NO20013881L - Fremstilling av iodixanol - Google Patents

Fremstilling av iodixanol

Info

Publication number
NO20013881L
NO20013881L NO20013881A NO20013881A NO20013881L NO 20013881 L NO20013881 L NO 20013881L NO 20013881 A NO20013881 A NO 20013881A NO 20013881 A NO20013881 A NO 20013881A NO 20013881 L NO20013881 L NO 20013881L
Authority
NO
Norway
Prior art keywords
iodixanol
preparation
dimerization
compound
triiodisophthalamide
Prior art date
Application number
NO20013881A
Other languages
English (en)
Other versions
NO329363B1 (no
NO20013881D0 (no
Inventor
Ole Magne Homestad
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20013881(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO20013881D0 publication Critical patent/NO20013881D0/no
Publication of NO20013881L publication Critical patent/NO20013881L/no
Publication of NO329363B1 publication Critical patent/NO329363B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En prosess for fremstilling av iodixanol ved dimerisering av 5-acetamido-N,N'-bis(2,3-dihydroksypropyl)-2,4,6-trijodisoftalamid ("Forbindelse A") hvor ureagert forbindelse A utfelles fra reaksjonsblandingen etter dimeriseringstrinnet og tas vare på for å brukes om igjen. Prosessen øker nettoutbyttet av iodixanol betydelig og gjør det lettere å rense produktet.
NO20013881A 1999-02-11 2001-08-09 Fremgangsmate for fremstilling av iodixanol NO329363B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9903109.8A GB9903109D0 (en) 1999-02-11 1999-02-11 Process
PCT/GB2000/000413 WO2000047549A1 (en) 1999-02-11 2000-02-10 Preparation of iodixanol

Publications (3)

Publication Number Publication Date
NO20013881D0 NO20013881D0 (no) 2001-08-09
NO20013881L true NO20013881L (no) 2001-08-09
NO329363B1 NO329363B1 (no) 2010-10-04

Family

ID=10847565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013881A NO329363B1 (no) 1999-02-11 2001-08-09 Fremgangsmate for fremstilling av iodixanol

Country Status (18)

Country Link
US (8) US6974882B2 (no)
EP (1) EP1150943B1 (no)
JP (1) JP4545945B2 (no)
KR (1) KR100625139B1 (no)
CN (1) CN1178899C (no)
AT (1) ATE249420T1 (no)
AU (1) AU2449500A (no)
CA (1) CA2356942C (no)
CZ (1) CZ296353B6 (no)
DE (1) DE60005143T2 (no)
ES (1) ES2206190T3 (no)
GB (1) GB9903109D0 (no)
HU (1) HU228226B1 (no)
IL (1) IL143969A0 (no)
NO (1) NO329363B1 (no)
PL (1) PL197893B1 (no)
PT (1) PT1150943E (no)
WO (1) WO2000047549A1 (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
KR100700701B1 (ko) * 2004-10-28 2007-03-28 동국정밀화학(주) 이오딕사놀의 제조방법
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
NO20055702D0 (no) * 2005-12-02 2005-12-02 Amersham Health As Contrast agents
US20070148096A1 (en) * 2005-12-15 2007-06-28 Lars-Goran Wistrand Contrast Agents
EP1966110B1 (en) 2005-12-19 2013-04-24 Ge Healthcare As Purification process of iodixanol
CN101195587B (zh) * 2006-12-19 2010-07-21 浙江尖峰海洲制药有限公司 一种碘克沙醇水解物的制备方法
CN101293855B (zh) * 2007-04-27 2012-08-29 上海冠杰生物医药科技有限公司 一种碘克沙醇的纯化方法
AU2008273037B2 (en) 2007-07-12 2012-11-15 Ge Healthcare As Contrast agents
EP3311877A1 (en) 2007-07-19 2018-04-25 Medical Components, Inc. Venous access port assembly with x-ray discernable indicia
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021828A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US8962886B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US7696381B1 (en) * 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US20110021825A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Process for isolating iodixanol from an aqueous solution
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US20110020238A1 (en) 2009-07-21 2011-01-27 Ge Healthcare As Stabilizing aqueous solution of iodine chloride by adding sodium chloride
US20110021833A1 (en) 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US8969619B2 (en) * 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US20110021823A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Processing crude iodixanol mixture by nanofiltration
US8461600B2 (en) * 2009-09-11 2013-06-11 Ut-Battelle, Llc Method for morphological control and encapsulation of materials for electronics and energy applications
CN102079716B (zh) * 2009-11-26 2014-03-05 浙江台州海神制药有限公司 碘克沙醇的制备与纯化
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
ES2680019T3 (es) 2010-12-21 2018-09-03 Ge Healthcare As Desalinización de una composición que comprende un agente de contraste
CN103058880B (zh) * 2011-10-21 2015-08-05 连云港润众制药有限公司 碘克沙醇及其合成中间体的制备方法
KR20150061635A (ko) * 2012-09-27 2015-06-04 지이 헬스케어 에이에스 아이오포르미놀의 중간체 화합물의 제조법
CN102875411A (zh) * 2012-10-30 2013-01-16 广州牌牌生物科技有限公司 一种用大孔树脂分离纯化碘克沙醇注射剂原料的方法
CA2881707C (en) * 2012-11-12 2021-01-12 Ge Healthcare As Preparation of intermediates of x-ray contrast agents
CN103265449A (zh) * 2013-05-30 2013-08-28 四川铂瑞生物医药有限公司 5-氨基-2,4,6-三碘-n,n’-双(2,3-二羟基丙基)-1,3-苯二甲酰胺的合成
JP6506758B2 (ja) 2013-12-06 2019-04-24 ジーイー・ヘルスケア・アクスイェ・セルスカプ 非イオン性ｘ線造影剤の合成における中間体を精製するための代替プロセス

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816521A (en) 1967-10-02 1974-06-11 Ueno Pharm Co Ltd Process for the production of p-hydroxy benzoic acid
LU88639I2 (fr) * 1982-11-08 1996-02-01 Nycomed Imaging S A Agents de contraste pour rayons x
US5235116A (en) 1992-08-24 1993-08-10 Eastman Kodak Company Process for the preparation of 2-(1-phenylethyl)hydroquinone and 2-(1-phenylethyl)hydroquinone diacetate
GB9618055D0 (en) 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9624612D0 (en) * 1996-11-26 1997-01-15 Nycomed Imaging As Process

Also Published As

Publication number Publication date
US20060137602A1 (en) 2006-06-29
US20090112022A1 (en) 2009-04-30
DE60005143D1 (de) 2003-10-16
EP1150943A1 (en) 2001-11-07
US20020010368A1 (en) 2002-01-24
HU228226B1 (en) 2013-02-28
US20120083625A1 (en) 2012-04-05
EP1150943B1 (en) 2003-09-10
JP4545945B2 (ja) 2010-09-15
CA2356942C (en) 2008-09-02
CN1340042A (zh) 2002-03-13
US20110207963A1 (en) 2011-08-25
DE60005143T2 (de) 2004-07-08
KR100625139B1 (ko) 2006-09-20
GB9903109D0 (en) 1999-04-07
AU2449500A (en) 2000-08-29
NO329363B1 (no) 2010-10-04
ES2206190T3 (es) 2004-05-16
ATE249420T1 (de) 2003-09-15
CA2356942A1 (en) 2000-08-17
NO20013881D0 (no) 2001-08-09
CZ296353B6 (cs) 2006-02-15
HUP0105096A2 (hu) 2002-04-29
JP2002536429A (ja) 2002-10-29
WO2000047549A1 (en) 2000-08-17
PT1150943E (pt) 2004-02-27
US20080161606A1 (en) 2008-07-03
HUP0105096A3 (en) 2004-05-28
KR20010102005A (ko) 2001-11-15
PL197893B1 (pl) 2008-05-30
CN1178899C (zh) 2004-12-08
US20100069669A1 (en) 2010-03-18
CZ20012891A3 (cs) 2001-12-12
IL143969A0 (en) 2002-04-21
US20070203362A1 (en) 2007-08-30
US6974882B2 (en) 2005-12-13
PL348857A1 (en) 2002-06-17

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