AP587A - New erythromycin derivatives, their preparation process and their use as medicaments. - Google Patents

New erythromycin derivatives, their preparation process and their use as medicaments. Download PDF

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Publication number
AP587A
AP587A APAP/P/1995/000743A AP9500743A AP587A AP 587 A AP587 A AP 587A AP 9500743 A AP9500743 A AP 9500743A AP 587 A AP587 A AP 587A
Authority
AP
ARIPO
Prior art keywords
formula
compounds
methyl
radical
dideoxy
Prior art date
Application number
APAP/P/1995/000743A
Other languages
English (en)
Other versions
AP9500743A0 (en
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francis Chantot (Deceased)
Alexis Denis
Martret Odile Le
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AP9500743A0 publication Critical patent/AP9500743A0/xx
Application granted granted Critical
Publication of AP587A publication Critical patent/AP587A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
APAP/P/1995/000743A 1994-04-08 1995-03-17 New erythromycin derivatives, their preparation process and their use as medicaments. AP587A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (2)

Publication Number Publication Date
AP9500743A0 AP9500743A0 (en) 1995-07-31
AP587A true AP587A (en) 1997-04-29

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1995/000743A AP587A (en) 1994-04-08 1995-03-17 New erythromycin derivatives, their preparation process and their use as medicaments.

Country Status (49)

Country Link
US (2) US5656607A (ja)
EP (1) EP0676409B1 (ja)
JP (1) JP3000023B2 (ja)
KR (1) KR100317148B1 (ja)
CN (1) CN1059445C (ja)
AP (1) AP587A (ja)
AT (1) ATE234853T1 (ja)
AU (1) AU684939B2 (ja)
BG (1) BG61916B1 (ja)
BR (1) BR9506147A (ja)
CA (1) CA2164638C (ja)
CO (1) CO4370097A1 (ja)
CZ (1) CZ296005B6 (ja)
DE (1) DE69529934T2 (ja)
DK (1) DK0676409T3 (ja)
DZ (1) DZ1869A1 (ja)
EE (1) EE04498B1 (ja)
ES (1) ES2189820T3 (ja)
FI (1) FI111264B (ja)
FR (1) FR2718450B1 (ja)
GB (1) GB2288174A (ja)
GE (1) GEP19991836B (ja)
HR (1) HRP950217B1 (ja)
HU (1) HU215396B (ja)
IL (1) IL112954A (ja)
IS (1) IS1865B (ja)
JO (1) JO1850B1 (ja)
LV (1) LV11182B (ja)
MA (1) MA23501A1 (ja)
MD (1) MD663G2 (ja)
MY (1) MY114672A (ja)
NO (1) NO308361B1 (ja)
NZ (1) NZ284498A (ja)
OA (1) OA10200A (ja)
PE (1) PE2896A1 (ja)
PL (1) PL180837B1 (ja)
PT (1) PT676409E (ja)
RO (1) RO115634B1 (ja)
RU (1) RU2141965C1 (ja)
SA (1) SA97170757A (ja)
SI (1) SI0676409T1 (ja)
SK (1) SK284079B6 (ja)
SV (1) SV1995000018A (ja)
TN (1) TNSN95026A1 (ja)
TW (1) TW316908B (ja)
UA (1) UA44705C2 (ja)
WO (1) WO1995027720A1 (ja)
YU (1) YU49221B (ja)
ZA (1) ZA952059B (ja)

Families Citing this family (49)

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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
DK0922050T3 (da) * 1996-05-07 2003-11-24 Abbott Lab 3-Descladinose-2,3-anhydroerythromycin-derivater
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
IL128681A0 (en) * 1996-09-04 2000-01-31 Abbott Lab 6-O substituted ketolides having antibacterial activity
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
IL132767A0 (en) * 1997-06-11 2001-03-19 Pfizer Prod Inc 9-Oxime erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
EP1115732B1 (en) * 1998-09-22 2005-06-29 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
KR100710605B1 (ko) * 1999-04-16 2007-04-24 코산 바이오사이언시즈, 인코포레이티드 매크롤라이드 항감염제
US6399582B1 (en) 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AU3832100A (en) * 1999-05-24 2000-12-12 Pfizer Products Inc. 13-methyl-erythromycin derivatives
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
MXPA04012978A (es) 2002-07-01 2005-09-12 Arkion Life Sciences Llc D B A Proceso y material para la produccion de glucosamina y n-acetilglucosamina.
CA2801100A1 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
JP2006524702A (ja) * 2003-04-25 2006-11-02 カイロン コーポレイション ピリジル置換ケトライド抗体
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
EP2550286B1 (en) 2010-03-22 2015-12-09 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
PL2571506T3 (pl) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
IN2014DN08939A (ja) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
MX2015014026A (es) 2013-04-04 2016-08-03 Harvard College Macrolidos y metodos para su preparacion y uso.
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Family Cites Families (7)

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US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
NZ284498A (en) 1997-07-27
CA2164638C (fr) 2003-12-30
YU49221B (sh) 2004-11-25
SI0676409T1 (en) 2003-06-30
DK0676409T3 (da) 2003-06-23
LV11182B (en) 1997-04-20
IS1865B (is) 2003-05-02
PL311871A1 (en) 1996-03-18
IL112954A0 (en) 1995-06-29
NO308361B1 (no) 2000-09-04
WO1995027720A1 (fr) 1995-10-19
ZA952059B (en) 1996-03-13
CZ296005B6 (cs) 2005-12-14
CN1126997A (zh) 1996-07-17
FI955913A0 (fi) 1995-12-08
RU2141965C1 (ru) 1999-11-27
UA44705C2 (uk) 2002-03-15
MD663F1 (ro) 1997-01-31
IL112954A (en) 2000-07-16
NO954942D0 (no) 1995-12-06
TW316908B (ja) 1997-10-01
FR2718450B1 (fr) 1997-01-10
HRP950217A2 (en) 1997-08-31
HU9503505D0 (en) 1996-02-28
BG100150A (bg) 1996-06-28
MA23501A1 (fr) 1995-12-31
GB2288174A (en) 1995-10-11
RO115634B1 (ro) 2000-04-28
NO954942L (no) 1996-02-07
YU21695A (sh) 1997-12-05
AP9500743A0 (en) 1995-07-31
GB9506856D0 (en) 1995-05-24
ES2189820T3 (es) 2003-07-16
DE69529934T2 (de) 2003-09-04
OA10200A (fr) 1996-12-18
CN1059445C (zh) 2000-12-13
HU215396B (hu) 1998-12-28
PT676409E (pt) 2003-08-29
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
GEP19991836B (en) 1999-11-05
AU2310795A (en) 1995-10-30
TNSN95026A1 (fr) 1996-02-06
MD663G2 (ro) 1997-07-31
LV11182A (lv) 1996-04-20
JP3000023B2 (ja) 2000-01-17
CA2164638A1 (fr) 1995-10-19
PL180837B1 (pl) 2001-04-30
US5760233A (en) 1998-06-02
IS4309A (is) 1995-11-17
KR100317148B1 (ko) 2002-06-22
DZ1869A1 (fr) 2002-02-17
SK284079B6 (sk) 2004-09-08
FI111264B (fi) 2003-06-30
PE2896A1 (es) 1996-02-12
DE69529934D1 (de) 2003-04-24
BR9506147A (pt) 1996-04-16
EE9500080A (et) 1996-12-16
EE04498B1 (et) 2005-06-15
SA97170757A (ar) 2005-12-03
MY114672A (en) 2002-12-31
HRP950217B1 (en) 2004-06-30
CO4370097A1 (es) 1996-10-07
CZ322395A3 (en) 1996-08-14
SV1995000018A (es) 1997-10-24
SK154695A3 (en) 1996-10-02
FR2718450A1 (fr) 1995-10-13
EP0676409A1 (fr) 1995-10-11
US5656607A (en) 1997-08-12
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
BG61916B1 (bg) 1998-09-30
AU684939B2 (en) 1998-01-08
FI955913A (fi) 1995-12-08
JPH07278177A (ja) 1995-10-24

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