BR9814335A - Proteìna, exceto as existentes ao natural, polinucleotìdeo substancialmente puro, anticorpo elaborado por um processo que compreende a etapa de injetar uma preparação farmaceuticamente aceitável, vetor para expressar o drr-1 de rato, vetor, célula hospedeira drr-1 de rato, drr-1 de ser humano, drr-2 de ser humano, drr-3 de ser humano, drr-4 de ser humano, drr-5 de ser humano, drr-6 de ser humano recombinantes, e, processo para ensaiar um composto de teste quanto à sua capacidade para ligar-se a ou para ativar um receptor especìfico de gânglios da raiz dorsal ligado à proteìna g (drr) - Google Patents

Proteìna, exceto as existentes ao natural, polinucleotìdeo substancialmente puro, anticorpo elaborado por um processo que compreende a etapa de injetar uma preparação farmaceuticamente aceitável, vetor para expressar o drr-1 de rato, vetor, célula hospedeira drr-1 de rato, drr-1 de ser humano, drr-2 de ser humano, drr-3 de ser humano, drr-4 de ser humano, drr-5 de ser humano, drr-6 de ser humano recombinantes, e, processo para ensaiar um composto de teste quanto à sua capacidade para ligar-se a ou para ativar um receptor especìfico de gânglios da raiz dorsal ligado à proteìna g (drr)

Info

Publication number
BR9814335A
BR9814335A BR9814335-2A BR9814335A BR9814335A BR 9814335 A BR9814335 A BR 9814335A BR 9814335 A BR9814335 A BR 9814335A BR 9814335 A BR9814335 A BR 9814335A
Authority
BR
Brazil
Prior art keywords
drr
human
protein
vector
rat
Prior art date
Application number
BR9814335-2A
Other languages
English (en)
Inventor
Sultan Ahmad
Denis Banville
Yves Fortin
Paola Lembo
Dajan O'donell
Shi-Hsiang Shen
Original Assignee
Astrazeneca Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Canada Inc filed Critical Astrazeneca Canada Inc
Publication of BR9814335A publication Critical patent/BR9814335A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"PROTEìNA, EXCETO AS EXISTENTES AO NATURAL, POLINUCLEOTìDEO SUBSTANCIALMENTE PURO, ANTICORPO ELABORADO POR UM PROCESSO QUE COMPREENDE A ETAPA DE INJETAR UMA PREPARAçãO FARMACEUTICAMENTE ACEITáVEL, VETOR PARA EXPRESSAR O DRR-1 DE RATO, VETOR, CéLULA HOSPEDEIRA DRR-1 DE RATO, DRR-1 DE SER HUMANO, DRR-2 DE SER HUMANO, DRR-3 DE SER HUMANO, DRR-4 DE SER HUMANO, DRR-5 DE SER HUMANO, DRR-6 DE SER HUMANO RECOMBINANTES, E, PROCESSO PARA ENSAIAR UM COMPOSTO DE TESTE QUANTO à SUA CAPACIDADE PARA LIGAR-SE A OU PARA ATIVAR UM RECEPTOR ESPECìFICO DE GâNGLIOS DA RAIZ DORSAL LIGADO à PROTEìNA G (DRR)" A presente invenção está direcionada a novos receptores ligados à proteína G que são encontrados predominantemente nos gânglios da raiz dorsal. A invenção abrange tanto as proteínas do receptor bem como os ácidos nucleicos que codificam as proteínas. A angiotensina I e III efetuam a sinalização do Cálcio em Células transformadas com o DNA que codifica o receptor. Além disso, a presente invenção está direcionada a processos e a composições que utilizam os receptores.
BR9814335-2A 1997-12-22 1998-12-16 Proteìna, exceto as existentes ao natural, polinucleotìdeo substancialmente puro, anticorpo elaborado por um processo que compreende a etapa de injetar uma preparação farmaceuticamente aceitável, vetor para expressar o drr-1 de rato, vetor, célula hospedeira drr-1 de rato, drr-1 de ser humano, drr-2 de ser humano, drr-3 de ser humano, drr-4 de ser humano, drr-5 de ser humano, drr-6 de ser humano recombinantes, e, processo para ensaiar um composto de teste quanto à sua capacidade para ligar-se a ou para ativar um receptor especìfico de gânglios da raiz dorsal ligado à proteìna g (drr) BR9814335A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704836A SE9704836D0 (sv) 1997-12-22 1997-12-22 Novel receptor
PCT/SE1998/002348 WO1999032519A1 (en) 1997-12-22 1998-12-16 Novel g protein-coupled receptor

Publications (1)

Publication Number Publication Date
BR9814335A true BR9814335A (pt) 2000-10-10

Family

ID=20409539

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814335-2A BR9814335A (pt) 1997-12-22 1998-12-16 Proteìna, exceto as existentes ao natural, polinucleotìdeo substancialmente puro, anticorpo elaborado por um processo que compreende a etapa de injetar uma preparação farmaceuticamente aceitável, vetor para expressar o drr-1 de rato, vetor, célula hospedeira drr-1 de rato, drr-1 de ser humano, drr-2 de ser humano, drr-3 de ser humano, drr-4 de ser humano, drr-5 de ser humano, drr-6 de ser humano recombinantes, e, processo para ensaiar um composto de teste quanto à sua capacidade para ligar-se a ou para ativar um receptor especìfico de gânglios da raiz dorsal ligado à proteìna g (drr)

Country Status (19)

Country Link
US (3) US6696257B1 (pt)
EP (1) EP1051434B1 (pt)
JP (1) JP2001526064A (pt)
KR (1) KR20010033486A (pt)
CN (1) CN1284966A (pt)
AT (1) ATE325132T1 (pt)
AU (1) AU756861B2 (pt)
BR (1) BR9814335A (pt)
CA (1) CA2316280C (pt)
DE (1) DE69834432T2 (pt)
ES (1) ES2262252T3 (pt)
IL (1) IL136728A0 (pt)
IS (1) IS5543A (pt)
NO (1) NO20003221L (pt)
PL (1) PL341524A1 (pt)
SE (1) SE9704836D0 (pt)
SK (1) SK8752000A3 (pt)
TR (1) TR200001861T2 (pt)
WO (1) WO1999032519A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
WO2000020456A1 (en) * 1998-10-01 2000-04-13 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
AU774850B2 (en) * 1999-01-04 2004-07-08 Lexicon Pharmaceuticals, Inc. Human seven-transmembrane receptors
NZ518662A (en) * 1999-11-17 2004-10-29 Arena Pharm Inc Endogenous and non-endogenous versions of human G protein-coupled receptors
US20020062013A1 (en) * 1999-12-28 2002-05-23 Peter Lind Novel G protein-coupled receptors
EP1268795A2 (en) * 2000-03-24 2003-01-02 Bayer Aktiengesellschaft Regulation of human mas oncogene-related g protein-coupled receptor
JP2003530834A (ja) * 2000-03-27 2003-10-21 ピーイー コーポレーション （エヌワイ） 単離した癌原遺伝子サブファミリーに属するヒトｇタンパク質共役受容体、ヒトｇｐｃｒタンパク質をコード化している核酸分子、及びそれらの使用
CA2404533A1 (en) * 2000-03-29 2001-10-04 Pe Corporation (Ny) Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
GB0008252D0 (en) * 2000-04-04 2000-05-24 Janssen Pharmaceutica Nv G protien coupled receptor
WO2001077330A2 (en) * 2000-04-06 2001-10-18 Pharmacia & Upjohn Company G protein-coupled receptors
WO2001081409A2 (en) * 2000-04-24 2001-11-01 Pe Corporation (Ny) Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
US7691604B1 (en) 2000-05-04 2010-04-06 California Institute Of Technology MRG polypeptides and nucleic acids encoding the same
US20030092035A1 (en) 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
US7510845B2 (en) * 2000-05-04 2009-03-31 California Institute Of Technology Assay employing G protein-coupled receptor expressed in dorsal root ganglia
EP1280904B1 (en) * 2000-05-04 2005-12-14 California Institute Of Technology Pain signaling molecules
CA2413435A1 (en) * 2000-06-20 2001-12-27 Euroscreen S.A. A recombinant cell line expressing gpcrx11 as a functional receptor validated by angiopeptin and useful for screening of agonists and antagonists
WO2002010204A2 (en) * 2000-08-02 2002-02-07 Pharmacia & Upjohn Company G protein-coupled receptors
CA2354253A1 (en) * 2000-08-04 2002-02-04 Switch Biotech Ag Polypeptides or nucleic acids encoding these of a family of g-protein coupled receptors and their use for the diagnosis or treatment of disorders, for example skin disorders and their use for the identification of pharmacologically active substances
WO2002028901A2 (en) * 2000-10-05 2002-04-11 Millennium Pharmaceuticals, Inc. Seven-transmembrane (7tm) receptors and uses thereof
EP1334362B1 (en) 2000-10-17 2008-09-10 AstraZeneca AB Assays
US20040076951A1 (en) * 2000-10-25 2004-04-22 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
WO2002040990A1 (fr) * 2000-11-15 2002-05-23 Akiko Itai Procede permettant de determiner le profil d'une proteine
CA2430719A1 (en) * 2000-12-22 2002-07-04 Astrazeneca Ab A method of assaying for agonists or antagonist of dynorphin a binding to the mas receptor
EP1360294A2 (en) * 2001-02-08 2003-11-12 Bayer Aktiengesellschaft Regulation of human dorsal root receptor-like g protein-coupled receptor
AU2002317013B2 (en) 2001-06-27 2007-11-01 Janssen Pharmaceutica N.V. EPF receptor assays, compounds and therapeutic compositions
WO2003021263A1 (fr) * 2001-09-03 2003-03-13 Takeda Chemical Industries, Ltd. Utilisation d'une proteine de recepteur couple a une proteine g
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
MXPA04009959A (es) 2002-04-12 2004-12-13 Schering Corp Ligandos del receptor acoplado a la proteina g y metodos.
US20040121410A1 (en) * 2002-12-20 2004-06-24 Anderson David J. Pain signaling molecules
WO2004111642A2 (en) * 2003-06-16 2004-12-23 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 1 (snsr1)
WO2005003779A2 (en) * 2003-06-17 2005-01-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 3 (snsr3)
WO2005003762A2 (en) * 2003-06-17 2005-01-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 2 (snsr2)
WO2005003780A2 (en) * 2003-06-17 2005-01-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 4 (snsr4)
WO2005003763A2 (en) * 2003-06-18 2005-01-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor 3 (mrgx3)
AU2011256098A1 (en) * 2010-05-18 2013-01-10 The Royal Institution For The Advancement Of Learning / Mcgill University Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4855393A (en) 1992-09-10 1994-03-29 New York University Polypeptides of g-coupled receptor proteins, and compositions and methods thereof
US5556780A (en) * 1993-07-30 1996-09-17 The Board Of Trustees For The Leland Stanford Junior University CDNAS encoding mouse and rat type-2 angiotensin II receptors and their expression in host cells

Also Published As

Publication number Publication date
TR200001861T2 (tr) 2000-11-21
CN1284966A (zh) 2001-02-21
US7217693B2 (en) 2007-05-15
JP2001526064A (ja) 2001-12-18
WO1999032519A1 (en) 1999-07-01
AU756861B2 (en) 2003-01-23
US20090226932A1 (en) 2009-09-10
NO20003221L (no) 2000-08-10
SK8752000A3 (en) 2001-01-18
WO1999032519A9 (en) 1999-09-30
ATE325132T1 (de) 2006-06-15
KR20010033486A (ko) 2001-04-25
SE9704836D0 (sv) 1997-12-22
ES2262252T3 (es) 2006-11-16
AU1990499A (en) 1999-07-12
PL341524A1 (en) 2001-04-23
EP1051434B1 (en) 2006-05-03
DE69834432T2 (de) 2007-04-12
DE69834432D1 (de) 2006-06-08
CA2316280A1 (en) 1999-07-01
EP1051434A1 (en) 2000-11-15
US6696257B1 (en) 2004-02-24
IS5543A (is) 2000-06-21
US20060068466A1 (en) 2006-03-30
CA2316280C (en) 2010-07-13
NO20003221D0 (no) 2000-06-21
IL136728A0 (en) 2001-06-14

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.