PT3077368T - Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x - Google Patents

Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x

Info

Publication number
PT3077368T
PT3077368T PT14814793T PT14814793T PT3077368T PT 3077368 T PT3077368 T PT 3077368T PT 14814793 T PT14814793 T PT 14814793T PT 14814793 T PT14814793 T PT 14814793T PT 3077368 T PT3077368 T PT 3077368T
Authority
PT
Portugal
Prior art keywords
ionic
purification
synthesis
contrast agents
alternative process
Prior art date
Application number
PT14814793T
Other languages
English (en)
Inventor
Haaland Torfinn
Askildsen Arne
Silalahi Sumihar
Martin Farbrot Alf
Dagny Saanum Inger
Kalleberg Rita
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PT3077368T publication Critical patent/PT3077368T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT14814793T 2013-12-06 2014-12-08 Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x PT3077368T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361912799P 2013-12-06 2013-12-06
US201461969951P 2014-03-25 2014-03-25

Publications (1)

Publication Number Publication Date
PT3077368T true PT3077368T (pt) 2018-10-19

Family

ID=52117869

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14814793T PT3077368T (pt) 2013-12-06 2014-12-08 Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x

Country Status (7)

Country Link
US (2) US9834504B2 (pt)
EP (1) EP3077368B1 (pt)
JP (1) JP6506758B2 (pt)
CN (1) CN105873898B (pt)
ES (1) ES2683143T3 (pt)
PT (1) PT3077368T (pt)
WO (1) WO2015082720A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2683143T3 (es) 2013-12-06 2018-09-25 Ge Healthcare As Proceso alternativo para la purificación de un intermedio en la síntesis de agentes de contraste de rayos X no iónicos
CN105669488A (zh) * 2016-01-11 2016-06-15 浙江海洲制药有限公司 X-ct造影剂含碘中间体母液的预处理及中间体回收方法
GB202004773D0 (en) * 2020-03-31 2020-05-13 Ge Healthcare As Continuous crystallisation method

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
CN1109272C (zh) * 1993-03-10 2003-05-21 株式会社亚玛托亚商会 彩色析象器
CN1078201C (zh) * 1995-11-20 2002-01-23 江苏省原子医学研究所 一种碘海醇的制备方法
GB9618055D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9903109D0 (en) 1999-02-11 1999-04-07 Nycomed Imaging As Process
US20030236407A1 (en) * 2002-02-28 2003-12-25 Schering Ag Perfluoroalkyl group-containing micelle-forming triiodoaromatic compounds, process for their production and their use as contrast media
US20110021828A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
EP2277851A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
EP2277859A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced concentration of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
US20110021823A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Processing crude iodixanol mixture by nanofiltration
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
PT3077367T (pt) * 2013-12-06 2018-10-03 Ge Healthcare As Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x
ES2683143T3 (es) 2013-12-06 2018-09-25 Ge Healthcare As Proceso alternativo para la purificación de un intermedio en la síntesis de agentes de contraste de rayos X no iónicos

Also Published As

Publication number Publication date
EP3077368B1 (en) 2018-07-11
US20170253556A1 (en) 2017-09-07
JP2016539142A (ja) 2016-12-15
ES2683143T3 (es) 2018-09-25
US9834504B2 (en) 2017-12-05
EP3077368A1 (en) 2016-10-12
WO2015082720A1 (en) 2015-06-11
CN105873898B (zh) 2019-06-25
JP6506758B2 (ja) 2019-04-24
CN105873898A (zh) 2016-08-17
US20160297749A1 (en) 2016-10-13
US10011560B2 (en) 2018-07-03

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