AR029000A1 - COMPUESTO ESPIRO CONDENSADO, PROCESO DESTINADO A SU PRODUCCIoN; ANTAGONISTA DEL RECEPTOR DEL NEUROPÉPTIDO Y Y AGENTE PARA EL TRATAMIENTO DE LA BULIMIA, LA OBESIDAD O LA DIABETES QUE LO COMPRENDEN Y COMPUESTO ESPIRO CONDENSADO CARBOXíLICO. - Google Patents

COMPUESTO ESPIRO CONDENSADO, PROCESO DESTINADO A SU PRODUCCIoN; ANTAGONISTA DEL RECEPTOR DEL NEUROPÉPTIDO Y Y AGENTE PARA EL TRATAMIENTO DE LA BULIMIA, LA OBESIDAD O LA DIABETES QUE LO COMPRENDEN Y COMPUESTO ESPIRO CONDENSADO CARBOXíLICO.

Info

Publication number
AR029000A1
AR029000A1 ARP000104265A ARP000104265A AR029000A1 AR 029000 A1 AR029000 A1 AR 029000A1 AR P000104265 A ARP000104265 A AR P000104265A AR P000104265 A ARP000104265 A AR P000104265A AR 029000 A1 AR029000 A1 AR 029000A1
Authority
AR
Argentina
Prior art keywords
alkyl
condensed
group
alkoxy
spiro compound
Prior art date
Application number
ARP000104265A
Other languages
English (en)
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of AR029000A1 publication Critical patent/AR029000A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un compuesto espiro condensado representado por la formula general (1) en donde Ar1 representa arilo o heteroarilo que puede estar sustituido, seleccionándose el sustituyente de grupo que consiste en halogeno, nitro, alquilo, inferior, halo û alquilo (inferior), hidroxi û alquilo (inferior), ciclo û alquilo (inferior), alquenilo inferior, alcoxi inferior, halo û alcoxi (inferior), alquiltio inferior, carboxilo, alcanoilo inferior, alcoxicarbonilo inferior, alquileno inferior sustituido opcionalmente por oxo y un grupo representado por la formula de ûQ-AR2, en donde AR2 y Q son como se describe en la memoria; n representa 0 o 1; T, U, V y W representan, de modo independiente, un átomo de nitrogeno o un grupo metino, que puede tener un sustituyente seleccionado del grupo compuesto por halogeno, alquilo inferior, hidroxi y alcoxi inferior, donde por lo menos dos de ellos representan el grupo metino mencionado; X representa metino o nitrogeno; Y representa imino que puede ser sustituido por alquilo inferior, u oxígeno; una sal o éter de los mismos. Un proceso destinado a obtener el compuesto descripto. Un compuesto espiro condensado de la formula general (2) en donde t, u, v y w representan, de modo independiente, un átomo de nitrogeno o un grupo metino, que puede tener un sustituyente seleccionado del grupo que consiste en halogeno, alquilo inferior, alcoxi inferior e hidroxi opcionalmente protegido, donde por lo menos dos de ellos representan el grupo metino mencionado. Los compuestos de la formula (1) exhiben actividad antagonista del receptor del neuropéptido y (NPY) y son utiles como agentes para el tratamiento de enfermedades relacionadas con el mismo.
ARP000104265A 1999-08-20 2000-08-17 COMPUESTO ESPIRO CONDENSADO, PROCESO DESTINADO A SU PRODUCCIoN; ANTAGONISTA DEL RECEPTOR DEL NEUROPÉPTIDO Y Y AGENTE PARA EL TRATAMIENTO DE LA BULIMIA, LA OBESIDAD O LA DIABETES QUE LO COMPRENDEN Y COMPUESTO ESPIRO CONDENSADO CARBOXíLICO. AR029000A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23357399 1999-08-20
JP2000137692 2000-05-10

Publications (1)

Publication Number Publication Date
AR029000A1 true AR029000A1 (es) 2003-06-04

Family

ID=26531087

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000104265A AR029000A1 (es) 1999-08-20 2000-08-17 COMPUESTO ESPIRO CONDENSADO, PROCESO DESTINADO A SU PRODUCCIoN; ANTAGONISTA DEL RECEPTOR DEL NEUROPÉPTIDO Y Y AGENTE PARA EL TRATAMIENTO DE LA BULIMIA, LA OBESIDAD O LA DIABETES QUE LO COMPRENDEN Y COMPUESTO ESPIRO CONDENSADO CARBOXíLICO.

Country Status (36)

Country Link
US (3) US6326375B1 (es)
EP (1) EP1204663B1 (es)
KR (1) KR100749713B1 (es)
CN (2) CN100457757C (es)
AR (1) AR029000A1 (es)
AT (1) ATE253064T1 (es)
AU (1) AU767229B2 (es)
BG (1) BG65805B1 (es)
BR (1) BR0013423A (es)
CA (1) CA2379103C (es)
CO (1) CO5200768A1 (es)
CZ (1) CZ2002533A3 (es)
DE (1) DE60006251T2 (es)
DK (1) DK1204663T3 (es)
DZ (1) DZ3175A1 (es)
EA (1) EA004507B1 (es)
EE (1) EE05248B1 (es)
ES (1) ES2206287T3 (es)
GE (1) GEP20053488B (es)
HK (1) HK1043123B (es)
HR (1) HRP20020102B1 (es)
HU (1) HUP0203107A3 (es)
IL (1) IL148119A0 (es)
IS (1) IS2420B (es)
MX (1) MXPA02001693A (es)
MY (1) MY130769A (es)
NO (1) NO323514B1 (es)
NZ (1) NZ517057A (es)
PE (1) PE20010645A1 (es)
PL (1) PL353743A1 (es)
PT (1) PT1204663E (es)
RS (1) RS50484B (es)
SK (1) SK286609B6 (es)
TR (1) TR200200408T2 (es)
TW (1) TWI279402B (es)
WO (1) WO2001014376A1 (es)

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