DK1319007T3 - Kondenserede heterocykliske succinimidforbindelser og analoger deraf, modulatorer af nukleær hormonreceptorfunktion - Google Patents

Kondenserede heterocykliske succinimidforbindelser og analoger deraf, modulatorer af nukleær hormonreceptorfunktion

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Publication number
DK1319007T3
DK1319007T3 DK01948503T DK01948503T DK1319007T3 DK 1319007 T3 DK1319007 T3 DK 1319007T3 DK 01948503 T DK01948503 T DK 01948503T DK 01948503 T DK01948503 T DK 01948503T DK 1319007 T3 DK1319007 T3 DK 1319007T3
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Prior art keywords
modulators
analogs
hormone receptor
receptor function
condensed heterocyclic
Prior art date
Application number
DK01948503T
Other languages
English (en)
Inventor
Mark E Salvati
Soren Giese
Aberra Fura
Wenying Li
Ramesh N Patel
Ronald L Hanson
James Aaron Balog
Dacia A Pickering
Original Assignee
Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
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Publication of DK1319007T3 publication Critical patent/DK1319007T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
DK01948503T 2000-09-19 2001-06-20 Kondenserede heterocykliske succinimidforbindelser og analoger deraf, modulatorer af nukleær hormonreceptorfunktion DK1319007T3 (da)

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US23351900P 2000-09-19 2000-09-19
US28443801P 2001-04-18 2001-04-18
US28473001P 2001-04-18 2001-04-18

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DK1319007T3 true DK1319007T3 (da) 2006-06-19

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US (1) US20040176324A1 (da)
EP (1) EP1319007B9 (da)
JP (1) JP4966477B2 (da)
KR (1) KR100765670B1 (da)
CN (2) CN1307181C (da)
AR (1) AR035340A1 (da)
AT (1) ATE318822T1 (da)
AU (2) AU6994301A (da)
BG (1) BG107675A (da)
BR (1) BR0113980A (da)
CA (1) CA2423071A1 (da)
CZ (1) CZ2003780A3 (da)
DE (1) DE60117551T2 (da)
DK (1) DK1319007T3 (da)
EE (1) EE200300108A (da)
ES (1) ES2260244T3 (da)
GE (1) GEP20074144B (da)
HK (1) HK1054230B (da)
HR (1) HRP20030305B9 (da)
HU (1) HUP0400455A3 (da)
IL (1) IL155019A0 (da)
IS (1) IS6750A (da)
MX (1) MXPA03002412A (da)
MY (1) MY138531A (da)
NO (1) NO329931B1 (da)
NZ (1) NZ524803A (da)
PE (1) PE20020729A1 (da)
PL (1) PL361707A1 (da)
PT (1) PT1319007E (da)
SK (1) SK4982003A3 (da)
TW (1) TWI305208B (da)
UA (1) UA78686C2 (da)
UY (1) UY26808A1 (da)
WO (1) WO2002024702A1 (da)
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PT1319007E (pt) 2006-05-31
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HK1054230B (zh) 2006-07-28
AU6994301A (en) 2002-04-02
GEP20074144B (en) 2007-07-10
AR035340A1 (es) 2004-05-12
BG107675A (bg) 2003-12-31
EP1319007B1 (en) 2006-03-01
US20040176324A1 (en) 2004-09-09
CN1307181C (zh) 2007-03-28
PE20020729A1 (es) 2002-08-11
KR20030028847A (ko) 2003-04-10
HRP20030305B1 (en) 2007-12-31
JP4966477B2 (ja) 2012-07-04
CN1995039A (zh) 2007-07-11
ATE318822T1 (de) 2006-03-15
DE60117551T2 (de) 2007-01-18
WO2002024702A1 (en) 2002-03-28
CZ2003780A3 (cs) 2004-01-14
UA78686C2 (en) 2007-04-25
HUP0400455A3 (en) 2007-10-29
TWI305208B (en) 2009-01-11
HRP20030305A2 (en) 2005-04-30
CA2423071A1 (en) 2002-03-28
EP1319007A1 (en) 2003-06-18
EP1319007B9 (en) 2007-10-10
CN1608069A (zh) 2005-04-20
HUP0400455A2 (hu) 2004-06-28
MY138531A (en) 2009-06-30
AU2001269943B2 (en) 2006-11-09
KR100765670B1 (ko) 2007-10-10
NO20031266L (no) 2003-05-13
DE60117551D1 (de) 2006-04-27
MXPA03002412A (es) 2004-05-05
HK1054230A1 (en) 2003-11-21
NZ524803A (en) 2004-09-24
ES2260244T3 (es) 2006-11-01
ZA200302963B (en) 2004-07-15
IS6750A (is) 2003-03-18
YU20003A (sh) 2006-03-03
NO329931B1 (no) 2011-01-24
IL155019A0 (en) 2003-10-31
BR0113980A (pt) 2003-06-24
PL361707A1 (en) 2004-10-04
EE200300108A (et) 2005-02-15
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SK4982003A3 (en) 2004-05-04
UY26808A1 (es) 2002-01-31

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