ATE304878T1 - Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut - Google Patents

Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut

Info

Publication number
ATE304878T1
ATE304878T1 AT01981531T AT01981531T ATE304878T1 AT E304878 T1 ATE304878 T1 AT E304878T1 AT 01981531 T AT01981531 T AT 01981531T AT 01981531 T AT01981531 T AT 01981531T AT E304878 T1 ATE304878 T1 AT E304878T1
Authority
AT
Austria
Prior art keywords
skin
microelements
composition
microstructures
agent
Prior art date
Application number
AT01981531T
Other languages
English (en)
Inventor
Vladimir Gartstein
Faiz Feisal Sherman
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of ATE304878T1 publication Critical patent/ATE304878T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D26/00—Hair-singeing apparatus; Apparatus for removing superfluous hair, e.g. tweezers
    • A45D26/0004—Hair-singeing apparatus; Apparatus for removing superfluous hair, e.g. tweezers by abrasion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/54—Chiropodists' instruments, e.g. pedicure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01981531T 2000-10-16 2001-10-15 Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut ATE304878T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24078700P 2000-10-16 2000-10-16
US24073000P 2000-10-16 2000-10-16
PCT/US2001/031978 WO2002032480A2 (en) 2000-10-16 2001-10-15 Microstructures for delivering a composition cutaneously to skin

Publications (1)

Publication Number Publication Date
ATE304878T1 true ATE304878T1 (de) 2005-10-15

Family

ID=26933655

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01981530T ATE353687T1 (de) 2000-10-16 2001-10-15 Mikrostrukturen zur behandlung und aufbereitung der haut
AT01981531T ATE304878T1 (de) 2000-10-16 2001-10-15 Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01981530T ATE353687T1 (de) 2000-10-16 2001-10-15 Mikrostrukturen zur behandlung und aufbereitung der haut

Country Status (10)

Country Link
US (4) US7108681B2 (de)
EP (2) EP1326674B8 (de)
JP (2) JP4676128B2 (de)
CN (2) CN100427159C (de)
AT (2) ATE353687T1 (de)
AU (2) AU2002213168A1 (de)
CA (2) CA2422909C (de)
DE (2) DE60126637T2 (de)
ES (2) ES2281450T3 (de)
WO (2) WO2002032331A2 (de)

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
IL134997A0 (en) * 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
WO2002015960A2 (en) * 2000-08-21 2002-02-28 The Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
RU2275871C2 (ru) * 2000-10-13 2006-05-10 Алза Корпорейшн Устройство и способ для прокалывания кожи микровыступами
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
AU2002237703A1 (en) * 2000-11-09 2002-06-18 Biovalve Technologies, Inc. Microneedle adapter
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
EP1256316A1 (de) 2001-05-07 2002-11-13 Move2Health B.V. Tragbare Vorrichtung mit einem Beschleunigungssensor und ein Verfahren zur Erzeugung von Befehlen oder Ratschläge
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
SE0102736D0 (sv) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
EP1424928B1 (de) * 2001-09-14 2019-09-11 Corium International, Inc. Verfahren zur hautabschälung mit dicht gepackten mikrostrukturen
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003024518A2 (en) * 2001-09-14 2003-03-27 The Procter & Gamble Company Microstructures for delivering a composition cutaneously to skin using rotatable structures
EP1439870B1 (de) * 2001-10-29 2009-01-14 Becton, Dickinson and Company Vorrichtung für die abgabe einer substanz
US20030199810A1 (en) * 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6916120B2 (en) * 2002-01-30 2005-07-12 Adc Telecommunications, Inc. Fiber optic connector and method
US7392080B2 (en) 2002-03-11 2008-06-24 Altea Therapeutics Corporation Transdermal drug delivery patch system, method of making same and method of using same
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
DE10219523A1 (de) * 2002-05-02 2003-11-13 Wella Ag Verfahren zur technischen Produktion haar- oder hautkosmetischer Produkte unter Verwendung von Apparaturen mit Mikrostruktureinheiten
JP2005533625A (ja) * 2002-07-19 2005-11-10 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルデバイスおよびマイクロニードル送達装置
US7422567B2 (en) * 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
US7449307B2 (en) * 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
EP1435253B1 (de) 2002-12-31 2007-01-17 Abbott Laboratories Vascular Enterprises Limited Katheter mit einem flexibleren Bereich zwischen Schaft und Spitze sowie Verfahren zu seiner Herstellung
US7087063B2 (en) * 2003-02-19 2006-08-08 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Abrasion device and method
US7226457B2 (en) * 2003-02-19 2007-06-05 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Epidermal sampling apparatus and method
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20040227199A1 (en) * 2003-05-15 2004-11-18 Toshiba Kikai Kabushiki Kaisha Minute flow passage and micro-chemical chip including the same
US7572405B2 (en) * 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US7480530B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7486989B2 (en) 2003-06-30 2009-02-03 Johnson & Johnson Consumer Companies, Inc. Device for delivery of oxidizing agents to barrier membranes
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7477939B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of treating a wound with galvanic generated electricity
US7477941B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of exfoliating the skin with electricity
US7507228B2 (en) 2003-06-30 2009-03-24 Johnson & Johnson Consumer Companies, Inc. Device containing a light emitting diode for treatment of barrier membranes
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
US7477940B2 (en) * 2003-06-30 2009-01-13 J&J Consumer Companies, Inc. Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
US7476222B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of reducing the appearance of pigmentation with galvanic generated electricity
US7477938B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Cosumer Companies, Inc. Device for delivery of active agents to barrier membranes
US7888546B2 (en) 2003-07-03 2011-02-15 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
KR20060115722A (ko) * 2003-08-26 2006-11-09 알자 코포레이션 진피내 세포 이식용 장치 및 방법
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
EP1713533A4 (de) * 2003-11-21 2008-01-23 Univ California Verfahren und/oder vorrichtung zur punktierung einer fläche zur extraktion, in-situ-analyse und/oder substanzzufuhr unter verwendung von mikronadeln
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
US7914813B2 (en) 2004-02-03 2011-03-29 Hisamitsu Pharmaceutical Co., Inc. Interface for transdermal drug administration device
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US7591618B2 (en) * 2004-02-25 2009-09-22 Agency For Science, Technology And Research Machining method for micro abraders and micro abraders produced thereby
US7611481B2 (en) 2004-03-24 2009-11-03 Corium International, Inc. Transdermal delivery device
US20080082090A1 (en) * 2004-04-01 2008-04-03 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
GB2438372A (en) * 2006-05-25 2007-11-28 Ball Burnishing Mach Tools A procedure for cosmetic treatment of skin by sliding a tool over the skin
US7785439B2 (en) 2004-09-29 2010-08-31 Abbott Laboratories Vascular Enterprises Limited Method for connecting a catheter balloon with a catheter shaft of a balloon catheter
US7794448B2 (en) 2004-05-27 2010-09-14 Abbott Laboratories Multiple lumen catheter and method of making same
US7658723B2 (en) 2004-05-27 2010-02-09 Abbott Laboratories Catheter having plurality of stiffening members
US7785318B2 (en) 2004-05-27 2010-08-31 Abbott Laboratories Catheter having plurality of stiffening members
WO2005118045A1 (en) * 2004-05-27 2005-12-15 Abbott Laboratories Catheter having main body portion with coil-defined guidewire passage
US7815627B2 (en) * 2004-05-27 2010-10-19 Abbott Laboratories Catheter having plurality of stiffening members
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060100584A1 (en) * 2004-08-10 2006-05-11 Orest Olejnik Needleless microprotrusion elastoplast system
US8417352B2 (en) * 2004-10-19 2013-04-09 Meagan Medical, Inc. System and method for stimulating sensory nerves
US8086322B2 (en) * 2004-10-19 2011-12-27 Meagan Medical Inc. Method and means for electrical stimulation of cutaneous sensory receptors
US7373820B1 (en) 2004-11-23 2008-05-20 James Terry L Accelerometer for data collection and communication
WO2006057619A1 (en) * 2004-11-26 2006-06-01 Agency For Science, Technology And Research Method and apparatus for forming microstructures
ATE468961T1 (de) 2004-12-07 2010-06-15 3M Innovative Properties Co Verfahren zum formen einer mikronadel
MX2007006742A (es) * 2004-12-10 2007-07-25 3M Innovative Properties Co Dispositivo medico.
JPWO2006075689A1 (ja) * 2005-01-14 2008-06-12 久光製薬株式会社 医薬物運搬用器具とその製造方法
WO2006083681A2 (en) * 2005-01-31 2006-08-10 Alza Corporation Coated microprojections having reduced variability and method for producing same
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20060253079A1 (en) * 2005-04-25 2006-11-09 Mcdonough Justin Stratum corneum piercing device
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
GB0509863D0 (en) * 2005-05-16 2005-06-22 Cambridge Biostability Ltd Apparatus for administrating substances into a body
US20100256568A1 (en) 2005-06-27 2010-10-07 Frederickson Franklyn L Microneedle cartridge assembly and method of applying
WO2007005734A2 (en) * 2005-07-01 2007-01-11 C.R. Bard, Inc. Indwelling urinary drainage catheter
US8376984B2 (en) * 2005-07-14 2013-02-19 Terry L. James Apparatus, system, and method to deliver optimal elements in order to enhance the aesthetic appearance of the skin
DE102005040251A1 (de) * 2005-08-24 2007-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Transcorneales System zur Abgabe eines Arzneimittel-Wirkstoffes
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
JP4908893B2 (ja) * 2006-03-30 2012-04-04 久光製薬株式会社 医薬物運搬用器具とその製造方法及び医薬物運搬用器具製造用金型の製造方法
US20090171314A1 (en) * 2006-04-20 2009-07-02 Ferguson Dennis E Molded articles comprising microneedle arrays
EP2010269A4 (de) * 2006-04-25 2009-06-03 Alza Corp Mikroprojektions-array mit geformten mikroprojektionen für wirkstoffbeladung
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
EP2789363B1 (de) 2006-07-27 2016-11-02 Toppan Printing Co., Ltd. Verfahren zur Herstellung einer Mikronadel
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US9820888B2 (en) 2006-09-26 2017-11-21 Smith & Nephew, Inc. Wound dressing
US8680360B2 (en) * 2006-09-26 2014-03-25 Smith & Nephew Inc. Lattice dressing
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
EP2664323B1 (de) 2007-04-16 2020-07-29 Corium, Inc. Lösemittelgegossene Mikronadelfelder mit Wirkstoffen
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20090048493A1 (en) * 2007-08-17 2009-02-19 James Terry L Health and Entertainment Device for Collecting, Converting, Displaying and Communicating Data
ES2612061T3 (es) * 2007-09-28 2017-05-11 The Queen's University Of Belfast Dispositivo y método de suministro
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US7676332B2 (en) 2007-12-27 2010-03-09 Kersh Risk Management, Inc. System and method for processing raw activity energy expenditure data
RU2450914C1 (ru) * 2008-05-23 2012-05-20 Дзе Жиллетт Компани Бритва, содержащая трехмерный микроструктурированный абразивный материал
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
AU2009322463B2 (en) 2008-12-02 2015-10-08 Allergan, Inc. Injection device
US7982087B2 (en) * 2009-01-09 2011-07-19 Smith & Nephew, Inc. Wound dressing
GB0902368D0 (en) 2009-02-13 2009-04-01 Smith & Nephew Wound packing
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
US8615295B2 (en) * 2009-03-17 2013-12-24 Cardiothrive, Inc. External defibrillator
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
ES2634667T3 (es) * 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
US20110266724A1 (en) * 2009-05-08 2011-11-03 Hoowaki, Llc Method for manufacturing microstructured metal or ceramic parts from feedstock
US8764712B2 (en) * 2009-08-04 2014-07-01 Cook Medical Technologies Llc Micro-needle array and method of use thereof
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
BR112012011411A2 (pt) 2009-11-13 2017-12-12 Johnson & Johnson Consumer Companies Inc dispositivo galvânico de tratamento da pele
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US8454975B1 (en) 2010-01-11 2013-06-04 Elizabeth VanderVeer Method for enhancing skin appearance
WO2011135532A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Composite microneedle array including nanostructures thereon
EP2563450B1 (de) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Vorrichtung zur verabreichung eines medikaments gegen rheumatoide arthritis
MX2012012567A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Metodo para aumentar la permeabilidad de una barrera epitelial.
KR101794376B1 (ko) 2010-04-28 2017-11-06 킴벌리-클라크 월드와이드, 인크. ｓｉＲＮＡ 전달용 의료 기구
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
US8854357B2 (en) * 2011-01-27 2014-10-07 Microsoft Corporation Presenting selectors within three-dimensional graphical environments
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
US20130072808A1 (en) * 2011-09-16 2013-03-21 Imtek Structured probes for neural applications
CN103874518A (zh) 2011-10-12 2014-06-18 3M创新有限公司 一体化微针阵列递送系统
US9427253B2 (en) * 2011-10-17 2016-08-30 Carefusion 303, Inc. Device for applying medical fluid to an area and for cutting within the area
US11110066B2 (en) 2011-10-27 2021-09-07 Sorrento Therapeutics, Inc. Implantable devices for delivery of bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
EP3574950B1 (de) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermale freisetzung von hochviskosen bioaktiven wirkstoffen
US9492001B2 (en) * 2011-11-01 2016-11-15 Derma Dream Group Ltd. System and method for treating a surface
WO2013155146A2 (en) * 2012-04-12 2013-10-17 The Procter & Gamble Company Skin exfoliation devices and kits
US9944019B2 (en) 2012-05-01 2018-04-17 University of Pittsburgh—of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
