EP1749203A4 - Elektronisches echtzeit-zellenerfassungssystem und anwendungen für die cytotoxizitätsprofilierung und zusammengesetzte assays - Google Patents
Elektronisches echtzeit-zellenerfassungssystem und anwendungen für die cytotoxizitätsprofilierung und zusammengesetzte assaysInfo
- Publication number
- EP1749203A4 EP1749203A4 EP05722991A EP05722991A EP1749203A4 EP 1749203 A4 EP1749203 A4 EP 1749203A4 EP 05722991 A EP05722991 A EP 05722991A EP 05722991 A EP05722991 A EP 05722991A EP 1749203 A4 EP1749203 A4 EP 1749203A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- real
- applications
- sensing system
- time electronic
- cell sensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
- G01N33/4836—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
- C12M25/08—Plates; Walls; Drawers; Multilayer plates electrically charged
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/021—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance before and after chemical transformation of the material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Sustainable Development (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11193882.5A EP2450698B1 (de) | 2004-02-09 | 2005-02-09 | Elektronisches Echtzeit-Zellenerkennungssystem und Anwendungen für das Zytotoxizitätsprofil und Verbindungsassays |
EP13171137.6A EP2639576B1 (de) | 2004-02-09 | 2005-02-09 | Elektronisches Echtzeit-Zellenerkennungssystem und Anwendungen für das Zytotoxizitätsprofil und Verbindungsassays |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54292704P | 2004-02-09 | 2004-02-09 | |
US54871304P | 2004-02-27 | 2004-02-27 | |
US61460104P | 2004-09-29 | 2004-09-29 | |
US10/987,732 US7192752B2 (en) | 2002-12-20 | 2004-11-12 | Real time electronic cell sensing systems and applications for cell-based assays |
PCT/US2005/004481 WO2005077104A2 (en) | 2004-02-09 | 2005-02-09 | Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13171137.6A Division EP2639576B1 (de) | 2004-02-09 | 2005-02-09 | Elektronisches Echtzeit-Zellenerkennungssystem und Anwendungen für das Zytotoxizitätsprofil und Verbindungsassays |
EP11193882.5A Division EP2450698B1 (de) | 2004-02-09 | 2005-02-09 | Elektronisches Echtzeit-Zellenerkennungssystem und Anwendungen für das Zytotoxizitätsprofil und Verbindungsassays |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1749203A2 EP1749203A2 (de) | 2007-02-07 |
EP1749203A4 true EP1749203A4 (de) | 2009-05-06 |
Family
ID=40518464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05722991A Withdrawn EP1749203A4 (de) | 2004-02-09 | 2005-02-09 | Elektronisches echtzeit-zellenerfassungssystem und anwendungen für die cytotoxizitätsprofilierung und zusammengesetzte assays |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1749203A4 (de) |
CN (1) | CN101400780B (de) |
CA (1) | CA2556219A1 (de) |
WO (1) | WO2005077104A2 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
WO2005047482A2 (en) | 2003-11-12 | 2005-05-26 | Xiao Xu | Real time electronic cell sensing systems and applications for cell-based assays |
US7560269B2 (en) | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
WO2006015387A2 (en) | 2004-08-04 | 2006-02-09 | Xiao Xu | Method for assaying cytolytic activity of target cells |
CN101395471A (zh) | 2006-01-04 | 2009-03-25 | 诺华公司 | 抗体依赖性细胞毒性检测 |
WO2008036375A2 (en) * | 2006-09-20 | 2008-03-27 | Acea Biosciences Corporation | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
EP2103933B1 (de) | 2008-02-25 | 2011-07-27 | Universität Leipzig | Vorrichtung und Verfahren zur Messung der Impedanz in organischem Gewebe |
EP2291645B1 (de) | 2008-05-05 | 2015-09-09 | Acea Biosciences, Inc. | Markierungsfreie überwachung der elektromechanischen kopplung und erregbaren zellen anhand von systemen auf impedanzbasis mit millisekunden-zeitauflösung |
US8771202B2 (en) | 2010-01-19 | 2014-07-08 | Becton Dickinson And Company | Electrode layout for blood test sensor strip |
WO2011146531A1 (en) | 2010-05-18 | 2011-11-24 | Acea Biosciences, Inc | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments |
CN103675031B (zh) * | 2013-12-18 | 2015-09-02 | 江苏大学 | 一种高通量细胞毒性检测方法 |
EP3035052A1 (de) | 2014-12-18 | 2016-06-22 | Helmholtz-Zentrum für Infektionsforschung GmbH | Verfahren und Vorrichtung zur Bestimmung der Wachstumsrate von Biofilmen |
CN108473926A (zh) * | 2015-11-20 | 2018-08-31 | 美国艾森生物科学公司 | 癌细胞的细胞基质阻抗监测 |
WO2018161063A1 (en) | 2017-03-03 | 2018-09-07 | Acea Biosciences, Inc. | METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES |
EP3662281A4 (de) * | 2017-08-01 | 2021-04-21 | Agilent Technologies, Inc. | Überwachung der zellsubstratimpedanz von krebszellen verschiedener abstammung, herkunft oder phase |
US11733323B2 (en) | 2018-06-13 | 2023-08-22 | Centrul International De Biodinamica | Systems and methods for measuring cellular response to target analytes by controlled application of an oscillating stimulus |
RO133794A2 (ro) * | 2018-06-13 | 2019-12-30 | Centrul Internaţional De Biodinamică | Metodă şi dispozitiv de detecţie a unor compuşi bioactivi, de ex. citotoxici, utilizând senzori cu celule stimulate |
CN111751522B (zh) * | 2019-03-27 | 2023-06-20 | 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 | 一种细胞检测分析仪及细胞增殖信息的检测方法 |
CN110568037B (zh) * | 2019-09-02 | 2021-12-03 | 江南大学 | 用于啶虫脒和吡虫啉联合毒性评价的电化学细胞传感器的构建方法及其应用 |
CN111735752A (zh) * | 2020-07-01 | 2020-10-02 | 京东方科技集团股份有限公司 | 细胞检测装置和细胞检测系统 |
CN112485301B (zh) * | 2020-11-25 | 2023-07-14 | 三诺生物传感股份有限公司 | 一种电化学测试装置的测试方法、系统、设备及介质 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187096A (en) * | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
WO2004010103A2 (en) * | 2002-07-20 | 2004-01-29 | Acea Biosciences, Inc. | Impedance based devices and methods for use in assays |
WO2005047482A2 (en) * | 2003-11-12 | 2005-05-26 | Xiao Xu | Real time electronic cell sensing systems and applications for cell-based assays |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3890201A (en) * | 1974-09-26 | 1975-06-17 | Bactomatic Inc | Multi-chamber impedance measuring module-cap combination |
US4067951A (en) * | 1975-11-19 | 1978-01-10 | Bactomatic Inc. | Process for making impedance measuring module |
JPH11187865A (ja) * | 1997-12-25 | 1999-07-13 | Matsushita Electric Ind Co Ltd | 細胞電位測定電極及びこれを用いた測定装置 |
US6477479B1 (en) * | 1998-12-11 | 2002-11-05 | Symyx Technologies | Sensor array for rapid materials characterization |
AU780157B2 (en) * | 1999-10-01 | 2005-03-03 | Sophion Bioscience A/S | A substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
TWI245895B (en) * | 2001-11-29 | 2005-12-21 | Sun-Wing Tong | Molecular detection and assay by electrobiochip micro-array |
-
2005
- 2005-02-09 EP EP05722991A patent/EP1749203A4/de not_active Withdrawn
- 2005-02-09 CA CA002556219A patent/CA2556219A1/en not_active Abandoned
- 2005-02-09 WO PCT/US2005/004481 patent/WO2005077104A2/en active Application Filing
- 2005-02-09 CN CN2005800122559A patent/CN101400780B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187096A (en) * | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
WO2004010103A2 (en) * | 2002-07-20 | 2004-01-29 | Acea Biosciences, Inc. | Impedance based devices and methods for use in assays |
WO2005047482A2 (en) * | 2003-11-12 | 2005-05-26 | Xiao Xu | Real time electronic cell sensing systems and applications for cell-based assays |
Non-Patent Citations (3)
Title |
---|
EHRET R ET AL: "Monitoring of cellular behaviour by impedance measurements on interdigitated electrode structures", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 12, no. 1, 1 January 1997 (1997-01-01), pages 29 - 41, XP002272321, ISSN: 0956-5663 * |
WOLF B ET AL: "Monitoring of cellular signalling and metabolism with modular sensor-technique: the PhysioControl-Microsystem (PCM)", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 13, no. 5, 15 March 1998 (1998-03-15), pages 501 - 509, XP002408458, ISSN: 0956-5663 * |
XIAO C ET AL: "An In-Depth Analysis of Electric Cell-Substrate Impedance Sensing to Study the Attachment and Spreading of Mammalian Cells", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 74, no. 6, 15 March 2002 (2002-03-15), pages 1333 - 1339, XP002977290, ISSN: 0003-2700 * |
Also Published As
Publication number | Publication date |
---|---|
CN101400780A (zh) | 2009-04-01 |
EP1749203A2 (de) | 2007-02-07 |
WO2005077104A3 (en) | 2008-08-14 |
CA2556219A1 (en) | 2005-08-25 |
CN101400780B (zh) | 2012-06-20 |
WO2005077104A2 (en) | 2005-08-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20060906 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR LV MK YU |
|
DAX | Request for extension of the european patent (deleted) | ||
PUAK | Availability of information related to the publication of the international search report |
Free format text: ORIGINAL CODE: 0009015 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20090403 |
|
17Q | First examination report despatched |
Effective date: 20110608 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20111220 |