ATE281155T1 - Medikamentöse verabreichung von proteinen aus polymergemischen - Google Patents

Medikamentöse verabreichung von proteinen aus polymergemischen

Info

Publication number
ATE281155T1
ATE281155T1 AT99919915T AT99919915T ATE281155T1 AT E281155 T1 ATE281155 T1 AT E281155T1 AT 99919915 T AT99919915 T AT 99919915T AT 99919915 T AT99919915 T AT 99919915T AT E281155 T1 ATE281155 T1 AT E281155T1
Authority
AT
Austria
Prior art keywords
proteins
drug administration
polymer mixtures
polycaprolactone
biologically active
Prior art date
Application number
AT99919915T
Other languages
English (en)
Inventor
Pericles Calias
Robert J Miller
James R Olson
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE281155T1 publication Critical patent/ATE281155T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99919915T 1998-04-20 1999-04-20 Medikamentöse verabreichung von proteinen aus polymergemischen ATE281155T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6309898A 1998-04-20 1998-04-20
PCT/US1999/008643 WO1999053900A1 (en) 1998-04-20 1999-04-20 Drug delivery of proteins from polymeric blends

Publications (1)

Publication Number Publication Date
ATE281155T1 true ATE281155T1 (de) 2004-11-15

Family

ID=22046924

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99919915T ATE281155T1 (de) 1998-04-20 1999-04-20 Medikamentöse verabreichung von proteinen aus polymergemischen

Country Status (8)

Country Link
US (1) US7189413B2 (de)
EP (1) EP1071400B1 (de)
JP (1) JP2002512182A (de)
AT (1) ATE281155T1 (de)
AU (1) AU766959B2 (de)
CA (1) CA2325983C (de)
DE (1) DE69921636T2 (de)
WO (1) WO1999053900A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1019111E (pt) 1998-04-27 2002-10-31 Surmodics Inc Revestimento que liberta um agente bioactivo
US20040224030A1 (en) * 2003-05-06 2004-11-11 Shastri Venkatram R. Microsphere delivery systems
JP5087274B2 (ja) 2003-06-30 2012-12-05 ドマンティス リミテッド ポリペプチド
CA2528150A1 (en) * 2003-07-01 2005-01-20 Mayo Foundation For Medical Education And Research Self-crosslinkable poly(caprolactone fumarate)
CN1964749A (zh) 2004-04-06 2007-05-16 苏莫迪克斯公司 用于生物活性剂的涂料组合物
CN1997356A (zh) * 2004-04-23 2007-07-11 安姆根有限公司 持续释放制剂
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
JP5108523B2 (ja) 2004-11-12 2012-12-26 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ 光架橋性ポリ（カプロラクトンフマレート）
CA2606396A1 (en) * 2005-04-29 2006-11-09 Mayo Foundation For Medical Education And Research Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof
US20070255422A1 (en) * 2006-04-25 2007-11-01 Mei Wei Calcium phosphate polymer composite and method
MX2011000501A (es) 2008-07-18 2011-05-23 Squibb Bristol Myers Co Composiciones monovalentes para union a cd28 y metodos de uso.
GB201009037D0 (en) 2010-05-28 2010-07-14 Univ Surrey Compositions and methods for treating disorders associated with atherosclerotic plaques
US9724367B2 (en) 2010-11-10 2017-08-08 Regenmed (Cayman) Ltd. Injectable formulations for organ augmentation
AU2013334276B2 (en) 2012-10-24 2019-07-04 ProKidney IPCo, LLC Renal cell populations and uses thereof
WO2014120916A1 (en) 2013-02-01 2014-08-07 Bristol-Myers Squibb Company Pegylated domain antibodies monovalent for cd28 binding and methods of use
JP2020525003A (ja) 2017-06-21 2020-08-27 バートナム，ティモシー，エー． 腎臓病治療のための免疫特権を有する生物活性腎細胞
CN109407133B (zh) * 2017-08-18 2023-09-22 南京中硼联康医疗科技有限公司 生物剂量计及具有其的中子捕获治疗系统
BR112021002703A2 (pt) 2018-08-31 2021-05-11 Timothy A. Bertram composições compreendendo vesículas derivadas de células e usos das mesmas
US12095825B2 (en) * 2021-02-15 2024-09-17 Charter Communications Operating, Llc System and method for evaluating a customer premise equipment (CPE) device

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2576576A (en) * 1946-04-19 1951-11-27 American Cyanamid Co Lubricated thread
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3896814A (en) * 1972-10-31 1975-07-29 Daniel Vivien Collagen based threads
US4201216A (en) * 1976-12-15 1980-05-06 Ethicon, Inc. Absorbable coating composition for sutures
US4137279A (en) * 1977-12-27 1979-01-30 Union Carbide Corporation Copolymers of polycaprolactone derivatives and ethylenically unsaturated monomers
US4210216A (en) * 1979-01-16 1980-07-01 Eldec Corporation Heated platform scale
US4786501A (en) * 1985-07-15 1988-11-22 International Minerals & Chemical Corp. Cylindrical implants for the controlled release of growth hormones
US4624256A (en) * 1985-09-11 1986-11-25 Pfizer Hospital Products Group, Inc. Caprolactone polymers for suture coating
US4649920A (en) * 1986-01-30 1987-03-17 Pfizer Hospital Products Group, Inc. Coated suture
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5610214A (en) * 1988-12-29 1997-03-11 Deknatel Technology Corporation, Inc. Method for increasing the rate of absorption of polycaprolactone
EP0573094B1 (de) * 1988-12-29 2002-09-18 Genzyme Corporation Absorbierbare Mischung für gesteuerte Abgabe
US5084267A (en) * 1989-11-17 1992-01-28 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
SE9100610D0 (sv) * 1991-03-04 1991-03-04 Procordia Ortech Ab Bioresorbable material for medical use
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5641502A (en) * 1995-06-07 1997-06-24 United States Surgical Corporation Biodegradable moldable surgical material

Also Published As

Publication number Publication date
WO1999053900A1 (en) 1999-10-28
DE69921636D1 (de) 2004-12-09
DE69921636T2 (de) 2005-11-03
AU766959B2 (en) 2003-10-30
CA2325983A1 (en) 1999-10-28
US20020182254A1 (en) 2002-12-05
CA2325983C (en) 2009-02-17
EP1071400A1 (de) 2001-01-31
US7189413B2 (en) 2007-03-13
EP1071400B1 (de) 2004-11-03
AU3752799A (en) 1999-11-08
EP1071400A4 (de) 2003-04-02
JP2002512182A (ja) 2002-04-23

Similar Documents

Publication Publication Date Title
DE69921636D1 (de) Medikamentöse verabreichung von proteinen aus polymergemischen
ATE383169T1 (de) Komponente und zusammensetzungen zur verabreichung von wirkstoffen
ES2055112T3 (es) Revestimiento y mezcla absorbibles.
DK0591392T3 (da) Farmaceutiske formuleringer af osteogene proteiner
DE69927388D1 (de) Gerät zur verabreichung von medikamenten und genen in gewebe
ATE249422T1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
PT724459E (pt) Formulacoes para administracao de proteinas osteogenicas
DE69942928D1 (de) Therapeutische formulierung zur verabreichung von tolterodin mit kontrollierter freisetzung
DE69931930D1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiven substanzen
FI962154A0 (fi) Koostumus terapeuttisten tuotteiden in vivo valmistusta varten
BR9507999A (pt) Conjugado biologicamente ativo composto substancialmente purificado polimero solúvel em água e composição farmacêutica
DE69727158D1 (de) Pharmazeutische zusammensetzungen enthaltend eine mischung von selbstvernetzter und nichtselbstvernetzter hyaluronsäure zur behandlung von arthropathien
FI964583L (fi) Tokoferolikoostumuksia biologisesti aktiivisten aineiden antamiseksi
ATE345133T1 (de) Laktose-freie, nicht-hygroskopische und wasserfreie pharmazeutische zusammensetzungen von descarboethoxyloratadin
MX9101035A (es) Quinazolinonas biologicamente activas y composicion farmaceutica que las contiene
DE60024414T2 (de) Oxadiazolverbindungen und -zusammensetzungen zur abgabe von wirkstoffen
DE69939075D1 (de) Pharmazeutische Zusammenstellung zur Vorbeugung und Behandlung von mit Zellkrankheiten des Augenhintergrundes zusammenhängenden Krankheiten
HUP9802897A3 (en) Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, the use thereof in the treatment of vascular diseases and pharmaceutical composition containing the compound as active ingredient
HUP0104238A3 (en) Benzoxazole derivatives and drugs containing the same as the active ingredient and their use
DE50005213D1 (de) Endoparasitizide synergistische kombination enthaltend cyclische depsipeptide und piperazine
TR200102265T2 (tr) Anestezi düzenlemesi.
DE60010230D1 (de) Pharmazeutische zusammensetzung von hydrophob modifizierten hedgehog-proteinen und deren verwendung
ATE215361T1 (de) Liposomen mit mehrfach verzweigten peptidkonstruktionen zur verwendung gegen hiv
ATE132877T1 (de) Emulgatorfreie emulsionspolymere in pharmazeutischen zubereitungen mit verzögerter wirkstofffreigabe und ihre herstellung
BR0202759A (pt) Composição farmacêutica de liberação modificada contendo bupropiona como substância ativa

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties