PT1150943E - Preparacao de iodixanol - Google Patents
Preparacao de iodixanolInfo
- Publication number
- PT1150943E PT1150943E PT00902754T PT00902754T PT1150943E PT 1150943 E PT1150943 E PT 1150943E PT 00902754 T PT00902754 T PT 00902754T PT 00902754 T PT00902754 T PT 00902754T PT 1150943 E PT1150943 E PT 1150943E
- Authority
- PT
- Portugal
- Prior art keywords
- iodixanol
- preparation
- dimerisation
- compound
- triiodo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9903109.8A GB9903109D0 (en) | 1999-02-11 | 1999-02-11 | Process |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1150943E true PT1150943E (pt) | 2004-02-27 |
Family
ID=10847565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00902754T PT1150943E (pt) | 1999-02-11 | 2000-02-10 | Preparacao de iodixanol |
Country Status (18)
Country | Link |
---|---|
US (8) | US6974882B2 (pt) |
EP (1) | EP1150943B1 (pt) |
JP (1) | JP4545945B2 (pt) |
KR (1) | KR100625139B1 (pt) |
CN (1) | CN1178899C (pt) |
AT (1) | ATE249420T1 (pt) |
AU (1) | AU2449500A (pt) |
CA (1) | CA2356942C (pt) |
CZ (1) | CZ296353B6 (pt) |
DE (1) | DE60005143T2 (pt) |
ES (1) | ES2206190T3 (pt) |
GB (1) | GB9903109D0 (pt) |
HU (1) | HU228226B1 (pt) |
IL (1) | IL143969A0 (pt) |
NO (1) | NO329363B1 (pt) |
PL (1) | PL197893B1 (pt) |
PT (1) | PT1150943E (pt) |
WO (1) | WO2000047549A1 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100574087B1 (ko) | 2004-09-09 | 2006-04-27 | 주식회사태준제약 | 아이오디사놀의 제조방법 |
KR100700701B1 (ko) * | 2004-10-28 | 2007-03-28 | 동국정밀화학(주) | 이오딕사놀의 제조방법 |
NO20053687D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process. |
NO20055702D0 (no) * | 2005-12-02 | 2005-12-02 | Amersham Health As | Contrast agents |
US20070148096A1 (en) * | 2005-12-15 | 2007-06-28 | Lars-Goran Wistrand | Contrast Agents |
ES2413761T3 (es) | 2005-12-19 | 2013-07-17 | Ge Healthcare As | Procedimiento de purificación de iodixanol |
CN101195587B (zh) * | 2006-12-19 | 2010-07-21 | 浙江尖峰海洲制药有限公司 | 一种碘克沙醇水解物的制备方法 |
CN101293855B (zh) * | 2007-04-27 | 2012-08-29 | 上海冠杰生物医药科技有限公司 | 一种碘克沙醇的纯化方法 |
AU2008273037B2 (en) * | 2007-07-12 | 2012-11-15 | Ge Healthcare As | Contrast agents |
EP2180915B1 (en) | 2007-07-19 | 2017-10-04 | Medical Components, Inc. | Venous access port assembly with x-ray discernable indicia |
US8962887B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol |
US20110021821A1 (en) | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Continuous acetylation process in synthesis of non-ionic x-ray contrast agents |
US20110021823A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Processing crude iodixanol mixture by nanofiltration |
US7696381B1 (en) * | 2009-07-21 | 2010-04-13 | Ge Healthcare As | Alternative dimerisation reagents for synthesis of iodixanol |
US20110021822A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents |
US20110020238A1 (en) | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Stabilizing aqueous solution of iodine chloride by adding sodium chloride |
US7999135B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
US20110021832A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Synthesis of iodixanol in water |
US7999134B2 (en) * | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using milling |
US20110021833A1 (en) | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents |
US7754920B1 (en) * | 2009-07-21 | 2010-07-13 | Ge Healthcare As | Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents |
US8969619B2 (en) * | 2009-07-21 | 2015-03-03 | Ge Healthcare As | Synthesis of iodixanol in propyleneglycol |
US8962886B2 (en) * | 2009-07-21 | 2015-02-24 | Ge Healthcare As | Synthesis of iodixanol in methanol |
US20110021828A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration |
US20110021825A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Process for isolating iodixanol from an aqueous solution |
US8461600B2 (en) * | 2009-09-11 | 2013-06-11 | Ut-Battelle, Llc | Method for morphological control and encapsulation of materials for electronics and energy applications |
JP5775524B2 (ja) * | 2009-11-26 | 2015-09-09 | アイマックス ダイアグノスティック イメージング ホールディング リミテッド | イオジキサノールの調製及び精製 |
CN102079716B (zh) * | 2009-11-26 | 2014-03-05 | 浙江台州海神制药有限公司 | 碘克沙醇的制备与纯化 |
US9474808B2 (en) | 2010-12-21 | 2016-10-25 | Ge Healthcare As | Desalination of a composition comprising a contrast agent |
CN103058880B (zh) * | 2011-10-21 | 2015-08-05 | 连云港润众制药有限公司 | 碘克沙醇及其合成中间体的制备方法 |
US9884808B2 (en) | 2012-09-27 | 2018-02-06 | Ge Healthcare As | Preparation of an intermediate compound of ioforminol |
CN102875411A (zh) * | 2012-10-30 | 2013-01-16 | 广州牌牌生物科技有限公司 | 一种用大孔树脂分离纯化碘克沙醇注射剂原料的方法 |
CN110229079A (zh) * | 2012-11-12 | 2019-09-13 | 通用电气医疗集团股份有限公司 | X-射线造影剂中间体的制备 |
CN103265449A (zh) * | 2013-05-30 | 2013-08-28 | 四川铂瑞生物医药有限公司 | 5-氨基-2,4,6-三碘-n,n’-双(2,3-二羟基丙基)-1,3-苯二甲酰胺的合成 |
JP6506758B2 (ja) | 2013-12-06 | 2019-04-24 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 非イオン性x線造影剤の合成における中間体を精製するための代替プロセス |
CN113831256B (zh) * | 2021-09-17 | 2024-06-11 | 江苏宇田医药有限公司 | 一种碘克沙醇的中间体及其制备碘克沙醇的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3816521A (en) | 1967-10-02 | 1974-06-11 | Ueno Pharm Co Ltd | Process for the production of p-hydroxy benzoic acid |
ATE20733T1 (de) * | 1982-11-08 | 1986-08-15 | Nyegaard & Co As | Roentgenkontrastmittel. |
US5235116A (en) | 1992-08-24 | 1993-08-10 | Eastman Kodak Company | Process for the preparation of 2-(1-phenylethyl)hydroquinone and 2-(1-phenylethyl)hydroquinone diacetate |
GB9618055D0 (en) | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
GB9624612D0 (en) * | 1996-11-26 | 1997-01-15 | Nycomed Imaging As | Process |
-
1999
- 1999-02-11 GB GBGB9903109.8A patent/GB9903109D0/en not_active Ceased
-
2000
- 2000-02-10 AU AU24495/00A patent/AU2449500A/en not_active Abandoned
- 2000-02-10 JP JP2000598470A patent/JP4545945B2/ja not_active Expired - Lifetime
- 2000-02-10 CN CNB008037051A patent/CN1178899C/zh not_active Expired - Lifetime
- 2000-02-10 PT PT00902754T patent/PT1150943E/pt unknown
- 2000-02-10 WO PCT/GB2000/000413 patent/WO2000047549A1/en active IP Right Grant
- 2000-02-10 DE DE60005143T patent/DE60005143T2/de not_active Expired - Lifetime
- 2000-02-10 ES ES00902754T patent/ES2206190T3/es not_active Expired - Lifetime
- 2000-02-10 IL IL14396900A patent/IL143969A0/xx not_active IP Right Cessation
- 2000-02-10 EP EP00902754A patent/EP1150943B1/en not_active Expired - Lifetime
- 2000-02-10 CZ CZ20012891A patent/CZ296353B6/cs not_active IP Right Cessation
- 2000-02-10 KR KR1020017010055A patent/KR100625139B1/ko active IP Right Grant
- 2000-02-10 CA CA002356942A patent/CA2356942C/en not_active Expired - Lifetime
- 2000-02-10 HU HU0105096A patent/HU228226B1/hu unknown
- 2000-02-10 PL PL348857A patent/PL197893B1/pl unknown
- 2000-02-10 AT AT00902754T patent/ATE249420T1/de not_active IP Right Cessation
-
2001
- 2001-08-06 US US09/923,074 patent/US6974882B2/en not_active Expired - Lifetime
- 2001-08-09 NO NO20013881A patent/NO329363B1/no not_active IP Right Cessation
-
2005
- 2005-11-28 US US11/288,029 patent/US20060137602A1/en not_active Abandoned
-
2007
- 2007-03-01 US US11/680,716 patent/US20070203362A1/en not_active Abandoned
- 2007-12-18 US US11/958,714 patent/US20080161606A1/en not_active Abandoned
-
2008
- 2008-10-06 US US12/245,886 patent/US20090112022A1/en not_active Abandoned
-
2009
- 2009-08-24 US US12/545,884 patent/US20100069669A1/en not_active Abandoned
-
2010
- 2010-08-24 US US12/862,023 patent/US20110207963A1/en not_active Abandoned
-
2011
- 2011-10-06 US US13/267,133 patent/US20120083625A1/en not_active Abandoned
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