DK1239916T3 - Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring - Google Patents

Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring

Info

Publication number
DK1239916T3
DK1239916T3 DK00984064T DK00984064T DK1239916T3 DK 1239916 T3 DK1239916 T3 DK 1239916T3 DK 00984064 T DK00984064 T DK 00984064T DK 00984064 T DK00984064 T DK 00984064T DK 1239916 T3 DK1239916 T3 DK 1239916T3
Authority
DK
Denmark
Prior art keywords
skin
microprotrusions
stretching
microprotection
improving
Prior art date
Application number
DK00984064T
Other languages
English (en)
Inventor
Joseph C Trautman
Wei-Qi Lin
Hyunok L Kim
Armand P Neukermans
Andrew I Poutiatine
J Richard Gyory
Michel J N Cormier
Kellee P Eng
Sara L Sendelbeck
Bruce P Edwards
Wai-Loong Lim
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DK1239916T3 publication Critical patent/DK1239916T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
DK00984064T 1999-12-10 2000-12-07 Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring DK1239916T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17270399P 1999-12-10 1999-12-10
US21687700P 2000-07-07 2000-07-07

Publications (1)

Publication Number Publication Date
DK1239916T3 true DK1239916T3 (da) 2006-04-03

Family

ID=26868367

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00984064T DK1239916T3 (da) 1999-12-10 2000-12-07 Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring

Country Status (10)

Country Link
US (2) US7087035B2 (da)
EP (1) EP1239916B1 (da)
AT (1) ATE310561T1 (da)
AU (1) AU2074301A (da)
CY (1) CY1105306T1 (da)
DE (1) DE60024312T2 (da)
DK (1) DK1239916T3 (da)
ES (1) ES2253278T3 (da)
HK (1) HK1048604B (da)
WO (1) WO2001041863A1 (da)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
EP1315459A1 (en) 2000-08-24 2003-06-04 Alza Corporation Method for transdermal nucleic acid sampling
NZ524646A (en) * 2000-09-08 2004-10-29 Alza Corp Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003052125A1 (en) * 2001-12-17 2003-06-26 Powderject Research Limited Non-or minimally invasive monitoring methods
DE60223844T2 (de) 2001-12-20 2008-08-28 Alza Corp., Mountain View Mikrovorsprünge zum durchstechen der haut mit stechtiefensteuerung
US20030130621A1 (en) * 2002-01-04 2003-07-10 Bryan Vincent E. Spinal needle system
US20030130614A1 (en) * 2002-01-09 2003-07-10 Johnson Lanny L. Device for delivering liquid medications or nutrients and gases to local tissue
AU2003209645A1 (en) * 2002-03-04 2003-09-16 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
JP2007511318A (ja) * 2003-11-18 2007-05-10 ナノ パス テクノロジーズ リミテッド 改良された挿入システム及びマイクロニードルを摺動させるための方法
RU2006119485A (ru) * 2003-12-18 2008-01-27 Ново Нордиск А/С (DK) Струйное устройство для инъекций и способ ввода лекарств через кожу
EP1706171A1 (en) * 2003-12-29 2006-10-04 3M Innovative Properties Company Medical devices and kits including same
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US7591806B2 (en) 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
BRPI0517749A (pt) 2004-11-18 2008-10-21 3M Innovative Properties Co dispositivo de aplicação para aplicar um dispositivo de micro-agulha a uma superfìcie de pele, e, método para usar um dispositivo de aplicação
US9174035B2 (en) 2004-11-18 2015-11-03 3M Innovative Properties Company Microneedle array applicator and retainer
EP1869414A4 (en) * 2005-03-29 2010-07-28 Arkal Medical Inc DEVICES, SYSTEMS, METHODS, AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
JP5144510B2 (ja) 2005-06-27 2013-02-13 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイ適用装置
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
WO2007064486A1 (en) 2005-11-30 2007-06-07 3M Innovative Properties Company Microneedle arrays and methods of use thereof
US20090227942A1 (en) 2005-12-20 2009-09-10 Novo Nordisk A/S Skin Retention Device for a Medical Jet Injection Unit
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
WO2008091602A2 (en) * 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
CA2682216A1 (en) * 2007-03-22 2008-09-25 Alza Corporation Multiple part electrotransport drug delivery device
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
WO2008136271A1 (ja) * 2007-04-27 2008-11-13 Terumo Kabushiki Kaisha 穿刺器具
US20090093775A1 (en) * 2007-10-03 2009-04-09 Raju Remesh S O Govinda Microstructures
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
EP2231257A4 (en) 2007-12-24 2013-11-06 Univ Queensland APPLICATION METHOD
US9066738B2 (en) * 2008-07-14 2015-06-30 Syneron Medical Ltd. Devices and methods for percutaneous energy delivery
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
WO2011005894A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
WO2011011392A2 (en) * 2009-07-20 2011-01-27 Ams Research Corporation Needleless injection device components, systems, and methods
EP2566535A4 (en) * 2010-05-03 2013-12-18 Izhar Halahmi DISTRIBUTION DEVICE FOR THE ADMINISTRATION OF AN ORGANIC ACTIVE AGENT
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9687640B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Applicators for microneedles
JP5562138B2 (ja) * 2010-06-24 2014-07-30 シスメックス株式会社 微細孔形成装置
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
IT1403293B1 (it) * 2010-12-27 2013-10-17 Fond Don Carlo Gnocchi Onlus Apparecchiatura ad aghi per la somministrazione transdermica di farmaci.
US8428709B1 (en) 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
US8301238B2 (en) 2011-03-31 2012-10-30 Incline Therapeutics, Inc. Two-part electrotransport device
US8428708B1 (en) 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
EP2510911A1 (en) * 2011-04-13 2012-10-17 Sanofi-Aventis Deutschland GmbH Apparatus for intraocular injection
WO2012166965A2 (en) * 2011-05-31 2012-12-06 Microlin, Llc An apparatus and method for dermal delivery
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
KR102378235B1 (ko) 2012-12-14 2022-03-25 민데라 코포레이션 바이오마커의 검출 및 취득을 위한 방법 및 디바이스
CN105073178B (zh) 2012-12-21 2019-07-30 考里安国际公司 用于治疗剂递送的微阵列及其使用方法
WO2014126101A1 (ja) * 2013-02-13 2014-08-21 久光製薬株式会社 マイクロニードル・アレイ
CA2901568C (en) * 2013-02-28 2021-02-16 Kimberly-Clark Worldwide, Inc. Transdermal drug delivery device
WO2014164314A1 (en) 2013-03-12 2014-10-09 Corium International, Inc. Microprojection applicators
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
JP2016512754A (ja) 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
GB201420946D0 (en) * 2014-11-25 2015-01-07 Kirby Andrew J And Xobaderm Ltd Flexible device incorporating microperforators
CA2975275C (en) 2015-02-02 2023-08-29 Vaxxas Pty Limited Microprojection array applicator and method
JPWO2016129184A1 (ja) * 2015-02-13 2017-04-27 株式会社 メドレックス マイクロニードルの穿刺装置及びマイクロニードルパッチの貼付装置
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
ES2928981T3 (es) 2015-12-21 2022-11-23 Medrx Co Ltd Alojamiento para aplicador de parches de microagujas
WO2017143345A1 (en) 2016-02-19 2017-08-24 Zp Opco, Inc. Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
EP4306803A3 (en) 2017-03-31 2024-04-10 Vaxxas Pty Limited Device and method for coating surfaces
WO2018204503A1 (en) 2017-05-03 2018-11-08 Z Surgical Llc Minimal-access percutaneous and self-retracting surgical system
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
AU2018309562A1 (en) 2017-08-04 2020-02-20 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
KR20210155817A (ko) 2017-08-23 2021-12-23 조사노 파마 코포레이션 편두통 및 군발성 두통의 치료를 위한 졸미트립탄의 치료적 농도를 신속하게 달성하는 방법
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
JP1632957S (da) 2018-10-30 2019-06-03
CN109621093A (zh) * 2018-11-28 2019-04-16 王英华 检疫用简便注射装置
US20230028295A1 (en) * 2019-12-18 2023-01-26 Uprax Microsolutions B.V. Applicators and methods for applying a microneedle patch to a skin of a subject, and microneedle patches

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
US4340480A (en) 1978-05-15 1982-07-20 Pall Corporation Process for preparing liquophilic polyamide membrane filter media and product
US4379454A (en) 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4753651A (en) 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
EP0132940A1 (en) * 1983-06-17 1985-02-13 Avvari Rangaswamy Arterial puncture unit
US4725439A (en) 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4655766A (en) 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4698062A (en) 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US5080646A (en) 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4832953A (en) 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5077104A (en) 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
DE69115471T2 (de) 1990-03-30 1996-05-02 Alza Corp Gerät zur iontophoretischen verabreichung von medikamenten
US5242406A (en) 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
ES2072134T3 (es) 1990-10-29 1995-07-01 Alza Corp Electrodo iontoforetico para suministrar farmacos y metodo para su hidratacion.
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
AT397466B (de) * 1992-03-18 1994-04-25 Diem Karl Spritze mit einem rohrartigen gehäuse zur aufnahme einer ampulle
US5310404A (en) 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
DE59505328D1 (de) 1994-12-09 1999-04-15 Novartis Ag Transdermales system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US6230051B1 (en) 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling
DE69722414T2 (de) 1996-07-03 2004-05-19 Altea Therapeutics Corp. Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
CN1133472C (zh) 1996-12-20 2004-01-07 阿尔萨公司 增加经皮样剂流量的装置
DK1037686T3 (da) * 1997-12-11 2006-01-02 Alza Corp Apparat til forögelse af transdermal gennemströmning af midler
CA2376128C (en) * 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers

Also Published As

Publication number Publication date
HK1048604A1 (en) 2003-04-11
US20020032415A1 (en) 2002-03-14
US20050085766A1 (en) 2005-04-21
CY1105306T1 (el) 2010-03-03
EP1239916B1 (en) 2005-11-23
DE60024312D1 (de) 2005-12-29
WO2001041863A1 (en) 2001-06-14
EP1239916A1 (en) 2002-09-18
ATE310561T1 (de) 2005-12-15
ES2253278T3 (es) 2006-06-01
US7087035B2 (en) 2006-08-08
AU2074301A (en) 2001-06-18
DE60024312T2 (de) 2006-08-17
HK1048604B (zh) 2006-05-04

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