ATE513040T1 - Zinkfingerdomänenbibliotheken - Google Patents

Zinkfingerdomänenbibliotheken

Info

Publication number
ATE513040T1
ATE513040T1 AT02758924T AT02758924T ATE513040T1 AT E513040 T1 ATE513040 T1 AT E513040T1 AT 02758924 T AT02758924 T AT 02758924T AT 02758924 T AT02758924 T AT 02758924T AT E513040 T1 ATE513040 T1 AT E513040T1
Authority
AT
Austria
Prior art keywords
zinc finger
finger domains
finger domain
libraries
domain libraries
Prior art date
Application number
AT02758924T
Other languages
English (en)
Inventor
Jin-Soo Kim
Kwang-Hee Bae
Kyung-Soon Park
Young-Do Kwon
Eun-Huyn Ryu
Moon-Sun Hwang
Original Assignee
Toolgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toolgen Inc filed Critical Toolgen Inc
Application granted granted Critical
Publication of ATE513040T1 publication Critical patent/ATE513040T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT02758924T 2001-08-17 2002-08-17 Zinkfingerdomänenbibliotheken ATE513040T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31340201P 2001-08-17 2001-08-17
US37435502P 2002-04-22 2002-04-22
PCT/KR2002/001560 WO2003016571A1 (en) 2001-08-17 2002-08-17 Zinc finger domain libraries

Publications (1)

Publication Number Publication Date
ATE513040T1 true ATE513040T1 (de) 2011-07-15

Family

ID=26978841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02758924T ATE513040T1 (de) 2001-08-17 2002-08-17 Zinkfingerdomänenbibliotheken

Country Status (9)

Country Link
US (2) US20030165997A1 (de)
EP (1) EP1417344B1 (de)
JP (1) JP4128955B2 (de)
KR (1) KR100961722B1 (de)
CN (1) CN1289522C (de)
AT (1) ATE513040T1 (de)
AU (1) AU2002324352B2 (de)
CA (1) CA2457095A1 (de)
WO (1) WO2003016571A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003048345A1 (en) 2001-12-07 2003-06-12 Toolgen, Inc. Phenotypic screen of chimeric proteins
WO2004053130A1 (en) * 2002-12-09 2004-06-24 Toolgen, Inc. Regulatory zinc finger proteins
KR20060054196A (ko) * 2003-06-10 2006-05-22 주식회사 툴젠 전달가능한 ｄｎａ-결합 단백질
EP1720911A1 (de) * 2004-01-20 2006-11-15 Man-Wook Hur Tatdmt-polypeptid enthaltendes fusionsprotein
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
KR100812110B1 (ko) * 2006-10-24 2008-03-12 한국과학기술원 징크 핑거 단백질과 원핵 생물의 전사 인자를 포함하는인공 전사 인자의 제조 및 이의 이용
WO2009042163A2 (en) 2007-09-27 2009-04-02 Sangamo Biosciences, Inc. Rapid in vivo identification of biologically active nucleases
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
KR101896518B1 (ko) * 2011-03-30 2018-10-24 주식회사 툴젠 Ｃｍａｈ 유전자를 표적으로 하는 징크 핑거 뉴클레아제 및 이의 용도
WO2018071672A1 (en) * 2016-10-12 2018-04-19 The Regents Of The University Of Colorado Novel engineered and chimeric nucleases
CN107012174A (zh) * 2017-05-04 2017-08-04 昆明理工大学 CRISPR/Cas9技术在获得家蚕锌指蛋白基因突变体中的应用
US10011849B1 (en) 2017-06-23 2018-07-03 Inscripta, Inc. Nucleic acid-guided nucleases
US9982279B1 (en) 2017-06-23 2018-05-29 Inscripta, Inc. Nucleic acid-guided nucleases
GB201710620D0 (en) 2017-07-03 2017-08-16 Glaxosmithkline Intellectual Property Ltd Targeted protein degradation

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US567973A (en) * 1896-09-22 Island
US5763209A (en) * 1988-09-26 1998-06-09 Arch Development Corporation Methods and materials relating to the functional domains of DNA binding proteins
US6107059A (en) * 1992-04-29 2000-08-22 Affymax Technologies N.V. Peptide library and screening method
EP0672131B1 (de) * 1992-10-30 2003-12-17 The General Hospital Corporation Ein neues zellzyklus kontrollprotein
US6140466A (en) * 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6242568B1 (en) * 1994-01-18 2001-06-05 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5882941A (en) * 1994-05-04 1999-03-16 Massachusette Institute Of Technology Programmable genotoxic agents and uses therefor
JP4118327B2 (ja) * 1994-08-20 2008-07-16 ゲンダック・リミテッド Ｄｎａ認識のための結合タンパク質におけるまたはそれに関連する改良
US6326166B1 (en) * 1995-12-29 2001-12-04 Massachusetts Institute Of Technology Chimeric DNA-binding proteins
US5789538A (en) * 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
US5869250A (en) * 1996-12-02 1999-02-09 The University Of North Carolina At Chapel Hill Method for the identification of peptides that recognize specific DNA sequences
GB9710809D0 (en) * 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6410248B1 (en) * 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
JP4309051B2 (ja) * 1998-03-02 2009-08-05 マサチューセッツ インスティテュート オブ テクノロジー 改善したリンカーを有するポリジンクフィンガータンパク質
EP1112355A1 (de) * 1998-09-14 2001-07-04 Aston University Gen- und proteinbibliotheken, und damit in zusammenhang stehende verfahren
AU7539800A (en) * 1999-10-01 2001-05-10 Sangamo Biosciences, Inc. Dna library
ATE309536T1 (de) * 1999-12-06 2005-11-15 Sangamo Biosciences Inc Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
AU2693501A (en) * 2000-01-24 2001-07-31 Gendaq Ltd Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
US20030077808A1 (en) * 2000-01-31 2003-04-24 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020061512A1 (en) * 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same
WO2003048345A1 (en) * 2001-12-07 2003-06-12 Toolgen, Inc. Phenotypic screen of chimeric proteins
US20040259258A1 (en) * 2001-12-07 2004-12-23 Kim Jin-Soo Regulation of prokaryotic gene expression with zinc finger proteins

Also Published As

Publication number Publication date
KR20040030133A (ko) 2004-04-08
EP1417344B1 (de) 2011-06-15
WO2003016571A1 (en) 2003-02-27
EP1417344A4 (de) 2005-01-26
CA2457095A1 (en) 2003-02-27
CN1289522C (zh) 2006-12-13
US20090176653A1 (en) 2009-07-09
AU2002324352B2 (en) 2006-06-15
KR100961722B1 (ko) 2010-06-10
JP4128955B2 (ja) 2008-07-30
JP2005500068A (ja) 2005-01-06
US20030165997A1 (en) 2003-09-04
EP1417344A1 (de) 2004-05-12
CN1543510A (zh) 2004-11-03

Similar Documents

Publication Publication Date Title
ATE513040T1 (de) Zinkfingerdomänenbibliotheken
ATE359365T1 (de) Zink-finger domänen und verfahren zur identifizierung derselben
DE60041505D1 (de) Inzektizide proteinen von bacillus thuringiensis
DE60023936D1 (de) Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
WO2003011115A3 (en) Peptide-based multimeric targeted contrast agents
ATE483733T1 (de) Hochaffine humane antikörper gegen tumorantigene
IL226717A (en) Isolated nucleic acids encoded by anti-beta human antibodies 7
IS7974A (is) Tjáningarsnælda og ferja til varanlegrar eða sammvinnrar tjáningar á framandi sameindum
IL195338A (en) An antibody comprising an FC variant containing amino acid replaces d or e at position 239, a medicament containing it and its use
DK1549333T3 (da) Compstatinanaloge med forbedret aktivitet
BRPI0312331A2 (pt) composições de ácido hialurônico e métodos de emprego.
DE60300734D1 (de) Anordnungen zur Vorbehandlung von Proben
ATE460429T1 (de) Polypeptide enthaltend extrazellulären domäne von il-20ra und/oderr il-20rb
HK1049501B (zh) 用鋅指蛋白使基因組產生影響官能的特性
ATE172743T1 (de) Nachweis von kollagenabbau -i(in vivo)
DE60233955D1 (de) Spezifische bindungsmittel von human angiopoietin-2
DE50112802D1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
EP1575992A4 (de) Chimäre proteine aus proteintransduzierender domäne/deaminase, verwandte verbindungen und deren verwendungen
DE60114617D1 (de) Zolpidem hemitartrat
TW200700089A (en) Recombinant protein comprising starch binding domain and use thereof
EP1412388A4 (de) Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin
AUPP472398A0 (en) Protease susceptibility II
DE60316984D1 (de) Benzoylsulfonamide als antitumor-mittel
HK1088016A1 (en) Isolated fluorescent protein from clytia gregaria cgfp and use thereof
DE60118935D1 (de) Dna & protein bindende miniatur proteine

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties