DE60117551D1 - Kondensierte heterozyklische succinimid derivate und deren analoga, modulatoren der kern hormon rezeptor funktionen - Google Patents

Kondensierte heterozyklische succinimid derivate und deren analoga, modulatoren der kern hormon rezeptor funktionen

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Publication number
DE60117551D1
DE60117551D1 DE60117551T DE60117551T DE60117551D1 DE 60117551 D1 DE60117551 D1 DE 60117551D1 DE 60117551 T DE60117551 T DE 60117551T DE 60117551 T DE60117551 T DE 60117551T DE 60117551 D1 DE60117551 D1 DE 60117551D1
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Germany
Prior art keywords
analogu
modulators
hormone receptor
condensed heterocyclic
receptor functions
Prior art date
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Expired - Lifetime
Application number
DE60117551T
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English (en)
Other versions
DE60117551T2 (de
Inventor
E Salvati
Aaron Balog
A Pickering
Soeren Giese
Aberra Fura
Wenying Li
N Patel
L Hanson
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of DE60117551D1 publication Critical patent/DE60117551D1/de
Publication of DE60117551T2 publication Critical patent/DE60117551T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
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    • A61P5/26—Androgens
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    • A61P5/30—Oestrogens
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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DE60117551T 2000-09-19 2001-06-20 Kondensierte heterocyclische Succinimidverbindungen und deren Analoga, Modulatoren der nukleären Hormonrezeptorfunktion Expired - Lifetime DE60117551T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23351900P 2000-09-19 2000-09-19
US233519P 2000-09-19
US28473001P 2001-04-18 2001-04-18
US28443801P 2001-04-18 2001-04-18
US284438P 2001-04-18
US284730P 2001-04-18
PCT/US2001/019655 WO2002024702A1 (en) 2000-09-19 2001-06-20 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Publications (2)

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DE60117551D1 true DE60117551D1 (de) 2006-04-27
DE60117551T2 DE60117551T2 (de) 2007-01-18

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DE60117551T Expired - Lifetime DE60117551T2 (de) 2000-09-19 2001-06-20 Kondensierte heterocyclische Succinimidverbindungen und deren Analoga, Modulatoren der nukleären Hormonrezeptorfunktion

Country Status (36)

Country Link
US (1) US20040176324A1 (de)
EP (1) EP1319007B9 (de)
JP (1) JP4966477B2 (de)
KR (1) KR100765670B1 (de)
CN (2) CN1995039A (de)
AR (1) AR035340A1 (de)
AT (1) ATE318822T1 (de)
AU (2) AU2001269943B2 (de)
BG (1) BG107675A (de)
BR (1) BR0113980A (de)
CA (1) CA2423071A1 (de)
CZ (1) CZ2003780A3 (de)
DE (1) DE60117551T2 (de)
DK (1) DK1319007T3 (de)
EE (1) EE200300108A (de)
ES (1) ES2260244T3 (de)
GE (1) GEP20074144B (de)
HK (1) HK1054230B (de)
HR (1) HRP20030305B9 (de)
HU (1) HUP0400455A3 (de)
IL (1) IL155019A0 (de)
IS (1) IS6750A (de)
MX (1) MXPA03002412A (de)
MY (1) MY138531A (de)
NO (1) NO329931B1 (de)
NZ (1) NZ524803A (de)
PE (1) PE20020729A1 (de)
PL (1) PL361707A1 (de)
PT (1) PT1319007E (de)
SK (1) SK4982003A3 (de)
TW (1) TWI305208B (de)
UA (1) UA78686C2 (de)
UY (1) UY26808A1 (de)
WO (1) WO2002024702A1 (de)
YU (1) YU20003A (de)
ZA (1) ZA200302963B (de)

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EP1854798A3 (de) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
TWI263640B (en) * 2001-12-19 2006-10-11 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002364082A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
CN1688527A (zh) 2002-08-12 2005-10-26 武田药品工业株式会社 稠合的苯衍生物以及用途
WO2004110978A2 (en) * 2003-06-10 2004-12-23 Smithkline Beecham Corporation 1-aminonaphthalenes as modulators of androgen, glucocorticoid, mineralocorticoid and progesterone receptors
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
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