EP2934660B1 (de) 2012-12-21 2019-07-17 Corium, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur herstellung davon
CN104575500B (zh) * 2013-10-24 2018-09-11 中国科学院苏州纳米技术与纳米仿生研究所 电子皮肤在语音识别上的应用、语音识别系统和方法
CN104555883A (zh) * 2013-10-24 2015-04-29 中国科学院苏州纳米技术与纳米仿生研究所 电子皮肤及其制作方法
AU2014219240B2 (en) 2013-02-20 2018-12-20 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
US9962546B2 (en) 2013-02-21 2018-05-08 Meagan Medical, Inc. Cutaneous field stimulation with disposable and rechargeable components
WO2014132239A1 (en) * 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
CA2903748C (en) 2013-03-12 2021-11-02 Corium International, Inc. Microprojection applicators
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
JP2016512754A (ja) 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CN105246458B (zh) 2013-03-15 2020-09-15 考里安公司 用于治疗剂递送的微阵列及其使用方法
PT2991600T (pt) * 2013-05-03 2018-11-05 Cytrellis Biosystems Inc Micro-oclusões e métodos relacionados para o tratamento da pele
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
AU2014270014A1 (en) * 2013-05-23 2015-12-17 Kimberly-Clark Worldwide, Inc. Microneedles with improved open channel cross-sectional geometries
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
EP3013258B1 (de) * 2013-06-26 2017-06-07 3M Innovative Properties Company Kürettenkopf
KR102349218B1 (ko) 2013-08-09 2022-01-10 사이트렐리스 바이오시스템즈, 인크. 비-열적 조직 절제를 사용한 피부 치료를 위한 방법 및 기구
US20150174386A1 (en) * 2013-12-19 2015-06-25 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
EP3082897A4 (de) 2013-12-19 2017-07-26 Cytrellis Biosystems, Inc. Verfahren und vorrichtungen zur manipulation von unterhautfett
US20150201969A1 (en) * 2014-01-06 2015-07-23 Foot Innovations, Llc Skin Exfoliating Device
FR3018440B1 (fr) * 2014-03-14 2019-05-17 Alain FAVIE Dispositif pour la microdermabrasion et procede de microdermabrasion
WO2015168214A1 (en) * 2014-04-30 2015-11-05 Kimberly-Clark Worldwide, Inc. Draped microneedle array
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
KR101724655B1 (ko) 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016039333A1 (ja) * 2014-09-08 2016-03-17 株式会社かいわ 穿刺器具
JP5967595B2 (ja) * 2014-09-08 2016-08-10 株式会社かいわ 穿刺器具
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
BR112017006730A2 (pt) * 2014-10-09 2017-12-26 Zoetis Services Llc agulha para aplicar um fluido de tratamento a uma ave de aviário, e conjunto e método associados
USD762848S1 (en) * 2014-10-17 2016-08-02 Minas Theodore Coroneo Intravitreal injection device
EP3216482B1 (de) * 2014-11-06 2019-03-20 Toppan Printing Co., Ltd. Transdermale verabreichungsvorrichtung und verfahren zur herstellung einer transdermalen verabreichungsvorrichtung
JP6662296B2 (ja) 2014-11-07 2020-03-11 凸版印刷株式会社 経皮投薬用針集成体及びその製造方法
KR102670286B1 (ko) 2014-11-14 2024-05-30 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
US9986988B2 (en) 2014-11-27 2018-06-05 AOD Holdings, LLC Surgical retractor
JP2018507771A (ja) 2015-03-10 2018-03-22 アラーガン ファーマシューティカルズ ホールディングス （アイルランド） アンリミテッド カンパニー 多針注入器
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US10070886B2 (en) 2015-04-22 2018-09-11 Medline Industries, Inc. Method of harvesting tissue using sequential sections of a two dimensional array of needles
CN104922791B (zh) * 2015-05-26 2018-10-26 上海交通大学 无创针灸贴片及其制备方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6606939B2 (ja) * 2015-09-17 2019-11-20 凸版印刷株式会社 経皮投与デバイス、および、経皮投与デバイスの製造方法
CH711561A1 (de) * 2015-09-24 2017-03-31 Regent Beleuchtungskörper Ag Optische Schicht und Leuchte mit einer solchen.
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2019513070A (ja) 2016-03-01 2019-05-23 キトテック メディカル， インコーポレイテッド 創傷閉鎖のための微細構造に基づくシステム、装置および方法
KR20230117470A (ko) 2016-03-29 2023-08-08 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
WO2017176476A1 (en) 2016-04-08 2017-10-12 Allergan, Inc. Aspiration and injection device
JP2019529043A (ja) 2016-09-21 2019-10-17 サイトレリス バイオシステムズ，インコーポレーテッド 美容スキンリサーフェシング装置及び方法
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
CN106963268A (zh) * 2017-04-27 2017-07-21 苏州纳通生物纳米技术有限公司 微型针在皮肤清洁中的应用
JP1601442S (de) * 2017-07-28 2018-04-09
CN107334495A (zh) * 2017-08-24 2017-11-10 广州新诚生物科技有限公司 用于植发的可溶针以及其制作方法
WO2019046392A1 (en) * 2017-08-29 2019-03-07 Hoowaki, Llc MICROSTRUCTURED SURFACE HAVING A DISCRETE TOUCH AESTHETIC
USD872370S1 (en) * 2017-09-22 2020-01-07 Davinci Ii Csj, Llc Abrasive skin treatment device
USD886384S1 (en) * 2017-09-22 2020-06-02 Davinci Ii Csj, Llc Abrasive skin treatment device
US9968767B1 (en) 2017-10-10 2018-05-15 King Saud University Combination microarray patch for drug delivery and electrochemotherapy device
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
CN107976728A (zh) * 2017-12-28 2018-05-01 武汉华星光电技术有限公司 微结构、显示装置及其显示面板
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
EP3883619A1 (de) * 2018-11-21 2021-09-29 BVW Holding AG Mikrostrukturierte oberfläche
EP4061334A4 (de) 2019-11-22 2024-02-14 Veradermics Incorporated Mikronadelpflaster für die verabreichung immunstimulierender medikamente
US11766548B2 (en) * 2020-01-21 2023-09-26 Korea Institute Of Science And Technology Phototherapeutic needle patches and methods of manufacturing the same
EP4106638A4 (de) * 2020-02-19 2024-03-27 Kitotech Medical, Inc. Wundverschlussvorrichtung für breite behandlungsareale
WO2022043956A1 (es) * 2020-08-31 2022-03-03 Universidad De Los Andes Dispositivo de dermoabrasión
USD1017136S1 (en) 2020-12-23 2024-03-05 Telebrands Corp. Abrasive skin treatment device
USD1022327S1 (en) 2020-12-23 2024-04-09 International Edge, Inc. Foot file
USD1005504S1 (en) 2020-12-23 2023-11-21 Telebrands Corp. Abrasive skin treatment device
CN114949592A (zh) * 2021-02-26 2022-08-30 中国科学院理化技术研究所 柔性离子导入美容装置
USD1023468S1 (en) 2021-03-29 2024-04-16 Telebrands Corp. Foot file
KR102302034B1 (ko) * 2021-07-12 2021-09-13 김철하 고광택 손발톱 광택기가 함께 구비되는 발각질 제거기 및 전동용 발각질 제거 키트
CN118201670A (zh) * 2021-09-20 2024-06-14 舒万诺知识产权公司 使用微针的非粘合性医学附接制品

Family Cites Families (240)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1554510A (en) * 1924-04-23 1925-09-22 Elsie W Kirby Massaging device
US1770632A (en) 1928-07-02 1930-07-15 Arthur E Smith Ampul syringe
US2046240A (en) 1932-07-01 1936-06-30 Thomas W Bayley Abrasive article
US2434407A (en) 1946-01-05 1948-01-13 Hofe George Douglas Depilatory device
NL92403C (de) 1954-10-04
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3704194A (en) 1970-07-02 1972-11-28 Gen Electric Perforated reinforced plastic member and method for making
US3917785A (en) 1971-01-27 1975-11-04 Johnson & Johnson Method for producing nonwoven fabric
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2319591C2 (de) 1973-04-18 1982-02-25 Kirchner & Wilhelm, 7000 Stuttgart Medizinischer Apparat
FR2232331B1 (de) 1973-06-06 1978-03-24 Guerin A Ets
AT347283B (de) 1975-03-07 1978-12-27 Collo Gmbh Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl.
US4151240A (en) * 1976-10-19 1979-04-24 The Procter & Gamble Company Method for debossing and perforating a running ribbon of thermoplastic film
US4180232A (en) 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
US4117841A (en) 1977-02-07 1978-10-03 Anthony Perrotta Medicated bandage pocket
US4342314A (en) 1979-03-05 1982-08-03 The Procter & Gamble Company Resilient plastic web exhibiting fiber-like properties
US4402696A (en) 1979-10-15 1983-09-06 Gulko Bruce N Folded applicator
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4509908A (en) 1981-02-02 1985-04-09 The Procter & Gamble Company Apparatus for uniformly debossing and aperturing a resilient plastic web
US4395215A (en) 1981-02-02 1983-07-26 The Procter & Gamble Company Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its construction
US4463045A (en) 1981-03-02 1984-07-31 The Procter & Gamble Company Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impression
US4460370A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication application cell
US4460368A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
US4585991A (en) 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
FR2535602B1 (fr) 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US4556441A (en) 1983-01-24 1985-12-03 Faasse Jr Adrian L Pharmaceutical packaging method
US4515168A (en) * 1983-07-22 1985-05-07 Chester Martin H Clamp-on nerve stimulator and locator
US5591123A (en) 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US4708716A (en) 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4695422A (en) 1984-02-16 1987-09-22 The Procter & Gamble Company Production of formed material by solid-state formation with a high-pressure liquid stream
US4583982A (en) 1984-08-24 1986-04-22 Vlock D G Fluid dispenser
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
JPH029755Y2 (de) * 1985-02-26 1990-03-12
US4904475A (en) 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
US4609518A (en) 1985-05-31 1986-09-02 The Procter & Gamble Company Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimensional forming structures
US4630603A (en) * 1986-02-13 1986-12-23 The Kendall Company Wound dressing
US4743249A (en) 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
AU597890B2 (en) 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US4842794A (en) 1987-07-30 1989-06-27 Applied Extrusion Technologies, Inc. Method of making apertured films and net like fabrics
US5061258A (en) 1987-08-07 1991-10-29 Martz Joel D Vapor permeable dressing with releasable medication
US4846821A (en) 1987-08-24 1989-07-11 The Procter & Gamble Company Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement
US4812305A (en) 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
SU1641346A1 (ru) 1987-12-08 1991-04-15 Мгту Им.Н.Э.Баумана Устройство дл электростимул ции
DK157899C (da) 1987-12-15 1990-09-03 Coloplast As Hudpladeprodukt
FR2625937B1 (fr) 1988-01-19 1993-04-30 Vuillaume Andre Procede et dispositif pour perforer un produit en feuille, et produit perfore ainsi obtenu
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5198192A (en) 1988-05-18 1993-03-30 Inax Corporation Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
DE3844247A1 (de) 1988-12-29 1990-07-12 Minnesota Mining & Mfg Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments
SU1667864A1 (ru) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Электростимул тор
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5788983A (en) 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5531675A (en) 1989-05-10 1996-07-02 Yoo; Tae W. Micro-acupuncture needle for a finger of a hand
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5190558A (en) 1989-11-08 1993-03-02 Nec Corporation Method of eliminating stratum corneum from the skin and an instrument to be used therefor
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5244711A (en) 1990-03-12 1993-09-14 Mcneil-Ppc, Inc. Apertured non-woven fabric
US5162043A (en) 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US5139029A (en) 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
TW279133B (de) 1990-12-13 1996-06-21 Elan Med Tech
US5158073A (en) 1990-12-18 1992-10-27 Bukowski Voytek Z Acupressure foot massage mat
