DE69232555T2 - Biologisch abbaubare Polymermischungen zur Arzneistoffabgabe - Google Patents

Biologisch abbaubare Polymermischungen zur Arzneistoffabgabe

Info

Publication number
DE69232555T2
DE69232555T2 DE69232555T DE69232555T DE69232555T2 DE 69232555 T2 DE69232555 T2 DE 69232555T2 DE 69232555 T DE69232555 T DE 69232555T DE 69232555 T DE69232555 T DE 69232555T DE 69232555 T2 DE69232555 T2 DE 69232555T2
Authority
DE
Germany
Prior art keywords
blends
polyesters
polyanhydrides
polymers
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232555T
Other languages
English (en)
Other versions
DE69232555D1 (de
Inventor
J Domb
Manoj Maniar
T Haffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE69232555D1 publication Critical patent/DE69232555D1/de
Publication of DE69232555T2 publication Critical patent/DE69232555T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L73/00—Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
    • C08L73/02—Polyanhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69232555T 1991-02-01 1992-01-31 Biologisch abbaubare Polymermischungen zur Arzneistoffabgabe Expired - Fee Related DE69232555T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64892791A 1991-02-01 1991-02-01
PCT/US1992/000877 WO1992013567A1 (en) 1991-02-01 1992-01-31 Biodegradable polymer blends for drug delivery

Publications (2)

Publication Number Publication Date
DE69232555D1 DE69232555D1 (de) 2002-05-23
DE69232555T2 true DE69232555T2 (de) 2002-10-31

Family

ID=24602790

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232555T Expired - Fee Related DE69232555T2 (de) 1991-02-01 1992-01-31 Biologisch abbaubare Polymermischungen zur Arzneistoffabgabe

Country Status (10)

Country Link
US (1) US5919835A (de)
EP (1) EP0568651B1 (de)
JP (1) JP3137337B2 (de)
AT (1) ATE216262T1 (de)
AU (1) AU669479B2 (de)
CA (1) CA2101742C (de)
DE (1) DE69232555T2 (de)
DK (1) DK0568651T3 (de)
ES (1) ES2176189T3 (de)
WO (1) WO1992013567A1 (de)

Families Citing this family (35)

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US5571525A (en) * 1992-03-30 1996-11-05 Alza Corporation Erosion rate modifier for use in bioerodible drug delivery devices and method of use
US5321113A (en) * 1993-05-14 1994-06-14 Ethicon, Inc. Copolymers of an aromatic anhydride and aliphatic ester
ATE183092T1 (de) 1995-10-28 1999-08-15 Braun Melsungen Ag Lokalanästhetika und/oder zentralanalgetika enthaltende pharmazeutische zusammensetzungen
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6384105B1 (en) * 1999-04-16 2002-05-07 William Marsh Rice University Poly(Propylene Fumarate) cross linked with Poly(Ethylene Glycol)
US6113678A (en) * 1999-09-23 2000-09-05 Xerox Corporation Hot melt inks containing polyanhydrides
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
US20030170289A1 (en) * 2001-11-14 2003-09-11 Guohua Chen Injectable depot compositions and uses thereof
DE60239556D1 (de) * 2001-11-14 2011-05-05 Durect Corp Katheterinjizierbare depotzusammensetzungen und deren verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
MXPA05001244A (es) * 2002-07-31 2005-06-08 Alza Corp Composiciones de deposito de polimero multimodal inyectable y usos de las mismas.
AU2002359397B2 (en) * 2002-07-31 2009-01-29 Durect Corporation Injectable depot compositions and uses thereof
US20040115273A1 (en) * 2002-08-13 2004-06-17 Medtronic, Inc. Active agent delivery system including a hydrophobic cellulose derivative, medical device, and method
JP2006502136A (ja) * 2002-08-13 2006-01-19 メドトロニック・インコーポレーテッド 親水性ポリマーと、医療用デバイスと、そして方法とを含む活性剤送達システム
ATE459380T1 (de) * 2002-08-13 2010-03-15 Medtronic Inc Darreichungssysteme von wirkstoffen mit poly(ethylene-co(meth)akrylate, medizinische vorrichtung und verfahren
JP2006500088A (ja) * 2002-08-13 2006-01-05 メドトロニック・インコーポレーテッド ポリマーの被覆及び支持体間の改良された付着を示す医用デバイス
WO2004014451A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
US6911400B2 (en) 2002-11-05 2005-06-28 International Business Machines Corporation Nonlithographic method to produce self-aligned mask, articles produced by same and compositions for same
CA2535346A1 (en) * 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods
EP1684820A2 (de) * 2003-08-13 2006-08-02 Medtronic, Inc. Systeme zur abgabe von wirkstoffen mit einer mischbaren polymermischung, medizinprodukte und -verfahren
FR2859909B1 (fr) * 2003-09-22 2007-09-07 Biomerieux Sa Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
US20080038317A1 (en) * 2004-09-10 2008-02-14 Chin-Ming Chang Therapeutic Lacrimal Canalicular Inserts And Related Methods
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US20070200271A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from melt processing
US20070200268A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from solution processing
EP2124723A1 (de) 2007-03-07 2009-12-02 Echo Therapeutics, Inc. Überwachungssystem für transdermale marker und verfahren für den nachweis von markern
SI2152358T1 (sl) * 2007-04-27 2011-08-31 Echo Therapeutics Inc Naprava za prodiranje skozi koĺ˝o za analizno merjenje ali za transdermalni prenos zdravil
JP5139003B2 (ja) * 2007-08-17 2013-02-06 国立大学法人京都工芸繊維大学 組成物およびフィルム
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
TWI501781B (zh) * 2010-12-10 2015-10-01 Ind Tech Res Inst 可控制釋放的組合物及其製造方法
EP3079668A1 (de) 2013-12-09 2016-10-19 Durect Corporation Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit
CN109021215B (zh) * 2018-07-11 2021-03-02 中山大学 一种pH敏感型聚扁桃酸纳米药物载体及其制备方法和应用
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522804A (en) * 1983-01-03 1985-06-11 Verex Laboratories, Inc. Constant release rate solid oral dosage formulations of propranolol
US4757128A (en) * 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4888176A (en) * 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4891225A (en) * 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US4863457A (en) * 1986-11-24 1989-09-05 Lee David A Drug delivery device
FR2612198A1 (fr) * 1987-03-27 1988-09-16 Tyndale Plains Hunter Ltd Composition de polyurethane hydrophile et article qui en est produit
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
WO1990009783A1 (en) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
DE69028303T2 (de) * 1989-06-05 1997-01-30 Massachusetts Inst Technology Biodegradierbare polymere zur arzneimittelverabreichung in knochen
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
EP0423484B1 (de) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Pressling mit retardierter Wirkstofffreisetzung

Also Published As

Publication number Publication date
WO1992013567A1 (en) 1992-08-20
AU669479B2 (en) 1996-06-13
ATE216262T1 (de) 2002-05-15
DK0568651T3 (da) 2002-08-05
JP3137337B2 (ja) 2001-02-19
CA2101742C (en) 2005-04-12
EP0568651B1 (de) 2002-04-17
CA2101742A1 (en) 1992-08-02
ES2176189T3 (es) 2002-12-01
EP0568651A4 (en) 1996-11-27
EP0568651A1 (de) 1993-11-10
AU1643292A (en) 1992-09-07
US5919835A (en) 1999-07-06
JPH06508863A (ja) 1994-10-06
DE69232555D1 (de) 2002-05-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee