AR013169A1 - UN MÉTODO PARA PREPARAR UN POLIPÉPTIDO MODIFICADO QUE ES UN ANTICUERPO ANTI-IGE QUE NO EXHIBE DESACTIVACION DE ISOMERIZACIoN DE ASPARTILO Y QUE TIENE AFINIDAD A LA MOLÉCULA OBJETIVO IGE, UNA MOLÉCULA DE ANTICUERPO, UNA MOLECULA DE ACIDO NUCLEICO, UNA COMPOSICIoN Y USO DE UN ANTICUERPO PARA LA MANUFA - Google Patents

UN MÉTODO PARA PREPARAR UN POLIPÉPTIDO MODIFICADO QUE ES UN ANTICUERPO ANTI-IGE QUE NO EXHIBE DESACTIVACION DE ISOMERIZACIoN DE ASPARTILO Y QUE TIENE AFINIDAD A LA MOLÉCULA OBJETIVO IGE, UNA MOLÉCULA DE ANTICUERPO, UNA MOLECULA DE ACIDO NUCLEICO, UNA COMPOSICIoN Y USO DE UN ANTICUERPO PARA LA MANUFA

Info

Publication number
AR013169A1
AR013169A1 ARP980103225A ARP980103225A AR013169A1 AR 013169 A1 AR013169 A1 AR 013169A1 AR P980103225 A ARP980103225 A AR P980103225A AR P980103225 A ARP980103225 A AR P980103225A AR 013169 A1 AR013169 A1 AR 013169A1
Authority
AR
Argentina
Prior art keywords
ige
affinity
isomerization
multicula
aspartile
Prior art date
Application number
ARP980103225A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR013169A1 publication Critical patent/AR013169A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Se refiere a un método para ajustar la afinidad de un polipéptido a una molécula objetivo mediante una combinacion de pasos, que incluyen: (1) laidentificacion de residuos aspartilo que tienden a la isomerizacion; (2) la sustitucion deresidu os alternativos y la clasificacion de los mutantesresultantes para determinar la afinadad contra la molécula objetivo. Además describe una molécula de anticuerpo, una molécula de anticuerpo mejorado o sufragmento funcional, una moléculade ácido nucleico, una composicion y uso de un anticuerpo pra la manufactura de un medicamento util para reducir o evitarla produccion de histamina mediada por IgE.
ARP980103225A 1997-07-02 1998-07-02 UN MÉTODO PARA PREPARAR UN POLIPÉPTIDO MODIFICADO QUE ES UN ANTICUERPO ANTI-IGE QUE NO EXHIBE DESACTIVACION DE ISOMERIZACIoN DE ASPARTILO Y QUE TIENE AFINIDAD A LA MOLÉCULA OBJETIVO IGE, UNA MOLÉCULA DE ANTICUERPO, UNA MOLECULA DE ACIDO NUCLEICO, UNA COMPOSICIoN Y USO DE UN ANTICUERPO PARA LA MANUFA AR013169A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/887,352 US5994511A (en) 1997-07-02 1997-07-02 Anti-IgE antibodies and methods of improving polypeptides

Publications (1)

Publication Number Publication Date
AR013169A1 true AR013169A1 (es) 2000-12-13

Family

ID=25390964

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP980103225A AR013169A1 (es) 1997-07-02 1998-07-02 UN MÉTODO PARA PREPARAR UN POLIPÉPTIDO MODIFICADO QUE ES UN ANTICUERPO ANTI-IGE QUE NO EXHIBE DESACTIVACION DE ISOMERIZACIoN DE ASPARTILO Y QUE TIENE AFINIDAD A LA MOLÉCULA OBJETIVO IGE, UNA MOLÉCULA DE ANTICUERPO, UNA MOLECULA DE ACIDO NUCLEICO, UNA COMPOSICIoN Y USO DE UN ANTICUERPO PARA LA MANUFA
ARP070101154A AR060038A2 (es) 1997-07-02 2007-03-21 Una molecula de anticuerpo anti-ige que no exhibe desactivacion de isomerizacion de aspartilo y que tiene afinidad con la molecula objetivo ige y molecula de acido nucleico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP070101154A AR060038A2 (es) 1997-07-02 2007-03-21 Una molecula de anticuerpo anti-ige que no exhibe desactivacion de isomerizacion de aspartilo y que tiene afinidad con la molecula objetivo ige y molecula de acido nucleico

Country Status (28)

Country Link
US (4) US5994511A (es)
EP (1) EP0996728B1 (es)
JP (2) JP4286327B2 (es)
KR (1) KR100547538B1 (es)
CN (1) CN1260357C (es)
AR (2) AR013169A1 (es)
AT (1) ATE253116T1 (es)
AU (1) AU741115B2 (es)
BR (2) BRPI9810654C1 (es)
CA (1) CA2295540C (es)
CZ (1) CZ300724B6 (es)
DE (1) DE69819332T2 (es)
DK (1) DK0996728T3 (es)
ES (1) ES2210778T3 (es)
HU (1) HU228845B1 (es)
IL (2) IL133973A0 (es)
IS (1) IS2039B (es)
NO (1) NO324992B1 (es)
NZ (1) NZ501842A (es)
PL (1) PL194562B1 (es)
PT (1) PT996728E (es)
RO (1) RO120848B1 (es)
RU (1) RU2242515C2 (es)
SK (1) SK284395B6 (es)
TR (1) TR200000206T2 (es)
TW (2) TWI233946B (es)
WO (1) WO1999001556A2 (es)
ZA (1) ZA985500B (es)

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