ZA974893B - New benzimidazole derivatives with antihistaminic activity. - Google Patents

New benzimidazole derivatives with antihistaminic activity.

Info

Publication number
ZA974893B
ZA974893B ZA9704893A ZA974893A ZA974893B ZA 974893 B ZA974893 B ZA 974893B ZA 9704893 A ZA9704893 A ZA 9704893A ZA 974893 A ZA974893 A ZA 974893A ZA 974893 B ZA974893 B ZA 974893B
Authority
ZA
South Africa
Prior art keywords
benzimidazole derivatives
antihistaminic activity
new benzimidazole
new
antihistaminic
Prior art date
Application number
ZA9704893A
Other languages
English (en)
Inventor
Aurelio Orjales
Maravillas Bordell
Victor Rubio
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Publication of ZA974893B publication Critical patent/ZA974893B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9704893A 1996-06-04 1997-06-03 New benzimidazole derivatives with antihistaminic activity. ZA974893B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
ZA974893B true ZA974893B (en) 1997-12-30

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9704893A ZA974893B (en) 1996-06-04 1997-06-03 New benzimidazole derivatives with antihistaminic activity.

Country Status (27)

Country Link
US (1) US5877187A (en:Method)
EP (1) EP0818454B1 (en:Method)
JP (1) JP4218991B2 (en:Method)
CN (1) CN1105716C (en:Method)
AR (1) AR008386A1 (en:Method)
AT (1) ATE264317T1 (en:Method)
AU (1) AU725700B2 (en:Method)
BR (1) BR9703276A (en:Method)
CA (1) CA2206754C (en:Method)
CZ (1) CZ289278B6 (en:Method)
DE (2) DE122011000006I1 (en:Method)
DK (1) DK0818454T3 (en:Method)
ES (1) ES2124167B1 (en:Method)
FR (1) FR11C0023I2 (en:Method)
HR (1) HRP970307B1 (en:Method)
HU (1) HU227598B1 (en:Method)
IN (1) IN186319B (en:Method)
LU (1) LU91798I2 (en:Method)
MX (1) MXPA97004127A (en:Method)
NO (2) NO313195B1 (en:Method)
PL (1) PL188908B1 (en:Method)
PT (1) PT818454E (en:Method)
RU (1) RU2182150C2 (en:Method)
SI (1) SI0818454T1 (en:Method)
TR (1) TR199700464A3 (en:Method)
TW (1) TW438794B (en:Method)
ZA (1) ZA974893B (en:Method)

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HUP0102470A3 (en) 1998-07-01 2002-05-28 Takeda Chemical Industries Ltd 1,3-azole derivatives as retinoid-associated receptor regulators and their use
UA61158C2 (uk) 1998-11-27 2003-11-17 Басф Акціенгезелльшафт Похідні бензимідазолу та лікарський засіб на їх основі
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
SK288052B6 (sk) * 2002-04-19 2013-03-01 Faes Farma, S.A. Polymorph 1 of bilastine, process for preparing thereof, its antihistaminic and antiallergic use and pharmaceutical preparation containing it
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
AU2003245442B2 (en) * 2002-06-13 2009-02-05 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase IV inhibitors for the treatment of bacterial infections
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN104402773A (zh) * 2008-02-12 2015-03-11 柳韩洋行 2-甲基-2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
US20140271504A1 (en) * 2013-03-15 2014-09-18 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
CA2993134A1 (en) * 2015-07-24 2017-02-02 Urquima, S.A. Crystalline forms of bilastine and preparation methods thereof
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
WO2019076798A1 (en) 2017-10-16 2019-04-25 Faes Farma, S.A. AQUEOUS COMPOSITIONS COMPRISING BILASTIN AND MOMETASONE
PL3641735T3 (pl) 2017-12-18 2021-09-06 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Kompozycja farmaceutyczna tabletki zawierająca bilastynę w postaci 3 i rozpuszczalny w wodzie wypełniacz
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
CN111727035B (zh) 2018-01-18 2024-05-28 费斯制药股份有限公司 包含比拉斯汀、β-环糊精和至少一种胶凝剂的眼用组合物
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
PE20231844A1 (es) 2020-07-30 2023-11-21 Faes Farma Sa Sistema de liberacion de farmacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition
EP4479048A1 (en) 2022-02-17 2024-12-25 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
WO1991016313A1 (en) * 1990-04-13 1991-10-31 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
JP3041954B2 (ja) * 1992-08-03 2000-05-15 セプラコア インコーポレーテッド アレルギー疾患治療用のテルフェナジン代謝物及びその光学的に純粋な異性体
JP3712208B2 (ja) * 1993-06-25 2005-11-02 メレルファーマスーティカルズ インコーポレイテッド 抗ヒスタミン性の４−ジフェニルメチル／ジフェニルメトキシピペリジン誘導体類を製造する新規な中間体

Also Published As

Publication number Publication date
DK0818454T3 (da) 2004-07-12
PL188908B1 (pl) 2005-05-31
CN1176964A (zh) 1998-03-25
FR11C0023I1 (en:Method) 2011-08-19
JP4218991B2 (ja) 2009-02-04
HRP970307A2 (en) 1998-04-30
US5877187A (en) 1999-03-02
NO972525L (no) 1997-12-05
LU91798I2 (fr) 2011-05-23
ES2124167A1 (es) 1999-01-16
TR199700464A2 (xx) 1997-12-21
NO2011008I1 (no) 2011-06-06
RU2182150C2 (ru) 2002-05-10
NO2011008I2 (no) 2012-05-14
BR9703276A (pt) 2004-08-17
EP0818454A1 (en) 1998-01-14
NO313195B1 (no) 2002-08-26
TR199700464A3 (tr) 1997-12-21
ATE264317T1 (de) 2004-04-15
FR11C0023I2 (fr) 2012-03-16
HUP9700997A1 (hu) 1999-09-28
CA2206754C (en) 2007-01-23
JPH1059961A (ja) 1998-03-03
SI0818454T1 (en) 2004-08-31
DE69728608D1 (de) 2004-05-19
PT818454E (pt) 2004-08-31
HRP970307B1 (en) 2002-02-28
ES2124167B1 (es) 1999-09-16
CN1105716C (zh) 2003-04-16
MXPA97004127A (es) 2005-07-25
HU227598B1 (en) 2011-09-28
AU725700B2 (en) 2000-10-19
AR008386A1 (es) 2000-01-19
NO972525D0 (no) 1997-06-03
IN186319B (en:Method) 2001-08-04
CZ172397A3 (en) 1997-12-17
DE69728608T2 (de) 2005-04-21
TW438794B (en) 2001-06-07
DE122011000006I1 (de) 2011-06-16
CZ289278B6 (cs) 2001-12-12
EP0818454B1 (en) 2004-04-14
AU2467297A (en) 1997-12-11
HU9700997D0 (en) 1997-07-28
PL320358A1 (en) 1997-12-08
CA2206754A1 (en) 1997-12-04

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