ATE448482T1 - Vorrichtungen auf impedanzbasis sowie verfahren zur verwendung in assays - Google Patents

Vorrichtungen auf impedanzbasis sowie verfahren zur verwendung in assays

Info

Publication number
ATE448482T1
ATE448482T1 AT03748948T AT03748948T ATE448482T1 AT E448482 T1 ATE448482 T1 AT E448482T1 AT 03748948 T AT03748948 T AT 03748948T AT 03748948 T AT03748948 T AT 03748948T AT E448482 T1 ATE448482 T1 AT E448482T1
Authority
AT
Austria
Prior art keywords
electrodes
impedance
cells
assay
methods
Prior art date
Application number
AT03748948T
Other languages
English (en)
Inventor
Xiaobo Wang
Xiao Xu
Original Assignee
Acea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acea Biosciences Inc filed Critical Acea Biosciences Inc
Application granted granted Critical
Publication of ATE448482T1 publication Critical patent/ATE448482T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
AT03748948T 2002-07-20 2003-07-18 Vorrichtungen auf impedanzbasis sowie verfahren zur verwendung in assays ATE448482T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39774902P 2002-07-20 2002-07-20
US43540002P 2002-12-20 2002-12-20
US46957203P 2003-05-09 2003-05-09
PCT/US2003/022557 WO2004010103A2 (en) 2002-07-20 2003-07-18 Impedance based devices and methods for use in assays

Publications (1)

Publication Number Publication Date
ATE448482T1 true ATE448482T1 (de) 2009-11-15

Family

ID=30773523

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03751801T ATE442587T1 (de) 2002-07-20 2003-07-18 Impedanz basierende vorrichtungen und verfahren zur analyse von zellen und partikeln
AT03748948T ATE448482T1 (de) 2002-07-20 2003-07-18 Vorrichtungen auf impedanzbasis sowie verfahren zur verwendung in assays

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03751801T ATE442587T1 (de) 2002-07-20 2003-07-18 Impedanz basierende vorrichtungen und verfahren zur analyse von zellen und partikeln

Country Status (9)

Country Link
US (1) US7459303B2 (de)
EP (2) EP1539992B1 (de)
JP (2) JP4745056B2 (de)
CN (2) CN100577811C (de)
AT (2) ATE442587T1 (de)
AU (2) AU2003269911A1 (de)
CA (2) CA2493108C (de)
DE (2) DE60329187D1 (de)
WO (2) WO2004010103A2 (de)

Families Citing this family (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202439B2 (en) 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7732127B2 (en) * 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
EP1692258A4 (de) 2003-11-12 2007-03-21 Xiao Xu Elektronische echtzeit-zellwahrnehmungssysteme und anwendungen für tests auf zellbasis
CA2554027C (en) * 2004-01-29 2013-10-08 Biosilab S.R.L. Biochip electroporator and its use in multi-site, single-cell electroporation
CN101400780B (zh) * 2004-02-09 2012-06-20 美国艾森生物科学公司 实时细胞电子分析系统及其在细胞毒性检测和化合物分析上的应用
EP2639576B1 (de) * 2004-02-09 2016-04-20 ACEA Biosciences, Inc. Elektronisches Echtzeit-Zellenerkennungssystem und Anwendungen für das Zytotoxizitätsprofil und Verbindungsassays
DE102004010944A1 (de) * 2004-03-03 2005-09-22 Humboldt-Universität Zu Berlin Verfahren und Vorrichtung zum Messen einer physikalischen und/oder chemischen Eigenschaft eines biologischen Partikels in einem Mikrosystem
ES2294757T3 (es) * 2004-03-15 2008-04-01 Amaxa Ag Recipiente y dispositivo para generar campos electricos en espacios de reaccion individuales.
CN1997278B (zh) 2004-04-20 2014-04-23 艾森生物(杭州)有限公司 有取代的有机硫化合物及其使用方法
KR100613612B1 (ko) 2004-04-27 2006-08-18 삼성전자주식회사 인덕턴스 소자 및 캐패시턴스 소자를 이용한 바이오결합검출 장치 및 방법
JP4587281B2 (ja) * 2004-06-21 2010-11-24 則男 長尾 癌転移抑制能測定する方法およびその測定器
CA2575297C (en) 2004-08-04 2014-09-23 Acea Biosciences, Inc. Method for assaying for natural killer, cytotoxic t-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
EP1800312A4 (de) * 2004-09-27 2011-10-05 Acea Biosciences Inc Dynamische überwachung von zelladhäsion und -verteilung mithilfe des rt-ces-systems
WO2006078814A2 (en) * 2005-01-20 2006-07-27 The Regents Of The University Of California Cellular microarrays for screening differentiation factors
US7088116B1 (en) * 2005-02-09 2006-08-08 Haian Lin Optoelectronic probe
US20060216203A1 (en) * 2005-03-28 2006-09-28 Mds Sciex (Us) A Division Of Mds Pharma Services (Us) Inc. Multiwell sample plate with integrated impedance electrodes and connection scheme
US20060263873A1 (en) * 2005-05-21 2006-11-23 Levine Leanna M Controlled flow microfluidic device and method of fabrication
US20090149334A1 (en) * 2005-09-01 2009-06-11 Mcgill University Methods and apparatus for detecting liquid inside individual channels in a multi-channel plate
US7459918B2 (en) * 2005-09-09 2008-12-02 David Jones Impedance measurement system with incorporated internal measurement drift compensation networks
KR100801694B1 (ko) * 2005-09-15 2008-02-11 삼성전자주식회사 원핵 세포를 이용한 독성물질 유해성의 전기적 분석방법 및분석장치
US7686934B2 (en) * 2005-12-13 2010-03-30 Gamida For Life B.V. Three dimensional dielectrophoretic separator and methods of use
US7776193B2 (en) 2005-12-20 2010-08-17 Panasonic Corporation Cell electrophysiological sensor
US8003380B2 (en) * 2006-01-04 2011-08-23 Agency For Science, Technology And Research High throughput cell-based assays fabricated with integrated silicon and cell culture technologies
PT1977241E (pt) 2006-01-04 2010-09-16 Novartis Ag Ensaio de citotoxicidade celular dependente de anticorpos
US20070182417A1 (en) * 2006-02-03 2007-08-09 Ivar Giaever Electrical measurement of cell invasion
JP4858870B2 (ja) * 2006-02-16 2012-01-18 財団法人生産技術研究奨励会 培養細胞の電気シグナル計測デバイスおよび該デバイスを用いる電気シグナル計測方法
US8041515B2 (en) * 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
JP2008096235A (ja) * 2006-10-11 2008-04-24 Sharp Corp 電気化学計測マイクロチップ
US20080262740A1 (en) * 2007-04-20 2008-10-23 Infotonics Technology Center, Inc. Permittivity-based material sensor
CN101038284B (zh) 2007-04-25 2011-04-27 博奥生物有限公司 一种提高电阻抗检测装置的电阻抗检测灵敏度的方法
US20080297169A1 (en) * 2007-05-31 2008-12-04 Greenquist Alfred C Particle Fraction Determination of A Sample
CN101801942B (zh) 2007-07-17 2013-03-27 美国艾森生物科学公司 杂环化合物和作为抗癌剂的用途
ES2340118B1 (es) * 2008-01-16 2011-04-04 Consejo Superior De Investigaciones Cientificas (50%) Dispositivo y procedimiento para medir concentracion de biomasa, y uso de un elemento electronico chip para medir dicha concentracion de biomasa.
EP2103933B1 (de) 2008-02-25 2011-07-27 Universität Leipzig Vorrichtung und Verfahren zur Messung der Impedanz in organischem Gewebe
KR100952056B1 (ko) * 2008-02-29 2010-04-07 아주대학교산학협력단 기계적 자극에 대한 줄기세포 분화의 최적의 조건을 검출할수 있는 셀-칩 및 이의 자동 제어 시스템
KR100969667B1 (ko) * 2008-03-24 2010-07-14 디지탈 지노믹스(주) 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩
CN101556273B (zh) 2008-04-08 2013-03-20 博奥生物有限公司 利用电阻抗传感技术分析细胞迁移的方法及其专用装置
EP2291645B1 (de) 2008-05-05 2015-09-09 Acea Biosciences, Inc. Markierungsfreie überwachung der elektromechanischen kopplung und erregbaren zellen anhand von systemen auf impedanzbasis mit millisekunden-zeitauflösung
WO2009136157A2 (en) * 2008-05-07 2009-11-12 University Of Strathclyde A system and method for cell characterisation
CN101614729B (zh) 2008-06-27 2013-04-24 博奥生物有限公司 用于细胞操作及电生理信号检测的微电极阵列器件及专用装置
CA2682439A1 (en) * 2008-10-17 2010-04-17 F. Hoffmann-La Roche Ag Cell monitoring and molecular analysis
EP2199783A1 (de) 2008-12-17 2010-06-23 Koninklijke Philips Electronics N.V. Mikroelektronisches Gerät zum Messen der Zelladhäsion
US8227223B2 (en) * 2009-01-27 2012-07-24 Applied Biophysics, Inc. Method and apparatus for facilitating evaluating migration of cells in vitro
WO2010129725A1 (en) * 2009-05-05 2010-11-11 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
WO2010141320A1 (en) * 2009-06-01 2010-12-09 Mariposa Biotechnology, Inc. Device for removing cumulus from oocytes
DE102009035502A1 (de) * 2009-07-30 2011-02-03 Universitätsklinikum Jena Verfahren und Vorrichtung zur Erfassung der Bewegung und Anlagerung von Zellen und Partikeln an Zell-, Gewebe- und Implantatschichten bei der Simulation von Flussbedingungen
DE102009052673A1 (de) * 2009-11-12 2011-05-19 Nanoanalytics Gmbh Vorrichtung zur Bestimmung der Impedanz von Zellschichten
CN101712925B (zh) * 2009-11-23 2013-01-09 浙江大学 检测单细胞和群细胞行为的多尺度集成细胞阻抗传感器
CN101705184B (zh) * 2009-11-26 2012-01-11 浙江大学 基于多参数检测集成芯片的全自动细胞生理参数分析仪
US20110186428A1 (en) * 2010-01-29 2011-08-04 Roche Diagnostics Operations, Inc. Electrode arrangements for biosensors
JP2013520439A (ja) * 2010-02-19 2013-06-06 アセア バイオサイエンシズ インコーポレイテッド 抗癌剤としての複素環式化合物および使用
KR101862417B1 (ko) * 2010-02-25 2018-05-29 스토너릿지 인코포레이티드 수트 센서 시스템
US9029168B2 (en) * 2010-06-28 2015-05-12 The Trustees Of Princeton University Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring
WO2012009606A1 (en) * 2010-07-16 2012-01-19 University Of Utah Research Foundation Electrophysiological recording system and methods of using same
US9465003B2 (en) 2010-12-16 2016-10-11 Korea Research Institute Of Bioscience And Biotechnology Membrane phase electrode using printing and bio-molecule detection using same
WO2012081940A2 (ko) * 2010-12-16 2012-06-21 한국생명공학연구원 프린팅을 이용한 멤브레인 상 전극 및 이를 활용한 생체물질 검출
KR101291310B1 (ko) 2011-03-22 2013-07-30 서울대학교산학협력단 알루미늄 산화물 박막이 부착된 금속 전극을 이용한 미생물 측정 방법
US8399262B2 (en) * 2011-03-23 2013-03-19 Darrel A. Mazzari Biosensor
US8593727B2 (en) * 2011-04-25 2013-11-26 Vladimir G. Kozlov Single-shot laser ablation of a metal film on a polymer membrane
US8673628B2 (en) * 2011-06-10 2014-03-18 Essen Instruments, Inc. Methods and apparatus for improving in vitro measurements using boyden chambers
US8911603B2 (en) * 2011-07-22 2014-12-16 California Institute Of Technology LED-based screener for photoelectrochemical materials discovery
CN102393406B (zh) * 2011-08-05 2013-04-24 杭州柯氏生物科技有限公司 一种基于细胞学动态信息集成鉴别道地中药材的方法
DE102011082451B4 (de) * 2011-09-09 2013-05-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Sensorelement und Verfahren zum Versorgen und Erfassen von biologischem Material mit Nährstoffen
EP2581742A1 (de) 2011-10-14 2013-04-17 Universität Leipzig Vorrichtung und Verfahren zur parallelen Aufzeichnung von Impedanzspektren und Feldpotenzial
US9200246B2 (en) * 2011-12-01 2015-12-01 Acea Biosciences, Inc. Co-culture device assembly
US9034885B2 (en) 2012-01-13 2015-05-19 Acea Biosciences Inc. EGFR modulators and uses thereof
CN110194748A (zh) 2012-01-13 2019-09-03 艾森生物科学公司 杂环化合物及其作为抗癌药的用途
US9464089B2 (en) 2012-01-13 2016-10-11 Acea Biosciences Inc. Heterocyclic compounds and uses thereof
US9586965B2 (en) 2012-01-13 2017-03-07 Acea Biosciences Inc. Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
CN102539485B (zh) * 2012-01-13 2014-02-19 武汉介观生物科技有限责任公司 细胞迁移高分辨率阻抗实时跟踪测控装置及其制造方法和应用方法
FR2986802A1 (fr) * 2012-02-13 2013-08-16 Centre Nat Rech Scient Dispositif et procede de manipulation et traitement de cellules par champ electrique.
