AP480A - 3-Substituted indole 2-carboxylic acid derivatives. - Google Patents

3-Substituted indole 2-carboxylic acid derivatives. Download PDF

Info

Publication number
AP480A
AP480A APAP/P/1993/000524A AP9300524A AP480A AP 480 A AP480 A AP 480A AP 9300524 A AP9300524 A AP 9300524A AP 480 A AP480 A AP 480A
Authority
AP
ARIPO
Prior art keywords
compound
group
dichloroindole
formula
ethenyl
Prior art date
Application number
APAP/P/1993/000524A
Other languages
English (en)
Other versions
AP9300524A0 (en
Inventor
Alfredo Cugola
Giovannie Gaviraghi
Simone Giacobbe
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of AP9300524A0 publication Critical patent/AP9300524A0/xx
Application granted granted Critical
Publication of AP480A publication Critical patent/AP480A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
APAP/P/1993/000524A 1992-04-16 1993-04-16 3-Substituted indole 2-carboxylic acid derivatives. AP480A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
AP9300524A0 AP9300524A0 (en) 1993-04-30
AP480A true AP480A (en) 1996-03-22

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1993/000524A AP480A (en) 1992-04-16 1993-04-16 3-Substituted indole 2-carboxylic acid derivatives.

Country Status (41)

Country Link
US (4) US5374649A (forum.php)
EP (1) EP0568136A1 (forum.php)
JP (2) JPH0649027A (forum.php)
KR (1) KR100264114B1 (forum.php)
CN (1) CN1042331C (forum.php)
AP (1) AP480A (forum.php)
AT (1) AT403917B (forum.php)
AU (1) AU666927B2 (forum.php)
BE (1) BE1006343A5 (forum.php)
BG (1) BG62136B1 (forum.php)
BR (1) BR1100323A (forum.php)
CA (3) CA2094073A1 (forum.php)
CH (1) CH685630A5 (forum.php)
CY (1) CY2038B1 (forum.php)
CZ (1) CZ285799B6 (forum.php)
DK (1) DK169890B1 (forum.php)
ES (1) ES2105924B1 (forum.php)
FI (1) FI106198B (forum.php)
FR (1) FR2690919B1 (forum.php)
GB (2) GB9208492D0 (forum.php)
GE (1) GEP19991704B (forum.php)
GR (1) GR1001619B (forum.php)
HK (1) HK95797A (forum.php)
HU (2) HU217964B (forum.php)
IL (1) IL105412A (forum.php)
IS (1) IS3994A (forum.php)
IT (1) IT1265325B1 (forum.php)
LU (1) LU88248A1 (forum.php)
MX (1) MX9302195A (forum.php)
MY (1) MY112232A (forum.php)
NO (1) NO301879B1 (forum.php)
NZ (1) NZ247413A (forum.php)
OA (1) OA10103A (forum.php)
PL (1) PL176451B1 (forum.php)
RO (1) RO113242B1 (forum.php)
RU (1) RU2129544C1 (forum.php)
SE (1) SE504336C2 (forum.php)
SK (1) SK281941B6 (forum.php)
TW (1) TW224457B (forum.php)
WO (1) WO1993021153A1 (forum.php)
ZA (1) ZA932642B (forum.php)

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KR100314482B1 (ko) * 1993-05-27 2002-02-28 메렐 파마슈티칼스 인크. 3-(인돌-3-일)프로페노산유도체
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (forum.php) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
ATE309215T1 (de) * 1996-09-30 2005-11-15 Aventis Pharma Inc Nmda (n-methyl-d-aspartate) antagonists
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
DE69918074T2 (de) * 1998-03-26 2004-11-04 Fujisawa Pharmaceutical Co., Ltd. Makrolid-formulierung mit verzögerter wirkstoffabgabe
CN1247578C (zh) * 2000-07-31 2006-03-29 大日本住友制药株式会社 含有2－芳基－8－氧化二氢嘌呤衍生物作为活性成分的痴呆症治疗剂
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
MXPA04005427A (es) * 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
BRPI0410936A (pt) * 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
BRPI0416989A (pt) * 2003-11-26 2007-02-06 Pfizer Prod Inc derivados aminopirazole como inibidores gsk-3
BRPI0418244A (pt) * 2003-12-29 2007-04-17 Sepracor Inc composto, métodos para aumentar a concentração de d-serina e/ou diminuir a concentração de produtos tóxicos da oxidação de d-serina pela daao em um mamìfero, para tratar a esquizofrenia, para tratar ou prevenir a perda de memória e/ou cognição associadas com o mal de alzheimer, para tratar a ataxia ou para prevenir a perda da função neuronal caracterìstica de doenças neurodegenerativas, para intensificar a aprendizagem, memória e/ou cognição e para tratar dor neuropática, e, composição farmacêutica
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
JP2009500425A (ja) 2005-07-06 2009-01-08 セプラコア インコーポレーテッド エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
CN104276955A (zh) 2006-01-06 2015-01-14 赛诺维信制药公司 基于四氢萘酮的单胺再摄取抑制剂
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
WO2007115185A2 (en) 2006-03-31 2007-10-11 Sepracor Inc. Preparation of chiral amides and amines
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP2010516697A (ja) 2007-01-18 2010-05-20 セプラコール インク． Ｄ−アミノ酸オキシダーゼ阻害剤
CA2688493C (en) 2007-05-31 2016-04-19 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US20090247644A1 (en) * 2008-03-28 2009-10-01 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
CA2755118A1 (en) * 2009-03-10 2010-09-16 Santen Pharmaceutical Co., Ltd. Preventive or therapeutic agents for optic nerve disorders comprising 4,6-dichloro-1h-indole-2-carboxylic acid derivatives or salts thereof as active ingredients
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
CN106687626B (zh) 2014-04-30 2021-01-26 宇凤·简·曾 作为d-氨基酸氧化酶抑制剂的已知化合物的用途
ES2974883T3 (es) 2016-09-14 2024-07-02 Yufeng Jane Tseng Nuevos derivados de benzimidazol sustituidos utilizados como inhibidores de la D-aminoácido oxidasa (DAAO)
KR102609676B1 (ko) 2017-06-12 2023-12-05 글리테크 엘엘씨. Nmda 길항제 및 d2/5ht2a 또는 선택적 5ht2a 길항제를 이용한 우울증의 치료
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
EP0396124A2 (en) * 1989-05-05 1990-11-07 G.D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders

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DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
CA2087091C (en) * 1990-07-16 2001-09-11 Francesco G. Salituro Excitatory amino acid antagonists
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
EP0396124A2 (en) * 1989-05-05 1990-11-07 G.D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders

Also Published As

Publication number Publication date
ES2105924A1 (es) 1997-10-16
EP0568136A1 (en) 1993-11-03
IL105412A (en) 1998-02-22
HU211826A9 (en) 1995-12-28
US5374648A (en) 1994-12-20
DK43193A (da) 1993-10-17
SK124194A3 (en) 1995-05-10
CA2094073A1 (en) 1993-10-17
CZ285799B6 (cs) 1999-11-17
KR100264114B1 (ko) 2000-11-01
FI944800A0 (fi) 1994-10-12
WO1993021153A1 (en) 1993-10-28
BG62136B1 (bg) 1999-03-31
CA2094075A1 (en) 1993-10-17
CN1085212A (zh) 1994-04-13
HK95797A (en) 1997-08-08
ES2105924B1 (es) 1998-07-01
FI106198B (fi) 2000-12-15
GB2266091A (en) 1993-10-20
MX9302195A (es) 1994-03-31
AU3692393A (en) 1993-10-21
HUT70526A (en) 1995-10-30
MY112232A (en) 2001-05-31
GB9208492D0 (en) 1992-06-03
US5374649A (en) 1994-12-20
OA10103A (en) 1996-12-18
ATA75293A (de) 1997-11-15
CZ254394A3 (en) 1995-07-12
AU666927B2 (en) 1996-02-29
SK281941B6 (sk) 2001-09-11
NO301879B1 (no) 1997-12-22
CH685630A5 (fr) 1995-08-31
DK43193D0 (da) 1993-04-15
IL105412A0 (en) 1993-08-18
IT1265325B1 (it) 1996-10-31
FI944800L (fi) 1994-10-12
HU217964B (hu) 2000-05-28
ITRM930236A0 (it) 1993-04-15
CN1042331C (zh) 1999-03-03
IS3994A (is) 1993-10-17
US5510367A (en) 1996-04-23
ITRM930236A1 (it) 1994-10-15
LU88248A1 (fr) 1994-03-01
RU2129544C1 (ru) 1999-04-27
HU9402975D0 (en) 1995-02-28
TW224457B (forum.php) 1994-06-01
BE1006343A5 (fr) 1994-07-26
US5373018A (en) 1994-12-13
AT403917B (de) 1998-06-25
RU94045915A (ru) 1996-09-10
RO113242B1 (ro) 1998-05-29
GR1001619B (el) 1994-07-29
NO943913L (no) 1994-12-14
JPH0649027A (ja) 1994-02-22
PL176451B1 (pl) 1999-05-31
SE9301241D0 (sv) 1993-04-15
CA2094076A1 (en) 1993-10-17
AP9300524A0 (en) 1993-04-30
JPH07505407A (ja) 1995-06-15
GB2266091B (en) 1995-08-09
CY2038B1 (en) 1998-04-30
NO943913D0 (no) 1994-10-14
GB9307808D0 (en) 1993-06-02
DK169890B1 (da) 1995-03-27
BR1100323A (pt) 2000-06-27
SE9301241L (sv) 1993-10-17
ZA932642B (en) 1994-01-10
FR2690919A1 (fr) 1993-11-12
GEP19991704B (en) 1999-08-05
BG99111A (bg) 1995-05-31
FR2690919B1 (fr) 1995-05-05
NZ247413A (en) 1995-12-21
SE504336C2 (sv) 1997-01-13

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