CN105823817B - 抗癌药物长春瑞滨药效检测装置及检测方法 - Google Patents
抗癌药物长春瑞滨药效检测装置及检测方法 Download PDFInfo
- Publication number
- CN105823817B CN105823817B CN201610006567.9A CN201610006567A CN105823817B CN 105823817 B CN105823817 B CN 105823817B CN 201610006567 A CN201610006567 A CN 201610006567A CN 105823817 B CN105823817 B CN 105823817B
- Authority
- CN
- China
- Prior art keywords
- mrow
- msub
- computer
- vinorelbine
- signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 title claims abstract description 63
- 229960002066 vinorelbine Drugs 0.000 title claims abstract description 63
- 238000001514 detection method Methods 0.000 title claims abstract description 39
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 229940079593 drug Drugs 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 238000011275 oncology therapy Methods 0.000 title claims abstract description 20
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 39
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 39
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 16
- 201000011510 cancer Diseases 0.000 claims abstract description 16
- 239000000758 substrate Substances 0.000 claims abstract description 16
- 238000010438 heat treatment Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 10
- 238000004140 cleaning Methods 0.000 claims description 9
- 230000007423 decrease Effects 0.000 claims description 8
- 230000005284 excitation Effects 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 3
- 230000000737 periodic effect Effects 0.000 claims description 3
- 230000033228 biological regulation Effects 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 6
- PRPINYUDVPFIRX-UHFFFAOYSA-N 1-naphthaleneacetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CC=CC2=C1 PRPINYUDVPFIRX-UHFFFAOYSA-N 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 230000000857 drug effect Effects 0.000 abstract description 11
- 210000004027 cell Anatomy 0.000 description 24
- 238000010586 diagram Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000010422 painting Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610006567.9A CN105823817B (zh) | 2016-01-04 | 2016-01-04 | 抗癌药物长春瑞滨药效检测装置及检测方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610006567.9A CN105823817B (zh) | 2016-01-04 | 2016-01-04 | 抗癌药物长春瑞滨药效检测装置及检测方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105823817A CN105823817A (zh) | 2016-08-03 |
CN105823817B true CN105823817B (zh) | 2018-04-20 |
Family
ID=56986890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610006567.9A Active CN105823817B (zh) | 2016-01-04 | 2016-01-04 | 抗癌药物长春瑞滨药效检测装置及检测方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105823817B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105806904A (zh) * | 2016-01-04 | 2016-07-27 | 杭州电子科技大学 | 抗癌药物异环磷酰胺药效检测装置及检测方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113917095B (zh) * | 2021-09-29 | 2022-07-29 | 复旦大学附属肿瘤医院 | 一种胰腺癌肝转移化疗耐药用体外药物敏感性检测装置 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1309295A (zh) * | 2000-12-04 | 2001-08-22 | 浙江大学 | 用于药物筛选的多功能细胞微生理计 |
CN1554942A (zh) * | 2003-12-25 | 2004-12-15 | 浙江大学 | 用于细胞胞外动作电位测量的单细胞传感器及其制备方法 |
CN2709979Y (zh) * | 2003-12-25 | 2005-07-13 | 浙江大学 | 用于细胞胞外动作电位测量的单细胞传感器 |
JP2005537498A (ja) * | 2002-07-20 | 2005-12-08 | アセア バイオサイエンシーズ,インク. | インピーダンスによる測定装置および方法 |
CN101948805A (zh) * | 2010-09-27 | 2011-01-19 | 扬州大学 | 筛选化学预防剂的双信号转基因细胞传感器及其构建方法 |
CN104297249A (zh) * | 2014-09-15 | 2015-01-21 | 浙江大学 | 基于心肌细胞传感器的药物心脏毒性检测分析方法 |
-
2016
- 2016-01-04 CN CN201610006567.9A patent/CN105823817B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1309295A (zh) * | 2000-12-04 | 2001-08-22 | 浙江大学 | 用于药物筛选的多功能细胞微生理计 |
JP2005537498A (ja) * | 2002-07-20 | 2005-12-08 | アセア バイオサイエンシーズ,インク. | インピーダンスによる測定装置および方法 |
CN1554942A (zh) * | 2003-12-25 | 2004-12-15 | 浙江大学 | 用于细胞胞外动作电位测量的单细胞传感器及其制备方法 |
CN2709979Y (zh) * | 2003-12-25 | 2005-07-13 | 浙江大学 | 用于细胞胞外动作电位测量的单细胞传感器 |
CN101948805A (zh) * | 2010-09-27 | 2011-01-19 | 扬州大学 | 筛选化学预防剂的双信号转基因细胞传感器及其构建方法 |
CN104297249A (zh) * | 2014-09-15 | 2015-01-21 | 浙江大学 | 基于心肌细胞传感器的药物心脏毒性检测分析方法 |
Non-Patent Citations (1)
Title |
---|
Tastant quantitative analysis from complex mixtures using taste cell-based sensor and double-layered cascaded series stochastic resonance;Guohua Hui等;《Electrochimica Acte》;20140521;第75-88页 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105806904A (zh) * | 2016-01-04 | 2016-07-27 | 杭州电子科技大学 | 抗癌药物异环磷酰胺药效检测装置及检测方法 |
Also Published As
Publication number | Publication date |
---|---|
CN105823817A (zh) | 2016-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2763776A1 (en) | Systems and methods for the identification of compounds in medical fluids using admittance spectroscopy | |
US20160018347A1 (en) | Designs, systems, configurations, and methods for immittance spectroscopy | |
Park et al. | 1024-pixel CMOS multimodality joint cellular sensor/stimulator array for real-time holistic cellular characterization and cell-based drug screening | |
CN105823807B (zh) | 抗癌药物羟喜树碱药效检测装置及检测方法 | |
WO2009114115A1 (en) | Intravenous fluid monitoring | |
US20120065617A1 (en) | Systems and methods for intravenous drug management using immittance spectroscopy | |
CN105823817B (zh) | 抗癌药物长春瑞滨药效检测装置及检测方法 | |
ATE345733T1 (de) | Vorrichtung zur messung des abschnittsweisen volumens und der elektrischen parallelleitfähigkeit einer herzkammer oder eines blutgefässes | |
JPH04504511A (ja) | デリバリーシステムの操作の連続的監視方法、該方法を実施するための装置および該装置の使用 | |
CN107870055A (zh) | 用于微流道内压力检测系统及其制作方法、检测方法 | |
CN105866200B (zh) | 一种用于依托泊苷治疗效果评价的装置及方法 | |
CN105823808B (zh) | 抗癌药物拓扑替康药效检测装置及检测方法 | |
Stradolini et al. | Simultaneous monitoring of anesthetics and therapeutic compounds with a portable multichannel potentiostat | |
CN108267487A (zh) | 一种硫化氢的检测装置及方法 | |
CN105866210B (zh) | 一种用于抗癌药物长春新碱的药效检测装置及检测方法 | |
CN105823815B (zh) | 抗癌药物多烯紫杉醇药效检测装置及检测方法 | |
CN105806904A (zh) | 抗癌药物异环磷酰胺药效检测装置及检测方法 | |
CN105866217B (zh) | 三尖杉酯碱癌症治疗效果检测装置及方法 | |
CN105823816A (zh) | 抗癌药物依托泊苷药效检测装置及检测方法 | |
CN101975640A (zh) | 输液泵/注射泵堵塞压力和丸剂量检测装置 | |
CN105891283B (zh) | 用于榄香烯的药效量化装置及方法 | |
CN105823809A (zh) | 吉西他滨化疗药效检测装置及检测方法 | |
CN104800975B (zh) | 基于生理期检测及痛经治疗的女性健康管理系统 | |
Zhang et al. | Parameter identification of Randles impedance model using sweep-phase measurements and non-iterative least squares estimation | |
CN108426918A (zh) | 一种制备天然药物、中药等提取物过程的在线监控方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Shao Chenning Inventor after: Yang Xin Inventor after: Pan Fangqin Inventor after: Zhou Zhixin Inventor after: Zheng Haonan Inventor after: Zhou Huimin Inventor after: Lin Han Inventor after: Hui Guohua Inventor after: Li Jian Inventor after: Zhang Jianfeng Inventor after: Gao Yuanyuan Inventor before: Hui Guohua Inventor before: Li Jian Inventor before: Zhang Jianfeng Inventor before: Gao Yuanyuan |