CA2864437C (en) * 2012-02-15 2018-03-13 Becton, Dickinson And Company Impedance-based bacterial detection system
JP2013220066A (ja) * 2012-04-17 2013-10-28 Hitachi Ltd センサチップ及びそれを用いた測定方法
US20130330761A1 (en) 2012-06-12 2013-12-12 Celcuity, LLC Whole cell assays and methods
KR102181365B1 (ko) 2012-08-06 2020-11-23 에이시아 바이오사이언시스 인코포레이티드. 단백질 키나아제 억제제로서 새로운 피롤로피리미딘 화합물
JP6040423B2 (ja) * 2012-11-06 2016-12-07 パナソニックＩｐマネジメント株式会社 受精卵の検査デバイスおよび測定方法
DE102013200613A1 (de) * 2013-01-16 2014-07-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zum Bestimmen einer Stärke einer Adhäsion eines biologischen Materials
US9885031B2 (en) 2013-02-05 2018-02-06 Ohio State Innovation Foundation Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
US9809810B2 (en) 2013-02-05 2017-11-07 Ohio State Innovation Foundation Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
US9777265B2 (en) 2013-02-05 2017-10-03 Ohio State Innovation Foundation Non-contact method for accelerating wound healing using an electromagnetic coil to induce an electric field transverse to an axis of the wound
AU2014287016B2 (en) 2013-07-11 2018-11-01 Acea Biosciences Inc. Pyrimidine derivatives as kinase inhibitors
WO2015089380A2 (en) 2013-12-12 2015-06-18 Celcuity Llc Assays and methods for determining the responsiveness of an individual subject to a therapeutic agent
RU2016124174A (ru) * 2013-12-19 2018-01-24 Зе Реджентс Оф Зе Юниверсити Оф Калифорния Проводящие гидрогели для определения аффинности
US9274071B2 (en) * 2013-12-30 2016-03-01 General Electric Company Methods for assessing cell culture fluid by impedance spectra
CN106456041A (zh) * 2014-02-28 2017-02-22 Msp有限公司 人体内阻抗测量装置
WO2015179035A2 (en) * 2014-04-08 2015-11-26 William Marsh Rice University Production and use of flexible conductive films and inorganic layers in electronic devices
EP2950086A1 (de) * 2014-05-29 2015-12-02 Consejo Superior de Investigaciones Cientificas (CSIC) Vorrichtung zum Messen der schichtübergreifenden elektrischen Impedanz in einem In-vitro-Modell einer Zellbarriere
DE102014219633A1 (de) * 2014-09-29 2016-04-14 Robert Bosch Gmbh Vorrichtung zur Detektion von Substanzen in einer Probe
EP3035052A1 (de) 2014-12-18 2016-06-22 Helmholtz-Zentrum für Infektionsforschung GmbH Verfahren und Vorrichtung zur Bestimmung der Wachstumsrate von Biofilmen
WO2016139567A2 (en) 2015-03-03 2016-09-09 Abdolahad Mohammad Electrical cell-substrate impedance sensor (ecis)
CN104820134A (zh) * 2015-04-29 2015-08-05 业成光电（深圳）有限公司 线路检测装置及方法及其所应用的线路
DE102015219023B3 (de) 2015-10-01 2017-02-23 Technische Universität München Vorrichtung zum Analysieren von biologischen Substanzen in einer Testlösung, Herstellungsverfahren und Betriebsverfahren
RU2018115334A (ru) 2015-10-09 2019-11-11 Ацея Терапьютикс, Инк. Фармацевтические соли, физические формы и композиции пирролопиримидиновых ингибиторов киназ, и способы их получения
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
GB201522323D0 (en) 2015-12-17 2016-02-03 Vrije Universiteit Brussel And Katholieke Universiteit Leuven Systems and methods for conducting electrochemical impedance spectroscopy
CN105823817B (zh) * 2016-01-04 2018-04-20 浙江农林大学 抗癌药物长春瑞滨药效检测装置及检测方法
JP6705268B2 (ja) * 2016-04-14 2020-06-03 いすゞ自動車株式会社 センサ
JP6116080B1 (ja) * 2016-04-26 2017-04-19 日本航空電子工業株式会社 電気化学測定方法、電気化学測定装置及びトランスデューサ
US10761081B2 (en) * 2016-06-12 2020-09-01 Mohammad Abdolahad Method and system for metastasis diagnosis and prognosis
US11874268B2 (en) * 2016-06-12 2024-01-16 Nanohesgarsazan Salamat Arya Ncubation Center For Equipment And Devices Method and system for metastasis diagnosis and prognosis
US10613088B2 (en) * 2016-06-12 2020-04-07 Mohammad Abdolahad Method and system for metastasis diagnosis and prognosis
EP4478049A3 (de) * 2016-08-03 2024-12-25 Wake Forest University Health Sciences Krebsmodellierungsplattformen und verfahren zur verwendung davon
KR101862642B1 (ko) * 2016-08-30 2018-07-04 가천대학교 산학협력단 세포의 임피던스 측정 감도가 향상 된 전극 및 이를 이용한 세포 임피던스 측정센서
CN106198675A (zh) * 2016-09-28 2016-12-07 扬州大学 生物免疫电化学阻抗集成芯片传感器的制作方法
DE102016224865B8 (de) * 2016-12-13 2018-07-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Biopolare Elektrode zur impedimetrischen Untersuchung und Manipulation lebender Zellen in vitro
US20180266973A1 (en) * 2017-02-28 2018-09-20 Covidien Lp Pathogen detection
WO2018161063A1 (en) 2017-03-03 2018-09-07 Acea Biosciences, Inc. METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
CA3049472A1 (en) 2017-03-20 2018-09-27 Celcuity Inc. Methods of measuring signaling pathway activity for selection of therapeutic agents
CA3059072A1 (en) 2017-04-07 2018-10-11 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
CN107049587A (zh) * 2017-05-14 2017-08-18 郭宝煊 智能月经杯
CN107085097B (zh) * 2017-05-14 2020-08-28 浙江达普生物科技有限公司 一种血检芯片及其制作方法
CN107185850B (zh) * 2017-06-06 2023-04-07 浙江大学 一种基于高光谱成像及电阻抗的玉米种子活力检测装置
DE102017113748A1 (de) * 2017-06-21 2018-12-27 Institut für Bioprozess- und Analysenmesstechnik e.V. Vorrichtung und Verfahren zur Impedanzmessung
JP7007122B2 (ja) 2017-07-11 2022-01-24 浜松ホトニクス株式会社 試料観察装置及び試料観察方法
CN107890577B (zh) * 2017-10-23 2021-04-06 南方科技大学 一种灭菌机器人系统
KR102499114B1 (ko) * 2017-10-31 2023-02-13 주식회사 유스바이오글로벌 세포 및 배양액 조건에 따른 전기자극 변수 제어장치 및 방법
EP3499216B1 (de) * 2017-12-15 2022-05-04 Nokia Technologies Oy Vorrichtung und zugehörige verfahren zur erkennung von luftgetragenen partikeln
CN108303364B (zh) * 2018-02-02 2022-07-19 中国科学院电子学研究所 高通量检测细胞尺寸、尺寸无关单细胞电参数装置和方法
CN108190828B (zh) * 2018-02-07 2024-08-13 北京先通康桥医药科技有限公司 Mems传感器线阵、触诊探头及其制造方法
JP6486521B2 (ja) * 2018-02-28 2019-03-20 花王株式会社 着用物品
NL2020518B1 (en) 2018-03-02 2019-09-12 Mimetas B V Device and method for performing electrical measurements
CN108680608A (zh) * 2018-04-02 2018-10-19 东南大学 基于宽频电阻抗检测芯片的细胞检测方法
CN108982335A (zh) * 2018-06-29 2018-12-11 浙江大学 一种基于电阻抗的悬浮细胞计数芯片及其制作方法和计数方法
EP3818361B1 (de) * 2018-07-03 2024-01-24 Curi Bio, Inc. Vorrichtungen und verfahren zur topografisch geführten zellmigration
US20220113298A1 (en) * 2018-09-07 2022-04-14 Georgetown University Systems and methods for identifying and isolating invasive subpopulations of cancer cells in real-time
CN109350046A (zh) * 2018-09-07 2019-02-19 深圳市太空科技南方研究院 一种柔性电极及其制造方法
US12168794B2 (en) 2018-10-02 2024-12-17 Osler Diagnostics Limited Methods for immunoassays using electrochemical measurement
JP7162836B2 (ja) * 2018-11-21 2022-10-31 株式会社島津製作所 細胞評価用デバイス及び細胞評価用システム
JPWO2020162031A1 (ja) * 2019-02-08 2021-12-16 パナソニックＩｐマネジメント株式会社 細胞電位測定基板及びその製造方法並びに細胞培養基板
KR102639023B1 (ko) 2019-02-21 2024-02-20 스템바이오시스, 인크. 양수 세포-유래 ecm 상에서 심근세포 성숙을 위한 방법, 세포 구조, 및 약물 화합물의 심장 독성 및 전부정맥 스크리닝을 위한 용도
US11365386B2 (en) * 2019-05-03 2022-06-21 UNIVERSITé LAVAL Cellular behaviour monitoring device and method for monitoring changes in cellular behaviour
CN110243873B (zh) * 2019-07-01 2020-06-09 广州迈普再生医学科技股份有限公司 多功能细胞传感器系统及其测量方法
WO2021055670A1 (en) * 2019-09-20 2021-03-25 Avx Corporation Somatic cell-based electrical biosensor
JP7460110B2 (ja) * 2019-11-28 2024-04-02 学校法人立命館 測定方法及び測定装置
US11486842B2 (en) * 2019-12-23 2022-11-01 Nanodx, Inc. Sensor system and electrodes
CN110923635A (zh) * 2019-12-25 2020-03-27 重庆华渝电气集团有限公司 一种石英摆片镀膜及退膜方法
WO2021150631A1 (en) * 2020-01-21 2021-07-29 Synthego Corporation Devices and methods for transfection and for generation of clonal populations of cells
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
EP3913042A1 (de) 2020-05-18 2021-11-24 Incyton GmbH Analysevorrichtung
CN113683781B (zh) * 2020-05-18 2023-05-05 天津师范大学 锌配位聚合物及其合成方法和在检测卡那霉素中的应用
CN111625587B (zh) * 2020-05-28 2022-02-15 泰康保险集团股份有限公司 数据共享装置
BR112022026979A2 (pt) * 2020-07-14 2023-03-07 Illumina Inc Microarranjos, vedações para hibridização e métodos relacionados
EP3944764B1 (de) * 2020-07-28 2025-03-12 BSH Hausgeräte GmbH Haushaltsgerät und verfahren zum betrieb eines haushaltsgerätes
US12247189B1 (en) 2020-08-27 2025-03-11 United States Of America As Represented By The Secretary Of The Air Force Teer electrode alignment mount
CN112263323B (zh) * 2020-09-30 2021-10-08 杭州睿笛生物科技有限公司 一种阻抗测量装置及消融设备
ES2952456T3 (es) * 2020-12-15 2023-10-31 Usense Dispositivo de análisis de orina
US12385873B2 (en) 2020-12-25 2025-08-12 Aurangzeb Nafees Nagy Detection of target nucleic acid molecules
CN113589042B (zh) * 2021-07-29 2023-02-17 重庆理工大学 一种包含独立激励电极和感测电极的高精度阻抗传感器
CN113740423B (zh) * 2021-09-03 2022-11-22 电子科技大学 一种实时检测细胞形貌变化和细胞粘附特性变化的eqcm方法
CN113866240B (zh) * 2021-09-27 2024-05-28 四川成电医联科技咨询有限公司 基于测量电阻抗修正的白细胞检测电极结构和方法
US20240361297A1 (en) * 2021-11-08 2024-10-31 Illumina, Inc. Identifying nucleotides using changes in impedance between electrodes
TWI780996B (zh) * 2021-11-29 2022-10-11 樂盟科技有限公司 氣體捕捉裝置
CN114264590B (zh) * 2021-12-14 2024-04-05 江苏济纶医工智能科技有限公司 一种用于细胞检测的可拆卸便携传感器、装配方法、测量方法、设计方法
WO2023183920A2 (en) * 2022-03-24 2023-09-28 Georgetown University Systems and methods for real-time detection and capture of invasive cell subpopulations from co-cultures
EP4317397A1 (de) * 2022-08-02 2024-02-07 Simplinext SA Multiwell-plattensystem zum beurteilen von zellschichten
EP4659014A1 (de) * 2022-12-09 2025-12-10 President And Fellows Of Harvard College Fäulnisverhindernde dickschichtbeschichtung auf emulsionsbasis für hochempfindliche elektrochemische messung
CN115838625A (zh) * 2022-12-28 2023-03-24 中国科学院电工研究所 一种生物反应器内细胞状态实时检测装置
DE102023203746B3 (de) * 2023-04-24 2024-06-27 Karlsruher Institut für Technologie, Körperschaft des öffentlichen Rechts Zellkulturmembraneinsatz sowie Vorrichtung und Verfahren zur Erfassung mindestens einer elektrochemischen Größe einer Zellkultur
WO2025008642A1 (en) 2023-07-05 2025-01-09 Autolus Limited Method
WO2025186681A1 (en) 2024-03-04 2025-09-12 Universidade De Coimbra Porous electrode

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656508A (en) 1949-08-27 1953-10-20 Wallace H Coulter Means for counting particles suspended in a fluid
US3259842A (en) 1959-08-19 1966-07-05 Coulter Electronics Particle analyzing device
US3743581A (en) 1970-10-21 1973-07-03 Bactomatic Inc Microbiological detection apparatus
US3890201A (en) * 1974-09-26 1975-06-17 Bactomatic Inc Multi-chamber impedance measuring module-cap combination
US4067951A (en) 1975-11-19 1978-01-10 Bactomatic Inc. Process for making impedance measuring module
US4225410A (en) 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
US4686190A (en) 1986-02-19 1987-08-11 The Research Foundation Of State University Of New York Device useful for growing and/or testing biological materials
US5001048A (en) 1987-06-05 1991-03-19 Aurthur D. Little, Inc. Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film
US4920047A (en) 1988-05-20 1990-04-24 General Electric Company Electrical detection of the immune reaction
US5218312A (en) * 1988-07-20 1993-06-08 Ricardo Moro Measurement apparatus for measuring a biological substance within a fluid substrate
US5278048A (en) 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
US5766934A (en) 1989-03-13 1998-06-16 Guiseppi-Elie; Anthony Chemical and biological sensors having electroactive polymer thin films attached to microfabricated devices and possessing immobilized indicator moieties
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5643742A (en) 1990-04-03 1997-07-01 Cellstat Technologies, Inc. System for electronically monitoring and recording cell cultures
US5134070A (en) 1990-06-04 1992-07-28 Casnig Dael R Method and device for cell cultivation on electrodes
US5284753A (en) 1991-03-20 1994-02-08 Neuro Probe, Inc. Multiple-site chemotactic test apparatus and method
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
JPH07102153B2 (ja) * 1992-01-31 1995-11-08 工業技術院長 血管内皮モデル調製用器及びこれを用いた癌細胞の転移能の測定方法
US5247827A (en) * 1992-04-14 1993-09-28 Bell Communications Research, Inc. Resistive measurement of airborne contaminants
US5514555A (en) * 1993-03-12 1996-05-07 Center For Blood Research, Inc. Assays and therapeutic methods based on lymphocyte chemoattractants
US5810725A (en) 1993-04-16 1998-09-22 Matsushita Electric Industrial Co., Ltd. Planar electrode
DE4417079C2 (de) * 1994-05-17 1998-06-10 Fraunhofer Ges Forschung Objektträger zum Beobachten von biologischem Material
US5563067A (en) * 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
US5601997A (en) * 1995-02-03 1997-02-11 Tchao; Ruy Chemotaxis assay procedure
DE19512117A1 (de) 1995-04-04 1996-10-10 Itt Ind Gmbh Deutsche Meßeinrichtung
JP2930181B2 (ja) 1995-06-20 1999-08-03 松下電器産業株式会社 神経細胞活動測定用２次元センサ及びこれを用いた測定装置
US5626734A (en) 1995-08-18 1997-05-06 University Technologies International, Inc. Filter for perfusion cultures of animal cells and the like
US6573063B2 (en) 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
AU719454B2 (en) 1995-12-01 2000-05-11 Innogenetics N.V. Impedimetric detection system and method of production thereof
US6355436B1 (en) 1996-05-17 2002-03-12 L'ecole Centrale De Lyon Method for analyzing biological substances in a conductive liquid medium
US6235520B1 (en) 1996-06-27 2001-05-22 Cellstat Technologies, Inc. High-throughput screening method and apparatus
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
DE19646505A1 (de) * 1996-11-12 1998-05-14 Itt Ind Gmbh Deutsche Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US5801055A (en) 1997-09-10 1998-09-01 Becton Dickinson And Company Multi-well culture dish assembly
US6132683A (en) 1998-12-23 2000-10-17 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
USRE37977E1 (en) 1997-12-25 2003-02-04 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
WO1999039190A1 (en) 1998-02-02 1999-08-05 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US6287874B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6485905B2 (en) 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
DE19841337C1 (de) 1998-05-27 1999-09-23 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
FR2781886B1 (fr) 1998-07-31 2001-02-16 Commissariat Energie Atomique Micro-systeme a multiple points d'analyse chimique ou biologique
US6169394B1 (en) 1998-09-18 2001-01-02 University Of The Utah Research Foundation Electrical detector for micro-analysis systems
US6477479B1 (en) * 1998-12-11 2002-11-05 Symyx Technologies Sensor array for rapid materials characterization
US20030166015A1 (en) 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
DE19920811B4 (de) 1999-05-06 2004-08-19 Micronas Gmbh Vorrichtung zur Durchführung von Untersuchungen an Zellkulturen
NZ518057A (en) * 1999-10-01 2004-01-30 Sophion Bioscience As A substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
AU1241901A (en) * 1999-11-24 2001-06-04 Biotronics Technologies, Inc. Devices and methods for detecting analytes using electrosensor having capture reagent
US20020090649A1 (en) 1999-12-15 2002-07-11 Tony Chan High density column and row addressable electrode arrays
US6448030B1 (en) 2000-02-18 2002-09-10 University Of Nevada-Las Vegas Method for predicting the efficacy of anti-cancer drugs
CN1319761A (zh) 2000-03-15 2001-10-31 清华大学 高通量电旋转检测的装置和方法
EP1138758B1 (de) 2000-03-27 2007-01-17 Nte, S.A. Sonde, Zelle und Verfahren zur Messung der Konzentration und der Zusammensetzung von Biomasse
US6626902B1 (en) 2000-04-12 2003-09-30 University Of Virginia Patent Foundation Multi-probe system
CA2406133A1 (en) 2000-04-17 2001-10-25 Rashid Bashir Biosensor and related method
US7306924B2 (en) 2000-04-17 2007-12-11 Purdue Research Foundation Biosensor and related method
IL153545A0 (en) 2000-07-07 2003-07-06 Bristol Myers Squibb Co Apparatus for measuring cellular electrical activity
US7312043B2 (en) 2000-07-10 2007-12-25 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
US6740501B2 (en) * 2000-09-27 2004-05-25 Becton, Dickinson And Company Coated membrane for assessing the invasive capacity of a cell
US6451808B1 (en) * 2000-10-17 2002-09-17 Depomed, Inc. Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists
US20030072549A1 (en) 2000-10-26 2003-04-17 The Trustees Of Princeton University Method and apparatus for dielectric spectroscopy of biological solutions
AU2002239501A1 (en) * 2000-10-26 2002-06-03 University Of Connecticut A system and method for investigating the effect of chemical and other factors on cell movement
US20050048563A1 (en) 2000-11-30 2005-03-03 Novasite Pharmaceuticals, Inc Membrane molecule indicator compositions and methods
US6835552B2 (en) 2000-12-14 2004-12-28 The Regents Of The University Of California Impedance measurements for detecting pathogens attached to antibodies
US20040146849A1 (en) 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US6627461B2 (en) 2001-04-18 2003-09-30 Signature Bioscience, Inc. Method and apparatus for detection of molecular events using temperature control of detection environment
US6461808B1 (en) 2001-06-12 2002-10-08 Signature Bioscience, Inc. Pipette-loaded bioassay assembly for detecting molecular or cellular events
US20030032000A1 (en) 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
US20030116447A1 (en) 2001-11-16 2003-06-26 Surridge Nigel A. Electrodes, methods, apparatuses comprising micro-electrode arrays
US6637257B2 (en) * 2002-01-02 2003-10-28 Integrated Sensing Systems Micromachined fluid analysis device and method
US20040091397A1 (en) * 2002-11-07 2004-05-13 Corning Incorporated Multiwell insert device that enables label free detection of cells and other objects
US20050014130A1 (en) 2003-07-14 2005-01-20 Vivian Liu Label-free method for classification and characterization of cellular events
ATE371865T1 (de) 2003-07-14 2007-09-15 Mds Inc Dba Mds Sciex Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse
EP1692258A4 (de) 2003-11-12 2007-03-21 Xiao Xu Elektronische echtzeit-zellwahrnehmungssysteme und anwendungen für tests auf zellbasis

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