AP44A - Azithromycin dihydrate - Google Patents

Azithromycin dihydrate Download PDF

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Publication number
AP44A
AP44A APAP/P/1988/000093A AP8800093A AP44A AP 44 A AP44 A AP 44A AP 8800093 A AP8800093 A AP 8800093A AP 44 A AP44 A AP 44A
Authority
AP
ARIPO
Prior art keywords
water
azithromycin
dihydrate
water content
hexane
Prior art date
Application number
APAP/P/1988/000093A
Other languages
English (en)
Other versions
AP8800093A0 (en
Inventor
Douglas John Meldrum Allen
Kevin Michael Nepveux
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP44(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of AP8800093A0 publication Critical patent/AP8800093A0/xx
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of AP44A publication Critical patent/AP44A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
APAP/P/1988/000093A 1987-07-09 1988-06-15 Azithromycin dihydrate AP44A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate

Publications (2)

Publication Number Publication Date
AP8800093A0 AP8800093A0 (en) 1988-05-01
AP44A true AP44A (en) 1989-07-27

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1988/000093A AP44A (en) 1987-07-09 1988-06-15 Azithromycin dihydrate

Country Status (45)

Country Link
US (1) US6268489B1 (xx)
EP (1) EP0298650B1 (xx)
JP (1) JPH0631300B2 (xx)
KR (1) KR900006218B1 (xx)
CN (1) CN1016785B (xx)
AP (1) AP44A (xx)
AR (1) AR243532A1 (xx)
AT (1) ATE72446T1 (xx)
AU (1) AU604553B2 (xx)
BA (1) BA98213B1 (xx)
BG (1) BG47348A3 (xx)
CA (1) CA1314876C (xx)
CS (1) CS272241B2 (xx)
CY (1) CY1776A (xx)
DD (1) DD271705A5 (xx)
DE (1) DE3868296D1 (xx)
DK (1) DK172573B1 (xx)
EG (1) EG18527A (xx)
ES (1) ES2038756T3 (xx)
FI (1) FI91263C (xx)
GR (1) GR3003737T3 (xx)
HK (1) HK127594A (xx)
HU (1) HU211862A9 (xx)
IE (1) IE60354B1 (xx)
IL (1) IL86979A (xx)
IN (1) IN168879B (xx)
IS (1) IS1540B (xx)
LV (1) LV10624B (xx)
MA (1) MA21323A1 (xx)
MX (1) MX12213A (xx)
MY (1) MY103744A (xx)
NO (1) NO171556C (xx)
NZ (1) NZ225338A (xx)
OA (1) OA08743A (xx)
PH (1) PH30953A (xx)
PL (1) PL157145B1 (xx)
PT (1) PT87933B (xx)
RO (1) RO107257B1 (xx)
RU (1) RU2066324C1 (xx)
SG (1) SG27794G (xx)
SI (1) SI8811325A8 (xx)
UA (1) UA27040C2 (xx)
WO (1) WO1989000576A1 (xx)
YU (1) YU45075B (xx)
ZA (1) ZA884925B (xx)

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US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0539223A1 (en) * 1991-10-25 1993-04-28 Ono Pharmaceutical Co., Ltd. Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
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DE69824201T2 (de) * 1997-10-16 2005-09-22 Pliva - Istrazivacki Institut D.O.O. Neue 9a-azalide
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
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CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
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US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
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EP0109253A2 (en) * 1982-11-15 1984-05-23 Pfizer Inc. Epimeric azahomoerythromycin A derivative and intermediates therefor
DD243501A5 (de) * 1985-03-04 1987-03-04 ����@�����@������������k��������k@�����������@�@����������@����������k@�K���K�k�� Verfahren zur herstellung von 11-aza-10-deoxo-10-dihydroerythramycin a

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Also Published As

Publication number Publication date
UA27040C2 (uk) 2000-02-28
OA08743A (fr) 1989-03-31
LV10624A (lv) 1995-04-20
DK172573B1 (da) 1999-01-25
LV10624B (en) 1995-10-20
KR900006218B1 (ko) 1990-08-25
JPH0631300B2 (ja) 1994-04-27
DK380688A (da) 1989-01-10
PL157145B1 (en) 1992-04-30
NZ225338A (en) 1990-02-26
EP0298650B1 (en) 1992-02-05
HK127594A (en) 1994-11-25
CS489688A2 (en) 1990-03-14
IN168879B (xx) 1991-06-29
EP0298650A2 (en) 1989-01-11
IS3370A7 (is) 1989-01-10
FI91263C (fi) 1994-06-10
SI8811325A8 (en) 1996-12-31
NO900077L (no) 1990-01-08
FI91263B (fi) 1994-02-28
PT87933A (pt) 1989-06-30
IE882108L (en) 1989-01-09
US6268489B1 (en) 2001-07-31
IL86979A (en) 1992-11-15
PT87933B (pt) 1994-09-30
DK380688D0 (da) 1988-07-08
EG18527A (en) 1993-10-30
PL273590A1 (en) 1989-03-20
KR890002137A (ko) 1989-04-08
SG27794G (en) 1994-10-14
CS272241B2 (en) 1991-01-15
CY1776A (en) 1995-10-20
BG47348A3 (en) 1990-06-15
IS1540B (is) 1994-01-28
CN1030422A (zh) 1989-01-18
AU1883988A (en) 1989-01-12
BA98213B1 (bs) 1999-08-02
MA21323A1 (fr) 1989-04-01
CA1314876C (en) 1993-03-23
NO171556C (no) 1993-03-31
ZA884925B (en) 1990-02-28
PH30953A (en) 1997-12-23
NO171556B (no) 1992-12-21
AR243532A1 (es) 1993-08-31
WO1989000576A1 (en) 1989-01-26
IE60354B1 (en) 1994-06-29
GR3003737T3 (xx) 1993-03-16
MY103744A (en) 1993-09-30
EP0298650A3 (en) 1989-11-08
FI900087A (fi) 1990-01-08
YU132588A (en) 1990-02-28
FI900087A0 (fi) 1990-01-08
DE3868296D1 (de) 1992-03-19
RU2066324C1 (ru) 1996-09-10
IL86979A0 (en) 1988-12-30
HU211862A9 (en) 1995-12-28
NO900077D0 (no) 1990-01-08
AP8800093A0 (en) 1988-05-01
AU604553B2 (en) 1990-12-20
MX12213A (es) 1993-05-01
RO107257B1 (ro) 1993-10-30
ES2038756T3 (es) 1993-08-01
DD271705A5 (de) 1989-09-13
JPS6438096A (en) 1989-02-08
CN1016785B (zh) 1992-05-27
ATE72446T1 (de) 1992-02-15
YU45075B (en) 1991-08-31

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