ATE293159T1 - Stabilisierendes verdünnungsmittel für polypeptide und antigene - Google Patents

Stabilisierendes verdünnungsmittel für polypeptide und antigene

Info

Publication number
ATE293159T1
ATE293159T1 AT00984071T AT00984071T ATE293159T1 AT E293159 T1 ATE293159 T1 AT E293159T1 AT 00984071 T AT00984071 T AT 00984071T AT 00984071 T AT00984071 T AT 00984071T AT E293159 T1 ATE293159 T1 AT E293159T1
Authority
AT
Austria
Prior art keywords
antigens
polypeptides
stabilizing diluent
stabilizing
diluent
Prior art date
Application number
AT00984071T
Other languages
English (en)
Inventor
Jeffrey W Steaffens
Laura Panzarella
Original Assignee
Thermo Biostar Inc
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Biostar Inc, Asahi Chemical Ind filed Critical Thermo Biostar Inc
Application granted granted Critical
Publication of ATE293159T1 publication Critical patent/ATE293159T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/106664—Blood serum or blood plasma standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00984071T 1999-12-14 2000-12-07 Stabilisierendes verdünnungsmittel für polypeptide und antigene ATE293159T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17085099P 1999-12-14 1999-12-14
PCT/US2000/033337 WO2001044441A1 (en) 1999-12-14 2000-12-07 Stabilizing diluent for polypeptides and antigens

Publications (1)

Publication Number Publication Date
ATE293159T1 true ATE293159T1 (de) 2005-04-15

Family

ID=22621523

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00984071T ATE293159T1 (de) 1999-12-14 2000-12-07 Stabilisierendes verdünnungsmittel für polypeptide und antigene

Country Status (11)

