ATE249420T1 - Herstellung von iodixanol - Google Patents

Herstellung von iodixanol

Info

Publication number
ATE249420T1
ATE249420T1 AT00902754T AT00902754T ATE249420T1 AT E249420 T1 ATE249420 T1 AT E249420T1 AT 00902754 T AT00902754 T AT 00902754T AT 00902754 T AT00902754 T AT 00902754T AT E249420 T1 ATE249420 T1 AT E249420T1
Authority
AT
Austria
Prior art keywords
iodixanol
production
dimerisation
compound
triiodo
Prior art date
Application number
AT00902754T
Other languages
English (en)
Inventor
Ole Magne Homestad
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE249420(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amersham Health As filed Critical Amersham Health As
Application granted granted Critical
Publication of ATE249420T1 publication Critical patent/ATE249420T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
AT00902754T 1999-02-11 2000-02-10 Herstellung von iodixanol ATE249420T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9903109.8A GB9903109D0 (en) 1999-02-11 1999-02-11 Process
PCT/GB2000/000413 WO2000047549A1 (en) 1999-02-11 2000-02-10 Preparation of iodixanol

Publications (1)

Publication Number Publication Date
ATE249420T1 true ATE249420T1 (de) 2003-09-15

Family

ID=10847565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00902754T ATE249420T1 (de) 1999-02-11 2000-02-10 Herstellung von iodixanol

Country Status (18)

Country Link
US (8) US6974882B2 (de)
EP (1) EP1150943B1 (de)
JP (1) JP4545945B2 (de)
KR (1) KR100625139B1 (de)
CN (1) CN1178899C (de)
AT (1) ATE249420T1 (de)
AU (1) AU2449500A (de)
CA (1) CA2356942C (de)
CZ (1) CZ296353B6 (de)
DE (1) DE60005143T2 (de)
ES (1) ES2206190T3 (de)
GB (1) GB9903109D0 (de)
HU (1) HU228226B1 (de)
IL (1) IL143969A0 (de)
NO (1) NO329363B1 (de)
PL (1) PL197893B1 (de)
PT (1) PT1150943E (de)
WO (1) WO2000047549A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
KR100700701B1 (ko) * 2004-10-28 2007-03-28 동국정밀화학(주) 이오딕사놀의 제조방법
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
NO20055702D0 (no) * 2005-12-02 2005-12-02 Amersham Health As Contrast agents
US20070148096A1 (en) * 2005-12-15 2007-06-28 Lars-Goran Wistrand Contrast Agents
US7968745B2 (en) 2005-12-19 2011-06-28 Ge Healthcare As Purification process of iodixanol
CN101195587B (zh) * 2006-12-19 2010-07-21 浙江尖峰海洲制药有限公司 一种碘克沙醇水解物的制备方法
CN101293855B (zh) * 2007-04-27 2012-08-29 上海冠杰生物医药科技有限公司 一种碘克沙醇的纯化方法
JP5340281B2 (ja) 2007-07-12 2013-11-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
EP3311877A1 (de) 2007-07-19 2018-04-25 Medical Components, Inc. Venöser zugangsport mit röntgendichten kennzeichnungsmerkmalen
US8962886B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US20110021833A1 (en) 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US20110021828A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US7696381B1 (en) 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US20110020238A1 (en) 2009-07-21 2011-01-27 Ge Healthcare As Stabilizing aqueous solution of iodine chloride by adding sodium chloride
US8969619B2 (en) * 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US20110021825A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Process for isolating iodixanol from an aqueous solution
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US20110021823A1 (en) 2009-07-21 2011-01-27 Ge Healthcare As Processing crude iodixanol mixture by nanofiltration
US7999134B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US8461600B2 (en) * 2009-09-11 2013-06-11 Ut-Battelle, Llc Method for morphological control and encapsulation of materials for electronics and energy applications
CN102079716B (zh) * 2009-11-26 2014-03-05 浙江台州海神制药有限公司 碘克沙醇的制备与纯化
US8766002B2 (en) 2009-11-26 2014-07-01 Imax Diagnostic Imaging Holding Limited Preparation and purification of iodixanol
JP2014511344A (ja) 2010-12-21 2014-05-15 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤を含む組成物の脱塩
CN103058880B (zh) * 2011-10-21 2015-08-05 连云港润众制药有限公司 碘克沙醇及其合成中间体的制备方法
JP6431842B2 (ja) * 2012-09-27 2018-11-28 ジーイー・ヘルスケア・アクスイェ・セルスカプ イオホルミノールの中間体化合物の調製
CN102875411A (zh) * 2012-10-30 2013-01-16 广州牌牌生物科技有限公司 一种用大孔树脂分离纯化碘克沙醇注射剂原料的方法
KR102172700B1 (ko) * 2012-11-12 2020-11-03 지이 헬스케어 에이에스 X-선 조영제의 중간체의 제조 방법
CN103265449A (zh) * 2013-05-30 2013-08-28 四川铂瑞生物医药有限公司 5-氨基-2,4,6-三碘-n,n’-双(2,3-二羟基丙基)-1,3-苯二甲酰胺的合成
PT3077368T (pt) 2013-12-06 2018-10-19 Ge Healthcare As Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x
CN113831256A (zh) * 2021-09-17 2021-12-24 江苏宇田医药有限公司 一种碘克沙醇的中间体及其制备碘克沙醇的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816521A (en) * 1967-10-02 1974-06-11 Ueno Pharm Co Ltd Process for the production of p-hydroxy benzoic acid
ATE20733T1 (de) * 1982-11-08 1986-08-15 Nyegaard & Co As Roentgenkontrastmittel.
US5235116A (en) * 1992-08-24 1993-08-10 Eastman Kodak Company Process for the preparation of 2-(1-phenylethyl)hydroquinone and 2-(1-phenylethyl)hydroquinone diacetate
GB9618055D0 (en) 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9624612D0 (en) * 1996-11-26 1997-01-15 Nycomed Imaging As Process

Also Published As

Publication number Publication date
CN1340042A (zh) 2002-03-13
US20020010368A1 (en) 2002-01-24
KR100625139B1 (ko) 2006-09-20
NO20013881D0 (no) 2001-08-09
IL143969A0 (en) 2002-04-21
NO329363B1 (no) 2010-10-04
US20090112022A1 (en) 2009-04-30
PL197893B1 (pl) 2008-05-30
HUP0105096A2 (hu) 2002-04-29
DE60005143T2 (de) 2004-07-08
ES2206190T3 (es) 2004-05-16
CA2356942C (en) 2008-09-02
CA2356942A1 (en) 2000-08-17
CN1178899C (zh) 2004-12-08
US20100069669A1 (en) 2010-03-18
US20070203362A1 (en) 2007-08-30
HUP0105096A3 (en) 2004-05-28
CZ296353B6 (cs) 2006-02-15
US6974882B2 (en) 2005-12-13
EP1150943B1 (de) 2003-09-10
WO2000047549A1 (en) 2000-08-17
US20080161606A1 (en) 2008-07-03
HU228226B1 (en) 2013-02-28
US20060137602A1 (en) 2006-06-29
CZ20012891A3 (cs) 2001-12-12
JP4545945B2 (ja) 2010-09-15
EP1150943A1 (de) 2001-11-07
JP2002536429A (ja) 2002-10-29
GB9903109D0 (en) 1999-04-07
DE60005143D1 (de) 2003-10-16
NO20013881L (no) 2001-08-09
US20120083625A1 (en) 2012-04-05
PL348857A1 (en) 2002-06-17
PT1150943E (pt) 2004-02-27
US20110207963A1 (en) 2011-08-25
AU2449500A (en) 2000-08-29
KR20010102005A (ko) 2001-11-15

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