AR036659A1 - Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos - Google Patents
Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentosInfo
- Publication number
- AR036659A1 AR036659A1 ARP020103689A ARP020103689A AR036659A1 AR 036659 A1 AR036659 A1 AR 036659A1 AR P020103689 A ARP020103689 A AR P020103689A AR P020103689 A ARP020103689 A AR P020103689A AR 036659 A1 AR036659 A1 AR 036659A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkenyl
- alkyl
- alkynyl
- phenyl
- cycloalkyl
- Prior art date
Links
- LLSKXGRDUPMXLC-UHFFFAOYSA-N 1-phenylpiperidine Chemical compound C1CCCCN1C1=CC=CC=C1 LLSKXGRDUPMXLC-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
- 125000003342 alkenyl group Chemical group 0.000 abstract 8
- 125000001188 haloalkyl group Chemical group 0.000 abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 3
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000005741 alkyl alkenyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- FAZSTBCWNTWANH-UHFFFAOYSA-N 1-phenyl-3,4-dihydro-2h-pyridine Chemical compound C1CCC=CN1C1=CC=CC=C1 FAZSTBCWNTWANH-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101466 | 2001-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036659A1 true AR036659A1 (es) | 2004-09-22 |
Family
ID=8160750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103689A AR036659A1 (es) | 2001-10-04 | 2002-09-30 | Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos |
| ARP080101915A AR066460A2 (es) | 2001-10-04 | 2008-05-06 | Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101915A AR066460A2 (es) | 2001-10-04 | 2008-05-06 | Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos |
Country Status (38)
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| GB0305575D0 (en) * | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| KR101107536B1 (ko) * | 2003-04-04 | 2012-01-31 | 하. 룬트벡 아크티에 셀스카브 | 세로토닌 재흡수 저해제로서의4-(2-페닐술파닐-페닐)-피페리딘 유도체 |
| MXPA05010627A (es) * | 2003-04-04 | 2005-12-12 | Lundbeck & Co As H | Derivados de 4-(2-feniloxifenil)-piperidina o 1,2,3,6-tetrahidropiridina como inhibidores de la recaptacion de serotonina. |
| UA81300C2 (en) * | 2003-04-04 | 2007-12-25 | Lundbeck & Co As H | Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture |
| EA009417B1 (ru) * | 2003-04-04 | 2007-12-28 | Х. Лундбекк А/С | Производные 4-(2-фенилоксифенил)пиперидина или -1,2,3,6-тетрагидропиридина в качестве ингибиторов обратного захвата серотонина |
| ES2309514T3 (es) | 2003-04-04 | 2008-12-16 | H. Lundbeck A/S | Derivados de 4-(2-fenilsufanil-fenil)-piperidina como inhibidores de la recaptacion de serotonina. |
| PT1701940E (pt) | 2003-12-23 | 2008-07-30 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-benzil-amina como ssri |
| AR052308A1 (es) | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7923444B2 (en) * | 2005-02-10 | 2011-04-12 | Neurosearch A/S | Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| AR054394A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de 2- (1h-indolilsulfanil)-aril amina |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| JP2007106746A (ja) * | 2005-09-13 | 2007-04-26 | Tosoh Corp | 新規アリールホモピペラジン類、またはその塩と製造方法 |
| EA016054B1 (ru) * | 2006-06-16 | 2012-01-30 | Х. Лундбекк А/С | Кристаллические формы 4-[2-(4-метилфенилсульфанил)фенил] пиперидина с объединенным ингибированием повторного поглощения серотонина и норадреналина для лечения невропатической боли |
| CA2784304A1 (en) * | 2006-06-16 | 2007-12-21 | H. Lundbeck A/S | Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain |
| CN101472891B (zh) * | 2006-06-16 | 2013-08-21 | H.隆德贝克有限公司 | 有神经病痛治疗用血清素和去甲肾上腺素再摄取综合抑制作用的4-[2-(4-甲基苯硫基)苯基]哌啶的结晶形式 |
| WO2007144005A1 (en) * | 2006-06-16 | 2007-12-21 | H. Lundbeck A/S | 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment |
| JP7179035B2 (ja) * | 2006-06-16 | 2022-11-28 | ハー・ルンドベック・アクチエゼルスカベット | 認識機能障害（ｃｏｇｎｉｔｉｖｅ ｉｍｐａｉｒｍｅｎｔ）を治療するための、組み合わされたセロトニン再取り込み、５－ＨＴ３および５－ＨＴ１Ａ活性を有する化合物としての１－［２－（２，４－ジメチルフェニルスルファニル）－フェニル］ピペラジン |
| TW200848411A (en) * | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
| TWI405588B (zh) * | 2007-03-20 | 2013-08-21 | Lundbeck & Co As H | ４-〔２-（４-甲苯基硫基）-苯基〕哌啶之鹽類的液體調配物 |
| TWI432194B (zh) * | 2007-03-20 | 2014-04-01 | Lundbeck & Co As H | ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途 |
| HRP20140044T1 (hr) | 2007-06-15 | 2014-02-14 | H. Lundbeck A/S | 4-[2-(4-metilfenilsulfanil)fenil]piperidin za lijeäśenje iritabilnog sindroma crijeva (ibs) |
| AU2014200364B2 (en) * | 2007-11-13 | 2015-09-17 | H. Lundbeck A/S | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity |
| TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
| TW200932225A (en) * | 2007-12-14 | 2009-08-01 | Lundbeck & Co As H | 4-[2,3-difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine |
| TW200938194A (en) * | 2007-12-14 | 2009-09-16 | Lundbeck & Co As H | Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter |
| WO2009081259A1 (en) * | 2007-12-21 | 2009-07-02 | Pfizer Inc. | Phenoxy-pyridyl derivatives |
| UA98698C2 (en) * | 2008-03-03 | 2012-06-11 | Х. Луннбек А/С | Phenylsulfanylphenyl-piperidines and process for the preparation thereof |
| DK2358674T3 (da) | 2008-11-14 | 2013-04-08 | Theravance Inc | Fremgangsmåde til fremstilling af 4-[2-(2-fluorphenoxymethyl)phenyl]piperidinforbindelser |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
| PT2421534E (pt) * | 2009-04-24 | 2014-10-29 | Lundbeck & Co As H | Formulações líquidas de sais de 1-[2-(2,4-dimetilfenilsulfanil)fenil]-piperazina |
| JP2013502446A (ja) * | 2009-08-24 | 2013-01-24 | ハー・ルンドベック・アクチエゼルスカベット | １−［２−（２，４−ジメチル−フェニルスルファニル）−フェニル］ピペラジンの新規組成物 |
| RU2553453C2 (ru) * | 2009-10-30 | 2015-06-20 | Янссен Фармацевтика Нв | 4-замещенные-2-феноксифениламиновые модуляторы дельта-опиоидных рецепторов |
| WO2011085291A1 (en) * | 2010-01-11 | 2011-07-14 | Theravance, Inc. | 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors |
| JP5769348B2 (ja) * | 2010-03-22 | 2015-08-26 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | １−（２−フェノキシメチルヘテロアリール）ピペリジン化合物および１−（２−フェノキシメチルヘテロアリール）ピペラジン化合物 |
| CA2797812C (en) * | 2010-04-30 | 2018-02-20 | Takeda Pharmaceutical Company Limited | Enteric tablet |
| RU2593771C2 (ru) | 2010-04-30 | 2016-08-10 | Такеда Фармасьютикал Компани Лимитед | Энтеросолюбильная таблетка |
| EP2407467A1 (de) | 2010-07-14 | 2012-01-18 | Sandoz Ag | Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure |
| TW201212918A (en) | 2010-08-23 | 2012-04-01 | Lundbeck & Co As H | Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine |
| DK3135656T3 (en) | 2011-06-20 | 2019-04-23 | H Lundbeck As | DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF schizophrenia |
| BR112014011491A2 (pt) | 2011-11-14 | 2017-05-09 | Nestec Sa | ensaios e métodos para seleção de um regime de tratamento para um indivíduo com depressão |
| SG11201403835UA (en) * | 2012-01-03 | 2014-10-30 | Lundbeck & Co As H | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine |
| WO2014044721A1 (en) | 2012-09-19 | 2014-03-27 | Sandoz Ag | Novel crystalline form of vortioxetine hydrobromide |
| CN104853755B (zh) | 2012-12-13 | 2017-08-22 | H.隆德贝克有限公司 | 包含沃替西汀和多奈哌齐的组合物 |
| UA116236C2 (uk) * | 2013-02-22 | 2018-02-26 | Х. Луннбек А/С | Спосіб одержання вортіоксетину |
| WO2014161976A1 (en) * | 2013-04-04 | 2014-10-09 | Lek Pharmaceuticals D.D. | New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine |
| CN104109135B (zh) * | 2013-04-22 | 2018-10-26 | 江苏豪森药业集团有限公司 | 1-[2-(2,4-二甲基苯基硫烷基)-苯基]哌嗪的制备方法 |
| IN2013MU03121A (forum.php) | 2013-09-30 | 2015-07-17 | Cadila Healthcare Ltd | |
| EP2878596A1 (en) * | 2013-11-29 | 2015-06-03 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates |
| CN104710345B (zh) * | 2013-12-17 | 2017-09-05 | 江苏恩华药业股份有限公司 | 用于制备4‑（2‑（4‑甲基苯基硫基））苯基哌啶的化合物、其制备方法及应用 |
| KR20160093025A (ko) | 2013-12-20 | 2016-08-05 | 하. 룬트벡 아크티에 셀스카브 | 멜랑코리성 특색을 갖는 우울 장애의 치료를 위한 카파-활성을 갖는 오피오이드 수용체 길항제 및 보티옥세틴의 용도 |
| EP2894154A1 (en) * | 2014-01-14 | 2015-07-15 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates |
| CN103788019B (zh) * | 2014-01-22 | 2015-10-07 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
| EA029060B1 (ru) | 2014-01-31 | 2018-02-28 | Эгиш Дьёдьсердьяр Зрт. | Способ получения солей вортиоксетина |
| EP2930171A1 (en) | 2014-04-07 | 2015-10-14 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate |
| CN104059030B (zh) * | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途 |
| FR3023320B1 (fr) * | 2014-07-03 | 2017-03-10 | Ifp Energies Now | Systeme et procede de stockage et de recuperation d'energie par gaz comprime avec stockage de la chaleur au moyen d'un echangeur radial |
| CZ2014471A3 (cs) | 2014-07-08 | 2016-01-20 | Zentiva, K.S. | Způsob přípravy vortioxetinu |
| US9687484B2 (en) | 2014-07-18 | 2017-06-27 | Dipharma Francis S.R.L. | Crystalline forms of an antidepressant compound |
| CN104146953A (zh) * | 2014-07-24 | 2014-11-19 | 李雪梅 | 一种氢溴酸沃替西汀注射液 |
| CN104292183B (zh) * | 2014-09-29 | 2016-01-06 | 杨献美 | 一种抗抑郁药物沃替西汀的制备方法 |
| WO2016079751A2 (en) | 2014-11-17 | 2016-05-26 | Megafine Pharma (P) Ltd. | A process for preparation of vortioxetine and polymorphs thereof |
| ES2634496T3 (es) | 2014-11-21 | 2017-09-28 | Dipharma Francis S.R.L. | Proceso para la preparación de un antidepresivo y los intermedios del mismo |
| CN104447622B (zh) * | 2014-11-28 | 2017-01-04 | 郑州大明药物科技有限公司 | 氢溴酸沃替西汀β晶型的制备方法 |
| CN104586756A (zh) * | 2015-01-05 | 2015-05-06 | 万特制药(海南)有限公司 | 一种含沃替西汀的口服溶液及其制备方法 |
| CZ201531A3 (cs) | 2015-01-21 | 2016-08-03 | Zentiva, K.S. | Polymerem stabilizované amorfní formy vortioxetinu |
| CN104610195B (zh) * | 2015-01-30 | 2017-06-27 | 上虞京新药业有限公司 | 沃替西汀的天冬氨酸盐或其水合物及其制备方法和用途 |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| WO2016125190A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Novel crystalline forms of vortioxetine, premixes, and processes for the preparation thereof |
| EP3262031A1 (en) | 2015-02-25 | 2018-01-03 | Lupin Limited | Process for the preparation of vortioxetine |
| US20180072690A1 (en) | 2015-03-26 | 2018-03-15 | Cipla Limited | Methods for Making Serotonin Reuptake Inhibitors |
| CN104829557B (zh) * | 2015-04-23 | 2017-06-27 | 山东百诺医药股份有限公司 | 一种新化合物1‑[2‑（2,4‑二甲基苯基硫基）苯基]‑2‑氧哌嗪及其制备方法和在沃替西汀合成中的应用 |
| JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
| BR112018000841A8 (pt) * | 2015-07-17 | 2022-11-22 | Pasteur Institut | Agente estimulante de receptor 5-hidroxitriptamina1b para uso como um promotor de auto-renovação e/ou diferenciação de células satélites |
| EP3337789A1 (en) * | 2015-08-19 | 2018-06-27 | Amneal Pharmaceuticals Company GmbH | Process for preparation of vortioxetine hydrobromide |
| US20180303772A1 (en) * | 2015-10-14 | 2018-10-25 | Institut Pasteur | 5-hydroxytryptamine 1b receptor-stimulating agent for the treatment of myocardial infarction |
| CN105461635B (zh) * | 2015-11-18 | 2018-06-08 | 乳源瑶族自治县大众药品贸易有限公司 | 苯基哌嗪衍生物及其使用方法和用途 |
| CN105348204B (zh) * | 2015-11-18 | 2018-09-14 | 乳源瑶族自治县大众药品贸易有限公司 | 1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途 |
| US11013830B2 (en) * | 2015-11-20 | 2021-05-25 | Institut Pasteur | 5-hydroxytryptamine 1B receptor-stimulating agent for enhancing in vivo engraftment potential |
| WO2017162536A1 (en) | 2016-03-21 | 2017-09-28 | H. Lundbeck A/S | Vortioxetine prodrugs |
| MX2018015759A (es) | 2016-07-01 | 2019-03-21 | H Lundbeck As | Regimenes de dosificacion de vortioxetina para el rapido inicio del efecto antidepresivo. |
| KR20190038840A (ko) * | 2016-07-15 | 2019-04-09 | 앵스띠뛰 파스퇴르 | 피부 및/또는 모발 복구를 위한 5-하이드록시트립타민 1b 수용체-자극제 |
| CN109890799A (zh) * | 2016-07-22 | 2019-06-14 | 江苏恩华络康药物研发有限公司 | 沃替西汀类似物及其用途和制备 |
| US20190224192A1 (en) | 2016-08-29 | 2019-07-25 | Cipla Limited | Stable Pharmaceutical Composition of Vortioxetine Hydrobromide |
| CN106349132B (zh) * | 2016-08-30 | 2018-02-02 | 重庆植恩药业有限公司 | 沃替西汀中间体杂质及其制备方法和用途 |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| CN108409729B (zh) * | 2017-02-09 | 2020-11-24 | 广东东阳光药业有限公司 | 苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途 |
| CN108409728B (zh) * | 2017-02-09 | 2020-11-24 | 广东东阳光药业有限公司 | 苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途 |
| US10428033B2 (en) | 2017-02-15 | 2019-10-01 | Piramal Enterprises Limited | Process for the preparation of vortioxetine and salts thereof |
| WO2018150344A1 (en) | 2017-02-17 | 2018-08-23 | Unichem Laboratories Ltd | Bioequivalent pharmaceutical composition of vortioxetine hydrobromide |
| US10836730B2 (en) | 2017-02-23 | 2020-11-17 | Unichem Laboratories Ltd. | Process for preparation and purification of vortioxetine hydrobromide |
| SG11201909678PA (en) | 2017-04-25 | 2019-11-28 | H Lundbeck As | Process for the manufacture of vortioxetine hbr alpha-form |
| EP3412661A1 (en) | 2017-06-08 | 2018-12-12 | Enantia, S.L. | Cocrystals of vortioxetine hydrobromide and resorcinol |
| KR102026337B1 (ko) | 2017-07-07 | 2019-09-27 | 영진약품 주식회사 | 1-[2-(2,4-디메틸페닐설파닐)페닐]피페라진의 신규염 및 이의 제조방법 |
| CN107915685A (zh) * | 2017-12-11 | 2018-04-17 | 重庆植恩药业有限公司 | 一种氢溴酸沃替西汀中间体的制备方法 |
| CN108017595A (zh) * | 2017-12-20 | 2018-05-11 | 安徽源久源科技有限公司 | 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法 |
| ES2976985T3 (es) | 2018-06-20 | 2024-08-14 | Vio Ag Pharmaceuticals S A | Enfoque de activación C-H organo-pseudocatalítica de un recipiente para la preparación de vortioxetina y producto intermedio de vortioxetina |
| CN108863986B (zh) * | 2018-08-06 | 2020-01-21 | 广东东阳光药业有限公司 | 二氟甲基取代的苯基哌嗪衍生物及其用途 |
| CN108727393B (zh) * | 2018-08-06 | 2019-10-29 | 广东东阳光药业有限公司 | 苯基二氮杂双环衍生物及其用途 |
| WO2021198778A1 (en) | 2020-04-03 | 2021-10-07 | H. Lundbeck A/S | 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine for prevention or treatment of emotional blunting |
| US12281088B2 (en) | 2020-09-10 | 2025-04-22 | Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd | Process for the synthesis of vortioxetine |
| GB2622880A (en) | 2022-09-30 | 2024-04-03 | Alkaloid Ad Skopje | Palatable orodispersible formulation of vortioxetine |
| WO2025132869A1 (en) | 2023-12-21 | 2025-06-26 | H. Lundbeck A/S | Method for the preparation of vortioxetine pharmaceutical compositions with low amounts of nitrosamine impurities |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS151753B1 (forum.php) | 1971-04-13 | 1973-11-19 | ||
| CS151751B1 (forum.php) | 1971-04-13 | 1973-11-19 | ||
| CS151752B1 (forum.php) | 1971-04-13 | 1973-11-19 | ||
| CS151755B1 (forum.php) | 1971-04-13 | 1973-11-19 | ||
| YU163075A (en) * | 1975-07-21 | 1982-05-31 | Science Union & Cie | Process for preparing new phenoxy derivatives |
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| US4198417A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenoxyphenylpiperidines |
| US4198419A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenylthiophenylpiperidines |
| ES2004809A6 (es) | 1987-07-29 | 1989-02-01 | Ferrer Int | Procedimiento de obtencion de nuevas 1-(2-(fenilmetil)fenil)piperazinas |
| GB9126311D0 (en) | 1991-12-11 | 1992-02-12 | Wellcome Found | Substituted diphenylsulfides |
| WO1996022977A1 (fr) * | 1995-01-23 | 1996-08-01 | Suntory Limited | Ameliorant ou remede contre des symptomes provoques par des maladies ischemiques et composes utiles a cet effet |
| CZ293595A3 (cs) | 1995-11-09 | 1999-12-15 | Farmak A. S. | Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích |
| FR2757160B1 (fr) * | 1996-12-13 | 1999-03-12 | Sanofi Sa | 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
| US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| ATE285403T1 (de) * | 1997-10-31 | 2005-01-15 | Daiichi Suntory Pharma Co Ltd | Verfahren zur herstellung von n-((4- phenyl)methylphenyl)piperazinen |
| HUP0201904A3 (en) | 1999-04-02 | 2003-04-28 | Icos Corp Bothell | Inhibitors of lfa-1 binding to icams and uses thereof |
| AU6621600A (en) | 1999-08-04 | 2001-03-05 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| CA2384599A1 (en) * | 1999-09-14 | 2001-03-22 | Pharmacopeia, Inc. | Article comprising a multi-channel dispensing head |
| AU2351701A (en) * | 1999-12-30 | 2001-07-16 | H. Lundbeck A/S | A method for the preparation of substituted benzene derivatives |
| BR0016952A (pt) | 1999-12-30 | 2002-10-08 | Lundbeck & Co As H | Compostos derivados de fenil-piperazina substituìdos, composição farmacêutica, uso e método |
| US6813639B2 (en) | 2000-01-26 | 2004-11-02 | Viaclix, Inc. | Method for establishing channel-based internet access network |
| DE10033548C2 (de) | 2000-07-11 | 2002-05-16 | Wolfgang Papenbrock | Verfahren zur Vorschau von Internetseiten |
| US7291619B2 (en) * | 2001-01-23 | 2007-11-06 | Eli Lilly And Company | Melanocortin receptor agonists |
| EP1363890A4 (en) | 2001-02-07 | 2009-06-10 | Ore Pharmaceuticals Inc | MELANOCORTIN-4-RECEPTOR BINDING COMPOUNDS AND METHOD FOR THEIR APPLICATION |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| MXPA04005989A (es) * | 2001-12-20 | 2004-09-27 | Lundbeck & Co As H | Derivados de ariloxifenilo y arilsulfanilfenilo. |
| TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
| ES2309514T3 (es) * | 2003-04-04 | 2008-12-16 | H. Lundbeck A/S | Derivados de 4-(2-fenilsufanil-fenil)-piperidina como inhibidores de la recaptacion de serotonina. |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| WO2007144005A1 (en) * | 2006-06-16 | 2007-12-21 | H. Lundbeck A/S | 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment |
-
2002
- 2002-02-10 UA UA2004032271A patent/UA81749C2/uk unknown
- 2002-09-30 AR ARP020103689A patent/AR036659A1/es active IP Right Grant
- 2002-10-02 DK DK02800051.1T patent/DK1436271T6/da active
- 2002-10-02 KR KR1020047004897A patent/KR100770194B1/ko not_active Expired - Lifetime
- 2002-10-02 RS YU27704A patent/RS52326B/en unknown
- 2002-10-02 CA CA2462110A patent/CA2462110C/en not_active Expired - Lifetime
- 2002-10-02 HU HU0402313A patent/HU228956B1/hu active Protection Beyond IP Right Term
- 2002-10-02 HR HR20040220A patent/HRP20040220A2/hr not_active Application Discontinuation
- 2002-10-02 EA EA200601269A patent/EA011096B1/ru not_active IP Right Cessation
- 2002-10-02 IL IL16065502A patent/IL160655A0/xx active Protection Beyond IP Right Term
- 2002-10-02 PL PL392184A patent/PL210551B1/pl unknown
- 2002-10-02 SI SI200230678T patent/SI1436271T1/sl unknown
- 2002-10-02 DE DE60225162.1T patent/DE60225162T3/de not_active Expired - Lifetime
- 2002-10-02 ES ES02800051T patent/ES2298425T7/es active Active
- 2002-10-02 ME MEP-2008-65A patent/ME00039B/me unknown
- 2002-10-02 RS RS20120158A patent/RS52865B/en unknown
- 2002-10-02 PL PL368442A patent/PL209253B1/pl unknown
- 2002-10-02 DK DK06016609T patent/DK1749818T3/da active
- 2002-10-02 ES ES06016609T patent/ES2328725T3/es not_active Expired - Lifetime
- 2002-10-02 KR KR1020077022025A patent/KR100842702B1/ko not_active Expired - Lifetime
- 2002-10-02 AT AT06016609T patent/ATE441631T1/de active
- 2002-10-02 JP JP2003532482A patent/JP3896116B2/ja not_active Expired - Lifetime
- 2002-10-02 EP EP06016609A patent/EP1749818B1/en not_active Expired - Lifetime
- 2002-10-02 AT AT02800051T patent/ATE386730T1/de active
- 2002-10-02 CN CNB028190254A patent/CN1319958C/zh not_active Expired - Lifetime
- 2002-10-02 MX MXPA04002959A patent/MXPA04002959A/es active IP Right Grant
- 2002-10-02 BR BR122012009534D patent/BR122012009534C8/pt not_active IP Right Cessation
- 2002-10-02 BR BR122012023120A patent/BR122012023120B8/pt active IP Right Grant
- 2002-10-02 EP EP02800051.1A patent/EP1436271B3/en not_active Expired - Lifetime
- 2002-10-02 US US10/488,280 patent/US7144884B2/en active Active
- 2002-10-02 EA EA200400498A patent/EA007537B3/ru active Protection Beyond IP Right Term
- 2002-10-02 UA UAA200612495A patent/UA93857C2/uk unknown
- 2002-10-02 DE DE60233608T patent/DE60233608D1/de not_active Expired - Lifetime
- 2002-10-02 BR BRPI0212733A patent/BRPI0212733B8/pt active IP Right Grant
- 2002-10-02 PT PT06016609T patent/PT1749818E/pt unknown
- 2002-10-02 AU AU2002333220A patent/AU2002333220C1/en active Active
- 2002-10-02 WO PCT/DK2002/000659 patent/WO2003029232A1/en active IP Right Grant
- 2002-10-02 EG EG2002101084A patent/EG25095A/xx active
- 2002-10-02 HU HU1300028A patent/HU230189B1/hu unknown
- 2002-10-02 PT PT02800051T patent/PT1436271E/pt unknown
- 2002-10-02 KR KR1020067022562A patent/KR100783346B1/ko not_active Expired - Lifetime
- 2002-10-02 NZ NZ531556A patent/NZ531556A/en not_active IP Right Cessation
- 2002-10-03 MY MYPI20023705A patent/MY140950A/en unknown
-
2004
- 2004-02-26 ZA ZA2004/01583A patent/ZA200401583B/en unknown
- 2004-02-26 IS IS7164A patent/IS2578B/is unknown
- 2004-04-21 NO NO20041628A patent/NO326443B1/no active IP Right Maintenance
- 2004-04-30 CO CO04039958A patent/CO5580746A2/es not_active Application Discontinuation
-
2005
- 2005-12-06 US US11/296,835 patent/US7138407B2/en not_active Expired - Lifetime
- 2005-12-06 US US11/296,836 patent/US7148238B2/en not_active Expired - Lifetime
-
2006
- 2006-09-14 AU AU2006215994A patent/AU2006215994B2/en not_active Ceased
- 2006-10-03 JP JP2006271762A patent/JP3955614B2/ja not_active Expired - Lifetime
- 2006-10-03 JP JP2006271758A patent/JP3955613B2/ja not_active Expired - Lifetime
- 2006-10-19 US US11/551,188 patent/US7683053B2/en not_active Expired - Fee Related
-
2008
- 2008-04-18 CY CY20081100436T patent/CY1107924T1/el unknown
- 2008-05-06 AR ARP080101915A patent/AR066460A2/es active IP Right Grant
- 2008-08-06 NO NO20083446A patent/NO332355B1/no not_active IP Right Cessation
-
2009
- 2009-03-10 IS IS8806A patent/IS2732B/is unknown
- 2009-10-14 CY CY20091101068T patent/CY1110064T1/el unknown
-
2010
- 2010-02-04 US US12/700,521 patent/US8110567B2/en not_active Expired - Fee Related
-
2012
- 2012-02-06 US US13/367,065 patent/US8476279B2/en not_active Expired - Fee Related
-
2013
- 2013-06-26 US US13/927,678 patent/US9090575B2/en not_active Expired - Fee Related
-
2014
- 2014-03-07 NL NL300652C patent/NL300652I1/nl unknown
- 2014-03-12 HU HUS1400012C patent/HUS1400012I1/hu unknown
- 2014-03-12 LU LU92397C patent/LU92397I2/fr unknown
- 2014-03-13 LT LTPA2014013C patent/LTC1436271I2/lt unknown
- 2014-04-16 FR FR14C0033C patent/FR14C0033I2/fr active Active
- 2014-05-13 NO NO2014011C patent/NO2014011I2/no not_active IP Right Cessation
- 2014-06-03 BE BE2014C036C patent/BE2014C036I2/nl unknown
- 2014-06-11 CY CY2014022C patent/CY2014022I1/el unknown
-
2015
- 2015-06-19 US US14/744,197 patent/US9708280B2/en not_active Expired - Fee Related
-
2017
- 2017-06-15 US US15/624,417 patent/US10844029B2/en not_active Expired - Fee Related
-
2020
- 2020-10-22 US US17/078,055 patent/US20210276966A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR036659A1 (es) | Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos | |
| ES2963111T3 (es) | Derivados de 4-(1,3,4-oxadiazol-2-il)piridina-2(1H)-ona como inhibidores de la histona desacetilasa 6 (HDAC6) para el tratamiento de infecciones E.G | |
| AR041566A1 (es) | Derivados de indol utiles para el tratamiento de enfermedades | |
| EA200301306A1 (ru) | Производные 1-фенилсульфонил-1,3-дигидро-2h-индол-2-она, их получение и их терапевтическое применение | |
| SE0201635D0 (sv) | Novel compounds | |
| AR036596A1 (es) | Derivados de 4,5-dihidro-1h-pirazol que tienen actividad antagonista de cb1 | |
| AR038881A1 (es) | Compuestos que modulan la actividad de ppar, composicion farmaceutica que los contiene y un procedimiento para la preparcion de aquellos | |
| AR033379A1 (es) | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| AR032679A1 (es) | Derivados del acido isoftalico como inhibidores de metaloproteinasas de la matriz | |
| AR055878A1 (es) | Derivados de ciclopropanocarboxamida | |
| AR035325A1 (es) | Derivados de adamantano, un proceso para su preparacion, composicion farmaceutica, un proceso para la preparacion de dicha composicion, y el uso de dichos derivados para la fabricacion de un medicamento | |
| ECSP056016A (es) | Nuevos derivados de 2-piridinacarboxamida | |
| AR039566A1 (es) | Inhibidores de la histona deacetilasa, composicion farmaceutica que los contiene y sus procesos de preparacion | |
| AR038044A1 (es) | Compuesto derivado de pirazina, composicion farmaceutica, su uso en la fabricacion de un medicamento, proceso para su preparacion y compuesto intermediario en dicho proceso. | |
| NO20080391L (no) | Pyrazolbaserte LXR modulatorer | |
| AR029301A1 (es) | Compuestos derivados de biarilo, metodos para su preparacion composiciones que los contienen, su uso como agonistas en receptores beta-adreno-receptores atipicos | |
| AR036598A1 (es) | Derivados de 4,5-dihidro-1h-pirazol que tienen potente actividad antagonista de cb1 | |
| SE0303180D0 (sv) | Novel compounds | |
| AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
| SE0302232D0 (sv) | Novel Compounds | |
| CL2008002654A1 (es) | Compuestos derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, bloqueadores de los canales hcn; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cardiopatias isquemicas, insuficiencias cardiacas tanto sistolicas como diastolicas, entre otras. | |
| AR056892A1 (es) | Derivados de cinolin-3-carboxamida, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por la modulacion del receptor gabaa | |
| AR065297A1 (es) | Formulaciones biodisponibles de compuestos heterociclicos | |
| ECSP088257A (es) | Derivados de amida | |
| AR035818A1 (es) | Fenil-heterociclil-eteres con actividad como inhibidores selectivos de recaptacion de serotonina, composiciones farmaceuticas y su uso en la fabricacion de medicamentos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |