ATE533845T1 - Eukaryotische signalsequenzen zur polypeptid- expression und polypeptid-anzeigebibliotheken - Google Patents

Eukaryotische signalsequenzen zur polypeptid- expression und polypeptid-anzeigebibliotheken

Info

Publication number
ATE533845T1
ATE533845T1 AT08163005T AT08163005T ATE533845T1 AT E533845 T1 ATE533845 T1 AT E533845T1 AT 08163005 T AT08163005 T AT 08163005T AT 08163005 T AT08163005 T AT 08163005T AT E533845 T1 ATE533845 T1 AT E533845T1
Authority
AT
Austria
Prior art keywords
polypeptide
signaling sequences
expression
libraries
eukaryotic signaling
Prior art date
Application number
AT08163005T
Other languages
English (en)
Inventor
Jeff Gray
Joe Buechler
Uday Veeramallu
Original Assignee
Xoma Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Technology Ltd filed Critical Xoma Technology Ltd
Application granted granted Critical
Publication of ATE533845T1 publication Critical patent/ATE533845T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT08163005T 2002-02-13 2003-02-13 Eukaryotische signalsequenzen zur polypeptid- expression und polypeptid-anzeigebibliotheken ATE533845T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/076,802 US7094579B2 (en) 2002-02-13 2002-02-13 Eukaryotic signal sequences for prokaryotic expression

Publications (1)

Publication Number Publication Date
ATE533845T1 true ATE533845T1 (de) 2011-12-15

Family

ID=27732544

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08163005T ATE533845T1 (de) 2002-02-13 2003-02-13 Eukaryotische signalsequenzen zur polypeptid- expression und polypeptid-anzeigebibliotheken
AT03739833T ATE406439T1 (de) 2002-02-13 2003-02-13 Eukaryontische signalsequenzen für polypeptid- expressions- und polypeptid- präsentationsbibliotheken

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03739833T ATE406439T1 (de) 2002-02-13 2003-02-13 Eukaryontische signalsequenzen für polypeptid- expressions- und polypeptid- präsentationsbibliotheken

Country Status (9)

Country Link
US (5) US7094579B2 (de)
EP (2) EP1481059B1 (de)
JP (2) JP4303596B2 (de)
AT (2) ATE533845T1 (de)
AU (1) AU2003225578B2 (de)
CA (1) CA2475929C (de)
DE (1) DE60323210D1 (de)
DK (2) DK1481059T3 (de)
WO (1) WO2003068956A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US8293503B2 (en) 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
EP1847611B1 (de) * 2003-10-03 2009-09-09 Promega Corporation Rhamnose-induzierbares Expressionssystem
EP2172553A1 (de) * 2004-03-24 2010-04-07 Domantis Limited Universelles Signalpeptid gas1
CA2589937C (en) 2004-12-07 2014-04-22 Lonza Ag Rhamnose promoter expression system
JP5080269B2 (ja) 2004-12-07 2012-11-21 ロンザ アーゲー メリビオースオペロン発現系
CN101511997B (zh) * 2006-07-14 2013-09-04 诺维信股份有限公司 用于产生具有生物学活性的分泌型多肽的方法
GB0810154D0 (en) * 2008-06-04 2008-07-09 Avecia Biolog Ltd Expression vector
US8546307B2 (en) * 2008-10-03 2013-10-01 Xoma Technology, Ltd. Triple tag sequence and methods of use thereof
PT2401373E (pt) * 2009-02-25 2013-12-16 Nextera As Apresentação em pix de fago independente de sequência sinal
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
EP2658971A1 (de) 2010-12-28 2013-11-06 XOMA Technology Ltd. Zelloberflächendisplay mit pdz-domänen
AU2012212047A1 (en) 2011-02-03 2013-08-22 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
SG11201404991YA (en) 2012-02-23 2014-09-26 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
MX356162B (es) * 2012-07-05 2018-05-16 Genentech Inc Sistema de expresion y secrecion.
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
ES2923755T3 (es) * 2015-10-23 2022-09-30 Fred Hutchinson Cancer Center Procedimientos para crear sistemas de proteínas de dimerización inducidos químicamente para la regulación de eventos celulares
CN105734061B (zh) * 2016-03-25 2019-07-23 中国农业科学院生物技术研究所 从毕赤酵母中分离的鼠李糖诱导型启动子及其应用
WO2018197949A1 (en) 2017-04-27 2018-11-01 Juno Therapeutics Gmbh Oligomeric particle reagents and methods of use thereof
EP3444269A1 (de) 2017-08-17 2019-02-20 National Research Council of Canada Systeme und methoden für die produktion von diphteria-giftstoff-polypeptiden
US11795579B2 (en) 2017-12-11 2023-10-24 Abalone Bio, Inc. Yeast display of proteins in the periplasmic space
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
IT201900006656A1 (it) 2019-05-08 2020-11-08 Salvagnini Italia Spa Macchina piegatrice per lamiere metalliche
EP4110391A4 (de) * 2020-02-25 2024-07-03 Momenta Pharmaceuticals Inc Enzyme zur sialylierung von glycanen
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
EP0349578B2 (de) 1987-03-02 1998-10-28 Enzon Labs Inc. Organismus als Träger für "Single Chain Antibody Domain (SCAD)".
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9011861D0 (en) 1990-05-26 1990-07-18 Beecham Group Plc Novel compounds
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ　アンティボディー　テクノロジー　リミティド 特異的な結合ペアーの構成員の製造方法
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DE4022940A1 (de) 1990-07-19 1992-01-23 Bosch Gmbh Robert Einrichtung zur temperatursteuerung eines messwiderstands
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
DK1471142T3 (da) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
DE4122598C1 (de) * 1991-07-08 1992-07-30 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg, De
DE69229477T2 (de) 1991-09-23 1999-12-09 Cambridge Antibody Technology Ltd., Melbourn Methoden zur Herstellung humanisierter Antikörper
US5470997A (en) 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
US6555310B1 (en) * 1997-04-04 2003-04-29 Biosite Diagnostics, Inc. Polyclonal libraries
JP2002514919A (ja) 1997-04-04 2002-05-21 バイオサイト ダイアグノスティックス，インコーポレイテッド 多価ライブラリーおよびポリクローナルライブラリー
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
JP3374052B2 (ja) 1997-07-28 2003-02-04 株式会社堀場製作所 オゾン測定装置
US5932445A (en) 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins
US6545140B1 (en) * 1998-07-13 2003-04-08 University Of Georgia Research Foundation, Inc. DNA encoding an avian beta-defensin and uses thereof
DE60027409T2 (de) 1999-02-12 2007-04-12 Amgen Inc., Thousand Oaks Glykosylierte leptinzusammensetzungen und zugehörige verfahren
US6794132B2 (en) 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
DE20207301U1 (de) * 2002-05-10 2002-12-19 Eichler-Stahlberg, Alke, 93059 Regensburg Expressionssystem für synthetische Gene in Mikroalgen
CN103929153B (zh) 2013-01-11 2016-12-28 北大方正集团有限公司 一种倍频处理方法和装置

Also Published As

Publication number Publication date
US20030228660A1 (en) 2003-12-11
US20100009857A1 (en) 2010-01-14
CA2475929C (en) 2013-01-15
EP1481059B1 (de) 2008-08-27
CA2475929A1 (en) 2003-08-21
DK2060628T3 (da) 2012-01-23
US20110224102A1 (en) 2011-09-15
US20080214411A1 (en) 2008-09-04
DE60323210D1 (en) 2008-10-09
JP2009131286A (ja) 2009-06-18
AU2003225578B2 (en) 2008-04-03
AU2003225578A1 (en) 2003-09-04
EP2060628B1 (de) 2011-11-16
ATE406439T1 (de) 2008-09-15
EP1481059A4 (de) 2006-02-01
EP1481059A1 (de) 2004-12-01
US7972811B2 (en) 2011-07-05
US8476040B2 (en) 2013-07-02
WO2003068956A1 (en) 2003-08-21
JP4303596B2 (ja) 2009-07-29
DK1481059T3 (da) 2009-01-12
US7977068B2 (en) 2011-07-12
EP2060628A1 (de) 2009-05-20
JP5190963B2 (ja) 2013-04-24
US7396661B2 (en) 2008-07-08
JP2005517407A (ja) 2005-06-16
US20030162249A1 (en) 2003-08-28
US7094579B2 (en) 2006-08-22

Similar Documents

Publication Publication Date Title
ATE533845T1 (de) Eukaryotische signalsequenzen zur polypeptid- expression und polypeptid-anzeigebibliotheken
DE60325892D1 (de) Stellungs- und verwendungsverfahren
CY1116863T1 (el) Πρωτεϊνη δεσμευσης υποδοχεα nogo
IL161016A (en) Polypeptides capable of ang-2 binding
ATE451390T1 (de) Polypeptide zur bindung an das b-lymphozyten- stimulatorische protein (blys)
TW200611910A (en) Interferon-alpha polypeptides and conjugates
WO2004066958A3 (en) Caspase-9:bir3 domain of xiap complexes and methods of use
CY1114526T1 (el) Κατασταλτικες πρωτεϊνες μιας πρωτεασης (protease) και χρησεις αυτων
DE60310385D1 (de) Sekretion von proteinen mit mehreren disulfidbindungen in bakterien und verwendungen davon
WO2002066653A3 (en) Procaryotic libraries and uses
ATE327328T1 (de) Adipozyten-spezifische protein homologe
ATE412745T1 (de) Antiangiogene peptide vom n-terminus von endostatin
ATE323763T1 (de) Dna & protein bindende miniatur proteine
ATE550345T1 (de) Sfrp, mit sfrp-interagierende peptidmotive sowie verwendungsverfahren
WO2000058465A3 (en) Flint polypeptide analogs
ATE442444T1 (de) Glykosylphosphatidylinositolhaltige polypeptide
WO2002059282A3 (en) Adipocyte complement related protein zacrp13
DE60221273D1 (de) Verfahren zur steigerung der expression von menschlichen tnf-rezeptor
DK2186898T3 (da) Blomstrings-induktion
MY142798A (en) Methods for preventing glyconoylation of proteins
WO2002044373A3 (en) Adipocyte complement related protein zacrp12
ATE417105T1 (de) Spleissvariante des kopftrauma induzierten zytoplasmatischen calcium-bindenden proteins
WO2002070704A3 (en) Adipocyte complement related protein zacrp11
WO2005058229A3 (en) Antiviral proteins with improved properties and methods therefor