AU666927B2 - Indole derivatives - Google Patents

Indole derivatives Download PDF

Info

Publication number
AU666927B2
AU666927B2 AU36923/93A AU3692393A AU666927B2 AU 666927 B2 AU666927 B2 AU 666927B2 AU 36923/93 A AU36923/93 A AU 36923/93A AU 3692393 A AU3692393 A AU 3692393A AU 666927 B2 AU666927 B2 AU 666927B2
Authority
AU
Australia
Prior art keywords
group
compound
formula
ethenyl
dichloroindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU36923/93A
Other languages
English (en)
Other versions
AU3692393A (en
Inventor
Alfredo Cugola
Giovanni Gaviraghi
Simone Giacobbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo SpA filed Critical Glaxo SpA
Publication of AU3692393A publication Critical patent/AU3692393A/en
Application granted granted Critical
Publication of AU666927B2 publication Critical patent/AU666927B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AU36923/93A 1992-04-16 1993-04-15 Indole derivatives Ceased AU666927B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds
GB9208492 1992-04-16

Publications (2)

Publication Number Publication Date
AU3692393A AU3692393A (en) 1993-10-21
AU666927B2 true AU666927B2 (en) 1996-02-29

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36923/93A Ceased AU666927B2 (en) 1992-04-16 1993-04-15 Indole derivatives

Country Status (41)

Country Link
US (4) US5373018A (forum.php)
EP (1) EP0568136A1 (forum.php)
JP (2) JPH0649027A (forum.php)
KR (1) KR100264114B1 (forum.php)
CN (1) CN1042331C (forum.php)
AP (1) AP480A (forum.php)
AT (1) AT403917B (forum.php)
AU (1) AU666927B2 (forum.php)
BE (1) BE1006343A5 (forum.php)
BG (1) BG62136B1 (forum.php)
BR (1) BR1100323A (forum.php)
CA (3) CA2094076A1 (forum.php)
CH (1) CH685630A5 (forum.php)
CY (1) CY2038B1 (forum.php)
CZ (1) CZ285799B6 (forum.php)
DK (1) DK169890B1 (forum.php)
ES (1) ES2105924B1 (forum.php)
FI (1) FI106198B (forum.php)
FR (1) FR2690919B1 (forum.php)
GB (2) GB9208492D0 (forum.php)
GE (1) GEP19991704B (forum.php)
GR (1) GR1001619B (forum.php)
HK (1) HK95797A (forum.php)
HU (2) HU217964B (forum.php)
IL (1) IL105412A (forum.php)
IS (1) IS3994A (forum.php)
IT (1) IT1265325B1 (forum.php)
LU (1) LU88248A1 (forum.php)
MX (1) MX9302195A (forum.php)
MY (1) MY112232A (forum.php)
NO (1) NO301879B1 (forum.php)
NZ (1) NZ247413A (forum.php)
OA (1) OA10103A (forum.php)
PL (1) PL176451B1 (forum.php)
RO (1) RO113242B1 (forum.php)
RU (1) RU2129544C1 (forum.php)
SE (1) SE504336C2 (forum.php)
SK (1) SK281941B6 (forum.php)
TW (1) TW224457B (forum.php)
WO (1) WO1993021153A1 (forum.php)
ZA (1) ZA932642B (forum.php)

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WO1994027964A1 (en) * 1993-05-27 1994-12-08 Merrell Dow Pharmaceuticals Inc. 3-(indol-3-yl) propenoic acid derivatives and as nmda antagonists
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (forum.php) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
US6030968A (en) * 1996-09-17 2000-02-29 The Regents Of The University Of California Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
IL129187A0 (en) * 1996-09-30 2000-02-17 Hoechst Marion Roussel Inc NMDA (N-methyl-D-aspartate) antagonists
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
TW570814B (en) * 1998-03-26 2004-01-11 Fujisawa Pharmaceutical Co Sustained-release pharmaceutical composition
HUP0303714A3 (en) * 2000-07-31 2007-03-28 Dainippon Sumitomo Pharma Co Pharmaceutical compositions for dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
EP1463714A4 (en) * 2001-12-10 2005-10-19 Amgen Inc VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
MXPA05012895A (es) * 2003-06-05 2006-02-22 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa.
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
US7671072B2 (en) * 2003-11-26 2010-03-02 Pfizer Inc. Aminopyrazole derivatives as GSK-3 inhibitors
PL380887A1 (pl) * 2003-12-29 2007-04-02 Sepracor Inc. Pirolowe i pirazolowe inhibitory DAAO
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
AU2006264317B2 (en) 2005-07-06 2012-02-23 Sunovion Pharmaceuticals Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
KR101294014B1 (ko) 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
JP5438975B2 (ja) * 2006-01-06 2014-03-12 サノビオン ファーマシューティカルズ インク テトラロン系モノアミン再取り込み阻害剤
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
BRPI0806604A2 (pt) 2007-01-18 2011-09-06 Sepracor Inc inibidores de d-aminoácido oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
MX2009012685A (es) 2007-05-31 2009-12-14 Sepracor Inc Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110319463A1 (en) * 2009-03-10 2011-12-29 Saten Pharamaceuticals Co., Ltd. Preventive or therapeutic agents for optic nerve disorders comprising 4,6-dichloro-1h-indole-2-carboxylic acid derivatives or salts thereof as active ingredients
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
USRE49340E1 (en) 2014-04-30 2022-12-20 Yufeng Jane Tseng Use of known compounds as D-amino acid oxidase inhibitors
KR20240042153A (ko) 2016-09-14 2024-04-01 위펑 제인 쳉 D-아미노산 옥시다제 (daao) 저해제로서 신규한 치환된 벤즈이미다졸 유도체
BR112019026449A2 (pt) 2017-06-12 2020-08-11 Glytech Llc. composição e método para tratamento de depressão e psicose em humanos
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation

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US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
KR0178469B1 (ko) * 1990-07-16 1999-03-20 메이나드 알. 존슨 흥분성 아미노산 길항제
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Patent Citations (1)

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation

Also Published As

Publication number Publication date
HU211826A9 (en) 1995-12-28
GR1001619B (el) 1994-07-29
AP9300524A0 (en) 1993-04-30
FI944800A0 (fi) 1994-10-12
IT1265325B1 (it) 1996-10-31
CA2094076A1 (en) 1993-10-17
FR2690919A1 (fr) 1993-11-12
BG99111A (bg) 1995-05-31
ITRM930236A0 (it) 1993-04-15
US5510367A (en) 1996-04-23
FR2690919B1 (fr) 1995-05-05
AP480A (en) 1996-03-22
SK281941B6 (sk) 2001-09-11
GB9307808D0 (en) 1993-06-02
DK169890B1 (da) 1995-03-27
JPH0649027A (ja) 1994-02-22
GEP19991704B (en) 1999-08-05
MY112232A (en) 2001-05-31
NO943913D0 (no) 1994-10-14
IL105412A (en) 1998-02-22
KR100264114B1 (ko) 2000-11-01
DK43193D0 (da) 1993-04-15
EP0568136A1 (en) 1993-11-03
TW224457B (forum.php) 1994-06-01
AU3692393A (en) 1993-10-21
CN1042331C (zh) 1999-03-03
SK124194A3 (en) 1995-05-10
FI106198B (fi) 2000-12-15
GB2266091A (en) 1993-10-20
RU2129544C1 (ru) 1999-04-27
BE1006343A5 (fr) 1994-07-26
LU88248A1 (fr) 1994-03-01
HU217964B (hu) 2000-05-28
SE9301241L (sv) 1993-10-17
IS3994A (is) 1993-10-17
ZA932642B (en) 1994-01-10
PL176451B1 (pl) 1999-05-31
AT403917B (de) 1998-06-25
US5374649A (en) 1994-12-20
SE504336C2 (sv) 1997-01-13
CN1085212A (zh) 1994-04-13
GB9208492D0 (en) 1992-06-03
HUT70526A (en) 1995-10-30
GB2266091B (en) 1995-08-09
US5374648A (en) 1994-12-20
MX9302195A (es) 1994-03-31
IL105412A0 (en) 1993-08-18
JPH07505407A (ja) 1995-06-15
CZ254394A3 (en) 1995-07-12
CZ285799B6 (cs) 1999-11-17
OA10103A (en) 1996-12-18
DK43193A (da) 1993-10-17
RO113242B1 (ro) 1998-05-29
WO1993021153A1 (en) 1993-10-28
ATA75293A (de) 1997-11-15
CY2038B1 (en) 1998-04-30
BG62136B1 (bg) 1999-03-31
ES2105924A1 (es) 1997-10-16
US5373018A (en) 1994-12-13
ES2105924B1 (es) 1998-07-01
NZ247413A (en) 1995-12-21
RU94045915A (ru) 1996-09-10
BR1100323A (pt) 2000-06-27
NO943913L (no) 1994-12-14
CA2094073A1 (en) 1993-10-17
HK95797A (en) 1997-08-08
ITRM930236A1 (it) 1994-10-15
CA2094075A1 (en) 1993-10-17
CH685630A5 (fr) 1995-08-31
NO301879B1 (no) 1997-12-22
SE9301241D0 (sv) 1993-04-15
HU9402975D0 (en) 1995-02-28
FI944800L (fi) 1994-10-12

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired