DE60113381D1 - Automatisierung im proteinentwurf durch proteinbibliotheken - Google Patents
Automatisierung im proteinentwurf durch proteinbibliothekenInfo
- Publication number
- DE60113381D1 DE60113381D1 DE60113381T DE60113381T DE60113381D1 DE 60113381 D1 DE60113381 D1 DE 60113381D1 DE 60113381 T DE60113381 T DE 60113381T DE 60113381 T DE60113381 T DE 60113381T DE 60113381 D1 DE60113381 D1 DE 60113381D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- libraries
- automation
- dice
- pda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18163000P | 2000-02-10 | 2000-02-10 | |
US181630P | 2000-02-10 | ||
US18690400P | 2000-03-03 | 2000-03-03 | |
US186904P | 2000-03-03 | ||
US19785100P | 2000-04-14 | 2000-04-14 | |
US197851P | 2000-04-14 | ||
PCT/US2001/040091 WO2001059066A2 (en) | 2000-02-10 | 2001-02-12 | Protein design automation for protein libraries |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60113381D1 true DE60113381D1 (de) | 2005-10-20 |
DE60113381T2 DE60113381T2 (de) | 2006-06-29 |
Family
ID=27391439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60113381T Expired - Lifetime DE60113381T2 (de) | 2000-02-10 | 2001-02-12 | Automatisierung im proteinentwurf durch proteinbibliotheken |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1255826B1 (de) |
JP (1) | JP2003521933A (de) |
AT (1) | ATE304592T1 (de) |
AU (1) | AU5168701A (de) |
CA (1) | CA2399839A1 (de) |
DE (1) | DE60113381T2 (de) |
DK (1) | DK1255826T3 (de) |
WO (1) | WO2001059066A2 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0974111T3 (da) | 1997-04-11 | 2003-04-22 | California Inst Of Techn | Apparat og metode til automatiseret design af proteiner |
US20020048772A1 (en) | 2000-02-10 | 2002-04-25 | Dahiyat Bassil I. | Protein design automation for protein libraries |
US6946265B1 (en) | 1999-05-12 | 2005-09-20 | Xencor, Inc. | Nucleic acids and proteins with growth hormone activity |
US7662367B2 (en) | 2000-03-02 | 2010-02-16 | Xencor, Inc. | Pharmaceutical compositions for the treatment of TNF-α related disorders |
US7687461B2 (en) | 2000-03-02 | 2010-03-30 | Xencor, Inc. | Treatment of TNF-α related disorders with TNF-α variant proteins |
US7244823B2 (en) | 2000-03-02 | 2007-07-17 | Xencor | TNF-alpha variants proteins for the treatment of TNF-alpha related disorders |
US7446174B2 (en) | 2001-03-02 | 2008-11-04 | Xencor, Inc. | Protein based TNF-α variants for the treatment of TNF-α related disorders |
US7351690B2 (en) | 2000-12-19 | 2008-04-01 | Palatin Technologies, Inc. | Knockout identification of target-specific sites in peptides |
CA2447407A1 (en) | 2001-05-04 | 2002-11-14 | Xencor | Nucleic acids and proteins with thioredoxin reductase activity |
US7381792B2 (en) | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein |
US7662925B2 (en) | 2002-03-01 | 2010-02-16 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
DK2390803T3 (da) * | 2002-03-01 | 2014-01-27 | Codexis Mayflower Holdings Llc | Fremgangsmåder, systemer og software til identificering af funktionelle biomolekyler |
US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
EP1535235A1 (de) * | 2002-05-28 | 2005-06-01 | The Trustees of The University of Pennsylvania | Verfahren, systeme und computerprogrammprodukte zur rechnerischen analyse und den entwurf von amphiphilischen polymeren |
DE10233047A1 (de) * | 2002-07-19 | 2004-02-26 | Amaxa Gmbh | Verfahren zur Herstellung eines künstlichen Polypeptids und nach diesem Verfahren hergestelltes künstliches Protein |
US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
US7587286B2 (en) | 2003-03-31 | 2009-09-08 | Xencor, Inc. | Methods for rational pegylation of proteins |
US7642340B2 (en) | 2003-03-31 | 2010-01-05 | Xencor, Inc. | PEGylated TNF-α variant proteins |
US7610156B2 (en) | 2003-03-31 | 2009-10-27 | Xencor, Inc. | Methods for rational pegylation of proteins |
US9051373B2 (en) | 2003-05-02 | 2015-06-09 | Xencor, Inc. | Optimized Fc variants |
US8101720B2 (en) | 2004-10-21 | 2012-01-24 | Xencor, Inc. | Immunoglobulin insertions, deletions and substitutions |
US9714282B2 (en) | 2003-09-26 | 2017-07-25 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
JP2007512846A (ja) | 2003-12-04 | 2007-05-24 | ゼンコー・インコーポレイテッド | 増加した宿主ストリング含有量を有する変異体タンパク質の生成方法およびその組成物 |
US20150010550A1 (en) | 2004-07-15 | 2015-01-08 | Xencor, Inc. | OPTIMIZED Fc VARIANTS |
DK2325207T3 (en) | 2004-11-12 | 2017-06-06 | Xencor Inc | Fc variants with altered binding to FcRn |
US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
ATE534662T1 (de) * | 2005-01-03 | 2011-12-15 | Hoffmann La Roche | Methode zur identifizierung einer nukeinsäure kodierend für eine hemopexin-ähnliche struktur mit spezifischer bindung zu einem vorgegebenen molekul |
WO2007041635A2 (en) | 2005-10-03 | 2007-04-12 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
EP1951757B1 (de) | 2005-10-06 | 2014-05-14 | Xencor, Inc. | Optimierte anti-cd30-antikörper |
ME01786B (me) | 2006-08-14 | 2014-09-20 | Xencor Inc | Optimizovana antitela usmerena na cd19 |
CA2660795C (en) | 2006-09-18 | 2014-11-18 | Xencor, Inc. | Optimized antibodies that target hm1.24 |
US20090118130A1 (en) | 2007-02-12 | 2009-05-07 | Codexis, Inc. | Structure-activity relationships |
CA2693053C (en) | 2007-05-30 | 2021-01-05 | Xencor, Inc. | Methods and compositions for inhibiting cd32b expressing cells |
US20130338038A1 (en) | 2007-12-21 | 2013-12-19 | Pdl Biopharma, Inc. | Method of screening complex protein libraries to identify altered properties |
EP3825329A1 (de) | 2007-12-26 | 2021-05-26 | Xencor, Inc. | Fc-varianten mit veränderter bindung zu fcrn |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
KR20130000369A (ko) * | 2009-09-25 | 2013-01-02 | 오리진 테크놀로지스 인코포레이티드 | 단백질 어레이 및 이의 용도 |
WO2011091078A2 (en) | 2010-01-19 | 2011-07-28 | Xencor, Inc. | Antibody fc variants with enhanced complement activity |
DK3468997T3 (da) | 2016-06-08 | 2023-10-02 | Xencor Inc | Behandling af IgG4-relaterede sygdomme med anti-CD9-antistoffer med tværbinding til CD32B |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
GB9701425D0 (en) * | 1997-01-24 | 1997-03-12 | Bioinvent Int Ab | A method for in vitro molecular evolution of protein function |
DK0974111T3 (da) * | 1997-04-11 | 2003-04-22 | California Inst Of Techn | Apparat og metode til automatiseret design af proteiner |
AU8886798A (en) * | 1997-08-28 | 1999-03-22 | Isao Karube | Method for detecting highly functional polypeptides or nucleic acids |
AU774334B2 (en) * | 1998-10-16 | 2004-06-24 | Xencor | Protein design automation for protein libraries |
-
2001
- 2001-02-12 CA CA002399839A patent/CA2399839A1/en not_active Abandoned
- 2001-02-12 AT AT01925092T patent/ATE304592T1/de not_active IP Right Cessation
- 2001-02-12 WO PCT/US2001/040091 patent/WO2001059066A2/en active IP Right Grant
- 2001-02-12 DK DK01925092T patent/DK1255826T3/da active
- 2001-02-12 AU AU51687/01A patent/AU5168701A/en not_active Abandoned
- 2001-02-12 EP EP01925092A patent/EP1255826B1/de not_active Expired - Lifetime
- 2001-02-12 JP JP2001558206A patent/JP2003521933A/ja active Pending
- 2001-02-12 DE DE60113381T patent/DE60113381T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1255826A2 (de) | 2002-11-13 |
CA2399839A1 (en) | 2001-08-16 |
JP2003521933A (ja) | 2003-07-22 |
WO2001059066A2 (en) | 2001-08-16 |
DE60113381T2 (de) | 2006-06-29 |
WO2001059066A3 (en) | 2002-04-11 |
AU5168701A (en) | 2001-08-20 |
DK1255826T3 (da) | 2006-01-30 |
ATE304592T1 (de) | 2005-09-15 |
EP1255826B1 (de) | 2005-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |