BR0113980A - Compostos de succinimida heterocìclicos fundidos e seus análogos, moduladores de função de receptor de hormÈnio nuclear - Google Patents

Compostos de succinimida heterocìclicos fundidos e seus análogos, moduladores de função de receptor de hormÈnio nuclear

Info

Publication number
BR0113980A
BR0113980A BR0113980-0A BR0113980A BR0113980A BR 0113980 A BR0113980 A BR 0113980A BR 0113980 A BR0113980 A BR 0113980A BR 0113980 A BR0113980 A BR 0113980A
Authority
BR
Brazil
Prior art keywords
compounds
modulators
hormone receptor
analogs
fused heterocyclic
Prior art date
Application number
BR0113980-0A
Other languages
English (en)
Inventor
James Aaron Balog
Aberra Fura
Soeren Giese
Wenying Li
Dacia A Pickering
Mark E Salvati
Ramesh N Patel
Ronald L Hanson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0113980A publication Critical patent/BR0113980A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

"COMPOSTOS DE SUCCINIMIDA HETEROCìCLICOS FUNDIDOS E SEUS ANáLOGOS, MODULADORES DE FUNçãO DE RECEPTOR DE HORMÈNIO NUCLEAR". Compostos cíclicos fundidos, métodos de utilizar tais compostos no tratamento de condições associadas ao receptor de hormónio nuclear como câncer e distúrbios de imunidade, e composições farmacêuticas que contêm tais compostos.
BR0113980-0A 2000-09-19 2001-06-20 Compostos de succinimida heterocìclicos fundidos e seus análogos, moduladores de função de receptor de hormÈnio nuclear BR0113980A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23351900P 2000-09-19 2000-09-19
US28443801P 2001-04-18 2001-04-18
US28473001P 2001-04-18 2001-04-18
PCT/US2001/019655 WO2002024702A1 (en) 2000-09-19 2001-06-20 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Publications (1)

Publication Number Publication Date
BR0113980A true BR0113980A (pt) 2003-06-24

Family

ID=27398441

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Application Number Title Priority Date Filing Date
BR0113980-0A BR0113980A (pt) 2000-09-19 2001-06-20 Compostos de succinimida heterocìclicos fundidos e seus análogos, moduladores de função de receptor de hormÈnio nuclear

Country Status (36)

Country Link
US (1) US20040176324A1 (pt)
EP (1) EP1319007B9 (pt)
JP (1) JP4966477B2 (pt)
KR (1) KR100765670B1 (pt)
CN (2) CN1307181C (pt)
AR (1) AR035340A1 (pt)
AT (1) ATE318822T1 (pt)
AU (2) AU6994301A (pt)
BG (1) BG107675A (pt)
BR (1) BR0113980A (pt)
CA (1) CA2423071A1 (pt)
CZ (1) CZ2003780A3 (pt)
DE (1) DE60117551T2 (pt)
DK (1) DK1319007T3 (pt)
EE (1) EE200300108A (pt)
ES (1) ES2260244T3 (pt)
GE (1) GEP20074144B (pt)
HK (1) HK1054230B (pt)
HR (1) HRP20030305B9 (pt)
HU (1) HUP0400455A3 (pt)
IL (1) IL155019A0 (pt)
IS (1) IS6750A (pt)
MX (1) MXPA03002412A (pt)
MY (1) MY138531A (pt)
NO (1) NO329931B1 (pt)
NZ (1) NZ524803A (pt)
PE (1) PE20020729A1 (pt)
PL (1) PL361707A1 (pt)
PT (1) PT1319007E (pt)
SK (1) SK4982003A3 (pt)
TW (1) TWI305208B (pt)
UA (1) UA78686C2 (pt)
UY (1) UY26808A1 (pt)
WO (1) WO2002024702A1 (pt)
YU (1) YU20003A (pt)
ZA (1) ZA200302963B (pt)

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HRP20030305B9 (en) 2008-03-31
PT1319007E (pt) 2006-05-31
JP2004509895A (ja) 2004-04-02
HK1054230B (zh) 2006-07-28
AU6994301A (en) 2002-04-02
GEP20074144B (en) 2007-07-10
AR035340A1 (es) 2004-05-12
BG107675A (bg) 2003-12-31
EP1319007B1 (en) 2006-03-01
US20040176324A1 (en) 2004-09-09
CN1307181C (zh) 2007-03-28
PE20020729A1 (es) 2002-08-11
DK1319007T3 (da) 2006-06-19
KR20030028847A (ko) 2003-04-10
HRP20030305B1 (en) 2007-12-31
JP4966477B2 (ja) 2012-07-04
CN1995039A (zh) 2007-07-11
ATE318822T1 (de) 2006-03-15
DE60117551T2 (de) 2007-01-18
WO2002024702A1 (en) 2002-03-28
CZ2003780A3 (cs) 2004-01-14
UA78686C2 (en) 2007-04-25
HUP0400455A3 (en) 2007-10-29
TWI305208B (en) 2009-01-11
HRP20030305A2 (en) 2005-04-30
CA2423071A1 (en) 2002-03-28
EP1319007A1 (en) 2003-06-18
EP1319007B9 (en) 2007-10-10
CN1608069A (zh) 2005-04-20
HUP0400455A2 (hu) 2004-06-28
MY138531A (en) 2009-06-30
AU2001269943B2 (en) 2006-11-09
KR100765670B1 (ko) 2007-10-10
NO20031266L (no) 2003-05-13
DE60117551D1 (de) 2006-04-27
MXPA03002412A (es) 2004-05-05
HK1054230A1 (en) 2003-11-21
NZ524803A (en) 2004-09-24
ES2260244T3 (es) 2006-11-01
ZA200302963B (en) 2004-07-15
IS6750A (is) 2003-03-18
YU20003A (sh) 2006-03-03
NO329931B1 (no) 2011-01-24
IL155019A0 (en) 2003-10-31
PL361707A1 (en) 2004-10-04
EE200300108A (et) 2005-02-15
NO20031266D0 (no) 2003-03-19
SK4982003A3 (en) 2004-05-04
UY26808A1 (es) 2002-01-31

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