ATE468961T1 - Verfahren zum formen einer mikronadel - Google Patents

Verfahren zum formen einer mikronadel

Info

Publication number
ATE468961T1
ATE468961T1 AT05853130T AT05853130T ATE468961T1 AT E468961 T1 ATE468961 T1 AT E468961T1 AT 05853130 T AT05853130 T AT 05853130T AT 05853130 T AT05853130 T AT 05853130T AT E468961 T1 ATE468961 T1 AT E468961T1
Authority
AT
Austria
Prior art keywords
mold
mold apparatus
microneedle
shaping
closed position
Prior art date
Application number
AT05853130T
Other languages
English (en)
Inventor
Dennis Ferguson
Satinder Nayar
Donald Pochardt
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of ATE468961T1 publication Critical patent/ATE468961T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B29C45/568—Applying vibrations to the mould parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B29C45/561—Injection-compression moulding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C2045/0094—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor injection moulding of small-sized articles, e.g. microarticles, ultra thin articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2791/00—Shaping characteristics in general
    • B29C2791/004—Shaping under special conditions
    • B29C2791/008—Using vibrations during moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/2669—Moulds with means for removing excess material, e.g. with overflow cavities
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/34—Moulds having venting means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
AT05853130T 2004-12-07 2005-12-07 Verfahren zum formen einer mikronadel ATE468961T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63431904P 2004-12-07 2004-12-07
PCT/US2005/044121 WO2006062974A2 (en) 2004-12-07 2005-12-07 Method of molding a microneedle

Publications (1)

Publication Number Publication Date
ATE468961T1 true ATE468961T1 (de) 2010-06-15

Family

ID=36168440

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05853130T ATE468961T1 (de) 2004-12-07 2005-12-07 Verfahren zum formen einer mikronadel

Country Status (11)

