HRP20140649T1 - Kontrastna sredstva - Google Patents
Kontrastna sredstva Download PDFInfo
- Publication number
- HRP20140649T1 HRP20140649T1 HRP20140649AT HRP20140649T HRP20140649T1 HR P20140649 T1 HRP20140649 T1 HR P20140649T1 HR P20140649A T HRP20140649A T HR P20140649AT HR P20140649 T HRP20140649 T HR P20140649T HR P20140649 T1 HRP20140649 T1 HR P20140649T1
- Authority
- HR
- Croatia
- Prior art keywords
- bis
- diyl
- triiodoisophthalamide
- dihydroxypropyl
- formylazandiyl
- Prior art date
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- 239000002872 contrast media Substances 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- IFOHPCJVGRTIRF-UHFFFAOYSA-N 3-N-(2,3-dihydroxypropyl)-1-N-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCCNC(=O)c1c(I)cc(I)c(C(=O)NCC(O)CO)c1I IFOHPCJVGRTIRF-UHFFFAOYSA-N 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- SEXLCKSAZXEOGK-UHFFFAOYSA-N 3-N-(1,3-dihydroxypropan-2-yl)-1-N-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(CO)NC(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O SEXLCKSAZXEOGK-UHFFFAOYSA-N 0.000 claims 2
- VADMOVDECLBVPB-UHFFFAOYSA-N 3-n-(1,3-dihydroxypropan-2-yl)-1-n-(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C=C(I)C(C(=O)NC(CO)CO)=C1I VADMOVDECLBVPB-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- VQLQIYKCVIMSOL-UHFFFAOYSA-N 1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1-n,3-n-dimethylbenzene-1,3-dicarboxamide Chemical compound OCC(O)CN(C)C(=O)C1=C(I)C=C(I)C(C(=O)N(C)CC(O)CO)=C1I VQLQIYKCVIMSOL-UHFFFAOYSA-N 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- GIHRGYUVDLQWNU-UHFFFAOYSA-N 3-n-(1,3-dihydroxypropan-2-yl)-5-[[4-[3-(1,3-dihydroxypropan-2-ylcarbamoyl)-n-formyl-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodoanilino]-2,3-dihydroxybutyl]-formylamino]-1-n-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(CO)NC(=O)C1=C(I)C(C(=O)NCCO)=C(I)C(N(CC(O)C(O)CN(C=O)C=2C(=C(C(=O)NC(CO)CO)C(I)=C(C(=O)NCCO)C=2I)I)C=O)=C1I GIHRGYUVDLQWNU-UHFFFAOYSA-N 0.000 claims 1
- NVXZYRVSVWCXMY-UHFFFAOYSA-N 3-n-(1,3-dihydroxypropan-2-yl)-5-[[5-[3-(1,3-dihydroxypropan-2-ylcarbamoyl)-5-(2,3-dihydroxypropylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2,4-dihydroxypentyl]-formylamino]-1-n-(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(CO)NC(=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(N(CC(O)CC(O)CN(C=O)C=2C(=C(C(=O)NC(CO)CO)C(I)=C(C(=O)NCC(O)CO)C=2I)I)C=O)=C1I NVXZYRVSVWCXMY-UHFFFAOYSA-N 0.000 claims 1
- MJYFVDNMTKLGTH-UHFFFAOYSA-N 4-bromo-6-(3,4-dichlorophenyl)sulfanyl-1-[[4-(dimethylcarbamoyl)phenyl]methyl]indole-2-carboxylic acid Chemical group BrC1=C2C=C(N(C2=CC(=C1)SC1=CC(=C(C=C1)Cl)Cl)CC1=CC=C(C=C1)C(N(C)C)=O)C(=O)O MJYFVDNMTKLGTH-UHFFFAOYSA-N 0.000 claims 1
- OFQPPMREYJROGC-UHFFFAOYSA-N 5-[[3-[3,5-bis(1,3-dihydroxypropan-2-ylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2-hydroxypropyl]-formylamino]-1-n,3-n-bis(1,3-dihydroxypropan-2-yl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(CO)NC(=O)C1=C(I)C(C(=O)NC(CO)CO)=C(I)C(N(CC(O)CN(C=O)C=2C(=C(C(=O)NC(CO)CO)C(I)=C(C(=O)NC(CO)CO)C=2I)I)C=O)=C1I OFQPPMREYJROGC-UHFFFAOYSA-N 0.000 claims 1
- BFVVDRUCXCIALU-UHFFFAOYSA-N 5-[[3-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2-hydroxypropyl]-formylamino]-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(N(CC(O)CN(C=O)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCC(O)CO)C=2I)I)C=O)=C1I BFVVDRUCXCIALU-UHFFFAOYSA-N 0.000 claims 1
- UWDIKNAIUAEFHH-UHFFFAOYSA-N 5-[[4-[3,5-bis(1,3-dihydroxypropan-2-ylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2,3-dihydroxybutyl]-formylamino]-1-n,3-n-bis(1,3-dihydroxypropan-2-yl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(CO)NC(=O)C1=C(I)C(C(=O)NC(CO)CO)=C(I)C(N(CC(O)C(O)CN(C=O)C=2C(=C(C(=O)NC(CO)CO)C(I)=C(C(=O)NC(CO)CO)C=2I)I)C=O)=C1I UWDIKNAIUAEFHH-UHFFFAOYSA-N 0.000 claims 1
- ZFSKEDVKCQAGLF-UHFFFAOYSA-N 5-[[4-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2,3-dihydroxybutyl]-formylamino]-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(N(CC(O)C(O)CN(C=O)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCC(O)CO)C=2I)I)C=O)=C1I ZFSKEDVKCQAGLF-UHFFFAOYSA-N 0.000 claims 1
- GINVNCUUZHPFJX-UHFFFAOYSA-N 5-[[4-[3,5-bis[2,3-dihydroxypropyl(methyl)carbamoyl]-n-formyl-2,4,6-triiodoanilino]-2,3-dihydroxybutyl]-formylamino]-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1-n,3-n-dimethylbenzene-1,3-dicarboxamide Chemical compound OCC(O)CN(C)C(=O)C1=C(I)C(C(=O)N(CC(O)CO)C)=C(I)C(N(CC(O)C(O)CN(C=O)C=2C(=C(C(=O)N(C)CC(O)CO)C(I)=C(C(=O)N(C)CC(O)CO)C=2I)I)C=O)=C1I GINVNCUUZHPFJX-UHFFFAOYSA-N 0.000 claims 1
- ANFBOIJRTXZPPH-UHFFFAOYSA-N 5-[[5-[3,5-bis(1,3-dihydroxypropan-2-ylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2,4-dihydroxypentyl]-formylamino]-1-n,3-n-bis(1,3-dihydroxypropan-2-yl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(CO)NC(=O)C1=C(I)C(C(=O)NC(CO)CO)=C(I)C(N(CC(O)CC(O)CN(C=O)C=2C(=C(C(=O)NC(CO)CO)C(I)=C(C(=O)NC(CO)CO)C=2I)I)C=O)=C1I ANFBOIJRTXZPPH-UHFFFAOYSA-N 0.000 claims 1
- DXKJFXZRCGKIMW-UHFFFAOYSA-N 5-[[5-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2,3,4-trihydroxypentyl]-formylamino]-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(N(CC(O)C(O)C(O)CN(C=O)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCC(O)CO)C=2I)I)C=O)=C1I DXKJFXZRCGKIMW-UHFFFAOYSA-N 0.000 claims 1
- BZARFYYDLPIPGL-UHFFFAOYSA-N 5-[[5-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2,4-dihydroxypentyl]-formylamino]-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(N(CC(O)CC(O)CN(C=O)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCC(O)CO)C=2I)I)C=O)=C1I BZARFYYDLPIPGL-UHFFFAOYSA-N 0.000 claims 1
- IQSBNZKRYREBRM-UHFFFAOYSA-N 5-[[5-[3,5-bis[2,3-dihydroxypropyl(methyl)carbamoyl]-n-formyl-2,4,6-triiodoanilino]-2,4-dihydroxypentyl]-formylamino]-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1-n,3-n-dimethylbenzene-1,3-dicarboxamide Chemical compound OCC(O)CN(C)C(=O)C1=C(I)C(C(=O)N(CC(O)CO)C)=C(I)C(N(CC(O)CC(O)CN(C=O)C=2C(=C(C(=O)N(C)CC(O)CO)C(I)=C(C(=O)N(C)CC(O)CO)C=2I)I)C=O)=C1I IQSBNZKRYREBRM-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical class [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 235000013675 iodine Nutrition 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004437 phosphorous atom Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Steroid Compounds (AREA)
Claims (13)
1. Spoj formule (I)
R-N(CHO)-X-N(R3)-R (I)
Formula (I)
ili njegova sol ili optički aktivan izomer,
gdje
X predstavlja C3 do C8 ravni ili razgranati alkilenski dio sa po izboru jednom ili dvije CH2 skupine zamijenjen atomima kisika, sumpora ili NR1 skupinama i gdje je alkilenski dio po izboru supstituiran sa do šest -OR1 skupina;
R1 predstavlja vodik ili C1 do C4 ravnu ili razgranatu alkilnu skupinu;
R3 predstavlja atom vodika, formil ili acetil; i
svaki R je nezavisno jednak ili različit i predstavlja fenilnu skupinu s tri joda, nadalje supstituiranu sa dvije skupine R2 gdje je svaki R2 jednak ili različit i predstavlja atom vodika ili ne-ionski hidrofilni dio,
uz uvjet da je barem jedna R2 skupina u spoju formule (I) hidrofilni dio.
2. Spoj prema zahtjevu 1 gdje X predstavlja ravni C3 do C8 alkilenski lanac supstituiran jednom do šest -OR1 skupina.
3. Spoj prema zahtjevu 1 ili 2 gdje R1 predstavlja atom vodika ili metilnu skupinu.
4. Spoj prema bilo kojem od prethodnih zahtjeva gdje X predstavlja ravni C3 do C5 alkilenski lanac s barem jednom hidroksilnom skupinom supstituiran na položaju koji nije susjedan veznom atomu dušika.
5. Spoj prema bilo kojem od prethodnih zahtjeva gdje R3 predstavlja formilni dio.
6. Spoj prema bilo kojem od prethodnih zahtjeva gdje svaka od tri-jodirane fenilne skupine R predstavlja 2,4,6-trijodiranu fenilnu skupinu dalje supstituiranu s dvije skupine R2 u preostalim položajima 3 i 5 u fenilnom dijelu.
7. Spoj prema bilo kojem od prethodnih zahtjeva gdje je svaki R2 jednak ili različit i predstavlja ne-ionski hidrofilni dio koji obuhvaća estere, amide i amine, po izboru je dalje supstituiran ravnim ili razgranatim lancem C1-10 alkilne skupine, po izboru da su jedan ili više dijelova CH2 ili CH zamijenjeni atomima kisika ili dušika i po izboru supstituiran jednom ili više skupina izabranih između okso, hidroksil, amino ili karboksil derivata, i okso supstituiran atomima sumpora i fosfora.
8. Spoj prema zahtjevu 7 gdje je svaki R2 jednak ili različit i predstavlja ne-ionski hidrofilni dio koji obuhvaća estere, amide i amine, dalje je supstituiran ravnim ili razgranatim lancem C1-5 alkilne skupine supstituirane s 1 do 3 hidroksi skupine.
9. Spoj prema zahtjevu 7 ili zahtjevu 8 gdje je svaki R2 jednak ili različit i izabran između skupina s formulama
- CONH2
- CONHCH3
- CONH-CH2-CH2-OH
- CONH-CH2-CH2-OCH3
- CONH-CH2-CHOH-CH2-OH
- CONH-CH2-CHOCH3-CH2-OH
- CONH-CH2-CHOH-CH2-OCH3
- CON(CH3)CH2-CHOH-CH2OH
- CONH-CH-(CH2-OH)2
- CON-(CH2-CH2-OH)2
- CON-(CH2-CHOH-CH2-OH)2
- CONH-OCH3
- CON (CH2-CHOH-CH2-OH) (CH2-CH2-OH)
- CONH-C(CH2 -OH)2 CH3,
- CONH-C(CH2 -OH)3, i
- CONH-CH (CH2-OH) (CHOH -CH2-OH)
- NH(COCH3)
- N(COCH3) C1-3 alkil
- N(COCH3) - mono, bis ili tris-hidroksi C1-4 alkil
- N(COCH2OH) - vodik, mono, bis ili tris-hidroksi C1-alkil
- N(CO-CHOH-CH2OH) vodik, mono, bis ili trihidroksilirani C1-alkil.
- N(CO-CHOH-CHOH-CH2OH) - vodik, mono, bis ili trihidroksilirani C1-alkil
- N(CO-CH-(CH2OH)2) - vodik, mono, bis ili trihidroksilirani C1-alkil; i
- N(COCH2OH)2
10. Spoj prema zahtjevu 9 gdje sve R2 skupine predstavljaju dio -CONH-CH2-CHOH-CH2-OH.
11. Spoj prema prethodnim zahtjevima izabran između sljedećih:
5,5’-(2-hidroksipropan-1,3-diil)bis(formilazandiil)bis(N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid);
5,5’-(2,3-dihidroksibutan-1,4-diil)bis(formilazandiil)bis(N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid);
5,5’-(2,4-dihidroksipentan-1,5-diil)bis(formilazandiil)bis(N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid);
5,5’-(2,3,4-trihidroksipentan-1,5-diil)bis(formilazandiil)bis(N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid);
5,5’-(2,3-dihidroksibutan-1,4-diil)bis(formilazandiil)bis(N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodo-N1,N3-dimetilizoftalamid);
5,5’-(2,4-dihidroksipentan-1,5-diil)bis(formilazandiil)bis(N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodo-N1,N3-dimetilizoftalamid);
5,5’-(2-hidroksipropan-1,3-diil)bis(formilazandiil)bis(N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodo-
N1,N3-dimetilizoftalamid);
5,5’-(2-hidroksipropan-1,3-diil)bis(formilazandiil)bis(N1,N3-bis(1,3-dihidroksipropan-2-il)-2,4,6-trijodoizoftalamid);
5,5’-(2,3-dihidroksibutan-1,4-diil)bis(formilazandiil)bis(N1,N3-bis(1,3-dihidroksipropan-2-il)-2,4,6-trijodoizoftalamid);
5,5’-(2,4-dihidroksipentan-1,5-diil)bis(formilazandiil)bis(N1,N3-bis(1,3-dihidroksipropan-2-il)-2,4,6-trijodoizoftalamid);
5,5’-(2,3-dihidroksibutan-1,4-diil)bis(formilazandiil)bis(N1-(2,3-dihidroksipropil)-N3-(2-hidroksietil)-2,4,6-trijodoizoftalamid);
5,5’-(2-hidroksipropan-1,3-diil)bis(formilazandiil)bis(N1-(2,3-dihidroksipropil)-N3-(2-hidroksietil)-2,4,6-trijodoizoftalamid);
5,5’-(2,4-dihidroksipentan-1,5-diil)bis(formilazandiil)bis(N1-(2,3-dihidroksipropil)-N3-(2-hidroksietil)-2,4,6-trijodoizoftalamid);
5,5’-(2-hidroksipropan-1,3-diil)bis(formilazandiil)bis(N1-(1,3-dihidroksipropan-2-il)-N3-(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid);
5,5’-(2,3-dihidroksibutan-1,4-diil)bis(formilazandiil)bis(N1-(1,3-dihidroksipropan-2-il)-N3-(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid);
5,5’-(2,4-dihidroksipentan-1,5-diil)bis(formilazandiil)bis(N1-(1,3-dihidroksipropan-2-il)-N3-(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid);
5,5’-(2-hidroksipropan-1,3-diil)bis(formilazandiil)bis(N1-(1,3-dihidroksipropan-2-il)-N3-(2-hidroksietil)-2,4,6-trijodoizoftalamid);
5,5’-(2,3-dihidroksibutan-1,4-diil)bis(formilazandiil)bis(N1-(1,3-dihidroksipropan-2-il)-N3-(2-hidroksietil)-2,4,6-trijodoizoftalamid);
5,5’-(2,4-dihidroksipentan-1,5-diil)bis(formilazandiil)bis(N1-(1,3-dihidroksipropan-2-il)-N3-(2-hidroksietil)-2,4,6-trijodoizoftalamid);
5-((N-(3-(N-(3,5-bis(2,3-dihidroksipropilkarbamoil)-2,4,6-trijodofenil)acetamido)-2-hidroksipropil)formamido)-N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid; ili
5-((3-(N-(3,5-bis(2,3-dihidroksipropilkarbamoil)-2,4,6-trijodofenil)formamido)-2-hidroksipropilamino)-N1,N3-bis(2,3-dihidroksipropil)-2,4,6-trijodoizoftalamid
12. Sredstvo za rendgensku dijagnostiku koje sadrži spoj formule (I) kako je definiran u bilo kojem od zahtjeva 1 do 11 zajedno s farmaceutski prihvatljivim nosačima ili pomoćnim tvarima.
13. Uporaba spoja formule (I) kako je definiran u bilo kojem od zahtjeva 1 do 11 za proizvodnju dijagnostičkog sredstva za uporabu kao kontrastno sredstvo za rendgensko zračenje.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20073595 | 2007-07-12 | ||
| NO20073594 | 2007-07-12 | ||
| PCT/NO2008/000255 WO2009008734A2 (en) | 2007-07-12 | 2008-07-04 | Contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140649T1 true HRP20140649T1 (hr) | 2014-09-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140649AT HRP20140649T1 (hr) | 2007-07-12 | 2014-07-08 | Kontrastna sredstva |
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| Country | Link |
|---|---|
| US (2) | US8920780B2 (hr) |
| EP (1) | EP2178568B1 (hr) |
| JP (3) | JP5340281B2 (hr) |
| KR (2) | KR101555457B1 (hr) |
| CN (4) | CN103951585A (hr) |
| AU (1) | AU2008273037B2 (hr) |
| BR (1) | BRPI0814811A2 (hr) |
| CA (1) | CA2692646C (hr) |
| CO (1) | CO6351754A2 (hr) |
| DK (1) | DK2178568T3 (hr) |
| ES (1) | ES2486296T3 (hr) |
| HR (1) | HRP20140649T1 (hr) |
| IL (1) | IL202487A (hr) |
| NZ (1) | NZ581765A (hr) |
| PL (1) | PL2178568T3 (hr) |
| PT (1) | PT2178568E (hr) |
| RU (1) | RU2469021C2 (hr) |
| WO (1) | WO2009008734A2 (hr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008273037B2 (en) | 2007-07-12 | 2012-11-15 | Ge Healthcare As | Contrast agents |
| JP2012514622A (ja) * | 2009-01-09 | 2012-06-28 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影製剤組成物 |
| NZ598540A (en) | 2009-10-29 | 2014-03-28 | Ge Healthcare As | Diagnostic composition comprising plasma cations having superior safety profile |
| US11185598B2 (en) | 2010-03-23 | 2021-11-30 | Ge Healthcare As | Preparation of stabilised x-ray diagnostic composition |
| US20130116554A1 (en) * | 2010-07-12 | 2013-05-09 | Ge Healthcare As | X-ray imaging at low contrast agent concentrations and/or low dose radiation |
| ES2680019T3 (es) | 2010-12-21 | 2018-09-03 | Ge Healthcare As | Desalinización de una composición que comprende un agente de contraste |
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| US20140319005A1 (en) * | 2011-09-21 | 2014-10-30 | Ge Healthcare As | Packaging of contrast media |
| GB2496971A (en) * | 2011-11-25 | 2013-05-29 | Ge Healthcare As | Preparation of X-ray contrast agents |
| NO333914B1 (no) * | 2011-12-21 | 2013-10-21 | Ge Healthcare As | Stabilisering av diagnostisk røntgensammensetning |
| BR112014017008A8 (pt) * | 2012-01-11 | 2017-07-04 | Ge Healthcare As | composição de raio x, e, método de exame por raio x |
| KR20150061635A (ko) | 2012-09-27 | 2015-06-04 | 지이 헬스케어 에이에스 | 아이오포르미놀의 중간체 화합물의 제조법 |
| MX365249B (es) * | 2012-09-27 | 2019-05-28 | Ge Healthcare As | Preparacion de ioforminol, un agente de contraste de rayos x. |
| CA2881707C (en) * | 2012-11-12 | 2021-01-12 | Ge Healthcare As | Preparation of intermediates of x-ray contrast agents |
| CN104854080B (zh) * | 2012-12-19 | 2018-07-03 | 通用电气医疗集团股份有限公司 | X-射线造影剂的纯化 |
| KR20150134346A (ko) | 2013-03-27 | 2015-12-01 | 지이 헬스케어 에이에스 | 진단 조성물을 제조하기 위한 방법 및 시약 |
| EP3077367B1 (en) * | 2013-12-06 | 2018-07-11 | GE Healthcare AS | Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents |
| CN105017063B (zh) * | 2014-04-18 | 2018-11-20 | 沈阳中海生物技术开发有限公司 | 5-氨基-2,4,6-三碘间苯二甲酸衍生物及其盐、水合物或溶剂化物 |
| CN108341750B (zh) * | 2017-01-21 | 2020-10-23 | 浙江海洲制药有限公司 | 一种制备碘化造影剂中间体时所产生的杂质的合成方法 |
| CN114560775B (zh) * | 2022-03-17 | 2023-08-22 | 绵阳师范学院 | (r,s)-7-氟-1,1,3-三甲基-2,3-二氢-1h-茚-4-胺的制备方法 |
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| SE315974B (hr) * | 1967-12-28 | 1969-10-13 | Pharmacia Ab | |
| DE2628517C2 (de) | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
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| DE3038853A1 (de) | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
| LU88639I2 (fr) * | 1982-11-08 | 1996-02-01 | Nycomed Imaging S A | Agents de contraste pour rayons x |
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| FR2634571B1 (fr) | 1988-07-19 | 1990-10-19 | Kodak Pathe | Procede d'organisation et de lecture d'un support magnetique et support en faisant application |
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| GB9020091D0 (en) | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| IT1245853B (it) | 1990-11-16 | 1994-10-25 | Bracco Spa | 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono |
| WO1994014476A1 (en) | 1992-12-21 | 1994-07-07 | The Procter & Gamble Company | Use of s(+) antipodes of analgesic agents for the manufacture of a composition to treat respiratory disorders |
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| GB9303992D0 (en) | 1993-02-26 | 1993-04-14 | Nycomed Imaging As | Contrast agents |
| WO1994022810A1 (es) * | 1993-04-01 | 1994-10-13 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen |
| CN1164225A (zh) * | 1994-09-23 | 1997-11-05 | 尼科梅德成像有限公司 | 碘代x-射线造影剂 |
| GB9419203D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| WO1997000240A1 (en) | 1995-06-16 | 1997-01-03 | Biophysica Foundation | Formyl derivatives as nonionic contrast media |
| US6072069A (en) | 1998-11-04 | 2000-06-06 | Biophysica, Inc. | Biodegradable nonionic contrast media |
| GB9903109D0 (en) | 1999-02-11 | 1999-04-07 | Nycomed Imaging As | Process |
| EP1186305A1 (en) | 2000-09-07 | 2002-03-13 | Schering Aktiengesellschaft | New brominated compounds as contrast media for X-ray mammography |
| WO2003080554A2 (en) | 2002-03-27 | 2003-10-02 | Fuji Photo Film Co., Ltd. | Iodinated triglyceride analogs |
| JP4096908B2 (ja) * | 2004-03-31 | 2008-06-04 | 株式会社豊田自動織機 | 回転電機の製造方法 |
| US20050281746A1 (en) * | 2004-06-16 | 2005-12-22 | Melton Laura J | Anticoagulant contrast media |
| AU2008273037B2 (en) * | 2007-07-12 | 2012-11-15 | Ge Healthcare As | Contrast agents |
| JP6723006B2 (ja) | 2015-12-10 | 2020-07-15 | 株式会社オカムラ | 椅子 |
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