AR035340A1 - Compuestos de succinimida heterociclicos fusionados y analogos de los mismos, las composiciones farmaceuticas que los contienen y metodos para preparar dichos compuestos - Google Patents

Compuestos de succinimida heterociclicos fusionados y analogos de los mismos, las composiciones farmaceuticas que los contienen y metodos para preparar dichos compuestos

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AR035340A1
AR035340A1 ARP010103101A ARP010103101A AR035340A1 AR 035340 A1 AR035340 A1 AR 035340A1 AR P010103101 A ARP010103101 A AR P010103101A AR P010103101 A ARP010103101 A AR P010103101A AR 035340 A1 AR035340 A1 AR 035340A1
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Argentina
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substituted
alkyl
cycloalkenyl
cycloalkyl
heterocycle
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ARP010103101A
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English (en)
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Mark E Salvati
Dacia A Pickering
Aberra Fura
Soren Giese
Wenying Li
Ronald L Hanson
Neeta Patel
Bridget A Balogh
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Bristol Myers Squibb Co
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Abstract

Se describen compuestos cíclicos fusionados, útiles en el tratamiento de condiciones asociadas con receptores de hormonas nucleares, tales como el cáncer y trastornos inmunes, las composiciones farmacéuticas que contienen tales compuestos y métodos para preparar dichos compuestos. Dichos compuestos tienen la fórmula (1) en donde los símbolos tienen los siguientes significados y son, cada vez que ocurren, seleccionados independientemente: donde G es un grupo arilo o heterociclo, donde el grupo es mono- o policíclico, y el cual está opcionalmente sustituido en una o más posiciones; Z1 es O, S, NH, o NR6; Z2 es O, S, NH, o NR6; A1 es CR7 o N; A2 es CR7 o N; Y' es J-J'-J'' donde J es (CR7R7')n y n = 0-3; J' es un enlace o O, S, S=O, SO2, NH, NR7, CR7R7' R2P=O, R2P=S, R2OP=O, R2NHP=O, OP=OOR2, OP=ONHR2, OSO2, NHNH, NHNR6, NR6NH, N=N, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido,, heterociclo o heterociclo sustituido, y J'' es (CR7R7')n y n = 0-3, donde Y no es un enlace; y W' es CR7R7' - CR7R7', CR7R7'-C=O, NR9-CR7R7', N=CR8, N=N, NR9-NR9', cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, o arilo o arilo sustituido, donde cuando W no es NR9-CR7R7', N=CR8, N=N, NR9-NR9', o heterociclo o heterociclo sustituido, entonces J' debe ser O, S, S=O, SO2, NH, NR7, OP=OOR2, OP=ONHR2, OSO2, NHNH, NHNR6, NR6NH, o N=N; Y'es NR7-CR7R7' y W' es CR8=CR8; o, de manera alternativa; Y' es CR7R7'-C=O y W' es NR9-CR7R7'; Q1 es H, alquilo o alquilo sustituido, alquenilo o alquenilo sustituido,, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilalquilo o arilalquilo sustituido, alquinilo o alquinilo sustituido, arilo o arilo sustituido, heterociclo o heterociclo sustituido, halo, CN, R1OC=O, R4C=O, R5R6NC=O, HOCR7R7', nitro, R1OCH2, R1O, NH2, C=OSR1, SO2R1 o NR4R5; Q2 es H, alquilo o alquilo sustituido, alquenilo o alquenilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilalquilo o arilalquilo sustituido, alquinilo o alquinilo sustituido, arilo o arilo sustituido, heterociclo o heterociclo sustituido, halo, CN, R1OC=O, R4C=O, R5R6NC=O, HOCR7R7', nitro, R1OCH2, R1O, NH2, C=OSR1, SO2R1 o NR4R5; L es un enlace, (CR7R7')n, NH, NR5 o NR5(CR7R7')n, donde n = 0-3; R1 y R1' son cada uno independientemente H, alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido; R2 es alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, R3 y R3' son cada uno independientemente H, alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, halo, CN, hidroxilamina, hidroxamida, alcoxi o alcoxi sustituido, amino, NR1R2, tiol, alquiltio o alquiltio sustituido; R4 es H, alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, R1C=O, R1NHC=O, SO2OR1 o SO2NR1R1'; R5 es alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, R1C=O, R1NHC=O, SO2R1, SO2OR1 o SO2NR1R1'; R6 es alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, CN, OH, OR1, R1C=O, R1NHC=O, SO2R1, SO2OR1 o SO2NR1R1'; R7 y R7' son cada uno independientemente H, alquilo o alquilo sustituido, alquenilo o alquenilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, halo, CN, OR1, nitro, hidroxilamina, hidroxilamida, amino, NHR4, NR2R5, NOR1, tiol, alquiltio o alquiltio sustituido, R1C=O, R1OC=O, R1NHC=O, SO2R1, SOR1, PO3R1R1', R1R1'NC=O, C=OSR1, SO2R1, SO2OR1 o SO2NR1R1'; o donde A1 o A2 contienen un grupo R7 y W contiene un grupo R7, el grupo R7 de los grupos A1 o A2 y W, juntos forman un anillo heterocíclico; R8 y R8' son cada una independientemente H, alquilo o alquilo sustituido, alquenilo o alquenilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, nitro, halo, CN, OR1, amino, NHR4, NR2R5, NOR1, alquiltio o alquiltio sustituido, C=OSR1, R1OC=O, R1C=O, R1NHC=O, R1R1'NC=O, SO2OR1, S=OR1, SO2R1, PO3R1R1', o SO2NR1R1'; y R9 y R9' son cada uno independientemente H, alquilo o alquilo sustituido, alquenilo o alquenilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido, CN, OH, OR1, R1C=O, R1OC=O, R1NCH=O, SO2OR1 o SO2NR1R1'; con la condición de que: (1) cuando Y' es -O-, Q1 y Q2 son hidrógeno, Z1 y Z2 son O, W' es CH2-CH2-, y A1 y A2 son CH, entonces G-L no es fenilo o fenilo monosustituido o fenilo el cual está sustituido con dos o más de los siguientes grupos: metoxi, halo, NO2, metilo, CH3-S-, OH, CO2H, trifluorometilo, -C(O)-C6H5, NH2, 4-7-epoxi, hexahidro-1H-isoindol-1,3(2H)diona, o -C(O)-CH3; (2) cuando Y' es -O-, Q1 y Q2 son hidrógeno, Z1 y Z2 son O, W' es CH2-CH2- y uno de A1 y A2 son CH y el otro es CR7, y entonces G-L no es fenilo no sustituido; (3) cuando Y' es -O-, Q1 y Q2 son hidrógeno, Z1 y Z2 son O, W' es CH2-CH2, y uno de A1 y A2 es CH y el otro es C-CH3, entonces G-L no es fenilo sustituido con cloro y/o metilo, (4) cuando Y' es -O- o -S-, Q1 y Q2 son hidrógeno, Z1 y Z2 son O, W' es CH2-CH2, y uno de A1 y A2 es CH y el otro es CH o C-alquilo, entonces G-L es piperacin-alquil- sustituido del átomo de N o imidazolidin-alquil- sustituido del átomo de N; (5) cuando Y' es -O-; Q1 y Q2 son hidrógeno, Z1 y Z2 son O, W' es CH2-CH2, y A1 y A2 son CH, entonces G-L no es oxazol o triazol; (6) cuando Y' es -O-; Q1 y Q2 son hidrógeno o metilo; Z1 y Z2 son O, W' es CH2-CH2, y A1 y A2 son CH o C-CH3, entonces G-L no es tiazol o tiazol sustituido; (7) cuando Y' contiene un grupo J' seleccionado de S, S=O, SO2, NH, NR7, R2P=O, R2P=S, R2OP=O, R2NHP=O, OP=OOR2, OP=ONHR2, OSO2, NHNH, NHR6, NR6NH o N=N, W' es CR7R7' - CR7R7', y Z1 y Z2 son O, entonces G-L no es fenilo no sustituido; (8) cuando Y es NR7, W' es fenilo no sustituido o sustituido, y Q1 y Q2 son hidrógeno, entonces Z1 y Z2 no son O; (9) cuando Y' es -O-, Q1 y Q2 son hidrógeno, Z1 y Z2 son O, W' es dihidroisoxazol que contiene un grupo fenilo opcionalmente sustituido, y A1 y A2 son CH, entonces G-L es fenilo no sustituido o diclorofenilo; (10) cuando Y' es O, Q1 y Q2 son hidrógeno, Z1 y Z2 son O, W' es óxido de etileno, y A1 y A2 son CH, entonces G-L no es metilfenilo o clorofenilo; (11) cuando Y' es NR7-R7R7', W' es CR8=CR8, Q1 y Q2 son hidrógeno, A1 y A2 son CH, C-CH3, C-CH2-C6H5 o C-CH2-CH3, y Z1 y Z2 son O, entonces G-L es fenilo no sustituido, fenilo monosustituido o metilpiridinilo; (12) cuando Y' es CR7R7'-C=O, W' es NR9-CR7R7', Q1 y Q2 son hidrógeno, A1 y A2 son CH, y Z1 y Z2 son O, entonces G-L no es fenilo no sustituido, (13) cuando Y' es CHR7'-NR7 donde R7' es fenilo no sustituido, metoxi o etoxi y R7 es fenilo no sustituido, metilo o -C(O)-C6H5, W' es dimetoxifenileno o fenileno no sustituido, Z1 y Z2 son O, Q1 y Q2 son hidrógeno, y A1 y A2 son CH, C-CN, C-C(O)-C6H5 o -C(O) dimetoxifenilo, entonces G-L no es fenilo no sustituido; (14) el compuesto de fórmula (1S) no es 6,10-epitio-4H-tieno-[3',4':5,6]ciclooct[1,2-f]isoindol-7,9(5H,8H)-diona, 8-(3,5-diclorofenil)-6, 6S, 9S, 10, 11, 12-hexahidro-1, 3, 6, 10-tetrametil-2, 2, 13-trióxido, (6R, 6aR, 9aS, 10S); (15) cuando Y' es O, W' es CH2-CH2, Q1 y Q2 son metilo, Z1 y Z2 son O, y A1 y A2 son CH, entonces G-L n
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