Country Link
US (3) US8088321B2 (de)
EP (2) EP1824655B1 (de)
JP (1) JP2008522875A (de)
KR (1) KR20070098851A (de)
CN (2) CN102358015A (de)
AT (1) ATE468961T1 (de)
AU (1) AU2005314151B2 (de)
CA (1) CA2589733C (de)
DE (1) DE602005021541D1 (de)
IL (1) IL183556A (de)
WO (1) WO2006062974A2 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0517749A (pt) 2004-11-18 2008-10-21 3M Innovative Properties Co dispositivo de aplicação para aplicar um dispositivo de micro-agulha a uma superfìcie de pele, e, método para usar um dispositivo de aplicação
EP1824655B1 (de) * 2004-12-07 2010-05-26 3M Innovative Properties Company Verfahren zum formen einer mikronadel
WO2007112309A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007127976A2 (en) * 2006-05-01 2007-11-08 Georgia Tech Research Corporation Particle based molding
EP2679375A3 (de) * 2007-06-20 2014-04-23 3M Innovative Properties Company of 3M Center Ultraschallspritzgießverfahren auf einer Bahn
CN101340784A (zh) * 2007-07-04 2009-01-07 深圳富泰宏精密工业有限公司 电子装置机壳及其制造方法
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
CA2742853C (en) 2008-11-18 2019-01-08 3M Innovative Properties Company Hollow microneedle array and method
US9289925B2 (en) 2009-04-10 2016-03-22 3M Innovative Properties Company Methods of making hollow microneedle arrays and articles and uses therefrom
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
EP2563454A4 (de) * 2010-04-28 2014-01-22 Kimberly Clark Co Injektionsgeformtes mikronadel-array und verfahren zur formung des mikronadel-arrays
WO2011135531A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
PT2563453T (pt) * 2010-04-28 2017-03-15 Kimberly Clark Co Dispositivo medicinal possuindo uma nanoforma com melhor interacção celular e um método para a sua formação
JP5860032B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド 関節リウマチ薬の送達のためのデバイス
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
JP5969495B2 (ja) * 2010-12-02 2016-08-17 スリーエム イノベイティブ プロパティズ カンパニー 液晶ポリマーマイクロニードル
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
WO2012125697A2 (en) * 2011-03-15 2012-09-20 3M Innovative Properties Company Ultrasonic-assisted molding of precisely-shaped articles and methods
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
HUE058275T2 (hu) 2011-10-27 2022-07-28 Sorrento Therapeutics Inc Beültethetõ eszközök biológiailag hatásos szerek tobábbítására
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
KR102265775B1 (ko) 2011-10-27 2021-06-16 소렌토 쎄라퓨틱스, 인코포레이티드 고점도 생체활성 제제의 경피 전달 방법
US10155332B2 (en) * 2011-12-09 2018-12-18 National Taiwan University Of Science And Technology In-mold vibratile injection compression molding method and molding apparatus thereof
CN103301092B (zh) 2012-03-06 2014-12-03 中国科学院理化技术研究所 聚合物微针阵列芯片及其制备方法和应用
CN104703651A (zh) 2012-05-01 2015-06-10 高等教育联邦系统-匹兹堡大学 用于经皮插入的尖端负载的微针阵列
US8663537B2 (en) 2012-05-18 2014-03-04 3M Innovative Properties Company Injection molding apparatus and method
CN104884119B (zh) 2012-12-27 2018-04-20 3M创新有限公司 具有中空微针的制品及其制备方法
JP6494601B2 (ja) 2013-05-31 2019-04-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードル注射及び注入装置並びにその使用方法
EP3003458B1 (de) 2013-05-31 2019-12-04 3M Innovative Properties Company Mikronadelinjektionsvorrichtung mit doppelabdeckung
WO2014193729A1 (en) 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection apparatus comprising an inverted actuator
US10099043B2 (en) 2013-07-16 2018-10-16 3M Innovative Properties Company Hollow microneedle array article
WO2015009531A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Article comprising a microneedle
WO2015009523A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Hollow microneedle with bevel opening
EP3021930B1 (de) 2013-07-16 2020-10-07 3M Innovative Properties Company Hohle mikronadel mit abgeschrägter spitze
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10632653B2 (en) * 2014-10-17 2020-04-28 Kao Corporation Fine hollow protrusion manufacturing method
CN107206221B (zh) 2015-01-21 2021-02-09 3M创新有限公司 微针阵列及使用方法
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2017131397A (ja) * 2016-01-27 2017-08-03 花王株式会社 微細中空突起具の製造方法
KR101747099B1 (ko) * 2016-02-11 2017-06-14 권영덕 생체적합성 고분자를 이용한 마이크로니들의 제조방법
JP6626403B2 (ja) * 2016-05-10 2019-12-25 富士フイルム株式会社 凹状パターンを有するモールドの作製方法、及びパターンシートの製造方法
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
WO2018211421A1 (en) * 2017-05-19 2018-11-22 Sabic Global Technologies B.V. Methods and systems of producing polymer microneedle arrays via ultrasonic embossing, and resulting microneedle arrays
US11766809B2 (en) * 2018-03-05 2023-09-26 Bae Systems Plc Method of forming pre-defined recess in cured or cast explosive composition
EP3778169B1 (de) * 2018-03-27 2021-12-29 FUJIFILM Corporation Verfahren zur herstellung einer form mit konkavem sockelmuster und verfahren zur herstellung einer musterfolie
US20210228119A1 (en) 2018-05-16 2021-07-29 Kindeva Drug Delivery L.P. Microneedle biosensor
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
EP3698841A1 (de) * 2019-02-19 2020-08-26 L'oreal Injektionsvorrichtung
EP3938166A4 (de) * 2019-03-15 2022-11-23 Celanese International Corporation Verfahren zur reduktion von schleierbildung in eingussnähe und gussformgestaltung dafür
JP6618647B1 (ja) 2019-04-26 2019-12-11 三光化成株式会社 微細パターン転写用モールド及び微細パターン成形方法
DE102019122648B4 (de) * 2019-08-22 2021-04-29 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
CN113797435A (zh) * 2020-06-16 2021-12-17 苏州悦肤达医疗科技有限公司 一种微针浇注系统及微针制备方法
EP4365593A3 (de) 2020-07-29 2024-07-10 Biolinq, Inc. System zur kontinuierlichen analytüberwachung mit mikronadelanordnung
CN112454809A (zh) * 2020-09-27 2021-03-09 鹰潭荣嘉集团医疗器械实业有限公司 一种输液器注塑成型装置及方法
KR20220065661A (ko) * 2020-11-13 2022-05-20 주식회사 대웅테라퓨틱스 마이크로니들 어레이 및 이의 제조방법
US11389632B2 (en) 2020-12-21 2022-07-19 Mediccene Inc. Intradermal drug delivery device
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12029562B2 (en) 2021-04-14 2024-07-09 Satio, Inc. Dermal patch system
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
KR20240005085A (ko) 2021-05-08 2024-01-11 바이오링크 인코포레이티드 미세 바늘 어레이 기반 지속 분석물 모니터링 장치의 고장 감지
CA3226577A1 (en) 2021-07-07 2023-01-12 The Regents Of The University Of California Wearable, non-intrusive microneedle sensor
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
CN114260351B (zh) * 2021-12-23 2024-01-26 哈尔滨工业大学 一种大面积阵列微结构跨尺度模压成形装置和方法
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
TWI817854B (zh) * 2022-11-29 2023-10-01 淡江大學學校財團法人淡江大學 微針模具組及使用其製造微針貼片的方法
USD1035004S1 (en) 2023-02-28 2024-07-09 Biolinq Incorporated Wearable sensor

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US275400A (en) * 1883-04-10 Running-gear for vehicles
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US4381963A (en) * 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
JPS6058010B2 (ja) * 1981-04-14 1985-12-18 三井化学株式会社 射出圧縮成形方法
US4515543A (en) 1983-09-02 1985-05-07 The Budd Co. In-mold coating part ejection system
US4793954A (en) * 1987-08-17 1988-12-27 The B. F. Goodrich Company Shear processing thermoplastics in the presence of ultrasonic vibration
JPH01182016A (ja) * 1988-01-16 1989-07-19 Etsuhisa Abe プラスチック射出成形方法
JPH01218813A (ja) * 1988-02-29 1989-09-01 Komatsu Ltd プラスチックの成形方法
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
JP3131620B2 (ja) * 1990-11-12 2001-02-05 株式会社不二越 射出圧縮成形法
US5160823A (en) * 1991-01-03 1992-11-03 Hutchinson Technology, Inc. Moving mask laser imaging
US5141677A (en) * 1991-01-22 1992-08-25 Minnesota Mining And Manufacturing Company Method of hot stamping intraocular lens bodies
US5152917B1 (en) * 1991-02-06 1998-01-13 Minnesota Mining & Mfg Structured abrasive article
US5256360A (en) * 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
DE4222856C1 (de) * 1992-07-11 1993-05-27 Buerkert Gmbh
US5376317A (en) 1992-12-08 1994-12-27 Galic Maus Ventures Precision surface-replicating thermoplastic injection molding method and apparatus, using a heating phase and a cooling phase in each molding cycle
CA2170989A1 (en) * 1993-09-13 1995-03-23 Timothy L. Hoopman Abrasive article, method of manufacture of same, method of using same for finishing, and a production tool
JP2551742B2 (ja) * 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
WO1996010630A1 (en) 1994-09-30 1996-04-11 Rutgers, The State University Direct introduction of foreign materials into cells
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5645977A (en) * 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
CA2265906C (en) * 1996-09-17 2003-11-11 Deka Products Limited Partnership System for delivery of drugs by transport
US6021559A (en) 1996-11-01 2000-02-08 3M Innovative Properties Company Methods of making a cube corner article master mold
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6248281B1 (en) 1996-11-14 2001-06-19 Idemitsu Petrochemical Co., Ltd. Compression apparatus for molding, injection compression molding machine, and injection compression molding method using the compression device
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
DE69839969D1 (de) * 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
EP1086214B1 (de) * 1998-06-10 2009-11-25 Georgia Tech Research Corporation Mikronadel-einrichtungen und verfahren zur deren herstellung
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
ATE280615T1 (de) * 1998-08-31 2004-11-15 Johnson & Johnson Consumer Elektrotransportvorrichtung mit klingen
EP1163024B1 (de) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Einbringen von makromolekülen in zellen
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
AU3478200A (en) 1999-02-02 2000-08-25 Ortho-Mcneil Pharmaceutical, Inc. Method of manufacture for transdermal matrices
US6306331B1 (en) * 1999-03-24 2001-10-23 International Business Machines Corporation Ultra mold for encapsulating very thin packages
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6361733B1 (en) * 1999-09-22 2002-03-26 Delphi Technologies, Inc. Ultrasonic injection molding
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20020198509A1 (en) * 1999-10-14 2002-12-26 Mikszta John A. Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US6551849B1 (en) * 1999-11-02 2003-04-22 Christopher J. Kenney Method for fabricating arrays of micro-needles
MXPA02004863A (es) 1999-11-15 2003-01-28 Velcro Ind Miembro de sujecion dermica.
US6511463B1 (en) * 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
WO2001093930A1 (en) * 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
CA2430590C (en) * 2000-11-30 2012-08-14 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
AU2002231207A1 (en) * 2000-12-21 2002-07-01 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US20030078549A1 (en) * 2001-06-08 2003-04-24 Stupar Philip Anthony Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
AU2002337788A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
CN100387318C (zh) * 2001-10-31 2008-05-14 中国科学院电工研究所 透过皮肤给药的微型针阵列片及其制造方法
ATE509272T1 (de) * 2001-11-09 2011-05-15 3Dbiosurfaces Technologies Llc Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon
EP1485317A2 (de) * 2001-11-30 2004-12-15 Alza Corporation Verfahren und vorrichtungen zur herstellung von mikroprojektoranordnungen
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US20030215816A1 (en) 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
EP1523367A1 (de) * 2002-07-19 2005-04-20 3M Innovative Properties Company Mikronadel anordnung und mikronadel verabreichungsgerät
NL1021421C2 (nl) * 2002-09-10 2004-03-11 Fountain Patents B V Inrichting en werkwijze voor het vervaardigen van producten uit een warm plastische massa.
JP2004114552A (ja) * 2002-09-27 2004-04-15 Mitsuboshi Belting Ltd 針状体の製造方法および針状体
DE10246942A1 (de) * 2002-10-08 2004-04-22 Battenfeld Gmbh Vorrichtung zum Erzeugen von Mikrostrukturen
KR100563330B1 (ko) * 2003-01-16 2006-03-22 포스트마이크로 주식회사 Ｌｉｇａ공정을 이용한 폴리머 재질의 미세 바늘 어레이제조방법
DE10325260A1 (de) * 2003-06-03 2004-12-30 Gauss, Ralph Kunststoffeinspritzeinheit durch Doppelnadel
EP1633250A2 (de) * 2003-06-04 2006-03-15 Georgia Tech Research Corporation Vorrichtung zum bohren mit mikronadeln
PE20050288A1 (es) * 2003-07-02 2005-04-29 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
BRPI0415466A (pt) * 2003-10-24 2006-12-19 Alza Corp método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
CN1905842A (zh) 2003-11-21 2007-01-31 阿尔扎公司 超声促进疫苗透皮释放的方法和系统
EP1718452A1 (de) * 2004-02-23 2006-11-08 3M Innovative Properties Company Verfahren zum formen von mikronadelanordnungen
EP1824655B1 (de) * 2004-12-07 2010-05-26 3M Innovative Properties Company Verfahren zum formen einer mikronadel
US20080275400A1 (en) * 2005-12-23 2008-11-06 Ferguson Dennis E Manufacturing Microneedle Arrays

Also Published As

Publication number Publication date
EP1824655B1 (de) 2010-05-26
US20080088066A1 (en) 2008-04-17
US8821779B2 (en) 2014-09-02
US20110163479A1 (en) 2011-07-07
WO2006062974A3 (en) 2006-09-28
EP2067599A2 (de) 2009-06-10
EP2067599B1 (de) 2016-10-26
CA2589733C (en) 2014-02-11
CN102358015A (zh) 2012-02-22
IL183556A0 (en) 2007-09-20
US20120280428A1 (en) 2012-11-08
CN101072668B (zh) 2011-08-31
AU2005314151A1 (en) 2006-06-15
CA2589733A1 (en) 2006-06-15
JP2008522875A (ja) 2008-07-03
WO2006062974A2 (en) 2006-06-15
DE602005021541D1 (de) 2010-07-08
EP2067599A3 (de) 2010-01-27
KR20070098851A (ko) 2007-10-05
EP1824655A2 (de) 2007-08-29
AU2005314151B2 (en) 2011-09-08
CN101072668A (zh) 2007-11-14
IL183556A (en) 2011-11-30
US8246893B2 (en) 2012-08-21
US8088321B2 (en) 2012-01-03

Similar Documents

Publication Publication Date Title
ATE468961T1 (de) Verfahren zum formen einer mikronadel
DE10195634T1 (de) Formgebungsvorrichtung und Verfahren unter Verwendung eines Roboters, um einen Einsatz in eine Form einzuführen
JP2008522875A5 (de)
AU2003275819A1 (en) Molded part removing apparatus and method for an injection molding machine
DE60311453D1 (de) Verfahren und Vorrichtung zum kontinuierlichen Herstellen eines gekrümmten, faserverstärkten Kunststoffteils
DE602004020825D1 (de) Form zum Einsatzformen und Verfahren zum Formen eines hohlen Bauteils
EP1919686A4 (de) Spritzgiessvorrichtung mit trennform und steuerverfahren dafür
EP2444225A3 (de) Ultraschallspritzgiessen auf einer bahn
HUP9904349A2 (hu) Készülék és eljárás nyitóeszköz csomagolóanyag-lemezre öntésére
ATE411151T1 (de) Verfahren zum herstellen eines behälters mit einem datenträger und behälter mit einem datenträger
ATE446179T1 (de) Verbessertes verfahren zum laden eines formsatzes in eine formmaschine
PL1737634T3 (pl) Stanowisko do rozformowywania
DE69812996D1 (de) Entgasungsvorrichtung, entlüftete form und verfahren zum herstellen eines geformten gegenstands
DE502009000597D1 (de) Vorrichtung zum herstellen blasgeformter behältererzeugnisse aus kunststoffmaterial
ATE415262T1 (de) Verfahren zum herstellen einer trägerbahn sowie trägerbahn
DE50105557D1 (de) Verfahren und vorrichtung zum herstellen von dickwandingen formteilen
ATE54598T1 (de) Verfahren und vorrichtung zum herstellen von formteilen aus thermoplastichem kunststoff, insbesondere ungereinigten und unsortierten kunststoffabfaellen.
ATE241458T1 (de) Spritzgiessvorrichtung zum hinterspritzen eines obermaterials mit kunststoff und verfahren
ATE279099T1 (de) Verfahren und vorrichtung zur herstellung von käse, insbesondere zur herstellung von krümmeligen käse
ATE237449T1 (de) Verbesserte spritzgiessverfahren und -vorrichtung mit verbesserter abnehmbarer schliesseinheit mit horizontalen buchformen
WO2005058574A3 (de) Verfahren zum herstellen von spritzgussteilen, spritzgussvorrichtung zur durchführung des verfahrens sowie nach dem verfahren hergestelltes spritzgussteil
DE60109084D1 (de) Verfahren und Vorrichtung zum Spritzformen mit Einlegeteilen
SE0200195D0 (sv) Förfarande och anordning för framställning av plastdetaljer
ATE323590T1 (de) Verfahren zum formen eines faserverstärkten kunstharzgegenstandes sowie faserverstärkter kunstharzgegenstand
DE60137901D1 (de) Verfahren und Formvorrichtung zum Herstellen von Kunststoffbehältern

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties