ATE448274T1 - Polypropylenfumarat vernetzt mit polyethylenglykol-dimethacrylat - Google Patents

Polypropylenfumarat vernetzt mit polyethylenglykol-dimethacrylat

Info

Publication number
ATE448274T1
ATE448274T1 AT00928174T AT00928174T ATE448274T1 AT E448274 T1 ATE448274 T1 AT E448274T1 AT 00928174 T AT00928174 T AT 00928174T AT 00928174 T AT00928174 T AT 00928174T AT E448274 T1 ATE448274 T1 AT E448274T1
Authority
AT
Austria
Prior art keywords
linked
polyethylene glycol
glycol dimethacrylate
composites
polypropylene fumarate
Prior art date
Application number
AT00928174T
Other languages
English (en)
Inventor
Shulin He
Michael Yaszemski
Antonios Mikos
Original Assignee
Univ Wm Marsh Rice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wm Marsh Rice filed Critical Univ Wm Marsh Rice
Application granted granted Critical
Publication of ATE448274T1 publication Critical patent/ATE448274T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/676—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/06—Unsaturated polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/918—Polycarboxylic acids and polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C08G81/024—Block or graft polymers containing sequences of polymers of C08C or C08F and of polymers of C08G
    • C08G81/025—Block or graft polymers containing sequences of polymers of C08C or C08F and of polymers of C08G containing polyether sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/06—Unsaturated polyesters
    • C08L67/07—Unsaturated polyesters having terminal carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Laminated Bodies (AREA)
AT00928174T 1999-04-16 2000-04-14 Polypropylenfumarat vernetzt mit polyethylenglykol-dimethacrylat ATE448274T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12957799P 1999-04-16 1999-04-16
US14699199P 1999-08-03 1999-08-03
US16732899P 1999-11-24 1999-11-24
US16738899P 1999-11-24 1999-11-24
PCT/US2000/010051 WO2000063268A1 (en) 1999-04-16 2000-04-14 Poly(propylene fumarate) cross linked with poly(ethylene glycol)

Publications (1)

Publication Number Publication Date
ATE448274T1 true ATE448274T1 (de) 2009-11-15

Family

ID=27494811

Family Applications (3)

Application Number Title Priority Date Filing Date
AT00928174T ATE448274T1 (de) 1999-04-16 2000-04-14 Polypropylenfumarat vernetzt mit polyethylenglykol-dimethacrylat
AT00923355T ATE357468T1 (de) 1999-04-16 2000-04-14 Bioabbaubare mit polypropylenfumaratdiacrylat- makromonomeren vernetzte polypropylenfumarat- netzwerke
AT00923381T ATE321803T1 (de) 1999-04-16 2000-04-14 Funktionalisiertes polypropylenfumarat und polypropylenfumarat-co-ethylenglykol

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT00923355T ATE357468T1 (de) 1999-04-16 2000-04-14 Bioabbaubare mit polypropylenfumaratdiacrylat- makromonomeren vernetzte polypropylenfumarat- netzwerke
AT00923381T ATE321803T1 (de) 1999-04-16 2000-04-14 Funktionalisiertes polypropylenfumarat und polypropylenfumarat-co-ethylenglykol

Country Status (9)

Country Link
US (4) US6384105B1 (de)
EP (3) EP1194463B1 (de)
JP (3) JP2002542349A (de)
KR (3) KR100696408B1 (de)
AT (3) ATE448274T1 (de)
AU (3) AU760358B2 (de)
CA (3) CA2369758C (de)
DE (3) DE60034045T2 (de)
WO (3) WO2000063263A1 (de)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384105B1 (en) 1999-04-16 2002-05-07 William Marsh Rice University Poly(Propylene Fumarate) cross linked with Poly(Ethylene Glycol)
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
WO2002096977A1 (fr) * 2001-05-30 2002-12-05 Nanocarrier Co., Ltd. Procede de liaison d'une substance a incorporer a une terminaison polymere
CA2451203A1 (en) * 2001-06-28 2003-01-09 Wm. Marsh Rice University Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US20050064587A1 (en) * 2001-09-07 2005-03-24 Lawrence Rosenberg Pancreatic small cells and uses thereof
US7629388B2 (en) * 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
DE10206517A1 (de) * 2002-02-16 2003-09-04 Stoess & Co Gelatine Depotarzneimittel, Trägermaterialien für Depotarzneimittel und Verfahren zu deren Herstellung
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
EP1530600B1 (de) * 2002-08-09 2007-03-14 Ottawa Health Research Institute Biosynthetische matrix und deren verwendung
JP2006508709A (ja) * 2002-09-13 2006-03-16 オキュラー サイエンシス インコーポレイテッド 視力を向上させる器具及び方法
CA2505821C (en) 2002-11-12 2012-08-21 The Polymer Technology Group Incorporated Control of polymer surface molecular architecture via amphipathic endgroups
US7186789B2 (en) * 2003-06-11 2007-03-06 Advanced Cardiovascular Systems, Inc. Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings
US7875273B2 (en) 2004-12-23 2011-01-25 Ethicon, Incorporated Treatment of Parkinson's disease and related disorders using postpartum derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
ES2564044T3 (es) 2003-06-27 2016-03-17 DePuy Synthes Products, Inc. Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US20060223177A1 (en) 2003-06-27 2006-10-05 Ethicon Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8491883B2 (en) 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
CA2528150A1 (en) * 2003-07-01 2005-01-20 Mayo Foundation For Medical Education And Research Self-crosslinkable poly(caprolactone fumarate)
ATE464341T1 (de) * 2003-07-01 2010-04-15 Mayo Foundation Hydroxyapatitgepfropfte makromonomere auf fumaratbasis für biologisch abbaubare komposite
JP4889505B2 (ja) 2004-02-02 2012-03-07 アンブレツクス・インコーポレイテツド 被修飾されたヒト成長ホルモンポリペプチドおよびこれらの使用
US20060018949A1 (en) * 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
JP2008503217A (ja) 2004-06-18 2008-02-07 アンブレツクス・インコーポレイテツド 新規抗原結合ポリペプチド及びそれらの使用
WO2009100255A2 (en) 2008-02-08 2009-08-13 Ambrx, Inc. Modified leptin polypeptides and their uses
CN101506355B (zh) 2004-09-24 2012-06-27 成血管细胞系统公司 多能扩增间充质前体细胞子代（memp）及其应用
AU2005287855B2 (en) 2004-09-24 2011-06-16 Mesoblast, Inc. Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC)
US8039258B2 (en) * 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
WO2006053031A2 (en) 2004-11-12 2006-05-18 Mayo Foundation For Medical Education And Research Photocrosslinkable poly(caprolactone fumarate)
WO2006083394A2 (en) * 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006101548A2 (en) * 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
KR101224781B1 (ko) 2004-12-22 2013-01-21 암브룩스, 인코포레이티드 비천연적으로 코딩된 아미노산을 포함하는 인간 성장호르몬의 조제물
WO2006068802A2 (en) 2004-12-22 2006-06-29 Ambrx, Inc. COMPOSITIONS OF AMINOACYL-tRNA SYNTHETASE AND USES THEREOF
JP2008525032A (ja) * 2004-12-22 2008-07-17 アンブレツクス・インコーポレイテツド 組換えヒト成長ホルモンを発現及び精製するための方法
KR20070090023A (ko) 2004-12-22 2007-09-04 암브룩스, 인코포레이티드 변형 인간 성장 호르몬
ES2654428T3 (es) 2005-04-12 2018-02-13 Mesoblast, Inc. Aislamiento de células multipotenciales adultas por fosfatasa alcalina no específica de tejido
CA2606396A1 (en) * 2005-04-29 2006-11-09 Mayo Foundation For Medical Education And Research Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof
CA2609205A1 (en) 2005-06-03 2006-12-14 Ambrx, Inc. Improved human interferon molecules and their uses
WO2007047468A2 (en) 2005-10-13 2007-04-26 Anthrogenesis Corporation Immunomodulation using placental stem cells
WO2007047465A1 (en) 2005-10-13 2007-04-26 Anthrogenesis Corporation Production of oligodendrocytes from placenta-derived stem cells
ES2547554T3 (es) 2005-11-16 2015-10-07 Ambrx, Inc. Métodos y composiciones que comprenden aminoácidos no naturales
PL1971681T3 (pl) * 2005-12-16 2018-01-31 Depuy Synthes Products Inc Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej
WO2007073552A1 (en) * 2005-12-19 2007-06-28 Ethicon, Inc. In vitro expansion of postpartum derived cells in roller bottles
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
ES2628129T3 (es) * 2005-12-28 2017-08-01 DePuy Synthes Products, Inc. Tratamiento de la enfermedad vascular periférica utilizando células derivadas del posparto
NZ595786A (en) 2005-12-29 2013-05-31 Anthrogenesis Corp Placental stem cell populations
TW200740416A (en) * 2006-02-08 2007-11-01 Coopervision Inc Corneal onlays and related methods
US7883520B2 (en) * 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
US8114150B2 (en) * 2006-06-14 2012-02-14 Advanced Cardiovascular Systems, Inc. RGD peptide attached to bioabsorbable stents
CN101541955B (zh) 2006-09-08 2016-09-28 Ambrx公司 用于脊椎动物细胞的杂合抑制tRNA
PT2064333E (pt) 2006-09-08 2014-06-09 Ambrx Inc Supressor híbrido arnt para células de vertebrados
EP2069396B1 (de) 2006-09-08 2015-10-21 Ambrx, Inc. Modifiziertes polypeptid oder fc-gerüste aus humanem plasma und ihre verwendung
WO2008051568A2 (en) 2006-10-23 2008-05-02 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
EP2630959A1 (de) 2007-02-12 2013-08-28 Anthrogenesis Corporation Behandlung von Infektionskrankheiten mithilfe von Plazenta-Stammzellen
US20100172830A1 (en) * 2007-03-29 2010-07-08 Cellx Inc. Extraembryonic Tissue cells and method of use thereof
PL2068909T3 (pl) 2007-03-30 2012-09-28 Ambrx Inc Modyfikowane polipeptydy fgf-21 i ich zastosowanie
EP2076533B1 (de) 2007-05-02 2014-10-08 Ambrx, Inc. Modifizierte interferon-beta-polypeptide und ihre verwendungen
KR101688449B1 (ko) 2007-08-06 2016-12-21 메소블라스트, 아이엔씨. 생체 내에서 결합 조직을 생성, 복구 및/또는 유지하는 방법
KR20230065354A (ko) 2007-09-28 2023-05-11 셀룰래리티 인코포레이티드 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
ES2525718T3 (es) * 2007-10-05 2014-12-29 DePuy Synthes Products, LLC Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano
ES2632504T3 (es) 2007-11-20 2017-09-13 Ambrx, Inc. Polipéptidos de insulina modificados y sus usos
US8236538B2 (en) 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
JP5680534B2 (ja) 2008-07-23 2015-03-04 イーライ リリー アンド カンパニー 修飾されているウシｇ−ｃｓｆポリペプチドおよびそれらの使用
NZ591293A (en) 2008-08-22 2012-10-26 Anthrogenesis Corp Methods and compositions for treatment of bone defects with osteogenic placental adherent cells (OPACs)
PE20110832A1 (es) 2008-09-26 2011-11-24 Ambrx Inc Polipeptidos de eritropoyetina felina modificados
MX348657B (es) 2008-09-26 2017-06-21 Ambrx Inc Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
US20100087920A1 (en) * 2008-10-07 2010-04-08 Forsight Labs, Llc Corneal Onlay Lenses and Related Methods for Improving Vision of Presbyopic Patients
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
CA2747794C (en) 2008-12-19 2018-10-30 Advanced Technologies And Regenerative Medicine, Llc Treatment of lung and pulmonary diseases and disorders
US20130302283A1 (en) 2012-05-14 2013-11-14 Advanced Technologies And Regenerative Medicine, Llc hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS
EP2379089B1 (de) * 2008-12-19 2019-04-17 DePuy Synthes Products, Inc. Regeneration und reparatur von nervengeweben nach einer verletzung
AU2009327382B2 (en) * 2008-12-19 2014-07-17 DePuy Synthes Products, LLC Umbilical cord tissue derived cells for treating neuropathic pain and spasticity
PT2411506T (pt) 2009-03-25 2019-03-19 Celularity Inc Supressão de tumores usando células assassinas naturais intermédias derivadas de placenta humana e compostos imunomoduladores
SG174551A1 (en) * 2009-03-26 2011-10-28 Ethicon Inc Human umbilical cord tissue cells as therapy for alzheimer' s disease
JP2013506681A (ja) * 2009-10-02 2013-02-28 バクスター・インターナショナル・インコーポレイテッド 腎損傷の処置における使用のための造血幹細胞
EA201290541A1 (ru) 2009-12-21 2013-05-30 Амбркс, Инк. Модифицированные бычьи соматотропиновые полипептиды и их применение
CN102666578A (zh) 2009-12-21 2012-09-12 Ambrx公司 经过修饰的猪促生长素多肽和其用途
CA2787992A1 (en) 2010-01-26 2011-08-04 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells
US9132199B2 (en) 2010-03-05 2015-09-15 University of Pittsburgh—of the Commonwealth System of Higher Education Reverse thermal gels and uses therefor
US9144598B2 (en) 2010-03-05 2015-09-29 University of Pittsburgh—of the Commonwealth System of Higher Education Reverse thermal gels and their use in cell therapy
KR20200047797A (ko) 2010-04-07 2020-05-07 안트로제네시스 코포레이션 태반 줄기 세포를 사용한 혈관신생
CN102933221A (zh) 2010-04-08 2013-02-13 人类起源公司 使用胎盘干细胞治疗结节病
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
CA2808596C (en) 2010-08-17 2020-12-15 Ambrx, Inc. Modified relaxin polypeptides and their uses
AR083006A1 (es) 2010-09-23 2013-01-23 Lilly Co Eli Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
US20120171180A1 (en) 2010-12-30 2012-07-05 Sascha Abramson Compositions comprising amnion derived adherent cells and platelet-rich plasma
WO2012092458A2 (en) 2010-12-30 2012-07-05 Anthrogenesis Corporation Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
DK2681247T3 (en) 2011-02-28 2018-06-25 Cadena Bio Inc Polymers containing an acid group and their use as catalyst
JP2014518862A (ja) * 2011-05-09 2014-08-07 インスティトゥト・キミク・デ・サリア 薬物送達用ポリマーナノ粒子
ES2707579T3 (es) 2011-06-01 2019-04-04 Celularity Inc Tratamiento del dolor usando citoblastos placentarios
ES2661587T3 (es) 2011-08-10 2018-04-02 Depuy Synthes Products Llc Tratamiento de enfermedad vascular periférica usando células derivadas de tejido del cordón umbilical
PL2794854T3 (pl) 2011-12-23 2018-12-31 DePuy Synthes Products, Inc. Wykrywanie ludzkich komórek pochodzących z tkanki pępowinowej
US20130216495A1 (en) 2012-02-21 2013-08-22 Baxter Healthcare Sa Pharmaceutical composition comprising cd34+ cells
ES2938886T3 (es) 2012-04-05 2023-04-17 Priavoid Gmbh Procedimiento para el tratamiento de sangre, productos sanguíneos y órganos
DE102012102999A1 (de) * 2012-04-05 2013-10-10 Forschungszentrum Jülich GmbH Verfahren zur Behandlung von Blut, Blutprodukten und Organen
CN107652356A (zh) 2012-04-05 2018-02-02 于利希研究中心有限公司 包含多价结合淀粉样β蛋白的D‑肽的聚合物及其应用
WO2013163230A2 (en) * 2012-04-24 2013-10-31 Midori Renewables, Inc. Bio-based polymers and methods of producing thereof
JP6498600B2 (ja) 2012-06-08 2019-04-10 ストロ バイオファーマ インコーポレーテッド 部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
US9732161B2 (en) 2012-06-26 2017-08-15 Sutro Biopharma, Inc. Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
EP2872619B1 (de) 2012-07-11 2018-02-14 Imstem Biotechnology Inc. Mesenchymale stammzellen aus menschlichen embryonalen stammzellen, verfahren dafür und verwendungen davon
US9238845B2 (en) 2012-08-24 2016-01-19 Midori Usa, Inc. Methods of producing sugars from biomass feedstocks
CN104981254B (zh) 2012-08-31 2018-05-22 苏特罗生物制药公司 含有叠氮基的经修饰的氨基酸
JP2015536326A (ja) 2012-10-19 2015-12-21 アントフロゲネシス コーポレーション 羊膜由来接着細胞を利用する疼痛の治療
US20150307879A1 (en) 2012-12-14 2015-10-29 Anthrogenesis Corporation Anoikis resistant placental stem cells and uses thereof
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
EP3622960A1 (de) 2013-02-05 2020-03-18 Celularity, Inc. Natürliche killerzellen aus plazenta
WO2014159806A1 (en) 2013-03-14 2014-10-02 Anthrogenesis Corporation Enhanced placental stem cells and uses thereof
CN111643663A (zh) 2013-03-15 2020-09-11 细胞基因公司 修饰的t淋巴细胞
EP3019522B1 (de) 2013-07-10 2017-12-13 Sutro Biopharma, Inc. Antikörper mit mehreren ortsspezifischen nichtnatürlichen aminosäureresten, verfahren zu deren herstellung und verfahren zu deren verwendung
US10173357B2 (en) 2013-09-26 2019-01-08 Northwestern University Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting
US9840493B2 (en) 2013-10-11 2017-12-12 Sutro Biopharma, Inc. Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
KR102514110B1 (ko) 2014-05-05 2023-03-24 어드밴스드 메디칼 솔루션스 이스라엘 (실란티스) 엘티디. 생물학적 접착제 및 밀봉제, 그리고 이들을 이용하는 방법
JP6702962B2 (ja) 2014-10-24 2020-06-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 改変ｆｇｆ−２１ポリペプチドおよびその使用
JP6797803B2 (ja) 2014-12-31 2020-12-09 セルジーン コーポレイション ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法
CN108367028A (zh) 2015-09-15 2018-08-03 细胞结构公司 使用胎盘细胞治疗糖尿病性周围神经病变
GB201603296D0 (en) 2016-02-25 2016-04-13 Ucl Business Plc Chemotactic,drug-containing polymersomes
GB201604553D0 (en) * 2016-03-17 2016-05-04 Ucl Business Plc Fumarate polymersomes
EP3481405A1 (de) 2016-07-05 2019-05-15 Janssen Biotech, Inc. Behandlung von netzhautgefässerkrankung mit vorläuferzellen
US20190314424A1 (en) 2016-12-05 2019-10-17 Celularity, Inc. Treatment of lymphedema and related conditions using placental adherent cells
CN106693039B (zh) * 2017-01-24 2019-10-01 南开大学 一种具有良好生物粘附性的医用水凝胶的制备方法
AU2018214596A1 (en) * 2017-02-02 2019-08-08 The University Of Akron Functionalized poly(propylene fumarate) polymers made by ring opening polymerization using magnesium catalysts
CN110637027A (zh) 2017-02-08 2019-12-31 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
AU2018313090A1 (en) * 2017-08-07 2020-02-27 The University Of Akron Synthesis and characterization of well defined poly(propylene fumarate) and poly(ethylene glycol) block copolymers
WO2019067792A1 (en) 2017-09-28 2019-04-04 Celularity, Inc. TUMOR CONTROL WITH INTERMEDIATE NATURAL KILLER CELLS DERIVED FROM HUMAN PLACENTA (PINK) IN COMBINATION WITH ANTIBODY
PL3849614T3 (pl) 2018-09-11 2024-04-22 Ambrx, Inc. Koniugaty polipeptydu interleukiny-2 i ich zastosowania
JP2022512746A (ja) 2018-10-19 2022-02-07 アンブルックス，インコーポレイテッド インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用
WO2020168017A1 (en) 2019-02-12 2020-08-20 Ambrx, Inc. Compositions containing, methods and uses of antibody-tlr agonist conjugates
JP2023517595A (ja) 2020-03-11 2023-04-26 アンブルックス，インコーポレイテッド インターロイキン－２ポリペプチド結合物およびその使用方法
GB2594243A (en) * 2020-04-15 2021-10-27 Arterius Ltd A bone cement
US11384176B2 (en) 2020-06-26 2022-07-12 Saudi Arabian Oil Company Method of producing acryloyl monomers and acryloyl-based polymers
US20230302150A1 (en) 2020-08-20 2023-09-28 Ambrx, Inc. Antibody-tlr agonist conjugates, methods and uses thereof
CN112175191B (zh) * 2020-09-22 2022-07-26 中山大学 一种可交联可降解多嵌段共聚物及其制备方法与应用
CN112973277B (zh) * 2021-03-17 2022-06-14 济南大学 一种超支化型高分子聚合物滤垫的制备及其应用
KR20240004342A (ko) 2021-04-03 2024-01-11 암브룩스, 인코포레이티드 항-her2 항체-약물 접합체 및 이의 용도
WO2022236187A1 (en) 2021-05-07 2022-11-10 Children's Hospital Los Angeles Methods for making stem cell-derived enteric neural crest cells and their use in enteric neuropathy treatment
CN114249863B (zh) * 2022-01-20 2023-01-24 西安交通大学 一种氢键增强的光固化硬组织粘合剂及其制备方法和使用方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701748A (en) * 1966-07-20 1972-10-31 Rohm & Haas Unsaturated polyester resinous compositions
DE2061421A1 (en) * 1970-12-14 1972-06-29 Rohm & Haas Liquid polyester compsn comprising polyester thermoplastic polymer - and monomer characterised by very low shrinkage during curing
US4331735A (en) * 1980-06-26 1982-05-25 The General Tire & Rubber Company One component in-mold coating
US5286763A (en) 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
US4722948A (en) * 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
US5989579A (en) * 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US4843112A (en) * 1987-03-12 1989-06-27 The Beth Israel Hospital Association Bioerodable implant composition
JPH072836B2 (ja) * 1987-08-18 1995-01-18 帝人株式会社 水分散性ポリエステル
US4888413A (en) * 1988-01-11 1989-12-19 Domb Abraham J Poly(propylene glycol fumarate) compositions for biomedical applications
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
DE69028303T2 (de) * 1989-06-05 1997-01-30 Massachusetts Inst Technology Biodegradierbare polymere zur arzneimittelverabreichung in knochen
AU639645B2 (en) * 1989-10-10 1993-07-29 Wm. Wrigley Jr. Company Gradual release structures made from fiber spinning techniques
FR2661682B1 (fr) * 1990-05-04 1993-12-10 Norsolor Nouvelles compositions resineuses a base de resines polyesters non saturees et de nouveaux additifs anti-retrait.
DE69232555T2 (de) * 1991-02-01 2002-10-31 Massachusetts Inst Technology Biologisch abbaubare Polymermischungen zur Arzneistoffabgabe
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
BR9306038A (pt) * 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
EP0580328B1 (de) * 1992-07-24 1997-04-02 Rohm And Haas Company Polyester mit Methacrylatgruppen
US5512600A (en) 1993-01-15 1996-04-30 Massachusetts Institute Of Technology Preparation of bonded fiber structures for cell implantation
US5514378A (en) 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5522895A (en) 1993-07-23 1996-06-04 Rice University Biodegradable bone templates
US5733951A (en) * 1994-04-28 1998-03-31 Yaszemski; Michael J. Poly(propylene fumarate)
US5527864A (en) * 1995-08-08 1996-06-18 Suggs; Laura J. Poly(propylene fumarate-co-ethylene oxide)
PT2111876E (pt) 1995-12-18 2011-12-23 Angiodevice Internat Gmbh Composições de polímero reticulado e seus métodos de utilização
US5998362A (en) 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US6124373A (en) * 1998-04-10 2000-09-26 Wm. Marsh Rice University Bone replacement compound comprising poly(polypropylene fumarate)
US6384105B1 (en) 1999-04-16 2002-05-07 William Marsh Rice University Poly(Propylene Fumarate) cross linked with Poly(Ethylene Glycol)

Also Published As

Publication number Publication date
EP1210379B1 (de) 2007-03-21
US20020022676A1 (en) 2002-02-21
CA2369758A1 (en) 2000-10-26
ATE321803T1 (de) 2006-04-15
EP1194463B1 (de) 2009-11-11
EP1171006A4 (de) 2002-09-25
ATE357468T1 (de) 2007-04-15
KR20010114243A (ko) 2001-12-31
KR100696407B1 (ko) 2007-03-19
JP2002542352A (ja) 2002-12-10
US6306821B1 (en) 2001-10-23
DE60034045T2 (de) 2007-11-22
DE60026983D1 (de) 2006-05-18
KR20010114244A (ko) 2001-12-31
KR20020005682A (ko) 2002-01-17
EP1171006B1 (de) 2006-03-29
DE60034045D1 (de) 2007-05-03
EP1171006A1 (de) 2002-01-16
US20020177668A1 (en) 2002-11-28
US6423790B1 (en) 2002-07-23
CA2370330A1 (en) 2000-10-26
JP4644374B2 (ja) 2011-03-02
DE60043304D1 (de) 2009-12-24
AU4349600A (en) 2000-11-02
WO2000063268A1 (en) 2000-10-26
US6759485B2 (en) 2004-07-06
WO2000062630A1 (en) 2000-10-26
AU770579B2 (en) 2004-02-26
AU775913B2 (en) 2004-08-19
CA2370357A1 (en) 2000-10-26
KR100619611B1 (ko) 2006-09-01
CA2369758C (en) 2007-04-03
EP1194463A4 (de) 2002-09-25
AU4644700A (en) 2000-11-02
EP1210379A4 (de) 2002-09-25
CA2370330C (en) 2009-01-20
CA2370357C (en) 2007-04-10
EP1194463A1 (de) 2002-04-10
EP1210379A1 (de) 2002-06-05
WO2000063263A1 (en) 2000-10-26
JP2002542349A (ja) 2002-12-10
KR100696408B1 (ko) 2007-03-19
US6384105B1 (en) 2002-05-07
AU4351800A (en) 2000-11-02
JP2002542339A (ja) 2002-12-10
DE60026983T2 (de) 2007-01-25
AU760358B2 (en) 2003-05-15

Similar Documents

Publication Publication Date Title
ATE448274T1 (de) Polypropylenfumarat vernetzt mit polyethylenglykol-dimethacrylat
ATE507857T1 (de) Einführschleuse
WO2002051463A3 (en) Implantable biodegradable devices for musculoskeletal repair or regeneration
EA200000278A1 (ru) Композиционный материал на основе бумаги с полимерным покрытием
AU2002247154A1 (en) Biocompatible fleece for hemostasis and tissue engineering
DE69831074D1 (de) Superporöse hydrogelverbundstoffe mit schneller quellung,hoher mechanischer festigkeit und superabsorbierenden eigenschaften
TW200503661A (en) Absorbent materials and absorbent articles incorporating such absorbent materials
ATE521372T1 (de) Supersaugfähiges polymer mit hoher permeabilität
WO2001013819A3 (en) A method of making biodegradable polymeric implants
DE69736462D1 (de) Ethylenpolymere mit ultra-niedrigem molekulargewicht
DE69502824T2 (de) Silanvernetzbare, im wesentlichen lineare ethylen-polymere und ihre verwendung
CA2449947A1 (en) Antiadhesive material
NO20006468D0 (no) Myk propylenpolymerblanding med höy smeltestyrke
HK1004119A1 (en) Cross-linked polymers made from 1,3,7-octatriene and like conjugated polyenes
EP1245201A4 (de) Künstliche trachea
DE60008085D1 (de) Herstellung von polypropylen mit verbesserten eigenschaften
ATE325151T1 (de) Methode zur herstellung von bioabbaubaren polyhydroxyalkanoat-copolymeren mit verbesserten kristallisationseigenschaften
DE69205741D1 (de) Zusammensetzung zum Vernetzen von Ethylenpolymer, Verfahren zum Vernetzen des Polymers und Starkstromkabel mit vernetztem Polymer.
TW200517403A (en) Biodegradable material and process for producing said biodegradable material
AU6986200A (en) High-strength polyester threads and method for producing the same
DE602004007155D1 (de) Kationische polymere mit abbaubaren vernetzungen
IT1282683B1 (it) Mescole di bitume e di polimeri olefinici atti alla modifica dei bitumi
DE69525938T2 (de) Antimikrobielle materialen
BRPI0515217A (pt) pelìcula polimérica, artigo composto, processo para preparar uma pelìcula e uso de uma pelìcula
FR2843523B1 (fr) Support fibreux biodegradable pour paillage de sol

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties