PT3077367T - Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x - Google Patents

Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x

Info

Publication number
PT3077367T
PT3077367T PT14814792T PT14814792T PT3077367T PT 3077367 T PT3077367 T PT 3077367T PT 14814792 T PT14814792 T PT 14814792T PT 14814792 T PT14814792 T PT 14814792T PT 3077367 T PT3077367 T PT 3077367T
Authority
PT
Portugal
Prior art keywords
ionic
purification
synthesis
contrast agents
alternative process
Prior art date
Application number
PT14814792T
Other languages
English (en)
Inventor
Haaland Torfinn
Askildsen Arne
Heskestad Kalleberg Rita
Silalahi Sumihar
Martin Farbrot Alf
Dagny Saanum Inger
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PT3077367T publication Critical patent/PT3077367T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT14814792T 2013-12-06 2014-12-08 Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x PT3077367T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361912807P 2013-12-06 2013-12-06
US201461969959P 2014-03-25 2014-03-25

Publications (1)

Publication Number Publication Date
PT3077367T true PT3077367T (pt) 2018-10-03

Family

ID=52117868

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14814792T PT3077367T (pt) 2013-12-06 2014-12-08 Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x

Country Status (7)

Country Link
US (1) US9695113B2 (pt)
EP (1) EP3077367B1 (pt)
JP (1) JP6506759B2 (pt)
CN (1) CN105793235B (pt)
ES (1) ES2683712T3 (pt)
PT (1) PT3077367T (pt)
WO (1) WO2015082718A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105873898B (zh) * 2013-12-06 2019-06-25 通用电气医疗集团股份有限公司 纯化在非离子x-射线造影剂的合成中的中间体的供选方法
CN105669488A (zh) * 2016-01-11 2016-06-15 浙江海洲制药有限公司 X-ct造影剂含碘中间体母液的预处理及中间体回收方法
GB202004773D0 (en) * 2020-03-31 2020-05-13 Ge Healthcare As Continuous crystallisation method
CN114853625A (zh) * 2022-03-31 2022-08-05 海南普利制药股份有限公司 一种工业化生产碘海醇中间体的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US5811581A (en) * 1994-08-04 1998-09-22 Dibra S.P.A. Process for the purification of opacifying contrast agents
CN1078201C (zh) * 1995-11-20 2002-01-23 江苏省原子医学研究所 一种碘海醇的制备方法
GB9618055D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
US20030236407A1 (en) * 2002-02-28 2003-12-25 Schering Ag Perfluoroalkyl group-containing micelle-forming triiodoaromatic compounds, process for their production and their use as contrast media
ES2413761T3 (es) * 2005-12-19 2013-07-17 Ge Healthcare As Procedimiento de purificación de iodixanol
HRP20140649T1 (hr) * 2007-07-12 2014-09-26 Ge Healthcare As, Intellectual Property Dept. Kontrastna sredstva
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US20110021823A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Processing crude iodixanol mixture by nanofiltration
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
EP2277859A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced concentration of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
US20110021828A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
EP2277851A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
JP2012051850A (ja) * 2010-09-02 2012-03-15 Terumo Corp 経カテーテル動脈化学塞栓術用抗癌剤溶液
WO2012084926A1 (en) * 2010-12-21 2012-06-28 Ge Healthcare As Desalination of a composition comprising a contrast agent

Also Published As

Publication number Publication date
ES2683712T3 (es) 2018-09-27
CN105793235B (zh) 2019-08-23
JP2017503764A (ja) 2017-02-02
EP3077367B1 (en) 2018-07-11
WO2015082718A1 (en) 2015-06-11
JP6506759B2 (ja) 2019-04-24
US9695113B2 (en) 2017-07-04
CN105793235A (zh) 2016-07-20
EP3077367A1 (en) 2016-10-12
US20160289174A1 (en) 2016-10-06

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