DK2060628T3 - Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker - Google Patents

Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker

Info

Publication number
DK2060628T3
DK2060628T3 DK08163005.5T DK08163005T DK2060628T3 DK 2060628 T3 DK2060628 T3 DK 2060628T3 DK 08163005 T DK08163005 T DK 08163005T DK 2060628 T3 DK2060628 T3 DK 2060628T3
Authority
DK
Denmark
Prior art keywords
polypeptide
signal sequences
display libraries
eukaryotic signal
expression
Prior art date
Application number
DK08163005.5T
Other languages
English (en)
Inventor
Jeff Gray
Joe Buechler
Uday Kumar Veeramallu
Original Assignee
Xoma Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Technology Ltd filed Critical Xoma Technology Ltd
Application granted granted Critical
Publication of DK2060628T3 publication Critical patent/DK2060628T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK08163005.5T 2002-02-13 2003-02-13 Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker DK2060628T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/076,802 US7094579B2 (en) 2002-02-13 2002-02-13 Eukaryotic signal sequences for prokaryotic expression
EP03739833A EP1481059B1 (en) 2002-02-13 2003-02-13 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries

Publications (1)

Publication Number Publication Date
DK2060628T3 true DK2060628T3 (da) 2012-01-23

Family

ID=27732544

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03739833T DK1481059T3 (da) 2002-02-13 2003-02-13 Eukaryote signalsekvenser for polypeptidekspression og polypeptiddisplaybiblioteker
DK08163005.5T DK2060628T3 (da) 2002-02-13 2003-02-13 Eukaryotiske signalsekvenser til polypeptidekspression og polypeptid-display-biblioteker

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK03739833T DK1481059T3 (da) 2002-02-13 2003-02-13 Eukaryote signalsekvenser for polypeptidekspression og polypeptiddisplaybiblioteker

Country Status (9)

Country Link
US (5) US7094579B2 (da)
EP (2) EP2060628B1 (da)
JP (2) JP4303596B2 (da)
AT (2) ATE533845T1 (da)
AU (1) AU2003225578B2 (da)
CA (1) CA2475929C (da)
DE (1) DE60323210D1 (da)
DK (2) DK1481059T3 (da)
WO (1) WO2003068956A1 (da)

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US8088387B2 (en) * 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US8293503B2 (en) 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
ATE442445T1 (de) * 2003-10-03 2009-09-15 Promega Corp Rhamnose-induzierbares expressionssystem
ATE479760T1 (de) 2004-03-24 2010-09-15 Domantis Ltd Universelles signalpeptid gas1
WO2006061173A2 (en) 2004-12-07 2006-06-15 Lonza Ag Melibiose operon expression system
JP5069124B2 (ja) 2004-12-07 2012-11-07 ロンザ アーゲー ラムノースプロモーター発現系
CN101511997B (zh) 2006-07-14 2013-09-04 诺维信股份有限公司 用于产生具有生物学活性的分泌型多肽的方法
GB0810154D0 (en) * 2008-06-04 2008-07-09 Avecia Biolog Ltd Expression vector
WO2010040073A1 (en) * 2008-10-03 2010-04-08 Xoma Technology Ltd. Novel triple tag sequences and methods of use thereof
DK2401373T3 (da) * 2009-02-25 2013-10-21 Nextera As Signalsekvens-uafhængig pix fag-display
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
US20140038842A1 (en) 2010-12-28 2014-02-06 Xoma Technology Cell surface display using pdz domains
CA2826142A1 (en) 2011-02-03 2012-08-09 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
CN106940268B (zh) 2012-02-23 2021-09-21 朱诺治疗有限公司 细胞和其它复杂生物材料的色谱分离
SI2870247T1 (sl) 2012-07-05 2019-10-30 Hoffmann La Roche Ekspresijski in sekrecijski sistem
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
US10954500B2 (en) 2015-10-23 2021-03-23 Fred Hutchinson Cancer Research Center Methods to create chemically-induced dimerizing protein systems for regulation of cellular events
CN105734061B (zh) * 2016-03-25 2019-07-23 中国农业科学院生物技术研究所 从毕赤酵母中分离的鼠李糖诱导型启动子及其应用
BR112019022356A2 (pt) 2017-04-27 2020-05-26 Juno Therapeutics Gmbh Reagentes de partícula oligoméricos e métodos de uso dos mesmos
EP3444269A1 (en) 2017-08-17 2019-02-20 National Research Council of Canada Systems and methods for the production of diphtheria toxin polypeptides
EP3724378A4 (en) 2017-12-11 2021-12-08 Abalone Bio, Inc. PRESENTATION OF PROTEIN ON YEAST IN THE PERIPLASMIC SPACE
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
IT201900006656A1 (it) 2019-05-08 2020-11-08 Salvagnini Italia Spa Macchina piegatrice per lamiere metalliche
MX2022010467A (es) * 2020-02-25 2022-12-15 Momenta Pharmaceuticals Inc Enzimas para la sialilación de glicanos.
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine

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Also Published As

Publication number Publication date
US7396661B2 (en) 2008-07-08
US7977068B2 (en) 2011-07-12
DE60323210D1 (en) 2008-10-09
US20080214411A1 (en) 2008-09-04
JP4303596B2 (ja) 2009-07-29
AU2003225578A1 (en) 2003-09-04
EP1481059A1 (en) 2004-12-01
JP2005517407A (ja) 2005-06-16
ATE406439T1 (de) 2008-09-15
US7094579B2 (en) 2006-08-22
US7972811B2 (en) 2011-07-05
EP1481059A4 (en) 2006-02-01
ATE533845T1 (de) 2011-12-15
DK1481059T3 (da) 2009-01-12
CA2475929C (en) 2013-01-15
AU2003225578B2 (en) 2008-04-03
EP1481059B1 (en) 2008-08-27
JP2009131286A (ja) 2009-06-18
EP2060628A1 (en) 2009-05-20
CA2475929A1 (en) 2003-08-21
US20110224102A1 (en) 2011-09-15
US20100009857A1 (en) 2010-01-14
US20030162249A1 (en) 2003-08-28
EP2060628B1 (en) 2011-11-16
WO2003068956A1 (en) 2003-08-21
JP5190963B2 (ja) 2013-04-24
US20030228660A1 (en) 2003-12-11
US8476040B2 (en) 2013-07-02

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