ATE406439T1 - Eukaryontische signalsequenzen für polypeptid- expressions- und polypeptid- präsentationsbibliotheken - Google Patents
Eukaryontische signalsequenzen für polypeptid- expressions- und polypeptid- präsentationsbibliothekenInfo
- Publication number
- ATE406439T1 ATE406439T1 AT03739833T AT03739833T ATE406439T1 AT E406439 T1 ATE406439 T1 AT E406439T1 AT 03739833 T AT03739833 T AT 03739833T AT 03739833 T AT03739833 T AT 03739833T AT E406439 T1 ATE406439 T1 AT E406439T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptide
- signal sequences
- eukaryontic
- presentation libraries
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/076,802 US7094579B2 (en) | 2002-02-13 | 2002-02-13 | Eukaryotic signal sequences for prokaryotic expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE406439T1 true ATE406439T1 (de) | 2008-09-15 |
Family
ID=27732544
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08163005T ATE533845T1 (de) | 2002-02-13 | 2003-02-13 | Eukaryotische signalsequenzen zur polypeptid- expression und polypeptid-anzeigebibliotheken |
| AT03739833T ATE406439T1 (de) | 2002-02-13 | 2003-02-13 | Eukaryontische signalsequenzen für polypeptid- expressions- und polypeptid- präsentationsbibliotheken |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08163005T ATE533845T1 (de) | 2002-02-13 | 2003-02-13 | Eukaryotische signalsequenzen zur polypeptid- expression und polypeptid-anzeigebibliotheken |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7094579B2 (de) |
| EP (2) | EP2060628B1 (de) |
| JP (2) | JP4303596B2 (de) |
| AT (2) | ATE533845T1 (de) |
| AU (1) | AU2003225578B2 (de) |
| CA (1) | CA2475929C (de) |
| DE (1) | DE60323210D1 (de) |
| DK (2) | DK2060628T3 (de) |
| WO (1) | WO2003068956A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| US7094579B2 (en) * | 2002-02-13 | 2006-08-22 | Xoma Technology Ltd. | Eukaryotic signal sequences for prokaryotic expression |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US8293503B2 (en) | 2003-10-03 | 2012-10-23 | Promega Corporation | Vectors for directional cloning |
| ATE442445T1 (de) * | 2003-10-03 | 2009-09-15 | Promega Corp | Rhamnose-induzierbares expressionssystem |
| PL1737962T3 (pl) * | 2004-03-24 | 2011-02-28 | Domantis Ltd | Uniwersalny lider GAS1 |
| EP1824961B1 (de) | 2004-12-07 | 2016-11-02 | Lonza Ltd | System zur expression von melibiose-operon |
| ATE466090T1 (de) | 2004-12-07 | 2010-05-15 | Lonza Ag | Rhamnosepromotor-expressionssystem |
| US8586330B2 (en) * | 2006-07-14 | 2013-11-19 | Novozymes A/S | Methods for producing secreted polypeptides having biological activity |
| GB0810154D0 (en) | 2008-06-04 | 2008-07-09 | Avecia Biolog Ltd | Expression vector |
| JP2012504424A (ja) | 2008-10-03 | 2012-02-23 | ゾーマ テクノロジー リミテッド | トリプルタグ配列およびその使用方法 |
| JP5745432B2 (ja) * | 2009-02-25 | 2015-07-08 | ネクステラ アーエス | シグナル配列非依存性ｐＩＸファージディスプレイ |
| WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
| JP2014504503A (ja) | 2010-12-28 | 2014-02-24 | ゾーマ テクノロジー リミテッド | Ｐｄｚドメインを用いた細胞表面提示 |
| JP6161541B2 (ja) | 2011-02-03 | 2017-07-12 | ゾーマ テクノロジー リミテッド | 細菌中の機能的タンパク質発現を向上させるための方法および物質 |
| JP6362543B2 (ja) | 2012-02-23 | 2018-07-25 | ジュノ セラピューティクス ゲーエムベーハー | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| PL2870247T3 (pl) * | 2012-07-05 | 2019-10-31 | Hoffmann La Roche | Układ ekspresji i wydzielania |
| EP2877589B1 (de) | 2012-07-26 | 2024-03-06 | Momenta Pharmaceuticals, Inc. | Glykoproteine mit entzündungshemmenden eigenschaften |
| HK1258932A1 (zh) | 2015-10-22 | 2019-11-22 | Juno Therapeutics Gmbh | 用於转导的方法、反应剂盒、反应剂和设备 |
| CN108474791B (zh) | 2015-10-22 | 2022-07-08 | 朱诺治疗学有限公司 | 培养细胞的方法及用于该方法的试剂盒和设备 |
| HK1258313A1 (zh) * | 2015-10-23 | 2019-11-08 | Fred Hutchinson Cancer Center | 建立化学诱导的二聚化蛋白体系以调节细胞事件的方法 |
| CN105734061B (zh) * | 2016-03-25 | 2019-07-23 | 中国农业科学院生物技术研究所 | 从毕赤酵母中分离的鼠李糖诱导型启动子及其应用 |
| MA49288A (fr) | 2017-04-27 | 2020-03-04 | Juno Therapeutics Gmbh | Reactifs particulaires oligomères et leurs méthodes d'utilisation |
| EP3444269A1 (de) | 2017-08-17 | 2019-02-20 | National Research Council of Canada | Systeme und methoden für die produktion von diphteria-giftstoff-polypeptiden |
| CA3084315A1 (en) | 2017-12-11 | 2019-06-20 | Abalone Bio, Inc. | Yeast display of proteins in the periplasmic space |
| EP3874024A1 (de) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Verfahren zur selektion und stimulation von zellen und vorrichtung dafür |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| IT201900006656A1 (it) | 2019-05-08 | 2020-11-08 | Salvagnini Italia Spa | Macchina piegatrice per lamiere metalliche |
| AU2021226352A1 (en) * | 2020-02-25 | 2022-09-29 | Momenta Pharmaceuticals, Inc. | Enzymes for sialylation of glycans |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
| CN116284288A (zh) * | 2023-02-01 | 2023-06-23 | 深圳大学 | 莱茵衣藻分泌导肽和转基因莱茵衣藻及其构建方法与应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| DE3852304T3 (de) | 1987-03-02 | 1999-07-01 | Enzon Labs Inc., Piscataway, N.J. | Organismus als Träger für "Single Chain Antibody Domain (SCAD)". |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9011861D0 (en) | 1990-05-26 | 1990-07-18 | Beecham Group Plc | Novel compounds |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| CA2109602C (en) | 1990-07-10 | 2002-10-01 | Gregory P. Winter | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| DE4022940A1 (de) | 1990-07-19 | 1992-01-23 | Bosch Gmbh Robert | Einrichtung zur temperatursteuerung eines messwiderstands |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
| AU662148B2 (en) | 1991-04-10 | 1995-08-24 | Scripps Research Institute, The | Heterodimeric receptor libraries using phagemids |
| DE4122598C1 (de) * | 1991-07-08 | 1992-07-30 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg, De | |
| EP0605522B1 (de) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methoden zur Herstellung humanisierter Antikörper |
| US5470997A (en) | 1992-04-06 | 1995-11-28 | Biosite Diagnostics Incorporated | Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| US6555310B1 (en) * | 1997-04-04 | 2003-04-29 | Biosite Diagnostics, Inc. | Polyclonal libraries |
| EP0985033A4 (de) | 1997-04-04 | 2005-07-13 | Biosite Inc | Polyvalente und polyklonale bibliotheken |
| NZ516848A (en) * | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| JP3374052B2 (ja) | 1997-07-28 | 2003-02-04 | 株式会社堀場製作所 | オゾン測定装置 |
| US5932445A (en) | 1997-11-07 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Signal peptide-containing proteins |
| US6545140B1 (en) * | 1998-07-13 | 2003-04-08 | University Of Georgia Research Foundation, Inc. | DNA encoding an avian beta-defensin and uses thereof |
| ATE323766T1 (de) | 1999-02-12 | 2006-05-15 | Amgen Inc | Glykosylierte leptinzusammensetzungen und zugehörige verfahren |
| US6794132B2 (en) | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| US7094579B2 (en) | 2002-02-13 | 2006-08-22 | Xoma Technology Ltd. | Eukaryotic signal sequences for prokaryotic expression |
| DE20207301U1 (de) | 2002-05-10 | 2002-12-19 | Eichler-Stahlberg, Alke, 93059 Regensburg | Expressionssystem für synthetische Gene in Mikroalgen |
| CN103929153B (zh) | 2013-01-11 | 2016-12-28 | 北大方正集团有限公司 | 一种倍频处理方法和装置 |
-
2002
- 2002-02-13 US US10/076,802 patent/US7094579B2/en not_active Expired - Lifetime
-
2003
- 2003-02-13 AU AU2003225578A patent/AU2003225578B2/en not_active Expired
- 2003-02-13 US US10/367,169 patent/US7396661B2/en not_active Expired - Lifetime
- 2003-02-13 DE DE60323210T patent/DE60323210D1/de not_active Expired - Lifetime
- 2003-02-13 EP EP08163005A patent/EP2060628B1/de not_active Expired - Lifetime
- 2003-02-13 WO PCT/US2003/004791 patent/WO2003068956A1/en not_active Ceased
- 2003-02-13 AT AT08163005T patent/ATE533845T1/de active
- 2003-02-13 DK DK08163005.5T patent/DK2060628T3/da active
- 2003-02-13 DK DK03739833T patent/DK1481059T3/da active
- 2003-02-13 CA CA2475929A patent/CA2475929C/en not_active Expired - Fee Related
- 2003-02-13 AT AT03739833T patent/ATE406439T1/de not_active IP Right Cessation
- 2003-02-13 JP JP2003568071A patent/JP4303596B2/ja not_active Expired - Lifetime
- 2003-02-13 EP EP03739833A patent/EP1481059B1/de not_active Expired - Lifetime
-
2008
- 2008-01-25 US US12/020,482 patent/US7977068B2/en not_active Expired - Fee Related
- 2008-01-28 US US12/021,098 patent/US7972811B2/en not_active Expired - Fee Related
-
2009
- 2009-03-17 JP JP2009065285A patent/JP5190963B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-20 US US13/112,600 patent/US8476040B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2475929C (en) | 2013-01-15 |
| EP1481059A4 (de) | 2006-02-01 |
| US8476040B2 (en) | 2013-07-02 |
| CA2475929A1 (en) | 2003-08-21 |
| US7094579B2 (en) | 2006-08-22 |
| DE60323210D1 (en) | 2008-10-09 |
| ATE533845T1 (de) | 2011-12-15 |
| JP2005517407A (ja) | 2005-06-16 |
| US20030162249A1 (en) | 2003-08-28 |
| EP1481059B1 (de) | 2008-08-27 |
| US20110224102A1 (en) | 2011-09-15 |
| WO2003068956A1 (en) | 2003-08-21 |
| US7977068B2 (en) | 2011-07-12 |
| EP1481059A1 (de) | 2004-12-01 |
| JP2009131286A (ja) | 2009-06-18 |
| JP4303596B2 (ja) | 2009-07-29 |
| US20100009857A1 (en) | 2010-01-14 |
| US20080214411A1 (en) | 2008-09-04 |
| US7972811B2 (en) | 2011-07-05 |
| EP2060628A1 (de) | 2009-05-20 |
| DK1481059T3 (da) | 2009-01-12 |
| DK2060628T3 (da) | 2012-01-23 |
| JP5190963B2 (ja) | 2013-04-24 |
| US20030228660A1 (en) | 2003-12-11 |
| EP2060628B1 (de) | 2011-11-16 |
| US7396661B2 (en) | 2008-07-08 |
| AU2003225578B2 (en) | 2008-04-03 |
| AU2003225578A1 (en) | 2003-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |