EP1749203A4 - Systemes de detection de cellules electroniques en temps reel et applications en matiere de profilage de cytotoxicite et dosages de composes - Google Patents

Systemes de detection de cellules electroniques en temps reel et applications en matiere de profilage de cytotoxicite et dosages de composes

Info

Publication number
EP1749203A4
EP1749203A4 EP05722991A EP05722991A EP1749203A4 EP 1749203 A4 EP1749203 A4 EP 1749203A4 EP 05722991 A EP05722991 A EP 05722991A EP 05722991 A EP05722991 A EP 05722991A EP 1749203 A4 EP1749203 A4 EP 1749203A4
Authority
EP
European Patent Office
Prior art keywords
real
applications
sensing system
time electronic
cell sensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05722991A
Other languages
German (de)
English (en)
Other versions
EP1749203A2 (fr
Inventor
Xiao Xu
Yama Abbassi
Xiaobo Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/987,732 external-priority patent/US7192752B2/en
Application filed by Individual filed Critical Individual
Priority to EP11193882.5A priority Critical patent/EP2450698B1/fr
Priority to EP13171137.6A priority patent/EP2639576B1/fr
Publication of EP1749203A2 publication Critical patent/EP1749203A2/fr
Publication of EP1749203A4 publication Critical patent/EP1749203A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C12M25/08—Plates; Walls; Drawers; Multilayer plates electrically charged
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/021—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance before and after chemical transformation of the material
EP05722991A 2004-02-09 2005-02-09 Systemes de detection de cellules electroniques en temps reel et applications en matiere de profilage de cytotoxicite et dosages de composes Withdrawn EP1749203A4 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11193882.5A EP2450698B1 (fr) 2004-02-09 2005-02-09 Système de détection de cellule électronique en temps réel et application pour le profilage de la cytotoxicité et l'analyse de composés
EP13171137.6A EP2639576B1 (fr) 2004-02-09 2005-02-09 Système de détection de cellule électronique en temps réel et application pour le profilage de la cytotoxicité et l'analyse de composés

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US54292704P 2004-02-09 2004-02-09
US54871304P 2004-02-27 2004-02-27
US61460104P 2004-09-29 2004-09-29
US10/987,732 US7192752B2 (en) 2002-12-20 2004-11-12 Real time electronic cell sensing systems and applications for cell-based assays
PCT/US2005/004481 WO2005077104A2 (fr) 2004-02-09 2005-02-09 Systemes de detection de cellules electroniques en temps reel et applications en matiere de profilage de cytotoxicite et dosages de composes

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP13171137.6A Division EP2639576B1 (fr) 2004-02-09 2005-02-09 Système de détection de cellule électronique en temps réel et application pour le profilage de la cytotoxicité et l'analyse de composés
EP11193882.5A Division EP2450698B1 (fr) 2004-02-09 2005-02-09 Système de détection de cellule électronique en temps réel et application pour le profilage de la cytotoxicité et l'analyse de composés

Publications (2)

Publication Number Publication Date
EP1749203A2 EP1749203A2 (fr) 2007-02-07
EP1749203A4 true EP1749203A4 (fr) 2009-05-06

Family

ID=40518464

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05722991A Withdrawn EP1749203A4 (fr) 2004-02-09 2005-02-09 Systemes de detection de cellules electroniques en temps reel et applications en matiere de profilage de cytotoxicite et dosages de composes

Country Status (4)

Country Link
EP (1) EP1749203A4 (fr)
CN (1) CN101400780B (fr)
CA (1) CA2556219A1 (fr)
WO (1) WO2005077104A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
CA2550274A1 (fr) 2003-11-12 2005-05-26 Acea Biosciences, Inc. Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules
EP1773980B1 (fr) 2004-08-04 2015-07-01 Acea Biosciences, Inc. Procede de dosage de la destruction de cellules cibles par des cellules tueuses naturelles, des lymphocytes t cytotoxiques et des neutrophiles, a l'aide de la technique de detection micro-electronique de cellules en temps reel
KR20080085080A (ko) 2006-01-04 2008-09-22 노파르티스 아게 항체-의존성 세포 세포독성 분석법
WO2008036375A2 (fr) * 2006-09-20 2008-03-27 Acea Biosciences Corporation Utilisation du profilage cytologique base sur l'impedance pour classer des profils de reponses cellulaires lors d'une exposition a des agents biologiquement actifs
EP2103933B1 (fr) 2008-02-25 2011-07-27 Universität Leipzig Dispositif et procédé de mesure d'impédance dans des tissus organotypiques
CA2723223C (fr) 2008-05-05 2017-06-06 Acea Biosciences, Inc. Surveillance sans marqueur d'un couplage excitation-contraction et cellules pouvant etre excitees utilisant des systemes fondes sur l'impedance avec une resolution dans le temps de l'ordre de la milliseconde
US8771202B2 (en) 2010-01-19 2014-07-08 Becton Dickinson And Company Electrode layout for blood test sensor strip
CN103675031B (zh) * 2013-12-18 2015-09-02 江苏大学 一种高通量细胞毒性检测方法
EP3035052A1 (fr) 2014-12-18 2016-06-22 Helmholtz-Zentrum für Infektionsforschung GmbH Procédé et dispositif de mesure pour la détermination de la vitesse de croissance d'un biofilm
WO2017087945A1 (fr) * 2015-11-20 2017-05-26 Acea Biosciences, Inc. Surveillance de l'impédance de substrat cellulaire de cellules cancéreuses
CN110582569B (zh) 2017-03-03 2024-04-02 安捷伦科技有限公司 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统
CN111492239A (zh) * 2017-08-01 2020-08-04 安捷伦科技有限公司 不同谱系、起源或分期的癌细胞的细胞-基质阻抗监测
RO133794A2 (ro) * 2018-06-13 2019-12-30 Centrul Internaţional De Biodinamică Metodă şi dispozitiv de detecţie a unor compuşi bioactivi, de ex. citotoxici, utilizând senzori cu celule stimulate
US11733323B2 (en) 2018-06-13 2023-08-22 Centrul International De Biodinamica Systems and methods for measuring cellular response to target analytes by controlled application of an oscillating stimulus
CN111751522B (zh) * 2019-03-27 2023-06-20 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 一种细胞检测分析仪及细胞增殖信息的检测方法
CN110568037B (zh) * 2019-09-02 2021-12-03 江南大学 用于啶虫脒和吡虫啉联合毒性评价的电化学细胞传感器的构建方法及其应用
CN111735752A (zh) * 2020-07-01 2020-10-02 京东方科技集团股份有限公司 细胞检测装置和细胞检测系统
CN112485301B (zh) * 2020-11-25 2023-07-14 三诺生物传感股份有限公司 一种电化学测试装置的测试方法、系统、设备及介质

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
WO2004010103A2 (fr) * 2002-07-20 2004-01-29 Acea Biosciences, Inc. Dispositifs a base d'impedance et procedes a utiliser dans des dosages
WO2005047482A2 (fr) * 2003-11-12 2005-05-26 Xiao Xu Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules

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US3890201A (en) * 1974-09-26 1975-06-17 Bactomatic Inc Multi-chamber impedance measuring module-cap combination
US4067951A (en) * 1975-11-19 1978-01-10 Bactomatic Inc. Process for making impedance measuring module
JPH11187865A (ja) * 1997-12-25 1999-07-13 Matsushita Electric Ind Co Ltd 細胞電位測定電極及びこれを用いた測定装置
US6477479B1 (en) * 1998-12-11 2002-11-05 Symyx Technologies Sensor array for rapid materials characterization
CN1204404C (zh) * 1999-10-01 2005-06-01 索菲昂生物科学有限公司 电生理学性质的测定组件及其构照方法
TWI245895B (en) * 2001-11-29 2005-12-21 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
WO2004010103A2 (fr) * 2002-07-20 2004-01-29 Acea Biosciences, Inc. Dispositifs a base d'impedance et procedes a utiliser dans des dosages
WO2005047482A2 (fr) * 2003-11-12 2005-05-26 Xiao Xu Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EHRET R ET AL: "Monitoring of cellular behaviour by impedance measurements on interdigitated electrode structures", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 12, no. 1, 1 January 1997 (1997-01-01), pages 29 - 41, XP002272321, ISSN: 0956-5663 *
WOLF B ET AL: "Monitoring of cellular signalling and metabolism with modular sensor-technique: the PhysioControl-Microsystem (PCM)", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 13, no. 5, 15 March 1998 (1998-03-15), pages 501 - 509, XP002408458, ISSN: 0956-5663 *
XIAO C ET AL: "An In-Depth Analysis of Electric Cell-Substrate Impedance Sensing to Study the Attachment and Spreading of Mammalian Cells", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 74, no. 6, 15 March 2002 (2002-03-15), pages 1333 - 1339, XP002977290, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
WO2005077104A2 (fr) 2005-08-25
CN101400780B (zh) 2012-06-20
EP1749203A2 (fr) 2007-02-07
CN101400780A (zh) 2009-04-01
WO2005077104A3 (fr) 2008-08-14
CA2556219A1 (fr) 2005-08-25

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