AR033918A1 - Composicion para acelerar la soldadura de una fractura osea - Google Patents

Composicion para acelerar la soldadura de una fractura osea

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Publication number
AR033918A1
AR033918A1 ARP020101912A ARP020101912A AR033918A1 AR 033918 A1 AR033918 A1 AR 033918A1 AR P020101912 A ARP020101912 A AR P020101912A AR P020101912 A ARP020101912 A AR P020101912A AR 033918 A1 AR033918 A1 AR 033918A1
Authority
AR
Argentina
Prior art keywords
possesses
composition
pde4
welding
compound
Prior art date
Application number
ARP020101912A
Other languages
English (en)
Inventor
N Sakurai
T Takagi
N Yanaka
Y Horikiri
Takashi Tamura
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of AR033918A1 publication Critical patent/AR033918A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Abstract

Una composición para acelerar la soldadura de la fractura que comprende un inhibidor de PDE4 como ingrediente activo, específicamente se provee una composición que comprende un inhibidor de PDE4 y un polímero biocompatible y biodegradable, dicha composición, cuando es formulada en una forma conveniente para administración local tal como preparación de microesferas, puede proveer una composición farmacéutica que ilustra un excelente efecto de curación temprana del hueso. El polímero biocompatible y biodegradable puede ser uno o más polímeros seleccioandos del grupo que consiste de ácido poliláctico, copolímero de ácido láctico ácido glicólico y copolímero de ácido 2-hidroxibutírico-ácido glicólico, con un peso molecular promedio de 2.000-800.000. El inhibidor de PDE4 es un compuesto que posee una estructura parcial, que posee actividad inhibitoria de PDE4 es un compuesto que posee una estructura parcial que posee actividad inhibitoria de PDE4 es un compuesto que posee una estructura parcial, que posee actividad inhibitoria de PDE4, como la siguiente: (A) naftaleno o una estructura química análoga al mismo; o (B) 3-ciclopentiloxi-4-metoxifenilo o una estructura química análoga al mismo. La composición es útil en la soldadura de fracturas rebelde de personas mayores y pacientes diabéticos o con osteosporosis.
ARP020101912A 2001-05-23 2002-05-23 Composicion para acelerar la soldadura de una fractura osea AR033918A1 (es)

Applications Claiming Priority (1)

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JP2001154064 2001-05-23

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AR033918A1 true AR033918A1 (es) 2004-01-07

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MXPA03010679A (es) 2004-03-02
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US20080031958A1 (en) 2008-02-07
WO2002094321A1 (fr) 2002-11-28
CA2447619A1 (en) 2002-11-28
KR20040007596A (ko) 2004-01-24
EP1389468A1 (en) 2004-02-18
US20040146561A1 (en) 2004-07-29
JP2010155849A (ja) 2010-07-15
JPWO2002094321A1 (ja) 2004-09-02
JP4510384B2 (ja) 2010-07-21
EP1389468A4 (en) 2007-01-10

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