE69738605T2 (de) 2009-04-30
EP2298931A1 (en) 2011-03-23
CA2256612C (en) 2012-09-25
CA2256773A1 (en) 1997-12-11
ES2215230T3 (es) 2004-10-01
EP1493826A1 (en) 2005-01-05
AU3380097A (en) 1998-01-05
EP1442794A3 (en) 2005-05-11
EP0912760B1 (en) 2005-11-09
ATE309388T1 (de) 2005-11-15
AU3154797A (en) 1998-01-05
EP0906449B1 (en) 2004-03-03
ATE321891T1 (de) 2006-04-15
DK2298931T3 (da) 2013-11-11
DE69734587T2 (de) 2006-07-20
DE69734587D1 (de) 2005-12-15
ES2434258T3 (es) 2013-12-16
EP1674585A1 (en) 2006-06-28
JP2000511435A (ja) 2000-09-05
ATE260988T1 (de) 2004-03-15
JP4281877B2 (ja) 2009-06-17
NZ333137A (en) 2000-03-27
WO1997046707A3 (en) 1998-10-08
NZ333135A (en) 2000-02-28
DE69735563D1 (de) 2006-05-18

Similar Documents

Publication Publication Date Title
ATE485397T1 (de) Vorrichtung zur durchführung von pcr unter zeitnaher beobachtung der fluoreszenz
DE19882221T1 (de) Verfahren und Vorrichtung zum automatischen Impfen von Kulturmedien mit bakteriellen Proben aus klinischen Probenbehältern
CA2442176A1 (en) Penetrable cap
ATE283346T1 (de) Gefäss zur trocknung von biologischer proben, verfahren zur herstellung desselben und verfahren zu seinem gebrauch
ATE71724T1 (de) Vorrichtung zur harnuntersuchung.
AR012351A1 (es) Un metodo y dispositivos para dividir muestras biologicas liquidas en microvolumenes
EP0977039A3 (en) Handling method of body fluid sample and analysis apparatus using the same
ATE245489T1 (de) Vorrichtung zur aufnahme und abgabe von flüssigkeitsproben
EP1074302A3 (en) Multichannel pipette system and pipette tips therefor
ATE250455T1 (de) Vorrichtung zum analysieren einer probe
DE69607476D1 (de) System zur blutanalyse, mit mitteln zur aufbewahrung und zum transport des blutes, sowie zur selbsttätigen herstellung von blutauftragsproben
DE50113911D1 (de) Biochip zur archivierung und labormedizinischen analyse von biologischem probenmaterial
ES2072399T3 (es) Aparato para toma y ensayo de muestras de fluidos.
ATE157395T1 (de) Vorrichtung zur konservierung und nachweis von proben, insbesondere zum nachweis van bakterien
EP2172269B1 (en) Forensic pipette for wetting and handling sample carriers on the basis of a micro litre pipette tip
DE59906125D1 (de) Vorrichtung zur durchführung biochemischer und mikrobiologischer reaktionen
DE69710063D1 (de) Probenrörchen zur biologischen analyse organischer flüssigkeiten unter verwendung elektro-optischen geräts
EP1607742A4 (en) LATEX REACTIONS FOR ADIPONECTIN ANALYSIS AND METHOD FOR ADIPONECTIN ANALYSIS
IT1216083B (it) Dispositivo perfezionato perl'esecuzione di esami microbiologici colturali.
ATE259426T1 (de) Methode zur trennung von nukleinsäuren in populationen
EP1188483A3 (en) Container for holding biological liquids for analysis
WO2003061831A3 (de) Probennahmevorrichtung und verfahren zur simultanen, quantifizierbaren bestimmung von infektologisch relevanten keimen
DE69503041D1 (de) Prüfröhrchen und gerät zur durchführung von immunohämatologischen analyse von blut und anderen biologischen flüssigkeiten
US20250258164A1 (en) Detection kit for detecting biomolecules in a reaction tube by means of integration of molecular biological amplification of nucleic acid and detection thereof by means of lateral flow detection
EP0731179A3 (en) Method for performing a laboratory test for the in vitro integrity of blood cells without fixation and / or permeabilization by DNA and general nucleic acid labeling and by flow cytometry reading

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties