AR044283A1 - Procedimeinto para preparar compuestos de espirolactona - Google Patents
Procedimeinto para preparar compuestos de espirolactonaInfo
- Publication number
- AR044283A1 AR044283A1 ARP040101583A ARP040101583A AR044283A1 AR 044283 A1 AR044283 A1 AR 044283A1 AR P040101583 A ARP040101583 A AR P040101583A AR P040101583 A ARP040101583 A AR P040101583A AR 044283 A1 AR044283 A1 AR 044283A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- spirolactone
- group
- forming
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicación 1: Un procedimiento para preparar un compuesto de la fórmula (1) o una sal del mismo, en el que: T, U, V y W se seleccionan cada uno independientemente del grupo que consiste en: nitrógeno; y metino; en los que el grupo metino no está sustituido o está opcionalmente sustituido con un sustituyente que se selecciona del grupo que consiste en: halógeno; alquilo inferior; hidroxi; y alcoxi inferior y en el que al menos dos de T, U, V y W son metino; que comprende las etapas de: a) formar un haluro de ácido de espirolactona de la fórmula (2), en el que X es cloro o bromo y T, U, V y W son tal como se define anteriormente, tratando el compuesto de la fórmula (1) con un agente de halogenación en un disolvente; b) formar un éster de espirolactona de la fórmula (3), en el que R3 se selecciona del grupo que consiste en terc-butilo, metilciclohexilo, metilciclopentilo y neopentilo y T, U, V y W son tal como se define anteriormente, tratando el haluro de ácido de espirolactona de la fórmula (2) con una base y un alcohol en un disolvente; c) formar un ácido de espirolactona de la fórmula (1), en el que T, U, V y W se definen como anteriormente, hidrolizando el éster de espirolactona de la fórmula (3) con un ácido acuoso; y d) aislar el producto resultante.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47168003P | 2003-05-19 | 2003-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR044283A1 true AR044283A1 (es) | 2005-09-07 |
Family
ID=33476871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101583A AR044283A1 (es) | 2003-05-19 | 2004-05-10 | Procedimeinto para preparar compuestos de espirolactona |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060241299A1 (es) |
AR (1) | AR044283A1 (es) |
AU (1) | AU2004240933A1 (es) |
CA (1) | CA2526027A1 (es) |
TW (1) | TW200510316A (es) |
WO (1) | WO2004104009A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004043501A1 (de) * | 2004-09-06 | 2006-03-09 | Chemetall Gmbh | Methyllithium/Lithiumbromid enthaltendes Synthesemittel und Verfahren zu dessen Herstellung |
EP1912642B1 (en) | 2005-07-28 | 2012-10-17 | Merck Sharp & Dohme Corp. | A crystalline form of a npy5 antagonist |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI279402B (en) * | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
PL375926A1 (en) * | 2002-10-18 | 2005-12-12 | Merck & Co, Inc. | Process for making spirolactone compounds |
-
2004
- 2004-05-10 AR ARP040101583A patent/AR044283A1/es unknown
- 2004-05-14 WO PCT/US2004/015051 patent/WO2004104009A1/en not_active Application Discontinuation
- 2004-05-14 US US10/550,136 patent/US20060241299A1/en not_active Abandoned
- 2004-05-14 CA CA002526027A patent/CA2526027A1/en not_active Abandoned
- 2004-05-14 AU AU2004240933A patent/AU2004240933A1/en not_active Abandoned
- 2004-05-18 TW TW093114019A patent/TW200510316A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004240933A1 (en) | 2004-12-02 |
CA2526027A1 (en) | 2004-12-02 |
US20060241299A1 (en) | 2006-10-26 |
TW200510316A (en) | 2005-03-16 |
WO2004104009A1 (en) | 2004-12-02 |
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Legal Events
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