ATE518136T1 - Vorrichtung und verfahren zur messung der impedanz in organischem gewebe - Google Patents

Vorrichtung und verfahren zur messung der impedanz in organischem gewebe

Info

Publication number
ATE518136T1
ATE518136T1 AT08003365T AT08003365T ATE518136T1 AT E518136 T1 ATE518136 T1 AT E518136T1 AT 08003365 T AT08003365 T AT 08003365T AT 08003365 T AT08003365 T AT 08003365T AT E518136 T1 ATE518136 T1 AT E518136T1
Authority
AT
Austria
Prior art keywords
organotypic tissue
impedance
tissue
organotypic
chamber
Prior art date
Application number
AT08003365T
Other languages
English (en)
Inventor
Andrea Robitzki
Andree Rothermel
Heinz-Georg Jahnke
Ina Sternberger
Frank Striggow
Till Mack
Original Assignee
Univ Leipzig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leipzig filed Critical Univ Leipzig
Application granted granted Critical
Publication of ATE518136T1 publication Critical patent/ATE518136T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/041—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT08003365T 2008-02-25 2008-02-25 Vorrichtung und verfahren zur messung der impedanz in organischem gewebe ATE518136T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08003365A EP2103933B1 (de) 2008-02-25 2008-02-25 Vorrichtung und Verfahren zur Messung der Impedanz in organischem Gewebe

Publications (1)

Publication Number Publication Date
ATE518136T1 true ATE518136T1 (de) 2011-08-15

Family

ID=40783947

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08003365T ATE518136T1 (de) 2008-02-25 2008-02-25 Vorrichtung und verfahren zur messung der impedanz in organischem gewebe

Country Status (3)

Country Link
US (2) US20090247898A1 (de)
EP (1) EP2103933B1 (de)
AT (1) ATE518136T1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE518136T1 (de) 2008-02-25 2011-08-15 Univ Leipzig Vorrichtung und verfahren zur messung der impedanz in organischem gewebe
US9527894B2 (en) * 2011-04-28 2016-12-27 Universitaet Leipzig Polymutant tau protein variants and their use for recapitulating human tauopathies
EP2581742A1 (de) * 2011-10-14 2013-04-17 Universität Leipzig Vorrichtung und Verfahren zur parallelen Aufzeichnung von Impedanzspektren und Feldpotenzial
EP2708889A1 (de) 2012-09-12 2014-03-19 Universität Leipzig Verfahren und Vorrichtung zum Erhalt einer Gewebeprobe und zur Charakterisierung der Gewebeprobe durch Bestimmung mindestens einer elektrischen Eigenschaft
WO2015110938A1 (en) * 2014-01-27 2015-07-30 Ecole Polytechnique Federale De Lausanne (Epfl) Device and method for testing a material response to a compound
CA2950306A1 (en) * 2014-05-26 2015-12-03 The Governing Council Of The University Of Toronto Device and method for assessing cell contraction
JP6550694B2 (ja) * 2014-07-08 2019-07-31 国立大学法人九州工業大学 細胞外電位計測デバイス及び細胞外電位計測方法
KR101617799B1 (ko) * 2014-11-03 2016-05-03 전남대학교병원 실험용 미세동물의 emg 측정용 미세전극 및 그 제작 방법, 및 미세전극을 이용한 실험용 미세동물의 emg 측정 시스템
KR101702739B1 (ko) 2015-01-27 2017-02-06 경희대학교 산학협력단 세포 및 조직 배양을 위한 실시간 모니터링 및 피드백 제어 장치 및 그 방법
CN104757972B (zh) * 2015-03-16 2024-02-06 思澜科技（成都）有限公司 一种用于生物阻抗测量的活检夹
WO2017192584A1 (en) * 2016-05-03 2017-11-09 Adverum Biotechnologies, Inc. Organotypic pig retina culture system
US20190017028A1 (en) * 2017-07-12 2019-01-17 The Regents Of The University Of Michigan Systems and methods for cardiomyocyte pacing
US11047821B2 (en) 2018-05-31 2021-06-29 Analog Devices International Unlimited Company Bio-impedance and contact impedances measurement
EE05830B1 (et) * 2019-02-08 2020-12-15 Tallinna Tehnikaülikool Mikrovooluti meetod ja seade
CN110658234B (zh) * 2019-09-30 2021-02-26 浙江大学 一种可抛弃式快拆型污染物阻抗检测装置
CN110658235B (zh) * 2019-09-30 2021-01-01 浙江大学 一种可抛弃式直压型污染物阻抗检测装置
US20230173255A1 (en) * 2021-09-21 2023-06-08 Nutech Ventures High-throughput porous substrate electroporation devices and methods
DE102023203746B3 (de) 2023-04-24 2024-06-27 Karlsruher Institut für Technologie, Körperschaft des öffentlichen Rechts Zellkulturmembraneinsatz sowie Vorrichtung und Verfahren zur Erfassung mindestens einer elektrochemischen Größe einer Zellkultur

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5178096A (en) 1992-02-10 1993-01-12 Lock Stanley L Livestock handling/feeding apparatus and method
US5624537A (en) * 1994-09-20 1997-04-29 The University Of British Columbia - University-Industry Liaison Office Biosensor and interface membrane
US20030033621A1 (en) * 1997-02-26 2003-02-13 De La Monte Suzanne Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US7087876B2 (en) 1998-06-15 2006-08-08 The Trustees Of Dartmouth College High-frequency melting of interfacial ice
US6387671B1 (en) 1999-07-21 2002-05-14 The Regents Of The University Of California Electrical impedance tomography to control electroporation
US6927049B2 (en) * 1999-07-21 2005-08-09 The Regents Of The University Of California Cell viability detection using electrical measurements
JP2001351029A (ja) * 2000-06-07 2001-12-21 Kobelco Contstruction Machinery Ltd 建設機械のレンタル方法およびレンタルシステム
JP4408537B2 (ja) * 2000-07-21 2010-02-03 シャープ株式会社 情報圧縮記録装置
EP1205541A1 (de) * 2000-11-14 2002-05-15 Klaus Dr. Giehl Verfahren zur Langzeit-Kultivierung organotypischer Slices von Gehirn und anderen Geweben postnataler, insbesondere adulter Säuger
US8263375B2 (en) * 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
CA2493108C (en) 2002-07-20 2011-08-30 Xiaobo Wang Impedance based devices and methods for use in assays
JP4072724B2 (ja) * 2003-04-16 2008-04-09 日立工機株式会社 自動分注装置
US20050014130A1 (en) * 2003-07-14 2005-01-20 Vivian Liu Label-free method for classification and characterization of cellular events
WO2005056788A1 (en) * 2003-12-08 2005-06-23 Excellin Life Sciences, Inc. Device and method for controlled electroporation and molecular delivery into cells and tissue
CA2556219A1 (en) 2004-02-09 2005-08-25 Acea Biosciences, Inc. Methods for assaying cells using cell-substrate impedance monitoring
WO2006047299A2 (en) 2004-10-22 2006-05-04 University Of Florida Research Foundation, Inc. Organotypic slice cultures and uses thereof
US20060216203A1 (en) 2005-03-28 2006-09-28 Mds Sciex (Us) A Division Of Mds Pharma Services (Us) Inc. Multiwell sample plate with integrated impedance electrodes and connection scheme
WO2007015878A2 (en) 2005-07-20 2007-02-08 University Of Louisville Research Foundation, Inc. Method for measuring cytopathic effect in cells using electric cell-substrate impedance sensing
JP4858870B2 (ja) * 2006-02-16 2012-01-18 財団法人生産技術研究奨励会 培養細胞の電気シグナル計測デバイスおよび該デバイスを用いる電気シグナル計測方法
US7443175B2 (en) * 2006-07-14 2008-10-28 Covidien Ag Surgical testing instrument and system
WO2009029519A2 (en) * 2007-08-24 2009-03-05 David Mark Evans Multiplexed electroporation apparatus
ATE518136T1 (de) 2008-02-25 2011-08-15 Univ Leipzig Vorrichtung und verfahren zur messung der impedanz in organischem gewebe

Also Published As

Publication number Publication date
EP2103933A1 (de) 2009-09-23
US10670576B2 (en) 2020-06-02
US20090247898A1 (en) 2009-10-01
EP2103933B1 (de) 2011-07-27
US20170191980A1 (en) 2017-07-06

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