BG62136B1 - Индолови производни - Google Patents

Индолови производни Download PDF

Info

Publication number
BG62136B1
BG62136B1 BG99111A BG9911194A BG62136B1 BG 62136 B1 BG62136 B1 BG 62136B1 BG 99111 A BG99111 A BG 99111A BG 9911194 A BG9911194 A BG 9911194A BG 62136 B1 BG62136 B1 BG 62136B1
Authority
BG
Bulgaria
Prior art keywords
formula
ethenyl
dichloroindole
group
compound
Prior art date
Application number
BG99111A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99111A (bg
Inventor
Alfredo Cugola
Giovanni Gavira
Simone Giacobbe
Original Assignee
Glaxo S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo S.P.A. filed Critical Glaxo S.P.A.
Publication of BG99111A publication Critical patent/BG99111A/bg
Publication of BG62136B1 publication Critical patent/BG62136B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
BG99111A 1992-04-16 1994-10-14 Индолови производни BG62136B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds
PCT/EP1993/000938 WO1993021153A1 (en) 1992-04-16 1993-04-15 Indole-2-carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
BG99111A BG99111A (bg) 1995-05-31
BG62136B1 true BG62136B1 (bg) 1999-03-31

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99111A BG62136B1 (bg) 1992-04-16 1994-10-14 Индолови производни

Country Status (41)

Country Link
US (4) US5374648A (forum.php)
EP (1) EP0568136A1 (forum.php)
JP (2) JPH07505407A (forum.php)
KR (1) KR100264114B1 (forum.php)
CN (1) CN1042331C (forum.php)
AP (1) AP480A (forum.php)
AT (1) AT403917B (forum.php)
AU (1) AU666927B2 (forum.php)
BE (1) BE1006343A5 (forum.php)
BG (1) BG62136B1 (forum.php)
BR (1) BR1100323A (forum.php)
CA (3) CA2094075A1 (forum.php)
CH (1) CH685630A5 (forum.php)
CY (1) CY2038B1 (forum.php)
CZ (1) CZ285799B6 (forum.php)
DK (1) DK169890B1 (forum.php)
ES (1) ES2105924B1 (forum.php)
FI (1) FI106198B (forum.php)
FR (1) FR2690919B1 (forum.php)
GB (2) GB9208492D0 (forum.php)
GE (1) GEP19991704B (forum.php)
GR (1) GR1001619B (forum.php)
HK (1) HK95797A (forum.php)
HU (2) HU217964B (forum.php)
IL (1) IL105412A (forum.php)
IS (1) IS3994A (forum.php)
IT (1) IT1265325B1 (forum.php)
LU (1) LU88248A1 (forum.php)
MX (1) MX9302195A (forum.php)
MY (1) MY112232A (forum.php)
NO (1) NO301879B1 (forum.php)
NZ (1) NZ247413A (forum.php)
OA (1) OA10103A (forum.php)
PL (1) PL176451B1 (forum.php)
RO (1) RO113242B1 (forum.php)
RU (1) RU2129544C1 (forum.php)
SE (1) SE504336C2 (forum.php)
SK (1) SK281941B6 (forum.php)
TW (1) TW224457B (forum.php)
WO (1) WO1993021153A1 (forum.php)
ZA (1) ZA932642B (forum.php)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
ES2103590T3 (es) * 1993-05-27 1997-09-16 Merrell Pharma Inc Derivados del acido 3-(indol-3-il) propenoico utilizables como antagonistas nmda.
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (forum.php) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
KR20000048715A (ko) * 1996-09-30 2000-07-25 게리 디. 스트리트, 스티븐 엘. 네스비트 Ｎｍｄａ (ｎ-메틸-ｄ-아스파르테이트) 길항제
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
SK286887B6 (sk) * 1998-03-26 2009-07-06 Astellas Pharma Inc. Farmaceutický prostriedok makrolidovej zlúčeniny s pomalým uvoľňovaním
RU2277096C2 (ru) * 2000-07-31 2006-05-27 ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. Средства против слабоумия, содержащие производное 2-арил-8-оксодигидропурина в качестве активного ингредиента
WO2003039540A2 (en) * 2001-11-09 2003-05-15 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
WO2003049702A2 (en) * 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands and their use in treatments
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
CA2528065A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
ATE473967T1 (de) * 2003-11-26 2010-07-15 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
AU2004312530A1 (en) * 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
CA2614282A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
ES2566479T3 (es) * 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
DK2816024T3 (en) 2006-03-31 2017-10-30 Sunovion Pharmaceuticals Inc CHIRALE AMINER
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
ZA200904686B (en) 2007-01-18 2010-09-29 Sepracor Inc Inhibitiors of D-amino acid oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
AU2008259841B2 (en) 2007-05-31 2015-02-05 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2010104093A1 (ja) 2009-03-10 2010-09-16 参天製薬株式会社 ４，６－ジクロロ－１ｈ－インドール－２－カルボン酸誘導体又はその塩を有効成分として含有する視神経障害の予防又は治療剤
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
USRE49340E1 (en) 2014-04-30 2022-12-20 Yufeng Jane Tseng Use of known compounds as D-amino acid oxidase inhibitors
JP7029129B2 (ja) 2016-09-14 2022-03-03 ユーフェン ジェーン ツェン Ｄ－アミノ酸オキシダーゼ（ｄａａｏ）阻害剤としての新規な置換ベンゾイミダゾール誘導体
JP7305560B2 (ja) 2017-06-12 2023-07-10 グリテック， エルエルシー Ｎｍｄａアンタゴニスト及びｄ２／５ｈｔ２ａ又は選択的５ｈｔ２ａアンタゴニストによるうつ病の治療
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
WO1992001670A1 (en) * 1990-07-16 1992-02-06 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
GB9307808D0 (en) 1993-06-02
RO113242B1 (ro) 1998-05-29
HU217964B (hu) 2000-05-28
IS3994A (is) 1993-10-17
SK124194A3 (en) 1995-05-10
US5510367A (en) 1996-04-23
US5373018A (en) 1994-12-13
SE504336C2 (sv) 1997-01-13
ITRM930236A0 (it) 1993-04-15
KR100264114B1 (ko) 2000-11-01
ZA932642B (en) 1994-01-10
SE9301241D0 (sv) 1993-04-15
NO943913D0 (no) 1994-10-14
GB9208492D0 (en) 1992-06-03
IL105412A (en) 1998-02-22
IL105412A0 (en) 1993-08-18
CN1042331C (zh) 1999-03-03
LU88248A1 (fr) 1994-03-01
FR2690919A1 (fr) 1993-11-12
CA2094076A1 (en) 1993-10-17
MY112232A (en) 2001-05-31
MX9302195A (es) 1994-03-31
DK43193D0 (da) 1993-04-15
AP9300524A0 (en) 1993-04-30
GB2266091A (en) 1993-10-20
NZ247413A (en) 1995-12-21
DK43193A (da) 1993-10-17
AU3692393A (en) 1993-10-21
US5374648A (en) 1994-12-20
CA2094073A1 (en) 1993-10-17
CA2094075A1 (en) 1993-10-17
FR2690919B1 (fr) 1995-05-05
HU211826A9 (en) 1995-12-28
BE1006343A5 (fr) 1994-07-26
GEP19991704B (en) 1999-08-05
FI944800A0 (fi) 1994-10-12
JPH07505407A (ja) 1995-06-15
IT1265325B1 (it) 1996-10-31
SE9301241L (sv) 1993-10-17
GR1001619B (el) 1994-07-29
AT403917B (de) 1998-06-25
RU2129544C1 (ru) 1999-04-27
CY2038B1 (en) 1998-04-30
US5374649A (en) 1994-12-20
PL176451B1 (pl) 1999-05-31
CZ254394A3 (en) 1995-07-12
CZ285799B6 (cs) 1999-11-17
JPH0649027A (ja) 1994-02-22
EP0568136A1 (en) 1993-11-03
DK169890B1 (da) 1995-03-27
ATA75293A (de) 1997-11-15
NO301879B1 (no) 1997-12-22
AU666927B2 (en) 1996-02-29
ES2105924A1 (es) 1997-10-16
CH685630A5 (fr) 1995-08-31
GB2266091B (en) 1995-08-09
CN1085212A (zh) 1994-04-13
NO943913L (no) 1994-12-14
HU9402975D0 (en) 1995-02-28
RU94045915A (ru) 1996-09-10
OA10103A (en) 1996-12-18
BR1100323A (pt) 2000-06-27
AP480A (en) 1996-03-22
WO1993021153A1 (en) 1993-10-28
FI106198B (fi) 2000-12-15
HUT70526A (en) 1995-10-30
TW224457B (forum.php) 1994-06-01
SK281941B6 (sk) 2001-09-11
ITRM930236A1 (it) 1994-10-15
FI944800L (fi) 1994-10-12
HK95797A (en) 1997-08-08
BG99111A (bg) 1995-05-31
ES2105924B1 (es) 1998-07-01

Similar Documents

Publication Publication Date Title
BG62136B1 (bg) Индолови производни
US5686461A (en) Indole derivatives
US5962496A (en) Indole derivatives as NMDA antagonists
AP877A (en) Tetrahydroquinoline derivatives as EAA antagonists.
CA3170664A1 (en) P2x3 modulators
KR19980702735A (ko) Ｅａａ 길항제로서의 인돌 유도체
JP4108123B2 (ja) Ｎｍｄａアンタゴニストとしてのテトラヒドロキノリン
EP0971896A1 (en) Quinoline-2-carboxylic acid derivative and its use as excitatory amino acids antagonist
CZ301052B6 (cs) Megluminová sul enantiomeru A 7-chlor-4-(2-oxo-1-fenyl-3-pyrolidinyliden)-1,2,3,4-tetrahydro-2-chinolinkarboxylové kyseliny
SK119699A3 (en) Crystalline hydrated sodium salt of (e)-4,6-dichloro-3-(2-oxo- -1-phenylpyrrolidin-3-ylidene methyl)-1h-indole-2-carboxylic acid
CZ340599A3 (cs) Derivát kyseliny chinolin-2-karboxylové