US5252279A (en) 1991-01-17 1993-10-12 Reinhold Industries Method for making perforated articles
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5160315A (en) 1991-04-05 1992-11-03 Minnesota Mining And Manufacturing Company Combined adhesive strip and transparent dressing delivery system
TW273531B (en) 1991-08-14 1996-04-01 Chicopee Textile-like apertured plastic films
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5308625A (en) 1992-09-02 1994-05-03 Cygnus Therapeutic Systems Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters
US5462743A (en) 1992-10-30 1995-10-31 Medipro Sciences Limited Substance transfer system for topical application
US5250067A (en) * 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
GB9305930D0 (en) 1993-03-22 1993-05-12 Moran Peter L Electrical circuit board
DE69426230T2 (de) 1993-03-22 2001-03-01 Minnesota Mining & Mfg Mit fensterlosem rahmen abgebener verband sowie herstellungsverfahren
US6685682B1 (en) 1993-03-22 2004-02-03 3M Innovative Properties Company Carrier delivered dressing and method of manufacture
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
NZ250994A (en) 1993-05-27 1995-09-26 Ndm Acquisition Corp Wound dressing comprising a hydrogel layer bound to a porous backing layer which is bound to a thin film layer by adhesive
US5330452A (en) 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5728089A (en) 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
US5320600A (en) 1993-06-14 1994-06-14 Lambert Wm S Plural content container for simultaneous ejection
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5962011A (en) 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5503843A (en) 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
KR0134152B1 (ko) 1994-05-23 1998-04-14 이형도 의약품 투여용 피부흠집 형성장치
KR0134151B1 (ko) 1994-05-23 1998-04-14 이형도 인슐린 패치
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
JP2551742B2 (ja) * 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
US5851549A (en) 1994-05-25 1998-12-22 Becton Dickinson And Company Patch, with system and apparatus for manufacture
US5512219A (en) * 1994-06-03 1996-04-30 Reflexite Corporation Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5496304A (en) 1994-07-20 1996-03-05 University Of Utah Research Foundation Surgical marking pen
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6120488A (en) * 1994-11-28 2000-09-19 The Procter & Gamble Company Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon
CA2205444A1 (en) 1994-12-09 1996-06-13 Novartis Ag Transdermal system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
JP2713255B2 (ja) 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5662127A (en) 1996-01-17 1997-09-02 Bio-Plas, Inc. Self-contained blood withdrawal apparatus and method
US5730721A (en) 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
JP3430771B2 (ja) 1996-02-05 2003-07-28 株式会社デンソー 半導体力学量センサの製造方法
JPH09215755A (ja) 1996-02-09 1997-08-19 Poritoronikusu:Kk 皮接治療具
US5948488A (en) 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
AR008242A1 (es) * 1996-06-18 1999-12-29 Alza Corp Dispositivo para atravesar el estrato corneo de una superficie corporal
DE19624578A1 (de) 1996-06-20 1998-01-08 Nancy L Divers Vorrichtung zur Hautpflege
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
DE69718495T2 (de) 1996-09-17 2003-11-20 Deka Products Lp System zur medikamentenabgabe durch transport
DE19649100A1 (de) 1996-11-27 1998-06-04 Lohmann Therapie Syst Lts Verfahren zur verlustarmen Herstellung wirkstoffhaltiger scheibenförmiger Formkörper und diese enthaltende transdermale therapeutische Systeme
AU722574B2 (en) * 1996-12-20 2000-08-10 Alza Corporation Device and method for enhancing transdermal agent flux
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5904712A (en) 1997-06-12 1999-05-18 Axelgaard Manufacturing Co., Ltd. Current-controlling electrode
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6047208A (en) 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US20010023324A1 (en) 1997-11-03 2001-09-20 Allan Pronovost Glucose detector and method for diagnosing diabetes
US5938684A (en) * 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
KR100572539B1 (ko) 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
CN1206004C (zh) 1997-12-11 2005-06-15 阿尔扎有限公司 增强透皮物剂流量的装置
CN1170603C (zh) 1997-12-11 2004-10-13 阿尔扎有限公司 增强透皮物剂流量的装置
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6135990A (en) 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6024553A (en) 1997-12-22 2000-02-15 Mcneil-Ppc, Inc. Apparatus for supporting a starting web during formation of the apertured web
PT1041975E (pt) 1997-12-22 2003-01-31 Alza Corp Membranas de controlo de taxa para dispositivos de fornecimento controlado de drogas
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6120792A (en) 1998-04-29 2000-09-19 Juni; Jack E. Medicated skin patch and method for its use
JP2002517300A (ja) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
DE69921489T2 (de) 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
JP2000146777A (ja) 1998-09-08 2000-05-26 Matsushita Electric Ind Co Ltd 検体採取方法、検体採取装置、検体採取用容器、検体測定方法、検体測定装置および検体測定用容器
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6038465A (en) 1998-10-13 2000-03-14 Agilent Technologies, Inc. Telemedicine patient platform
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
EP1003078A3 (de) 1998-11-17 2001-11-07 Corning Incorporated Verfahren zur Vervielfältigung eines Nanomusters
JP4214584B2 (ja) 1998-11-27 2009-01-28 株式会社デンソー 半導体力学量センサおよびその製造方法
CA2352974A1 (en) 1998-12-18 2000-06-22 John H. Livingston Insertion sets with micro-piercing members for use with medical devices and methods of using the same
JP2000194142A (ja) 1998-12-25 2000-07-14 Fujitsu Ltd パタ―ン形成方法及び半導体装置の製造方法
JP2000232095A (ja) 1999-02-12 2000-08-22 Nippon Telegr & Teleph Corp <Ntt> 半導体表面の微細パターン形成方法
JP2000232971A (ja) 1999-02-15 2000-08-29 Arkray Inc 吸引浸出液採取方法および装置
US5997549A (en) 1999-02-16 1999-12-07 Sauceda; Charles J. Wart removing tool
US6132449A (en) 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6183770B1 (en) 1999-04-15 2001-02-06 Acutek International Carrier patch for the delivery of agents to the skin
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
JP2000323461A (ja) 1999-05-11 2000-11-24 Nec Corp 微細パターン形成装置、その製造方法、および形成方法
JP4114761B2 (ja) 1999-05-14 2008-07-09 国立大学法人群馬大学 情報記録ディスク用スタンパー、その製造方法、情報記録ディスク、および情報記録ディスク製造方法
EP1187653B1 (de) 1999-06-04 2010-03-31 Georgia Tech Research Corporation Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
JP3654059B2 (ja) 1999-06-25 2005-06-02 松下電工株式会社 赤外線センサーの製造方法
JP3387897B2 (ja) 1999-08-30 2003-03-17 キヤノン株式会社 構造体の製造方法、並びに該製造方法により製造される構造体及び該構造体を用いた構造体デバイス
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20030093089A1 (en) 1999-10-20 2003-05-15 Greenberg Ronald Allan Apparatus for variable micro abrasion of human tissue and/or hides using different size and types of abrasive particles
US6355054B1 (en) 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
AU782610B2 (en) * 1999-12-10 2005-08-11 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
DK1239916T3 (da) * 1999-12-10 2006-04-03 Alza Corp Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring
JP2003516798A (ja) 1999-12-16 2003-05-20 アルザ・コーポレーション 抽出した薬剤の経皮流量を増進させるための装置
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
JP4001311B2 (ja) 2000-06-01 2007-10-31 株式会社リコー 液滴吐出ヘッド、インクジェット記録装置、マイクロアクチュエータ
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6494830B1 (en) 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
JP2002079499A (ja) * 2000-09-08 2002-03-19 Terumo Corp 針形状物の作製方法および作製された針
US6691752B2 (en) 2000-09-15 2004-02-17 Timberjack Inc. High rotation felling head mechanism
MXPA03003303A (es) 2000-10-13 2004-12-13 Johnson & Johnson Retenedor del miembro de microprotrusion para aplicador de impacto.
DE60111771T2 (de) 2000-10-13 2006-05-04 Alza Corp., Mountain View Mikroklingeanordungsaufprallapplikator
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6533884B1 (en) 2000-11-03 2003-03-18 Printpack Illinois, Inc. Method and system for extrusion embossing
JP3525177B2 (ja) 2000-11-14 2004-05-10 関西ティー・エル・オー株式会社 Ｘ線を用いた材料の加工方法
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6508947B2 (en) 2001-01-24 2003-01-21 Xerox Corporation Method for fabricating a micro-electro-mechanical fluid ejector
JP3696513B2 (ja) 2001-02-19 2005-09-21 住友精密工業株式会社 針状体の製造方法
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US7963935B2 (en) 2001-04-20 2011-06-21 Alza Corporation Microprojection array having a beneficial agent containing coating
US6585742B2 (en) 2001-05-08 2003-07-01 Dowling B. Stough Wart removal method and device
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
EP1395328B1 (de) 2001-06-08 2006-08-16 Becton, Dickinson and Company Vorrichtung zur manipulation von nadeln oder polierarray
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US20040204669A1 (en) 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
JP5055672B2 (ja) 2001-07-31 2012-10-24 大日本印刷株式会社 薄膜パターン形成用スタンプ
JP4919446B2 (ja) 2001-08-09 2012-04-18 学校法人東京電機大学 微細溝加工方法及びその装置
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024518A2 (en) 2001-09-14 2003-03-27 The Procter & Gamble Company Microstructures for delivering a composition cutaneously to skin using rotatable structures
EP1424928B1 (de) 2001-09-14 2019-09-11 Corium International, Inc. Verfahren zur hautabschälung mit dicht gepackten mikrostrukturen
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002327675A1 (en) 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030093028A1 (en) 2001-11-09 2003-05-15 Michael Spiegel Appararus and method for magnetic induction of therapeutic electric fields
US20030199810A1 (en) 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
ATE525108T1 (de) 2002-02-04 2011-10-15 Becton Dickinson Co Vorrichtung und verfahren zur versorgung oder entziehung einer substanz durch die haut
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
TW200409657A (en) 2002-08-08 2004-06-16 Alza Corp Transdermal vaccine delivery device having coated microprotrusions
US7422567B2 (en) 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
WO2005041871A2 (en) 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
CN100571643C (zh) 2003-10-31 2009-12-23 阿尔扎公司 用于微凸起阵列的自驱动施加器
AT500095B8 (de) 2004-01-23 2007-02-15 Braun Werner Mag Transdermales abgabesystem

