ATE169627T1 - Tetrahydrothieno-, furo und pyrrolopyridinderivate, ihre herstellung und verwendung als blutplaettchenaggregation- inhibitoren - Google Patents

Tetrahydrothieno-, furo und pyrrolopyridinderivate, ihre herstellung und verwendung als blutplaettchenaggregation- inhibitoren

Info

Publication number
ATE169627T1
ATE169627T1 AT92308180T AT92308180T ATE169627T1 AT E169627 T1 ATE169627 T1 AT E169627T1 AT 92308180 T AT92308180 T AT 92308180T AT 92308180 T AT92308180 T AT 92308180T AT E169627 T1 ATE169627 T1 AT E169627T1
Authority
AT
Austria
Prior art keywords
substd
alkoxy
opt
dioxolen
alkanoyl
Prior art date
Application number
AT92308180T
Other languages
English (en)
Inventor
Hiroyuki Koike
Fumitoshi Asai
Atsuhiro Sugidachi
Tomio Kimura
Teruhiko Inoue
Shigeyoshi Nishino
Yasunori Tsuzaki
Original Assignee
Sankyo Co
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26471534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE169627(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE169627T1 publication Critical patent/ATE169627T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
AT92308180T 1991-09-09 1992-09-09 Tetrahydrothieno-, furo und pyrrolopyridinderivate, ihre herstellung und verwendung als blutplaettchenaggregation- inhibitoren ATE169627T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22787591 1991-09-09
JP13852992 1992-05-29

Publications (1)

Publication Number Publication Date
ATE169627T1 true ATE169627T1 (de) 1998-08-15

Family

ID=26471534

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92308180T ATE169627T1 (de) 1991-09-09 1992-09-09 Tetrahydrothieno-, furo und pyrrolopyridinderivate, ihre herstellung und verwendung als blutplaettchenaggregation- inhibitoren

Country Status (24)

Country Link
US (2) US5288726A (de)
EP (1) EP0542411B1 (de)
JP (1) JP2683479B2 (de)
KR (1) KR0148023B1 (de)
CN (2) CN1041730C (de)
AT (1) ATE169627T1 (de)
AU (1) AU656798B2 (de)
CA (1) CA2077695C (de)
CZ (1) CZ287181B6 (de)
DE (2) DE69226607T2 (de)
DK (1) DK0542411T3 (de)
ES (1) ES2122984T3 (de)
FI (1) FI101150B (de)
GR (1) GR3027650T3 (de)
HK (1) HK1011017A1 (de)
HU (2) HU218785B (de)
IL (1) IL103098A (de)
LU (1) LU91589I2 (de)
MX (1) MX9205160A (de)
NL (1) NL300397I2 (de)
NO (2) NO303733B1 (de)
NZ (1) NZ244260A (de)
PH (1) PH29921A (de)
TW (1) TW213461B (de)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874581A (en) * 1994-10-07 1999-02-23 Ube Industries, Ltd. 2-silyloxy-tetrahydrothienopyridine, salt thereof and process for preparing the same
WO1997049397A1 (fr) * 1996-06-26 1997-12-31 Sankyo Company, Limited Nouvelles compositions medicinales d'hydropyridines
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
ID25589A (id) * 1998-02-27 2000-10-19 Sankyo Company Ltd Cs Senyawa-senyawa amino siklik
US6509348B1 (en) 1998-11-03 2003-01-21 Bristol-Myers Squibb Company Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
AU776276B2 (en) 1999-01-19 2004-09-02 Neurosearch A/S Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases
KR100768034B1 (ko) 1999-03-17 2007-10-17 다이이찌 세이야꾸 가부시기가이샤 의약 조성물
US7099027B1 (en) * 1999-11-12 2006-08-29 Electronics For Imaging, Inc. Method and apparatus for distributing print jobs
PT1728794E (pt) * 2000-07-06 2008-07-15 Ube Industries Sal de adição maleato de derivados de hidropiridina
PL206138B1 (pl) * 2000-12-25 2010-07-30 Daiichi Sankyo Company Limiteddaiichi Sankyo Company Limited Kompozycja farmaceutyczna zawierająca aspirynę oraz zestaw i zastosowanie składników kompozycji
WO2005051913A1 (ja) * 2003-11-28 2005-06-09 Sankyo Company, Limited ヘテロアリール環を有する環状アミン誘導体
JP5557410B2 (ja) * 2004-07-13 2014-07-23 第一三共株式会社 経口投与による血栓・塞栓の予防治療剤
EP1812429A4 (de) * 2004-09-29 2010-07-21 Portola Pharm Inc Substituierte 2h-1,3-benzoxazin-4(3h)-one
TWI318571B (en) * 2005-06-10 2009-12-21 Lilly Co Eli Formulation of a thienopyridine platelet aggregation inhibitor
KR20080016647A (ko) * 2005-06-17 2008-02-21 일라이 릴리 앤드 캄파니 프라수그렐에 대한 투여 계획
TWI392681B (zh) * 2006-04-06 2013-04-11 Daiichi Sankyo Co Ltd 高純度普拉格雷及其酸加成鹽之製法
WO2008060934A2 (en) * 2006-11-14 2008-05-22 Acusphere, Inc. Formulations of tetrahydropyridine antiplatelet agents for parenteral or oral administration
KR101647842B1 (ko) * 2006-12-07 2016-08-11 다이이찌 산쿄 가부시키가이샤 저장 안정성이 개선된 의약 조성물
WO2008072535A1 (ja) 2006-12-07 2008-06-19 Daiichi Sankyo Company, Limited 低置換度ヒドロキシプロピルセルロースを含有する医薬組成物
KR101503083B1 (ko) 2006-12-07 2015-03-16 다이이찌 산쿄 가부시키가이샤 고형 제제의 제조 방법
EP2100609A4 (de) * 2006-12-07 2010-01-06 Daiichi Sankyo Co Ltd Mannitol- oder lactosehaltige feste medizinische zubereitung
KR101665705B1 (ko) 2006-12-07 2016-10-12 다이이찌 산쿄 가부시키가이샤 안정성이 개선된 필름 코팅 제제
CN102424686A (zh) * 2007-03-02 2012-04-25 第一三共株式会社 用于制备高纯度普拉格雷盐酸盐的方法
KR20160033792A (ko) 2007-04-27 2016-03-28 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
US8669268B2 (en) * 2007-09-12 2014-03-11 Deuterx, Llc Deuterium-enriched prasugrel
US20100261908A1 (en) * 2007-11-09 2010-10-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel , and its salts and polymorphs
HU230262B1 (hu) * 2007-11-27 2015-11-30 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás gyógyszeripari intermedierek előállítására
HU230261B1 (hu) * 2007-11-27 2015-11-30 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás gyógyszeripari intermedierek előállítására
CN101177430A (zh) * 2007-12-11 2008-05-14 鲁南制药集团股份有限公司 氢化吡啶衍生物及其盐的制备方法
WO2009098142A1 (en) 2008-02-06 2009-08-13 Helm Ag Prasugrel salts with improved properties
CN101245073B (zh) * 2008-03-21 2011-03-23 上海医药工业研究院 一种医药中间体及其制备方法
CN101245072B (zh) * 2008-03-21 2011-03-30 上海医药工业研究院 制备普拉格雷的中间体及其制备方法
CN101250192B (zh) * 2008-03-24 2010-08-11 上海医药工业研究院 5-(α-环丙基羰基-2-氟苄基)-2-氧-2,4,5,6,7,7a-六氢噻吩并[3,2-c]吡啶的制备方法
CN101250193B (zh) * 2008-03-28 2010-09-08 上海医药工业研究院 2-烷氧基-5-(α-环丙基羰基-2-氟苄基)-4,5,6,7-四氢噻吩并[3,2-c]吡啶的制备方法
WO2009122440A1 (en) * 2008-03-31 2009-10-08 Torrent Pharmaceuticals Ltd. PROCESS FOR THE PREPARATION OF 2-ACETOXY-5-(α -CYCLOPRPYLCARBONYL -2-FLUOROBENZYL)-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE
WO2009129983A1 (en) * 2008-04-21 2009-10-29 Ratiopharm Gmbh Acid addition salts of prasugrel and pharmaceutical compositions comprising the same
DE602008002820D1 (de) 2008-04-25 2010-11-11 Sandoz Ag Hydrogensulfat von 2-Acetoxy-5-(a-cyclopropylcarbonyl-2-fluorbenzyl)-4,5,6,7-tetrahydrothienoÄ3,2-cÜpyridin und dessen Zubereitung
US20090281136A1 (en) * 2008-05-08 2009-11-12 Sandeep Mhetre Prasugrel pharmaceutical formulations
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US20130303477A1 (en) * 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
US8759316B2 (en) * 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US20120141468A1 (en) 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
CN101591344B (zh) * 2008-05-27 2012-12-05 连云港恒邦医药科技有限公司 一种抗血栓的化合物、其制备方法和用途
CN101289454B (zh) * 2008-06-10 2011-02-16 上海医药工业研究院 2-氧-2,4,5,6,7,7α-六氢噻吩并[3,2-c]吡啶的制备方法
JP2011529859A (ja) 2008-08-02 2011-12-15 ルナン ファーマシューティカル グループ コーポレーション プラスグレル重硫酸塩及びその薬物組成物並びにその応用
CN103936756B (zh) * 2008-09-22 2017-09-19 广州赫尔氏药物开发有限公司 具有抗凝血作用的化合物
CN101684124B (zh) * 2008-09-22 2013-11-13 广州赫尔氏药物开发有限公司 新的具有抗凝血作用的化合物
CN101402643B (zh) * 2008-11-11 2012-11-28 上海现代制药股份有限公司 一种适于工业生产的普拉格雷的制备方法
CN101402642B (zh) * 2008-11-11 2013-01-09 上海现代制药股份有限公司 一种新型环保制备普拉格雷的方法
CN101402556B (zh) * 2008-11-11 2014-01-29 上海现代制药股份有限公司 新化合物1-环丙基-2-(2-氟苯基)-2-羟基乙酮及其制备方法和用途
CZ2008748A3 (cs) * 2008-11-26 2010-06-02 Zentiva, A. S Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu
WO2010070677A2 (en) * 2008-12-15 2010-06-24 Glenmark Generics Limited A process for the preparation of prasugrel and its pharmaceutically acceptable salts thereof
EP2415774B1 (de) 2009-03-31 2014-07-09 Shanghai Institute of Pharmaceutical Industry Kristalle aus essigsäure solvat von prasugrel-hydrobromat
CA2758322C (en) 2009-04-10 2019-04-02 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
CN101885730B (zh) * 2009-05-13 2012-07-04 连云港恒邦医药科技有限公司 抗血栓的化合物
US8236782B2 (en) 2009-05-13 2012-08-07 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
DE102009036646A1 (de) 2009-08-07 2011-02-10 Ratiopharm Gmbh Prasugrel in nicht-kristalliner Form und pharmazeutische Zusammensetzung davon
KR20110015254A (ko) * 2009-08-07 2011-02-15 한미홀딩스 주식회사 프라수그렐 디술폰산염 및 이의 결정
CN101993447A (zh) * 2009-08-26 2011-03-30 浙江华海药业股份有限公司 一种人工合成普拉格雷的方法
KR20110024057A (ko) * 2009-09-01 2011-03-09 한미홀딩스 주식회사 신규한 프라수그렐 황산수소염의 결정다형
WO2011036533A1 (en) 2009-09-23 2011-03-31 Glenmark Pharmaceuticals Limited Pharmaceutical composition comprising prasugrel and triflusal
WO2011042918A2 (en) * 2009-10-07 2011-04-14 Msn Laboratories Limited Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts
CN102040498B (zh) * 2009-10-10 2014-01-29 台州市华南医化有限公司 一种环丙基邻氟苄基甲酮的制备方法
CN102050828A (zh) * 2009-10-28 2011-05-11 北京万全阳光医学技术有限公司 普拉格雷盐及其制备方法
EA028885B1 (ru) 2009-11-11 2018-01-31 Чиези Фармачеутичи С.П.А. Способы лечения или предотвращения тромбоза стента и инфаркта миокарда (варианты)
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
CZ2009763A3 (cs) 2009-11-16 2011-05-25 Zentiva, K. S. Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráneným názvem prasugrel a jeho nových farmaceuticky prijatelných solí.
CZ2009762A3 (cs) 2009-11-16 2011-05-25 Zentiva, K. S. Nové soli 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráneným názvem prasugrel a zpusob jejich výroby
CZ2009828A3 (cs) 2009-12-09 2011-06-22 Zentiva, K.S. Zpusob prípravy hydrochloridu 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu hydrochloridu) v polymorfní forme B
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
CN102863457B (zh) * 2010-02-02 2013-10-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
EP2360159A1 (de) 2010-02-11 2011-08-24 Ratiopharm GmbH Prasugrel in mikronisierter, kristalliner Form und pharmazeutische Zusammensetzung davon
WO2011110219A1 (en) 2010-03-09 2011-09-15 Synthon Bv A process for making prasugrel
WO2011117782A1 (en) 2010-03-23 2011-09-29 Alembic Pharmaceuticals Limited A process for the preparation of prasugrel hcl salt
EP2377520A1 (de) 2010-03-24 2011-10-19 Ratiopharm GmbH Pharmazeutische Zusammensetzung des Prasugrels
CN102212069A (zh) * 2010-04-06 2011-10-12 刘桂坤 环烷衍生物及其制备方法和在心脑血管病药物上的应用
CN102212070B (zh) * 2010-04-08 2014-11-26 上海医药工业研究院 2-乙酰氧基-5-(α-环丙基羰基-2-氟苄基)-4,5,6,7-四氢噻吩并[3,2-c]吡啶的制备方法
SI2448945T1 (sl) 2010-04-08 2015-05-29 Teva Pharmaceutical Industries Ltd. Kristalinične oblike prasugrelovih soli
CN101812069A (zh) * 2010-04-10 2010-08-25 山东新华制药股份有限公司 一种普拉格雷合成工艺
CN102241690B (zh) 2010-05-13 2015-08-12 天津药物研究院 一类含腈基的噻吩并吡啶酯类衍生物、其制备方法和用途
CN101845052B (zh) * 2010-06-11 2012-01-11 天津药物研究院 一类含氮杂环的噻吩并吡啶酮衍生物、其制备方法和用途
WO2012001486A1 (en) 2010-06-28 2012-01-05 Mayuka Labs Pvt. Ltd. An improved process for the preparation of prasugrel hydrochloride and its intermediates
CN101899056A (zh) * 2010-08-02 2010-12-01 江苏万全特创医药生物技术有限公司 普拉格雷氢溴酸盐多晶型物及其制备方法
AU2015227476B2 (en) * 2010-10-18 2017-03-23 Cerenis Therapeutics Holding Sa Compounds, compositions and methods useful for cholesterol mobilisation
PT2629776T (pt) * 2010-10-18 2017-11-15 Cerenis Therapeutics Holding Sa Compostos, composições e métodos úteis para a mobilização de colesterol
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN102093385B (zh) * 2010-12-30 2013-03-27 天津药物研究院 希夫碱类化合物、制备方法和用途
CN102199163A (zh) * 2011-04-01 2011-09-28 中国药科大学 2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
CN102229616A (zh) * 2011-05-06 2011-11-02 伍复健 四氢噻吩并吡啶衍生物及其制备方法和用途
EP2736509B1 (de) 2011-07-28 2015-09-23 Laboratorios Lesvi, S.L. Verfahren zur herstellung von prasugrel
WO2013033178A1 (en) 2011-08-30 2013-03-07 University Of Utah Research Foundation Methods and compositions for treating nephrogenic diabetes insipidus
CN103102355A (zh) * 2011-11-09 2013-05-15 丁克 具有旋光性的四氢噻吩并吡啶化合物
CZ2011872A3 (cs) 2011-12-22 2013-07-03 Zentiva, K.S. Farmaceutická formulace prasugrelu hydrobromidu
CN103254211B (zh) * 2012-02-17 2015-12-16 江苏威凯尔医药科技有限公司 一种制备维卡格雷及其衍生物的方法
US8603537B2 (en) 2012-04-02 2013-12-10 Egis Pharmaceuticals Plc Prasugrel containing quickly released stable oral pharmaceutical compositions
ITMI20121494A1 (it) * 2012-09-07 2014-03-08 Erregierre Spa Processo per la produzione di prasugrel cloridrato
CN103694250B (zh) * 2012-09-28 2016-02-10 武汉启瑞药业有限公司 噻吩吡啶类衍生物及其制备方法和医药用途
HU230649B1 (hu) 2013-01-24 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Javított eljárás prasugrel gyógyszeripari hatóanyag és az 1-ciklopropil-2-(2-fluorofenil)-etanon intermedier előállítására
CN103193792A (zh) * 2013-03-13 2013-07-10 广东中科药物研究有限公司 一种治疗缺血性心脑血管疾病的新化合物
CN104725396B (zh) * 2013-12-18 2019-03-22 山东新时代药业有限公司 一种“一锅粥”法制备普拉格雷的方法
CN103694252A (zh) * 2014-01-14 2014-04-02 中国药科大学 一种噻吩并吡啶类化合物及其抗血小板聚集活性
DE102014108210A1 (de) * 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
EP2979693A1 (de) 2014-08-01 2016-02-03 Zaklady Farmaceutyczne Polpharma SA Pharmazeutische zusammensetzung mit prasugrel oder pharmazeutisch verträglichem salz davon und verfahren zu deren herstellung
CN105362266A (zh) * 2014-08-28 2016-03-02 杭州雷索药业有限公司 噻吩并吡啶类化合物或其在药学上可接受的盐在制备治疗或预防癫痫药物中的应用
CN105153192B (zh) * 2014-09-02 2019-03-29 南京曼杰生物科技有限公司 取代的四氢噻吩并吡啶衍生物及其应用
EP3156049A1 (de) 2015-10-15 2017-04-19 Alembic Pharmaceuticals Limited Pharmazeutische zusammensetzung von prasugrel
EP3158993A1 (de) 2015-10-22 2017-04-26 Zaklady Farmaceutyczne Polpharma SA Verfahren zur herstellung einer tablette mit prasugrel oder pharmazeutisch unbedenklichem salz davon
HU231079B1 (hu) 2016-06-23 2020-06-29 Richter Gedeon Nyrt. Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával
EP3528790A1 (de) 2016-10-21 2019-08-28 Laboratorios Lesvi S.L. Pharmazeutische formulierungen von prasugrel und verfahren zur herstellung davon
BR112019022676A2 (pt) 2017-06-23 2020-05-19 Chiesi Farm Spa método de prevenção de trombose de derivação da artéria sistêmica-para-pulmonar
WO2022028347A1 (zh) * 2020-08-03 2022-02-10 天地恒一制药股份有限公司 一种光学活性2-羟基四氢噻吩并吡啶类衍生物及其制备方法和用途
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215948B1 (de) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma
US4075215A (en) * 1973-02-01 1978-02-21 Centre D'etudes Pour L'industrie Pharmaceutique Thieno-pyridine derivatives
US4127580A (en) * 1975-02-07 1978-11-28 Parcor Process for the preparation of thieno-pyridine derivatives
FR2338703A1 (fr) * 1976-01-22 1977-08-19 Parcor Derives de thieno (3,2-c) pyridine, leur procede de preparation et leurs applications
GB2038178B (en) * 1978-12-29 1983-03-09 Parcor Antithrombotic therapeutic compsition
US4464377A (en) * 1977-06-22 1984-08-07 BLANCHARD Jean Anti-thrombotic therapeutic compositions
FR2508459A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives de la tetrahydro-5,6,7,7a 4h thieno (3,2-c) pyridinone-2
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2576901B1 (fr) * 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
IT1215251B (it) * 1985-03-14 1990-01-31 Ellem Ind Farmaceutica Farmaceutiche che li contengono. composti ad attivita'antiaggregante piastrinica, procedimento per la loro preparazione e composizioni
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
DK0439404T3 (da) * 1990-01-25 1996-02-12 Sanofi Sa Fremstilling af 2-(2-thienyl)-alkylaminer og derivater deraf samt synthese af 4,5,6,7-thieno- (3,2-c)pyridinderivater ud fra disse
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
EP0522956B1 (de) * 1991-07-08 1997-02-05 Sanofi Herstellung von 2-(2-Thienyl)Äthylamin und Synthese von Thieno(3,2-c)pyridinderivaten daraus

Also Published As

Publication number Publication date
CZ278492A3 (en) 1993-10-13
HK1011017A1 (en) 1999-07-02
EP0542411B1 (de) 1998-08-12
NL300397I1 (nl) 2009-10-01
CZ287181B6 (cs) 2000-10-11
US5288726A (en) 1994-02-22
MX9205160A (es) 1993-03-01
IL103098A0 (en) 1993-02-21
DE69226607T2 (de) 1999-04-22
ES2122984T3 (es) 1999-01-01
IL103098A (en) 1996-05-14
NO923484D0 (no) 1992-09-08
EP0542411A2 (de) 1993-05-19
CN1107502C (zh) 2003-05-07
HU211876A9 (en) 1995-12-28
US5436242A (en) 1995-07-25
GR3027650T3 (en) 1998-11-30
NO923484L (no) 1993-03-10
NO2009017I2 (no) 2011-10-17
FI924002A (fi) 1993-03-10
HU9202888D0 (en) 1992-11-30
NO2009017I1 (no) 2009-08-03
CN1041730C (zh) 1999-01-20
FI101150B (fi) 1998-04-30
DK0542411T3 (da) 1999-05-17
NO303733B1 (no) 1998-08-24
NL300397I2 (nl) 2009-12-01
AU2284792A (en) 1993-03-18
HU218785B (hu) 2000-12-28
CA2077695A1 (en) 1993-03-10
NZ244260A (en) 1994-07-26
DE122009000045I2 (de) 2010-07-08
DE69226607D1 (de) 1998-09-17
FI924002A0 (fi) 1992-09-07
PH29921A (en) 1996-09-16
DE122009000045I1 (de) 2009-11-05
JP2683479B2 (ja) 1997-11-26
HUT66195A (en) 1994-10-28
KR0148023B1 (ko) 1998-08-17
CN1217186A (zh) 1999-05-26
KR930006019A (ko) 1993-04-20
AU656798B2 (en) 1995-02-16
CN1074446A (zh) 1993-07-21
TW213461B (de) 1993-09-21
CA2077695C (en) 2002-08-20
LU91589I2 (fr) 2009-10-05
JPH0641139A (ja) 1994-02-15
EP0542411A3 (en) 1993-07-21

Similar Documents

Publication Publication Date Title
ATE169627T1 (de) Tetrahydrothieno-, furo und pyrrolopyridinderivate, ihre herstellung und verwendung als blutplaettchenaggregation- inhibitoren
IL117396A (en) Benzofuran derivatives and pharmaceutical compositions containing them
CY2111B1 (en) 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic-acid derivatives metho for their preparation and for substituted mono- and bi-cyclic pyrrolidine intermediates and their antibacterial
NO964093D0 (no) Substituerte chinolin-2-karboksylsyreamider, deres fremstilling og deres anvendelse som legemiddel, såvel som mellomprodukt
DE69221003T2 (de) Antibiotische Carbapenemderivate
JPS6431782A (en) 2-(heterocyclylalkyl)imidazopyridines
DK40890D0 (da) Substituerede urinstofforbindelser, deres fremstilling og anvendelse
TW197420B (de)
ATE239023T1 (de) Antiallergische imidazo(1,2-a)thieno(2,3- d)azepinderivate
EG18525A (en) 3,4 - dihydro - 2 - alkyl - 3 - oxo - n - aryl - 2 h - (1) benzothieno (3,2-e) - 1,2 thiazine - 4 - carboxamide - 1,1 - dioxides.
HUP9902890A2 (hu) Szubsztituált pirimidinszármazékok és gyógyászati felhasználásuk
DE59306238D1 (de) 3,9-Disubstituierte-spiro (5.5)undecane mit cardiovasculaire Wirkung, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
HUT60742A (en) Method for producing imidqzo-benzodiazepine-2-(1h)-one derivatives and pharmaceutical preparatives containing them