ZA200302963B - Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function. - Google Patents
Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function. Download PDFInfo
- Publication number
- ZA200302963B ZA200302963B ZA200302963A ZA200302963A ZA200302963B ZA 200302963 B ZA200302963 B ZA 200302963B ZA 200302963 A ZA200302963 A ZA 200302963A ZA 200302963 A ZA200302963 A ZA 200302963A ZA 200302963 B ZA200302963 B ZA 200302963B
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- ZA
- South Africa
- Prior art keywords
- substituted
- epoxy
- methyl
- heterocyclo
- isoindole
- Prior art date
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- 108020005497 Nuclear hormone receptor Proteins 0.000 title claims description 93
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- 125000000547 substituted alkyl group Chemical group 0.000 claims description 141
- 229910052760 oxygen Inorganic materials 0.000 claims description 84
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 79
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- 238000000034 method Methods 0.000 claims description 76
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Classifications
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- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23351900P | 2000-09-19 | 2000-09-19 | |
| US28443801P | 2001-04-18 | 2001-04-18 | |
| US28473001P | 2001-04-18 | 2001-04-18 |
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| Publication Number | Publication Date |
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| ZA200302963B true ZA200302963B (en) | 2004-07-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| ZA200302963A ZA200302963B (en) | 2000-09-19 | 2003-04-15 | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function. |
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| US (1) | US20040176324A1 (es) |
| EP (1) | EP1319007B9 (es) |
| JP (1) | JP4966477B2 (es) |
| KR (1) | KR100765670B1 (es) |
| CN (2) | CN1995039A (es) |
| AR (1) | AR035340A1 (es) |
| AT (1) | ATE318822T1 (es) |
| AU (2) | AU6994301A (es) |
| BG (1) | BG107675A (es) |
| BR (1) | BR0113980A (es) |
| CA (1) | CA2423071A1 (es) |
| CZ (1) | CZ2003780A3 (es) |
| DE (1) | DE60117551T2 (es) |
| DK (1) | DK1319007T3 (es) |
| EE (1) | EE200300108A (es) |
| ES (1) | ES2260244T3 (es) |
| GE (1) | GEP20074144B (es) |
| HK (1) | HK1054230B (es) |
| HR (1) | HRP20030305B9 (es) |
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| UA (1) | UA78686C2 (es) |
| UY (1) | UY26808A1 (es) |
| WO (1) | WO2002024702A1 (es) |
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Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| CZ20024214A3 (cs) * | 2000-06-28 | 2003-04-16 | Bristol-Myers Squibb Company | Selektivní androgen receptorový modulátor, způsob jeho identifikace, jeho konstrukce a použití |
| EP1854798A3 (en) * | 2000-09-19 | 2007-11-28 | Bristol-Myers Squibb Company | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| US20040087548A1 (en) | 2001-02-27 | 2004-05-06 | Salvati Mark E. | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| PL206962B1 (pl) | 2001-12-19 | 2010-10-29 | Bristol Myers Squibb Co | Związek heterocykliczny o budowie skondensowanej |
| TWI263640B (en) * | 2001-12-19 | 2006-10-11 | Bristol Myers Squibb Co | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| AU2002950217A0 (en) | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
| KR20050044902A (ko) | 2002-08-12 | 2005-05-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 축합 벤젠 유도체 및 용도 |
| WO2004110978A2 (en) * | 2003-06-10 | 2004-12-23 | Smithkline Beecham Corporation | 1-aminonaphthalenes as modulators of androgen, glucocorticoid, mineralocorticoid and progesterone receptors |
| US7417040B2 (en) * | 2004-03-01 | 2008-08-26 | Bristol-Myers Squibb Company | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
| EP1911743B8 (en) * | 2005-08-01 | 2013-01-16 | Takeda Pharmaceutical Company Limited | Cyclic amine compound |
| EP2039695A4 (en) * | 2006-07-11 | 2010-09-15 | Takeda Pharmaceutical | BICYCLIC HETEROCYLIC COMPOUND AND ITS USE |
| US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
| US20120135997A1 (en) | 2009-07-17 | 2012-05-31 | Shionogi & Co., Ltd. | Pharmaceutical composition comprising a lactam or benzenesulfonamide compound |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| HUE055562T2 (hu) | 2011-11-23 | 2021-11-29 | Therapeuticsmd Inc | Természetes kombinációjú hormon helyettesítõ kiszerelések, és terápiák ezekkel |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| AU2019285034B2 (en) | 2018-06-14 | 2022-09-22 | University Of Florida Research Foundation, Incorporated | Nonmuscle myosin II inhibitors for substance use relapse |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| WO2022061226A1 (en) * | 2020-09-19 | 2022-03-24 | Augusta University Research Institute, Inc. | Compositions and methods for inhibiting trem-1 |
| CN115340483A (zh) * | 2022-08-31 | 2022-11-15 | 南京吉星生物技术开发有限公司 | 一种萘基吡咯啉二酮化合物及其制备方法与它的用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3261845A (en) * | 1964-07-14 | 1966-07-19 | Dow Chemical Co | N-phenyl derivatives of 3,6-epoxyhexahydrophthalimide |
| JPS5046697A (es) * | 1973-08-20 | 1975-04-25 | ||
| US5539126A (en) * | 1994-04-20 | 1996-07-23 | Bristol-Myers Squibb Company | Method for preparing homochiral maleimide intermediates, via silylation techniques |
| PT800519E (pt) * | 1994-12-22 | 2004-03-31 | Ligand Pharm Inc | Compostos moduladores de receptores de esteroides e metodos |
| DK0918774T3 (da) * | 1996-06-27 | 2002-05-21 | Ligand Pharm Inc | Androgenreceptormodulatorforbindelser og fremgangsmåder |
| WO1998049555A1 (en) * | 1997-04-29 | 1998-11-05 | The Salk Institute For Biological Studies | Methods for identifying ligands for nuclear hormone receptors |
| US7101681B1 (en) * | 1997-11-21 | 2006-09-05 | Amgen, Inc. | Nuclear hormone receptor drug screens |
| ATE309250T1 (de) * | 1999-09-10 | 2005-11-15 | Novo Nordisk As | Modulatoren der protein tyrosin phosphatase (ptpases) |
| CZ20024214A3 (cs) * | 2000-06-28 | 2003-04-16 | Bristol-Myers Squibb Company | Selektivní androgen receptorový modulátor, způsob jeho identifikace, jeho konstrukce a použití |
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- 2001-06-20 AT AT01948503T patent/ATE318822T1/de active
- 2001-06-20 US US09/885,381 patent/US20040176324A1/en not_active Abandoned
- 2001-06-20 CN CNB018189350A patent/CN1307181C/zh not_active Expired - Fee Related
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