Also Published As

Publication number Publication date
DE60126637D1 (de) 2007-03-29
WO2002032331A8 (en) 2003-11-13
WO2002032480A3 (en) 2002-08-29
CN100427159C (zh) 2008-10-22
US6821281B2 (en) 2004-11-23
DE60113557D1 (de) 2005-10-27
US20050090803A1 (en) 2005-04-28
JP2004516868A (ja) 2004-06-10
CA2422909A1 (en) 2002-04-25
JP4676128B2 (ja) 2011-04-27
EP1326673A2 (de) 2003-07-16
DE60126637T2 (de) 2007-11-22
EP1326673B1 (de) 2007-02-14
EP1326674B1 (de) 2005-09-21
CN1477983A (zh) 2004-02-25
WO2002032331A2 (en) 2002-04-25
ATE353687T1 (de) 2007-03-15
AU2002213168A1 (en) 2002-04-29
AU2002213167A1 (en) 2002-04-29
JP2004521669A (ja) 2004-07-22
ES2250493T3 (es) 2006-04-16
US20060129174A1 (en) 2006-06-15
WO2002032331A3 (en) 2002-09-06
CA2422907C (en) 2009-05-26
WO2002032480A8 (en) 2003-11-13
EP1326674A2 (de) 2003-07-16
CN100528259C (zh) 2009-08-19
CA2422909C (en) 2009-02-24
CN1665561A (zh) 2005-09-07
WO2002032480A2 (en) 2002-04-25
US7108681B2 (en) 2006-09-19
US20020045859A1 (en) 2002-04-18
CA2422907A1 (en) 2002-04-25
ES2281450T3 (es) 2007-10-01
DE60113557T2 (de) 2006-07-13
US20020045907A1 (en) 2002-04-18
US8216190B2 (en) 2012-07-10
EP1326674B8 (de) 2005-11-23

Similar Documents

Publication Publication Date Title
ATE304878T1 (de) Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut
WO2003024518A3 (en) Microstructures for delivering a composition cutaneously to skin using rotatable structures
US7211062B2 (en) Solid solution perforator for drug delivery and other applications
MXPA03003815A (es) Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos.
CA2490137C (en) Rapidly dissolving micro-perforator for drug delivery and other applications
AR046307A1 (es) Metodo de pretratamiento y sistema para mejorar la administracion transdermica de drogas
AU2002312380A1 (en) Device for manipulating a needle or abrader array
TW200600132A (en) Frequency assisted transdermal agent delivery method and system
WO2005051455A3 (en) Ultrasound assisted transdermal vaccine delivery method and system
AU2001275260A1 (en) Method and apparatus for enhancing penetration of a puncturing member into the intradermal space
TW200602099A (en) Apparatus and method for transdermal delivery of fentanyl-based agents
WO1998029134A3 (en) Microporation of tissue for delivery of bioactive agents
WO2004105729A3 (en) Transdermal vaccine delivery device having coated microprotrusions
ATE298259T1 (de) Vorrichtung zur lokalen verabreichung einer arznei in einer körperhöhle
CA2584638A1 (en) Medical device for generating transient bubbles
BRPI0514252A (pt) sistema de elastoplasto de microprotusões sem agulha
Trelles et al. Transepidermal delivery of cosmeceuticals using radiofrequency and ultrasound: Study of the penetration of a cosmetic gel in vivo by fluorescence microscopy
TW200738252A (en) Apparatus and method for transdermal delivery of Epoetin-based agents
CA2569285A1 (en) Methods of device-assisted drug delivery
TWI271202B (en) Formula for stimulating biological active substance entering skin or mucous membrane and the application of the same
KR20190127235A (ko) 미용액의 전달성이 향상된 니들 패치
Oni The Use of Fractionated Ablative Lasers as a Transdermal Microporation Technique
RU2008152205A (ru) Способ оздоровления и омоложения кожи

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties