ATE342112T1 - Reinigung von biologischen substanzen - Google Patents

Reinigung von biologischen substanzen

Info

Publication number
ATE342112T1
ATE342112T1 AT00908806T AT00908806T ATE342112T1 AT E342112 T1 ATE342112 T1 AT E342112T1 AT 00908806 T AT00908806 T AT 00908806T AT 00908806 T AT00908806 T AT 00908806T AT E342112 T1 ATE342112 T1 AT E342112T1
Authority
AT
Austria
Prior art keywords
purification
biological substances
purifying
employing
types
Prior art date
Application number
AT00908806T
Other languages
English (en)
Inventor
Henry Kopf
Original Assignee
Ncsrt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/255,186 external-priority patent/US6214221B1/en
Application filed by Ncsrt Inc filed Critical Ncsrt Inc
Application granted granted Critical
Publication of ATE342112T1 publication Critical patent/ATE342112T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Jellies, Jams, And Syrups (AREA)
AT00908806T 1999-02-22 2000-02-22 Reinigung von biologischen substanzen ATE342112T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/255,186 US6214221B1 (en) 1999-02-22 1999-02-22 Method and apparatus for purification of biological substances
US09/300,891 US6139746A (en) 1999-02-22 1999-04-28 Method and apparatus for purification of biological substances

Publications (1)

Publication Number Publication Date
ATE342112T1 true ATE342112T1 (de) 2006-11-15

Family

ID=26944506

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00908806T ATE342112T1 (de) 1999-02-22 2000-02-22 Reinigung von biologischen substanzen

Country Status (10)

Country Link
US (1) US6383380B1 (de)
EP (1) EP1154827B1 (de)
AT (1) ATE342112T1 (de)
AU (1) AU756832B2 (de)
CA (1) CA2361545C (de)
DE (1) DE60031244T2 (de)
DK (1) DK1154827T3 (de)
IL (1) IL144421A (de)
NZ (1) NZ513242A (de)
WO (1) WO2000048703A1 (de)

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US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
NO20002828D0 (no) * 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
AU2003235875A1 (en) * 2002-05-07 2003-11-11 Asahi Kasei Kabushiki Kaisha Method and system for obtaining cells of specific type from biological material
KR100473703B1 (ko) * 2002-08-23 2005-03-10 한미약품 주식회사 형질전환 동물의 젖으로부터 재조합 펩타이드 또는단백질의 정제 방법
RU2005129745A (ru) * 2003-02-24 2006-03-20 Джитиси Байотерапьютикс, Инк. (Us) Способы и устройство проточной фильтрации вдоль потока
US8152999B2 (en) * 2004-05-21 2012-04-10 Wisconsin Alumni Research Foundation Membrane cascade-based separation
CA2576963C (en) 2004-08-20 2015-02-17 Prometic Biosciences Ltd. Sequential protein isolation and purification schemes by affinity chromatography
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
US7531632B2 (en) 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
EP3827841B1 (de) 2006-10-09 2024-04-03 Neurofluidics, Inc. System zur reinigung von liquor
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
CN101497649B (zh) * 2008-01-31 2011-06-08 上海依科赛生物制品有限公司 高融合率无噬菌体新生牛血清的生产工艺
FR2931838B1 (fr) 2008-06-02 2010-06-11 Millipore Corp Installation pour traiter un liquide biologique.
FR2940145B1 (fr) 2008-12-24 2011-03-25 Millipore Corp Chariot et installation de traitement d'un liquide biologique
US8795530B2 (en) 2009-01-21 2014-08-05 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
FR2941385B1 (fr) 2009-01-23 2011-04-01 Millipore Corp Procede pour fournir un circuit pour liquide biologique et circuit obtenu.
US7988859B2 (en) * 2009-02-05 2011-08-02 Chromatan Inc. Countercurrent tangential chromatography methods, systems, and apparatus
KR20100102926A (ko) * 2009-03-12 2010-09-27 삼성전자주식회사 표적물질 정제를 위한 필터유닛 및 이를 채용한 미세유동장치
KR20100111097A (ko) * 2009-04-06 2010-10-14 삼성전자주식회사 표적물질 분리를 위한 미세유동장치 및 그 정제방법
US9101883B2 (en) 2009-11-28 2015-08-11 Smartflow Technologies, Inc. Portable filtration unit
FR2955119B1 (fr) 2010-01-13 2012-12-28 Millipore Corp Circuit pour liquide biologique
FR2960796B1 (fr) 2010-06-08 2014-01-24 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960795B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960794B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2961711B1 (fr) 2010-06-23 2012-08-17 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
FR2961713B1 (fr) 2010-06-23 2012-08-10 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
FR2963573B1 (fr) 2010-08-03 2012-08-31 Millipore Corp Chariot de pompage pour une installation de traitement de liquide biologique
WO2012051517A2 (en) * 2010-10-15 2012-04-19 Xcellerex, Inc. Large volume disposable ultrafiltration systems and methods
US8919385B2 (en) 2010-11-24 2014-12-30 Pall Corporation Manifold plates and fluid treatment arrangements including manifold plates
US9163265B2 (en) 2011-02-21 2015-10-20 Smartflow Technologies, Inc. Method and systems for isolation and/or separation of products from production processes
US10005697B1 (en) 2011-02-21 2018-06-26 Smartflow Technologies, Inc. Method and systems for isolation and/or separation of target products from animal produced waste streams
US20120241391A1 (en) * 2011-03-25 2012-09-27 Receptors Llc Filtration article with microbial removal, micro-biocidal, or static growth capability
FR2973396B1 (fr) 2011-03-28 2013-05-10 Millipore Corp Installation de traitement de liquide biologique
US9284346B2 (en) * 2011-09-07 2016-03-15 Therapeutic Proteins International, LLC Preparative chromatography column and methods
US9783750B2 (en) 2012-02-16 2017-10-10 Smartflow Technologies, Inc. Biodiesel fuel production, separation methods and systems
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
FR2993572B1 (fr) 2012-07-23 2016-04-15 Emd Millipore Corp Circuit pour liquide biologique comportant une vanne a pincement
EP2892636A4 (de) 2012-09-06 2016-07-20 Smartflow Technologies Inc Permeatkanaländerungen für eine gegenstromfilterung zur verwendung in querströmungs-filterungsmodulen für osmosesysteme
WO2015001277A1 (fr) 2013-07-05 2015-01-08 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Matrice de chromatographie d'affinité
WO2015164511A1 (en) 2014-04-23 2015-10-29 Oleg Shinkazh High efficiency continuous countercurrent tangential chromatography
US10550148B2 (en) 2014-06-16 2020-02-04 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
US10207225B2 (en) 2014-06-16 2019-02-19 Emd Millipore Corporation Single-pass filtration systems and processes
KR102064888B1 (ko) 2014-06-25 2020-01-10 이엠디 밀리포어 코포레이션 밀집한 나권형 필터 엘리먼트, 모듈 및 시스템
ES2935333T3 (es) 2014-08-29 2023-03-06 Emd Millipore Corp Procesos para filtrar líquidos utilizando sistemas de filtración de flujo tangencial de paso único y sistemas de filtración de flujo tangencial con recirculación de retenido
SG10201901555UA (en) 2014-08-29 2019-03-28 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
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CA3006975C (en) 2015-12-04 2022-02-22 Minnetronix, Inc. Systems and methods for the conditioning of cerebrospinal fluid
CN109564198A (zh) * 2016-08-26 2019-04-02 纯化迪发有限公司 层析系统
EP3781284B1 (de) 2018-04-17 2024-08-07 Smartflow Technologies, Inc. Filterkassettenartikel und filter damit
US11028124B2 (en) * 2018-05-07 2021-06-08 Repligen Corporation Methods, devices and systems for 3-stage filtration
AU2019332100A1 (en) 2018-08-29 2021-03-18 Merck Biodevelopment S.A.S. New purification method

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US4443231A (en) * 1982-02-02 1984-04-17 Exxon Research And Engineering Co. Continuous chromatographic separations in a magnetically stabilized fluidized bed
US4606825A (en) 1985-04-22 1986-08-19 J. T. Baker Chemical Company Purification of immunoglobulin G
US4748234A (en) 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US5593580A (en) * 1986-11-26 1997-01-14 Kopf; Henry B. Filtration cassette article, and filter comprising same
US5868930A (en) 1986-11-26 1999-02-09 Kopf; Henry B. Filtration cassette article and filter comprising same
DE3640513A1 (de) 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
US4882050A (en) 1987-10-02 1989-11-21 Kopf Henry B Filter plate, filter plate element, and filter comprising same
US5049268A (en) 1987-10-02 1991-09-17 Kopf Henry B Filter plate, filter plate element, and filter comprising same
US5342517A (en) 1987-10-02 1994-08-30 Kopf Henry B Filtration cassette article, and filter comprising same
US5232589A (en) 1987-10-02 1993-08-03 Kopf Henry B Filter element and support
US4867876A (en) 1987-10-02 1989-09-19 Kopf Henry B Filter plate, filter plate element, and filter comprising same
US5118796A (en) 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
US5077391A (en) 1989-12-01 1991-12-31 Raison Robert L Purification of immunoglobulin M
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US5259971A (en) 1992-03-02 1993-11-09 Cryolife, Inc. Method of preparing fibrinogen
AU667530B2 (en) * 1992-05-28 1996-03-28 New York Blood Center, Inc., The Removal of antibodies from blood-derived compositions while retaining coagulation factors
CA2090989C (en) * 1993-03-04 1995-08-15 Konstantin Volchek Removal of arsenic from aqueous liquids with selected alumina
CA2127605A1 (en) * 1993-12-23 1995-06-24 Peter J. Degen Affinity separation method
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US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances

Also Published As

Publication number Publication date
AU756832B2 (en) 2003-01-23
WO2000048703A1 (en) 2000-08-24
DE60031244D1 (de) 2006-11-23
WO2000048703B1 (en) 2000-12-07
IL144421A0 (en) 2002-05-23
NZ513242A (en) 2003-10-31
AU3008300A (en) 2000-09-04
WO2000048703A9 (en) 2002-08-08
EP1154827A4 (de) 2002-08-28
DK1154827T3 (da) 2007-02-19
EP1154827B1 (de) 2006-10-11
DE60031244T2 (de) 2007-05-24
EP1154827A1 (de) 2001-11-21
CA2361545C (en) 2009-01-27
CA2361545A1 (en) 2000-08-24
IL144421A (en) 2004-12-15
US6383380B1 (en) 2002-05-07

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