BRPI0814811A2 - Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem - Google Patents

Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem

Info

Publication number
BRPI0814811A2
BRPI0814811A2 BRPI0814811-2A2A BRPI0814811A BRPI0814811A2 BR PI0814811 A2 BRPI0814811 A2 BR PI0814811A2 BR PI0814811 A BRPI0814811 A BR PI0814811A BR PI0814811 A2 BRPI0814811 A2 BR PI0814811A2
Authority
BR
Brazil
Prior art keywords
compound
agent
image formation
diagnostic composition
formation method
Prior art date
Application number
BRPI0814811-2A2A
Other languages
English (en)
Inventor
Mikkel Thaning
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of BRPI0814811A2 publication Critical patent/BRPI0814811A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
BRPI0814811-2A2A 2007-07-12 2008-07-04 Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem BRPI0814811A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20073595 2007-07-12
NO20073594 2007-07-12
PCT/NO2008/000255 WO2009008734A2 (en) 2007-07-12 2008-07-04 Contrast agents

Publications (1)

Publication Number Publication Date
BRPI0814811A2 true BRPI0814811A2 (pt) 2015-02-03

Family

ID=39811676

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814811-2A2A BRPI0814811A2 (pt) 2007-07-12 2008-07-04 Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem

Country Status (18)

Country Link
US (2) US8920780B2 (pt)
EP (1) EP2178568B1 (pt)
JP (3) JP5340281B2 (pt)
KR (2) KR20100033405A (pt)
CN (4) CN101687051A (pt)
AU (1) AU2008273037B2 (pt)
BR (1) BRPI0814811A2 (pt)
CA (1) CA2692646C (pt)
CO (1) CO6351754A2 (pt)
DK (1) DK2178568T3 (pt)
ES (1) ES2486296T3 (pt)
HR (1) HRP20140649T1 (pt)
IL (1) IL202487A (pt)
NZ (1) NZ581765A (pt)
PL (1) PL2178568T3 (pt)
PT (1) PT2178568E (pt)
RU (1) RU2469021C2 (pt)
WO (1) WO2009008734A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009008734A2 (en) * 2007-07-12 2009-01-15 Ge Healthcare As Contrast agents
CN102271715A (zh) * 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
MX2012005021A (es) * 2009-10-29 2012-06-19 Ge Healthcare As Composicion diagnostica que comprende cationes de plasma teniendo un perfil de seguridad superior.
WO2011117236A1 (en) 2010-03-23 2011-09-29 Ge Healthcare As Preparation of stabilised x-ray diagnostic composition
CA2801828A1 (en) * 2010-07-12 2012-01-19 Ge Healthcare As X-ray imaging at low contrast agent concentrations and/or low dose radiation
EP2655318B1 (en) 2010-12-21 2018-06-20 GE Healthcare AS Desalination of a composition comprising a contrast agent
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
ES2584659T3 (es) * 2011-09-21 2016-09-28 Ge Healthcare As Envasado de medios de contraste
GB2496971A (en) * 2011-11-25 2013-05-29 Ge Healthcare As Preparation of X-ray contrast agents
NO333914B1 (no) * 2011-12-21 2013-10-21 Ge Healthcare As Stabilisering av diagnostisk røntgensammensetning
CN104114190A (zh) * 2012-01-11 2014-10-22 通用电气医疗集团股份有限公司 具有低碘浓度的x-射线成像造影介质和x-射线成像方法
US9827334B2 (en) 2012-09-27 2017-11-28 Ge Healthcare As Preparation of ioforminol, an x-ray contrast agent
JP6431842B2 (ja) * 2012-09-27 2018-11-28 ジーイー・ヘルスケア・アクスイェ・セルスカプ イオホルミノールの中間体化合物の調製
ES2692071T3 (es) * 2012-11-12 2018-11-30 Ge Healthcare As Preparación de intermedios de agentes de contraste para rayos X
CN104854080B (zh) * 2012-12-19 2018-07-03 通用电气医疗集团股份有限公司 X-射线造影剂的纯化
EP2978454A1 (en) 2013-03-27 2016-02-03 Ge Healthcare As Method and reagent for preparing a diagnostic composition
WO2015082718A1 (en) * 2013-12-06 2015-06-11 Ge Healthcare As Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
CN105017063B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 5-氨基-2,4,6-三碘间苯二甲酸衍生物及其盐、水合物或溶剂化物
CN108341750B (zh) * 2017-01-21 2020-10-23 浙江海洲制药有限公司 一种制备碘化造影剂中间体时所产生的杂质的合成方法
CN114560775B (zh) * 2022-03-17 2023-08-22 绵阳师范学院 (r,s)-7-氟-1,1,3-三甲基-2,3-二氢-1h-茚-4-胺的制备方法

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SE344166B (pt) 1966-12-13 1972-04-04 Pharmacia Ab
SE315974B (pt) * 1967-12-28 1969-10-13 Pharmacia Ab
US3804892A (en) 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
US3763227A (en) 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
DE2628517C2 (de) 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
LU88639I2 (fr) * 1982-11-08 1996-02-01 Nycomed Imaging S A Agents de contraste pour rayons x
WO1988009328A1 (en) * 1987-05-22 1988-12-01 Bracco Industria Chimica S.P.A. Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives
FR2634571B1 (fr) 1988-07-19 1990-10-19 Kodak Pathe Procede d'organisation et de lecture d'un support magnetique et support en faisant application
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
GB9020091D0 (en) 1990-09-14 1990-10-24 Nycomed As Contrast media
IT1245853B (it) 1990-11-16 1994-10-25 Bracco Spa 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
JPH08506808A (ja) 1992-12-21 1996-07-23 ザ、プロクター、エンド、ギャンブル、カンパニー 呼吸障害治療用組成物の製造における鎮痛剤ｓ（＋）対掌体の利用
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
GB9303992D0 (en) 1993-02-26 1993-04-14 Nycomed Imaging As Contrast agents
WO1994022810A1 (es) 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
CN1164225A (zh) * 1994-09-23 1997-11-05 尼科梅德成像有限公司 碘代x-射线造影剂
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
AU6114396A (en) * 1995-06-16 1997-01-15 Biophysica Foundation Formyl derivatives as nonionic contrast media
US6072069A (en) 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
EP1186305A1 (en) 2000-09-07 2002-03-13 Schering Aktiengesellschaft New brominated compounds as contrast media for X-ray mammography
US7371877B2 (en) 2002-03-27 2008-05-13 Fujifilm Corporation Glycerol ester derivative
JP4096908B2 (ja) * 2004-03-31 2008-06-04 株式会社豊田自動織機 回転電機の製造方法
US20050281746A1 (en) * 2004-06-16 2005-12-22 Melton Laura J Anticoagulant contrast media
WO2009008734A2 (en) * 2007-07-12 2009-01-15 Ge Healthcare As Contrast agents
JP6723006B2 (ja) 2015-12-10 2020-07-15 株式会社オカムラ 椅子

Also Published As

Publication number Publication date
JP2013151533A (ja) 2013-08-08
CN103980154B (zh) 2015-02-25
JP5628363B2 (ja) 2014-11-19
KR20100033405A (ko) 2010-03-29
ES2486296T3 (es) 2014-08-18
RU2469021C2 (ru) 2012-12-10
DK2178568T3 (da) 2014-07-21
EP2178568A2 (en) 2010-04-28
IL202487A0 (en) 2010-06-30
JP5830589B2 (ja) 2015-12-09
US9738596B2 (en) 2017-08-22
KR20140111350A (ko) 2014-09-18
CN103951585A (zh) 2014-07-30
CN101687051A (zh) 2010-03-31
US20150191422A1 (en) 2015-07-09
PL2178568T3 (pl) 2014-09-30
IL202487A (en) 2015-06-30
CO6351754A2 (es) 2011-12-20
CA2692646C (en) 2014-09-09
WO2009008734A2 (en) 2009-01-15
RU2009148141A (ru) 2011-08-20
JP5340281B2 (ja) 2013-11-13
PT2178568E (pt) 2014-08-25
WO2009008734A3 (en) 2009-10-29
US8920780B2 (en) 2014-12-30
JP2010533172A (ja) 2010-10-21
CN103951586A (zh) 2014-07-30
JP2015007084A (ja) 2015-01-15
AU2008273037B2 (en) 2012-11-15
HRP20140649T1 (hr) 2014-09-26
KR101555457B1 (ko) 2015-09-23
CN103980154A (zh) 2014-08-13
EP2178568B1 (en) 2014-07-02
AU2008273037A1 (en) 2009-01-15
US20100322868A1 (en) 2010-12-23
CA2692646A1 (en) 2009-01-15
NZ581765A (en) 2012-03-30
CN103951586B (zh) 2015-05-27

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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