DE60113381D1 - Automatisierung im proteinentwurf durch proteinbibliotheken - Google Patents

Automatisierung im proteinentwurf durch proteinbibliotheken

Info

Publication number
DE60113381D1
DE60113381D1 DE60113381T DE60113381T DE60113381D1 DE 60113381 D1 DE60113381 D1 DE 60113381D1 DE 60113381 T DE60113381 T DE 60113381T DE 60113381 T DE60113381 T DE 60113381T DE 60113381 D1 DE60113381 D1 DE 60113381D1
Authority
DE
Germany
Prior art keywords
protein
libraries
automation
dice
pda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60113381T
Other languages
English (en)
Other versions
DE60113381T2 (de
Inventor
I Dahiyat
Robert J Hayes
Joeerg Bentzien
Klaus M Fiebig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Application granted granted Critical
Publication of DE60113381D1 publication Critical patent/DE60113381D1/de
Publication of DE60113381T2 publication Critical patent/DE60113381T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60113381T 2000-02-10 2001-02-12 Automatisierung im proteinentwurf durch proteinbibliotheken Expired - Lifetime DE60113381T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18163000P 2000-02-10 2000-02-10
US181630P 2000-02-10
US18690400P 2000-03-03 2000-03-03
US186904P 2000-03-03
US19785100P 2000-04-14 2000-04-14
US197851P 2000-04-14
PCT/US2001/040091 WO2001059066A2 (en) 2000-02-10 2001-02-12 Protein design automation for protein libraries

Publications (2)

Publication Number Publication Date
DE60113381D1 true DE60113381D1 (de) 2005-10-20
DE60113381T2 DE60113381T2 (de) 2006-06-29

Family

ID=27391439

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60113381T Expired - Lifetime DE60113381T2 (de) 2000-02-10 2001-02-12 Automatisierung im proteinentwurf durch proteinbibliotheken

Country Status (8)

Country Link
EP (1) EP1255826B1 (de)
JP (1) JP2003521933A (de)
AT (1) ATE304592T1 (de)
AU (1) AU5168701A (de)
CA (1) CA2399839A1 (de)
DE (1) DE60113381T2 (de)
DK (1) DK1255826T3 (de)
WO (1) WO2001059066A2 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6188965B1 (en) 1997-04-11 2001-02-13 California Institute Of Technology Apparatus and method for automated protein design
US20020048772A1 (en) 2000-02-10 2002-04-25 Dahiyat Bassil I. Protein design automation for protein libraries
US6946265B1 (en) 1999-05-12 2005-09-20 Xencor, Inc. Nucleic acids and proteins with growth hormone activity
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7244823B2 (en) 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7687461B2 (en) 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US7351690B2 (en) 2000-12-19 2008-04-01 Palatin Technologies, Inc. Knockout identification of target-specific sites in peptides
WO2002090300A2 (en) 2001-05-04 2002-11-14 Xencor Nucleic acids and proteins with thioredoxin reductase activity
US7381792B2 (en) 2002-01-04 2008-06-03 Xencor, Inc. Variants of RANKL protein
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
DK2278509T3 (en) 2002-03-01 2014-12-15 Codexis Mayflower Holdings Llc Methods, systems and software for identification of functional biomolecules
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US8093357B2 (en) 2002-03-01 2012-01-10 Xencor, Inc. Optimized Fc variants and methods for their generation
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7657380B2 (en) 2003-12-04 2010-02-02 Xencor, Inc. Methods of generating variant antibodies with increased host string content
US7590517B2 (en) * 2002-05-28 2009-09-15 The Trustees Of The University Of Pennsylvania Methods, systems, and computer program products for computational analysis and design of amphiphilic polymers
DE10233047A1 (de) * 2002-07-19 2004-02-26 Amaxa Gmbh Verfahren zur Herstellung eines künstlichen Polypeptids und nach diesem Verfahren hergestelltes künstliches Protein
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
US7642340B2 (en) 2003-03-31 2010-01-05 Xencor, Inc. PEGylated TNF-α variant proteins
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
CA2520875A1 (en) 2003-03-31 2004-10-21 Xencor, Inc. Methods for rational pegylation of proteins
US9051373B2 (en) 2003-05-02 2015-06-09 Xencor, Inc. Optimized Fc variants
US8101720B2 (en) 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
US20150010550A1 (en) 2004-07-15 2015-01-08 Xencor, Inc. OPTIMIZED Fc VARIANTS
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
EP2332985A3 (de) 2004-11-12 2012-01-25 Xencor, Inc. Fc-Varianten mit modifizierter Bindung an fcrn
CN101098887B (zh) * 2005-01-03 2011-05-04 弗·哈夫曼-拉罗切有限公司 作为多肽支架的血红素结合蛋白样结构
EP1931709B1 (de) 2005-10-03 2016-12-07 Xencor, Inc. Fc-varianten mit optimierten rezeptorbindungseigenschaften
CA2625998C (en) 2005-10-06 2015-12-01 Xencor, Inc. Optimized anti-cd30 antibodies
WO2008022152A2 (en) 2006-08-14 2008-02-21 Xencor, Inc. Optimized antibodies that target cd19
AU2007299843B2 (en) 2006-09-18 2012-03-08 Xencor, Inc Optimized antibodies that target HM1.24
US20090118130A1 (en) 2007-02-12 2009-05-07 Codexis, Inc. Structure-activity relationships
EP3392273A1 (de) 2007-05-30 2018-10-24 Xencor, Inc. Verfahren und zusammensetzungen zur hemmung von cd32b-expressionszellen
US8633139B2 (en) 2007-12-21 2014-01-21 Abbvie Biotherapeutics Inc. Methods of screening complex protein libraries to identify altered properties
SI2235059T1 (sl) 2007-12-26 2015-06-30 Xencor, Inc. Fc variante s spremenjeno vezjo na fcrn
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
KR20130000369A (ko) * 2009-09-25 2013-01-02 오리진 테크놀로지스 인코포레이티드 단백질 어레이 및 이의 용도
US8362210B2 (en) 2010-01-19 2013-01-29 Xencor, Inc. Antibody variants with enhanced complement activity
HUE064454T2 (hu) 2016-06-08 2024-03-28 Xencor Inc IgG4-gyel kapcsolatos betegségek kezelése CD32B-vel keresztkötõ, CD-19 elleni ellenanyagokkal

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
GB9701425D0 (en) * 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US6188965B1 (en) * 1997-04-11 2001-02-13 California Institute Of Technology Apparatus and method for automated protein design
WO1999011818A1 (fr) * 1997-08-28 1999-03-11 Isao Karube Procede de detection d'acides nucleiques ou de polypeptides hautement fonctionnels
JP2003527072A (ja) * 1998-10-16 2003-09-16 ゼンコー 蛋白質ライブラリーに関する蛋白質設計オートメーション

Also Published As

Publication number Publication date
DE60113381T2 (de) 2006-06-29
WO2001059066A2 (en) 2001-08-16
JP2003521933A (ja) 2003-07-22
DK1255826T3 (da) 2006-01-30
WO2001059066A3 (en) 2002-04-11
CA2399839A1 (en) 2001-08-16
AU5168701A (en) 2001-08-20
ATE304592T1 (de) 2005-09-15
EP1255826A2 (de) 2002-11-13
EP1255826B1 (de) 2005-09-14

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