ES2094772T3 - Derivados de imidazonaftiridinas. - Google Patents

Derivados de imidazonaftiridinas.

Info

Publication number
ES2094772T3
ES2094772T3 ES91108908T ES91108908T ES2094772T3 ES 2094772 T3 ES2094772 T3 ES 2094772T3 ES 91108908 T ES91108908 T ES 91108908T ES 91108908 T ES91108908 T ES 91108908T ES 2094772 T3 ES2094772 T3 ES 2094772T3
Authority
ES
Spain
Prior art keywords
lower alkyl
substituted
represents hydrogen
hydroxy
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91108908T
Other languages
English (en)
Inventor
Fumio Suzuki
Takeshi Kuroda
Shigeto Kitamura
Kenji Ohmori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2094772T3 publication Critical patent/ES2094772T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

SE DESCRIBEN DERIVADOS DE IMIDAZONAFTIRIDINA REPRESENTADOS POR LA FORMULA (1) EN LA QUE: R ELEVADO 1 REPRESENTA ALQUILO INFERIOR O ARILO SUSTITUIDO O NO SUSTITUIDO; Y X-Y-Z REPRESENTA EN DONDE R ELEVADO 2 REPRESENTA HIDROGENO, ALQUILO INFERIOR, ALQUENILO, ARALQUENILO, O -C (R ELEVADO 5) H-(CH SUB 2) SUB NR ELEVADO 4 (DONDE R ELEVADO 4 REPRESENTA ARILO SUSTITUIDO O NO SUSTITUIDO, PIRIDILO SUSTITUIDO O NO SUSTITUIDO, FEVILO SUSTITUIDO O NO SUSTITUIDO, ALQUILO INFERIOR SUSTITUIDO POR HIDROXI, ALCANOILOXI INFERIOR, MORFOLINO, ALCANOILO INFERIOR, CARBOXI, ALCOXICARBONILO INFERIOR, CICLOALQUILO, HIDROXI, ALCOXI INFERIOR, HALOGENO O NR ELEVADO 6 R ELEVADO 7 DONDE R ELEVADO 6 Y R ELEVADO 7 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR; R ELEVADO 5 REPRESENTA HIDROGENO, ALQUILO INFERIOR, O FENILO; Y N REPRESENTA UN NUMERO ENTERO ENTRE 0 Y 3); Y R ELEVADO 3 REPRESENTA HIDROGENO, MERCAPTO, HIDROXI, ALQUILO INFERIOR, O ARILO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. LOS COMPUESTOS MUESTRAN UNA POTENTE ACTIVIDAD ANTI-INFLAMATORIA, ANTI-ALERGICA Y BRONCO-DILATADORA.
ES91108908T 1990-06-01 1991-05-31 Derivados de imidazonaftiridinas. Expired - Lifetime ES2094772T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14346090 1990-06-01
JP33465790 1990-11-30

Publications (1)

Publication Number Publication Date
ES2094772T3 true ES2094772T3 (es) 1997-02-01

Family

ID=26475184

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91108908T Expired - Lifetime ES2094772T3 (es) 1990-06-01 1991-05-31 Derivados de imidazonaftiridinas.

Country Status (9)

Country Link
US (3) US5364859A (es)
EP (1) EP0459505B1 (es)
JP (1) JP3016905B2 (es)
AT (1) ATE143661T1 (es)
CA (1) CA2043715C (es)
DE (1) DE69122427T2 (es)
DK (1) DK0459505T3 (es)
ES (1) ES2094772T3 (es)
GR (1) GR3021971T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2043715C (en) * 1990-06-01 1997-01-07 Fumio Suzuki Imidazonaphthyridine derivatives
JPH05194515A (ja) * 1991-07-31 1993-08-03 Kyowa Hakko Kogyo Co Ltd 縮合ナフチリジン誘導体
US5281610A (en) * 1991-07-31 1994-01-25 Kyowa Hakko Kogyo Co., Ltd. Condensed naphthyridine derivatives
EP0614897A4 (en) * 1991-11-25 1995-02-01 Kyowa Hakko Kogyo Kk IMIDAZONAPHTYRIDINE DERIVATIVE.
WO1994002481A1 (en) * 1992-07-20 1994-02-03 Kyowa Hakko Kogyo Co., Ltd. Imidazonaphthyridine derivative
US6365231B2 (en) 1998-06-26 2002-04-02 Kabushiki Kaisha Toshiba Ammonium halide eliminator, chemical vapor deposition system and chemical vapor deposition process
JP2000119271A (ja) * 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
SK287231B6 (sk) 1999-08-21 2010-04-07 Nycomed Gmbh Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
US6949247B2 (en) 2000-12-28 2005-09-27 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Stable skin care compositions containing a retinoid and a retinoid booster system
US20040146561A1 (en) 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
WO2002094320A1 (fr) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions therapeutiques permettant de reparer la chondropathie
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
BRPI0409229A (pt) 2003-04-01 2006-03-28 Applied Research Systems inibidores das fosfodiesterases na infertilidade
US8193356B2 (en) 2005-09-15 2012-06-05 Aska Pharmaceutical Co., Ltd. Heterocycle compound, and production process and application thereof
ES2550101T3 (es) 2008-12-17 2015-11-04 Merck Patent Gmbh Inhibidores de proteína quinasa de benzonaftiridinona tricíclica modificada con anillo C y su uso

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO66801A (fr) * 1973-05-25 1979-08-15 Lepetit Spa Procede pour obtenir des derives des triazoloizoquinolines
US4059584A (en) * 1974-08-07 1977-11-22 Pfizer 2-Acylamino-3-[3-(dialkylamino)propyl]imidazo[4,5-b]pyridines
ZA848968B (en) * 1983-11-18 1986-06-25 Riker Laboratories Inc 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines
IL73534A (en) * 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
CA1271477A (en) * 1983-11-18 1990-07-10 John F. Gerster 1h-imidazo[4,5-c]quinolin-4-amines
US4760073A (en) * 1986-04-11 1988-07-26 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents
EP0362299A1 (en) * 1987-07-22 1990-04-11 Schering Corporation Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
CA2043715C (en) * 1990-06-01 1997-01-07 Fumio Suzuki Imidazonaphthyridine derivatives

Also Published As

Publication number Publication date
EP0459505A1 (en) 1991-12-04
DE69122427T2 (de) 1997-03-06
US5468756A (en) 1995-11-21
EP0459505B1 (en) 1996-10-02
JPH04226985A (ja) 1992-08-17
CA2043715C (en) 1997-01-07
JP3016905B2 (ja) 2000-03-06
CA2043715A1 (en) 1991-12-02
DE69122427D1 (de) 1996-11-07
US5364859A (en) 1994-11-15
DK0459505T3 (da) 1996-11-18
US5536730A (en) 1996-07-16
ATE143661T1 (de) 1996-10-15
GR3021971T3 (en) 1997-03-31

Similar Documents

Publication Publication Date Title
ES2094772T3 (es) Derivados de imidazonaftiridinas.
ES2094204T3 (es) Derivados de piperazina.
PE34996A1 (es) Nuevo derivado de pirrocarbazol
NO882626L (no) Fremgangsmaate for fremstilling av farmakologisk aktive pyridin-derivater.
ES2054806T3 (es) Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas.
NO910804L (no) Substituerte beta-diketoner.
ES2109936T3 (es) Derivados de piperacina.
ES2097295T3 (es) Preparacion de 2-(2-tienil)etilamina y sintesis de sus derivados de tieno(3,2-c)piridina.
DE69303847T2 (de) Indolderivate
DE69103985D1 (de) N-Alkylthiazolidinderivate.
DE60103732D1 (de) Pyrimidinderivate mit antitumor-wirkung
ATE100449T1 (de) 1,3-dioxolan-benzoesaeure und derivate davon.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 459505

Country of ref document: ES