CN101400780B - 实时细胞电子分析系统及其在细胞毒性检测和化合物分析上的应用 - Google Patents
实时细胞电子分析系统及其在细胞毒性检测和化合物分析上的应用 Download PDFInfo
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- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
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Abstract
Description
癌细胞系 | 器官或组织来源 |
MDA.MB231 | 乳癌 |
MCF7 | 乳癌 |
NCI-H460 | 非小细胞肺癌 |
MV522SW | 非小细胞肺癌 |
A549 | 非小细胞肺癌 |
HT29 | 结肠癌 |
HCC2998 | 结肠癌 |
A2780 | 卵巢癌 |
OVCAR4 | 卵巢癌 |
PC-3 | 前列腺癌 |
HepG2 | 人肝肉瘤 |
A431 | 类上皮癌 |
HT1080 | 纤维肉瘤 |
Claims (82)
Applications Claiming Priority (9)
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US54292704P | 2004-02-09 | 2004-02-09 | |
US60/542,927 | 2004-02-09 | ||
US54871304P | 2004-02-27 | 2004-02-27 | |
US60/548,713 | 2004-02-27 | ||
US61460104P | 2004-09-29 | 2004-09-29 | |
US60/614,601 | 2004-09-29 | ||
US10/987,732 | 2004-11-12 | ||
US10/987,732 US7192752B2 (en) | 2002-12-20 | 2004-11-12 | Real time electronic cell sensing systems and applications for cell-based assays |
PCT/US2005/004481 WO2005077104A2 (en) | 2004-02-09 | 2005-02-09 | Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
Publications (2)
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CN101400780A CN101400780A (zh) | 2009-04-01 |
CN101400780B true CN101400780B (zh) | 2012-06-20 |
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EP (1) | EP1749203A4 (zh) |
CN (1) | CN101400780B (zh) |
CA (1) | CA2556219A1 (zh) |
WO (1) | WO2005077104A2 (zh) |
Families Citing this family (25)
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US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
US7560269B2 (en) | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
EP1692258A4 (en) | 2003-11-12 | 2007-03-21 | Xiao Xu | REAL-TIME ELECTRONIC CELL DETECTION SYSTEMS FOR CELL-BASED TESTS |
CA2575297C (en) | 2004-08-04 | 2014-09-23 | Acea Biosciences, Inc. | Method for assaying for natural killer, cytotoxic t-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology |
US20090155821A1 (en) | 2006-01-04 | 2009-06-18 | John Kunich | Antibody-dependent cellular cytotoxicity assay |
WO2008036375A2 (en) * | 2006-09-20 | 2008-03-27 | Acea Biosciences Corporation | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
ATE518136T1 (de) | 2008-02-25 | 2011-08-15 | Univ Leipzig | Vorrichtung und verfahren zur messung der impedanz in organischem gewebe |
CA2723223C (en) | 2008-05-05 | 2017-06-06 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
US8771202B2 (en) | 2010-01-19 | 2014-07-08 | Becton Dickinson And Company | Electrode layout for blood test sensor strip |
WO2011146531A1 (en) | 2010-05-18 | 2011-11-24 | Acea Biosciences, Inc | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments |
CN103675031B (zh) * | 2013-12-18 | 2015-09-02 | 江苏大学 | 一种高通量细胞毒性检测方法 |
EP3035052A1 (en) | 2014-12-18 | 2016-06-22 | Helmholtz-Zentrum für Infektionsforschung GmbH | Method and measuring device for determination of the growth rate of biofilm |
US20180246079A1 (en) * | 2015-11-20 | 2018-08-30 | Acea Biosciences, Inc. | Cell-substrate impedance monitoring of cancer cells |
US11746328B2 (en) | 2017-03-03 | 2023-09-05 | Agilent Technologies, Inc. | Methods and systems for functional maturation of iPSC and ESC derived cardiomyocytes |
CN111492239A (zh) * | 2017-08-01 | 2020-08-04 | 安捷伦科技有限公司 | 不同谱系、起源或分期的癌细胞的细胞-基质阻抗监测 |
US11733323B2 (en) | 2018-06-13 | 2023-08-22 | Centrul International De Biodinamica | Systems and methods for measuring cellular response to target analytes by controlled application of an oscillating stimulus |
RO133794A2 (ro) * | 2018-06-13 | 2019-12-30 | Centrul Internaţional De Biodinamică | Metodă şi dispozitiv de detecţie a unor compuşi bioactivi, de ex. citotoxici, utilizând senzori cu celule stimulate |
CN111751522B (zh) * | 2019-03-27 | 2023-06-20 | 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 | 一种细胞检测分析仪及细胞增殖信息的检测方法 |
CN110568037B (zh) * | 2019-09-02 | 2021-12-03 | 江南大学 | 用于啶虫脒和吡虫啉联合毒性评价的电化学细胞传感器的构建方法及其应用 |
CN111735752A (zh) * | 2020-07-01 | 2020-10-02 | 京东方科技集团股份有限公司 | 细胞检测装置和细胞检测系统 |
CN112485301B (zh) * | 2020-11-25 | 2023-07-14 | 三诺生物传感股份有限公司 | 一种电化学测试装置的测试方法、系统、设备及介质 |
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- 2005-02-09 CA CA002556219A patent/CA2556219A1/en not_active Abandoned
- 2005-02-09 WO PCT/US2005/004481 patent/WO2005077104A2/en active Application Filing
- 2005-02-09 CN CN2005800122559A patent/CN101400780B/zh active Active
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