Country Link
US (2) US6579688B2 (de)
EP (1) EP1242576B1 (de)
JP (1) JP3884652B2 (de)
KR (1) KR100771294B1 (de)
CN (1) CN1286969C (de)
AT (1) ATE293159T1 (de)
AU (1) AU783246C (de)
CA (1) CA2396503A1 (de)
DE (1) DE60019458T2 (de)
TW (1) TWI257953B (de)
WO (1) WO2001044441A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2400448T3 (es) * 2001-04-30 2013-04-10 Ventana Medical Systems, Inc. Reactivos y métodos para la hibridación automatizada in situ o para microarray
US20030157556A1 (en) * 2002-02-13 2003-08-21 Maggiore Jack A. Biological fluid stabilizing composition and method of use thereof
EP1499890B1 (de) * 2002-05-07 2010-04-28 The Research Foundation of State University of New York "High througput" Methode, um Biomolekülanlieferung Formulierungen zu kennzeichnen
US7034126B2 (en) * 2003-05-14 2006-04-25 Agennix, Inc. Lactoferrin in the treatment of diabetes mellitus
JP4199606B2 (ja) * 2003-06-30 2008-12-17 シスメックス株式会社 免疫クロマトグラフィー検査用検体前処理液、免疫クロマトグラフィー検査方法及び免疫クロマトグラフィー検査キット
EP1737435A4 (de) * 2004-02-12 2008-06-11 Univ Rush Medical Center Flüssige zusammensetzung zur simulierung von menschlicher synovialflüssigkeit
US20090111702A1 (en) * 2004-04-06 2009-04-30 Mount Sinai School Of Medicine Office Of Industrial Liason Methods of determining allergen response using microarray immunoassay techniques
US7678578B2 (en) * 2005-02-07 2010-03-16 Beckman Coulter, Inc. Cell permeabilization and stabilization reagent and method of use
CN100342909C (zh) * 2005-05-11 2007-10-17 北京双鹭药业股份有限公司 一种胸腺素α1的水溶液制剂、其制备方法及应用
CN100337684C (zh) * 2005-05-11 2007-09-19 北京双鹭药业股份有限公司 一种胸腺五肽的水溶液制剂、其制备方法及应用
CN100336557C (zh) * 2005-05-11 2007-09-12 北京双鹭药业股份有限公司 一种生长抑素的水溶液制剂、其制备方法及应用
US20070003564A1 (en) * 2005-06-30 2007-01-04 Hurley John K Diluent for immunohistochemistry
US8263539B2 (en) 2005-10-28 2012-09-11 Dynaloy, Llc Dynamic multi-purpose composition for the removal of photoresists and methods for its use
US7632796B2 (en) 2005-10-28 2009-12-15 Dynaloy, Llc Dynamic multi-purpose composition for the removal of photoresists and method for its use
JP4742342B2 (ja) * 2005-11-22 2011-08-10 独立行政法人農業・食品産業技術総合研究機構 抗原抗体反応の検出方法と抗原抗体反応検出用キット
EP2236520A1 (de) * 2009-03-31 2010-10-06 Leukocare Ag Stabilisierungszusammensetzung für immobilisierte Biomoleküle
ES2398646T3 (es) * 2010-07-24 2013-03-20 F. Hoffmann-La Roche Ag Estabilización de la interleuquina-6 en soluciones de suero
US9091677B2 (en) 2010-08-09 2015-07-28 Beckman Coulter, Inc. Isotonic buffered composition and method that enables counting of cells
CN102375056A (zh) * 2010-08-27 2012-03-14 烟台赛尔斯生物技术有限公司 固定生物大分子的稳定剂及其制备方法和应用
EA037797B1 (ru) 2011-10-25 2021-05-21 Протена Байосайенсиз Лимитед Состав антитела, пригодный для профилактики и лечения амилоидоза, его варианты и способ его получения
US9158202B2 (en) 2012-11-21 2015-10-13 Dynaloy, Llc Process and composition for removing substances from substrates
US9029268B2 (en) 2012-11-21 2015-05-12 Dynaloy, Llc Process for etching metals
MX2016014660A (es) * 2014-05-08 2017-02-28 Pfizer Medios y metodos para el tratamiento de cmv.
EP3319930A4 (de) * 2015-07-07 2019-04-10 NanoBio Corporation Verfahren und zusammensetzungen zur stabilisierung von proteinen
US11173197B2 (en) 2015-07-07 2021-11-16 Bluewillow Biologics, Inc. Methods and compositions for nanoemulsion vaccine formulations
CN105158454A (zh) * 2015-09-11 2015-12-16 无锡市长安曙光手套厂 一种试剂盒及其检测方法
CN105628914B (zh) * 2016-02-04 2019-01-08 广州科方生物技术股份有限公司 一种能使吖啶酯抗原抗体结合物稳定的稀释液及其制备方法
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
CN106526164B (zh) * 2016-10-27 2018-05-29 河南省医药科学研究院 一种酶标记抗体应用稀释液及其制备方法
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
CN110133253A (zh) * 2019-05-14 2019-08-16 上海赛唐生物技术有限公司 广谱型抗原抗体保护剂
TWI810589B (zh) 2020-06-21 2023-08-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽
CN114159555A (zh) * 2021-12-08 2022-03-11 江西赛基生物技术有限公司 抗原蛋白冻干小球及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082481B2 (de) * 1981-12-23 1990-09-12 Schering Corporation Stabilisierte alpha-Interferon-Zusammensetzungen und ihre Herstellung
US4956274A (en) 1987-04-06 1990-09-11 Microgenics Corporation Reagent stabilization in enzyme-donor and acceptor assay
JPH03133378A (ja) 1989-07-19 1991-06-06 Modrovich Ivan E 被験体を安定化させて液体中でのその生物学的活性を保存する方法
US5541057A (en) 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
US5550063A (en) 1991-02-11 1996-08-27 Biostar, Inc. Methods for production of an optical assay device
WO1992016619A1 (en) * 1991-03-19 1992-10-01 Us Army Expression of influenza nucleoprotein antigens in baculovirus
US5254350A (en) * 1991-07-22 1993-10-19 Helena Laboratories Corporation Method of preparing a thromboplastin extract
DE4211108A1 (de) 1992-04-03 1993-10-07 Boehringer Mannheim Gmbh Viruslösung zum Einsatz bei Immunoassays
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
CN1217746A (zh) * 1996-04-29 1999-05-26 勒芬研究与发展公司 多能性兔胚胎干(es)细胞系及其在嵌合兔的产生中的应用
WO1998017242A1 (en) * 1996-10-24 1998-04-30 Board Of Trustees Of The University Of Illinois Unique peptides for targeting fibronectin-enriched surfaces and a method for their delivery in the treatment of metastatic cancer
JPH10191972A (ja) * 1997-01-13 1998-07-28 Toyo Ink Mfg Co Ltd Ａｔｐ加水分解酵素の安定化方法
US5994511A (en) * 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6172213B1 (en) * 1997-07-02 2001-01-09 Genentech, Inc. Anti-IgE antibodies and method of improving polypeptides
ES2316171T3 (es) 1997-09-22 2009-04-01 Novartis Vaccines And Diagnostics, Inc. Tampones para estabilizar antigenos hcv.

Also Published As

Publication number Publication date
DE60019458T2 (de) 2006-02-23
EP1242576B1 (de) 2005-04-13
AU783246C (en) 2007-03-15
EP1242576A1 (de) 2002-09-25
CN1409758A (zh) 2003-04-09
AU2075001A (en) 2001-06-25
CA2396503A1 (en) 2001-06-21
US6579688B2 (en) 2003-06-17
JP3884652B2 (ja) 2007-02-21
JP2003517153A (ja) 2003-05-20
KR100771294B1 (ko) 2007-10-29
WO2001044441A1 (en) 2001-06-21
KR20020082206A (ko) 2002-10-30
TWI257953B (en) 2006-07-11
US20020076813A1 (en) 2002-06-20
CN1286969C (zh) 2006-11-29
DE60019458D1 (de) 2005-05-19
US20020160359A1 (en) 2002-10-31
AU783246B2 (en) 2005-10-06

Similar Documents

Publication Publication Date Title
ATE293159T1 (de) Stabilisierendes verdünnungsmittel für polypeptide und antigene
DE60113381D1 (de) Automatisierung im proteinentwurf durch proteinbibliotheken
DE602004032573D1 (de) Stabilisierte zusammensetzungen von faktor-vii-polypeptiden
SG157952A1 (en) Small molecule antagonists of bcl-2 family proteins
WO2000023564A3 (en) Protein design automation for protein libraries
DE60032367D1 (de) Aktivierbare rekombinante neurotoxine
DE69931507D1 (de) Interferon-beta fusionsproteine und deren verwendungen
DE60144145D1 (de) Subtilisin-variante
NZ521396A (en) Fusion proteins comprising two or more Neisseria polypeptides
EP2141243A3 (de) Proteingerüste für Antikörpermimetika und andere Bindungsproteine
TR200100056T2 (tr) Nörotrofik faktörler
WO2001049728A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
DE50112802D1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
ATE406439T1 (de) Eukaryontische signalsequenzen für polypeptid- expressions- und polypeptid- präsentationsbibliotheken
DE60226852D1 (de) Lentivirale verpackungskonstrukte
BR0109846A (pt) Uso de uma composição que compreende um anticorpo ou um fragmento de ligação de antìgeno deste, e conjunto
DE60116359D1 (de) Kahalalid f formulierung
IL145689A0 (en) Methods
DE60118935D1 (de) Dna & protein bindende miniatur proteine
DK1276763T3 (da) Anti-fryseproteiner, deres fremstilling og anvendelse
TR200101493T2 (tr) Eletriptan hidrobromid monohidrat
PT1235579E (pt) Composicoes farmaceuticas contendo trimegestona
SE8502540L (sv) Stabilt tandvardsmedel innehallande dextranas
PT723552E (pt) Oligopeptidos derivados de fragmentos de proteina reactiva c
EA200000875A1 (ru) Белки, взаимодействующие с каспазой-8

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties