ZA951372B - Antibody purification - Google Patents

Antibody purification

Info

Publication number
ZA951372B
ZA951372B ZA951372A ZA951372A ZA951372B ZA 951372 B ZA951372 B ZA 951372B ZA 951372 A ZA951372 A ZA 951372A ZA 951372 A ZA951372 A ZA 951372A ZA 951372 B ZA951372 B ZA 951372B
Authority
ZA
South Africa
Prior art keywords
antibody purification
purification
chromatography
application
relates
Prior art date
Application number
ZA951372A
Other languages
English (en)
Inventor
Paula J Shadle
John C Erickson
Robert G Scott
Thomas M Smith
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22740445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA951372(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA951372B publication Critical patent/ZA951372B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Detergent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA951372A 1994-02-22 1995-02-20 Antibody purification ZA951372B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/200,126 US5429746A (en) 1994-02-22 1994-02-22 Antibody purification

Publications (1)

Publication Number Publication Date
ZA951372B true ZA951372B (en) 1995-10-24

Family

ID=22740445

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA951372A ZA951372B (en) 1994-02-22 1995-02-20 Antibody purification

Country Status (22)

Country Link
US (4) US5429746A (xx)
EP (1) EP0746398B1 (xx)
JP (1) JP4198751B2 (xx)
KR (1) KR100372209B1 (xx)
CN (1) CN1146730A (xx)
AT (1) ATE218387T1 (xx)
AU (1) AU689552B2 (xx)
BR (1) BR9507100A (xx)
CA (1) CA2183888C (xx)
CZ (1) CZ292001B6 (xx)
DE (1) DE69526929T2 (xx)
DK (1) DK0746398T3 (xx)
ES (1) ES2177632T3 (xx)
HK (1) HK1013806A1 (xx)
HU (1) HU217850B (xx)
MX (1) MX9603637A (xx)
NO (1) NO319182B1 (xx)
NZ (1) NZ281480A (xx)
PT (1) PT746398E (xx)
SI (1) SI0746398T1 (xx)
WO (1) WO1995022389A1 (xx)
ZA (1) ZA951372B (xx)

Families Citing this family (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5935800A (en) * 1994-10-31 1999-08-10 Beth Israel Deaconess Medical Center Assays and kits for determining male fertility
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
ES2335365T3 (es) 1996-11-27 2010-03-25 Genentech, Inc. Purificacion por afinidad de polipeptido en una matriz de proteina a.
DK0998486T4 (da) 1997-06-13 2012-05-14 Genentech Inc Proteinoprensning ved kromatografi efterfulgt af filtrering på en ladet fase
US5993653C1 (en) * 1997-08-11 2001-11-06 Phenomenex Composition and column used in hplc
CN1088605C (zh) * 1997-09-30 2002-08-07 中国科学院新疆化学研究所 生产石油磺酸钠的质量控制方法
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
CN103641885A (zh) * 1998-05-06 2014-03-19 基因技术股份有限公司 用离子交换层析纯化蛋白质
EP1308455B9 (en) * 1998-05-06 2006-06-14 Genentech, Inc. A composition comprising anti-HER2 antibodies
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
GB9907553D0 (en) * 1999-04-01 1999-05-26 Cantab Pharma Res Purification of biological preparations
DE19932782A1 (de) 1999-07-14 2001-01-18 Biotest Pharma Gmbh Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung
DK1681299T3 (da) 2000-03-27 2010-02-01 Genetics Inst Llc Fremgangsmåde til rensning af højt anioniske proteiner
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
US7064191B2 (en) * 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
EP2336149A1 (en) * 2001-03-09 2011-06-22 Chugai Seiyaku Kabushiki Kaisha Protein purification method
JP4229704B2 (ja) * 2001-04-18 2009-02-25 ダイアックス、コープ Ｆｃ領域ポリペプチドの結合分子
DE60231016D1 (de) * 2001-06-05 2009-03-12 Genetics Inst Llc Verfahren zur Reinigung stark anionischer Proteine
US7452539B2 (en) * 2001-12-19 2008-11-18 Genentech, Inc. Stabilizing polypeptides which have been exposed to urea
ATE417858T1 (de) * 2002-02-05 2009-01-15 Genentech Inc Proteinaufreinigung
ES2564293T5 (es) † 2002-02-28 2019-04-04 Microsens Biophage Ltd Enlazamiento de formas patológicas de proteínas priónicas
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
GB0220894D0 (en) * 2002-09-09 2002-10-16 Millipore Uk Ltd Method of separation
HUE027134T2 (en) 2002-09-11 2016-10-28 Chugai Pharmaceutical Co Ltd Method for protein purification
CN1856324A (zh) * 2002-09-17 2006-11-01 Gtc生物治疗学公司 缺乏重链间二硫键的免疫球蛋白分子的分离
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
AU2004215653B2 (en) * 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
JPWO2004087761A1 (ja) * 2003-03-31 2006-07-27 麒麟麦酒株式会社 ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
WO2005000898A2 (en) 2003-06-27 2005-01-06 Biogen Idec Ma Inc. Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
US6913695B2 (en) * 2003-07-08 2005-07-05 Bayer Healthcare Llc Sanitization of chromatographic media
RS53476B (en) * 2003-07-18 2014-12-31 Amgen Fremont Inc. Hepatocyte Growth Factor Binders
EP3095793B1 (en) 2003-07-28 2020-03-25 Genentech, Inc. Reducing protein a leaching during protein a affinity chromatography
US20070017870A1 (en) 2003-09-30 2007-01-25 Belov Yuri P Multicapillary device for sample preparation
WO2005032688A1 (en) * 2003-09-30 2005-04-14 Chromba, Inc. Multicapillary column for chromatography and sample preparation
ATE462716T1 (de) 2003-10-24 2010-04-15 Amgen Inc Verfahren zur aufreinigung von proteinen in einer durchflussfraktion aus der chromatographie mit hydrophoben wechselwirkungen
NZ548126A (en) * 2004-02-27 2009-10-30 Ge Healthcare Bio Sciences Ab A process for the purification of antibodies involving addition of a second resin
SE0400501D0 (sv) * 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
SI1730191T1 (sl) 2004-03-30 2011-11-30 Glaxo Group Ltd Imunoglobulin-vezavni hOSM
SE0400886D0 (sv) * 2004-04-02 2004-04-02 Amersham Biosciences Ab Process of purification
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
JP5064225B2 (ja) * 2004-10-21 2012-10-31 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 抗体精製法
ES2343426T3 (es) * 2004-12-23 2010-07-30 Novo Nordisk A/S Ligandos de afinidad de union a anticuerpos.
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
WO2006084111A2 (en) * 2005-02-04 2006-08-10 Glaxo Group Limited Optimization of heterologous polypeptide expression
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
US8067182B2 (en) * 2005-03-11 2011-11-29 Wyeth Llc Method of weak partitioning chromatography
DE102005012594A1 (de) 2005-03-18 2006-09-21 Bayer Technology Services Gmbh Elektrofiltrationsverfahren
TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
US20070049732A1 (en) * 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
WO2007035283A1 (en) * 2005-09-15 2007-03-29 Wyeth Protein floculation using salts
GB0525662D0 (en) 2005-12-16 2006-01-25 Glaxo Group Ltd Immunoglobulins
EP1969007B1 (en) * 2005-12-20 2013-08-28 Bristol-Myers Squibb Company Compositions and methods for producing a composition
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US20070269863A1 (en) * 2005-12-22 2007-11-22 Bridon Dominique P Process for the production of preformed conjugates of albumin and a therapeutic agent
CN101935665B (zh) * 2006-03-17 2013-08-28 上海抗体药物国家工程研究中心有限公司 一种重组蛋白a基因及其表达产物的制备方法和用途
DE102006014579A1 (de) * 2006-03-29 2007-10-04 Epcos Ag Verfahren zur Reinigung einer Monomer-Lösung und Herstellungsverfahren für ein elektrisches Bauelement umfassend das Reinigungsverfahren
KR20140071452A (ko) 2006-04-05 2014-06-11 애브비 바이오테크놀로지 리미티드 항체 정제
US20100234577A1 (en) * 2006-06-14 2010-09-16 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
BRPI0716762A2 (pt) 2006-09-13 2013-09-24 Abbott Lab melhorias da cultura celular
US9109015B2 (en) * 2006-11-01 2015-08-18 Biogen Ma Inc Method of isolating biomacromolecules using low pH and divalent cations
US7589183B2 (en) * 2006-11-28 2009-09-15 Bio-Rad Laboratories, Inc. Prevention of leaching of ligands from affinity-based purification systems
US20100113746A1 (en) * 2007-04-23 2010-05-06 Arvind Mallinath Lali Process for purification of immunoglobulins using a pseudobioaffinity adsorbent
BRPI0812288A2 (pt) 2007-06-01 2014-11-25 Hoffmann La Roche Purificação de imunoglobulina.
US20090149638A1 (en) * 2007-10-03 2009-06-11 Ley Arthur C Systems and methods for purifying proteins
SI2215117T2 (en) 2007-10-30 2018-04-30 Genentech, Inc. Purification of the antibody by cation exchange chromatography
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
LT2220107T (lt) * 2007-11-12 2017-04-10 Chreto Aps Dvigubo giminingumo polipeptidai, skirti gryninimui
US20110107855A1 (en) * 2008-03-28 2011-05-12 Pelican Group Holdings, Inc. Sample preparation devices and methods for processing analytes
EP2274098B1 (en) * 2008-03-28 2013-12-25 Biotix, Inc. Multicapillary sample preparation devices and methods for processing analytes
MX2010011206A (es) * 2008-04-16 2010-11-12 Biogen Idec Inc Metodo para aislar biomacromoleculas usando glicol de polialquileno y metales de transicion.
MX2011001696A (es) * 2008-08-14 2011-03-25 Merck Sharp & Dohme Metodos para purificar anticuerpos usando cromatografia de afinidad con proteina a.
KR101722423B1 (ko) * 2008-10-20 2017-04-18 애브비 인코포레이티드 항체 정제 동안의 바이러스 불활성화
CN102257004A (zh) * 2008-10-20 2011-11-23 雅培制药有限公司 与il-12结合的抗体及其纯化方法
AU2009307728B2 (en) * 2008-10-20 2014-12-11 Abbvie Inc. Antibodies that bind to IL-18 and methods of purifying the same
EP2921501A1 (en) * 2008-10-20 2015-09-23 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
UY32341A (es) 2008-12-19 2010-07-30 Glaxo Group Ltd Proteínas de unión antígeno novedosas
AU2009331897A1 (en) 2008-12-22 2010-07-01 F. Hoffmann-La Roche Ag Immunoglobulin purification
CN102272144B (zh) * 2009-01-08 2014-09-17 通用电气健康护理生物科学股份公司 采用单一聚合物相系统的分离方法
JP5681166B2 (ja) 2009-03-31 2015-03-04 スリーエム イノベイティブ プロパティズ カンパニー 疎水性モノマー、疎水的に誘導体化された支持体、並びにその製造及び使用方法
MX2012004711A (es) * 2009-10-20 2012-05-23 Abbott Lab Aislamiento y purificacion de los anticuerpos anti-il-13 al usar cromatografia de afinidad con proteina a.
WO2011080050A2 (en) 2009-12-11 2011-07-07 Novartis Ag Binding molecules
ES2651065T3 (es) 2009-12-18 2018-01-24 Novartis Ag Solución de lavado y método para cromatografía de afinidad
SG182590A1 (en) 2010-01-28 2012-08-30 Glaxo Group Ltd Cd127 binding proteins
UA108227C2 (xx) 2010-03-03 2015-04-10 Антигензв'язуючий білок
US20130052209A1 (en) * 2010-04-23 2013-02-28 Purdue Research Foundation Protein drug formulations and packages
KR101152036B1 (ko) * 2010-04-27 2012-06-08 (주)셀트리온 컬럼 순환 및 시료 연속주입법을 이용한 단백질 ａ 크로마토그래피 정제 방법
AR081556A1 (es) 2010-06-03 2012-10-03 Glaxo Group Ltd Proteinas de union al antigeno humanizadas
US20130096284A1 (en) * 2010-06-21 2013-04-18 Kyowa Hakko Kirin Co., Ltd. Method for purifying protein using amino acid
WO2012010635A1 (en) 2010-07-22 2012-01-26 Glaxosmithkline Biologicals S.A. Novel antigen binding proteins
EP2649016B1 (en) * 2010-12-06 2020-06-10 Pall Corporation Continuous processing methods for biological products
MX357821B (es) 2010-12-21 2018-07-25 Hoffmann La Roche Preparación de anticuerpo enriquecida con isoforma y método para obtenerla.
PL3318571T3 (pl) 2011-03-16 2021-07-05 F. Hoffmann-La Roche Ag Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej
DK2691411T3 (da) 2011-03-29 2020-05-11 Glaxosmithkline Llc Buffersystem til proteinoprensning
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
AU2012250924B2 (en) 2011-05-02 2017-05-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
AU2012275133B2 (en) 2011-06-30 2017-08-17 Genzyme Corporation Inhibitors of T-cell activation
SG10201605397PA (en) 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
WO2013010749A1 (en) 2011-07-19 2013-01-24 Philogen S.P.A Sequential anti - ctla4 and targeted il-2 therapy
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
US8685241B1 (en) 2011-12-21 2014-04-01 Sepragen Corporation Axial and radial flow columns with inflatable seals to facilitate packing and unpacking
ES2567091T3 (es) 2012-04-05 2016-04-19 F. Hoffmann-La Roche Ag Compuestos de amina para la preparación selectiva de muestras biológicas
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
EP2855504B1 (en) * 2012-05-31 2018-10-24 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
EP2889617B1 (en) * 2012-08-27 2017-10-11 Asahi Kasei Medical Co., Ltd. Antibody purification method by means of temperature-responsive chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
KR102196230B1 (ko) 2012-09-17 2020-12-29 더블유.알. 그레이스 앤드 캄파니-콘. 크로마토그래피 매질 및 장치
CN103073616A (zh) * 2013-01-06 2013-05-01 西北大学 使用混合模式层析技术去除抗体聚集体的方法
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
ES2765206T3 (es) * 2013-03-15 2020-06-08 Glaxosmithkline Ip No 2 Ltd Procedimientos de purificación de anticuerpos
WO2014145744A1 (en) * 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
WO2014209508A1 (en) * 2013-05-13 2014-12-31 Medimmune, Llc Separation of recombinant polyclonal antibody multimers with minimal separation of monomers
ES2531459B1 (es) * 2013-06-10 2015-12-28 Antonio VILA SANJURJO Método para la separación física de "traductomas" convolucionados
AR096713A1 (es) 2013-06-25 2016-01-27 Cadila Healthcare Ltd Proceso de purificación para anticuerpos monoclonales
NZ718144A (en) 2013-09-13 2022-05-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
BR112016004437A2 (pt) 2013-09-13 2017-10-17 Genentech Inc métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit
HUE057005T2 (hu) * 2013-09-25 2022-04-28 Bioverativ Therapeutics Inc Oszlopon történõ vírusinaktiváló eljárások
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
EP3069137A1 (en) 2013-11-05 2016-09-21 Novartis Ag Organic compounds
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
PL3094390T3 (pl) 2014-01-16 2021-12-06 W.R. Grace & Co. - Conn. Nośniki do chromatografii powinowactwa i urządzenia do chromatografii
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
KR20160127087A (ko) * 2014-02-27 2016-11-02 에이전시 포 사이언스, 테크놀로지 앤드 리서치 알킬 양이온들로의 처리에 의한 단백질 제제들 내의 크로마틴 함량을 감소시키기 위한 방법들
CN106103465B (zh) 2014-03-10 2021-01-08 吉瑞工厂 使用预清洗步骤的免疫球蛋白纯化
EP3131589B1 (en) 2014-04-15 2023-05-17 Boehringer Ingelheim International GmbH Method and use for continuously inactivating a virus during manufacture of a biological product
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
CN106795215A (zh) 2014-06-24 2017-05-31 通用电气医疗集团生物工艺研发股份公司 层析方法
WO2016059602A2 (en) 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
CN107108720A (zh) 2014-11-06 2017-08-29 豪夫迈·罗氏有限公司 具有改变的FCRN结合的Fc区变体及其使用方法
GB201506868D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method for protein purification
JP2018517559A (ja) 2015-06-05 2018-07-05 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法
US10317329B2 (en) 2015-10-09 2019-06-11 Genzyme Corporation Early post-transfection isolation of cells (EPIC) for biologics production
CN109311965B (zh) 2016-03-11 2023-07-18 勃林格殷格翰国际公司 在制造蛋白质期间连续灭活病毒的方法
EP3487868A4 (en) 2016-07-25 2020-07-29 Cephalon, Inc. WASHING PAD FOR AFFINITY CHROMATOGRAPHY
BR112019000872A2 (pt) 2016-08-16 2019-04-30 Regeneron Pharmaceuticals, Inc. métodos para quantificar anticorpos individuais de uma mistura
EP4389757A2 (en) 2016-09-07 2024-06-26 GlaxoSmithKline Intellectual Property Development Limited Methods for purifying antibodies
AU2017341028B2 (en) 2016-10-07 2023-12-21 Genzyme Corporation Early post-transfection isolation of cells (EPIC) for biologics production
CA3039788A1 (en) 2016-10-25 2018-05-03 Regeneron Pharmaceuticals, Inc. Methods and systems for chromatography data analysis
GB201622343D0 (en) * 2016-12-29 2017-02-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
EP3606964A4 (en) 2017-04-03 2020-12-09 Immunomedics, Inc. SUBCUTANE ADMINISTRATION OF ANTIBODY DRUG CONJUGATES FOR CANCER THERAPY
EP3668985B1 (en) 2017-08-17 2021-06-16 Just-Evotec Biologics, Inc. Method of purifying glycosylated protein from host cell galectins and other contaminants
WO2019060062A1 (en) 2017-09-19 2019-03-28 Regeneron Pharmaceuticals Inc. METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM
CN111818980B (zh) * 2018-03-08 2022-10-11 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂
US11155575B2 (en) 2018-03-21 2021-10-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
TW202005694A (zh) 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
EP3843869A1 (en) 2018-08-31 2021-07-07 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
MA55529A (fr) 2019-04-03 2022-02-09 Genzyme Corp Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite
HU231498B1 (hu) 2019-04-04 2024-05-28 Richter Gedeon Nyrt Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával
MA56129A (fr) * 2019-06-10 2022-04-13 Takeda Pharmaceuticals Co Procédés de production d'un anticorps anti-alpha4béta7
CN114907430B (zh) * 2022-06-21 2023-12-01 中国科学院过程工程研究所 一种mRNA的分离纯化方法
WO2024062074A1 (en) 2022-09-21 2024-03-28 Sanofi Biotechnology Humanized anti-il-1r3 antibody and methods of use
CN117327189B (zh) * 2023-09-21 2024-06-11 南京京达生物技术有限公司 一种交联型异嗜性抗体阻断剂的生产工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
DK166763C (da) * 1983-03-16 1993-07-12 Immuno Ag Immunoglobulin-g-holdig fraktion
US5268306A (en) * 1988-02-29 1993-12-07 Boehringer Mannheim Gmbh Preparation of a solid phase matrix containing a bound specific binding pair
US5115101A (en) * 1988-06-08 1992-05-19 Miles Inc. Removal of protein A from antibody preparations
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt
EP0455757B1 (en) * 1989-08-04 1999-03-31 GRANDICS, Peter An integrated cell culture-protein purification system for the automated production and purification of cell culture products
JPH0778025B2 (ja) * 1990-03-20 1995-08-23 日本赤十字社 免疫グロブリンｇの製造方法
EP0447585B2 (de) * 1990-03-22 2003-05-07 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verträglichen Immunglobulin-G-Präparates
JPH0480959A (ja) * 1990-07-24 1992-03-13 Seiko Epson Corp 半導体装置
GB9019812D0 (en) 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
DK0605442T3 (da) 1991-07-25 2003-08-04 Idec Pharma Corp Rekombinante antistoffer til human terapi
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
KR0160900B1 (ko) * 1995-07-31 1998-12-15 배순훈 브이.씨.알의 드럼모터 장치

Also Published As

Publication number Publication date
USRE40070E1 (en) 2008-02-19
HK1013806A1 (en) 1999-09-10
WO1995022389A1 (en) 1995-08-24
JP4198751B2 (ja) 2008-12-17
DE69526929D1 (de) 2002-07-11
DK0746398T3 (da) 2002-09-16
CA2183888C (en) 2008-06-17
HU9602313D0 (en) 1996-10-28
EP0746398A4 (en) 1997-10-08
USRE41595E1 (en) 2010-08-31
EP0746398A1 (en) 1996-12-11
KR100372209B1 (ko) 2003-04-10
BR9507100A (pt) 1997-09-16
JPH09509658A (ja) 1997-09-30
ATE218387T1 (de) 2002-06-15
NZ281480A (en) 1998-06-26
CZ248196A3 (en) 1997-04-16
EP0746398B1 (en) 2002-06-05
CZ292001B6 (cs) 2003-07-16
US5429746A (en) 1995-07-04
HU217850B (hu) 2000-04-28
NO319182B1 (no) 2005-06-27
AU1843395A (en) 1995-09-04
MX9603637A (es) 1997-04-30
CN1146730A (zh) 1997-04-02
ES2177632T3 (es) 2002-12-16
NO963475L (no) 1996-10-21
CA2183888A1 (en) 1995-08-24
USRE41555E1 (en) 2010-08-24
SI0746398T1 (en) 2002-10-31
AU689552B2 (en) 1998-04-02
DE69526929T2 (de) 2003-01-02
PT746398E (pt) 2002-10-31
HUT74845A (en) 1997-02-28
NO963475D0 (no) 1996-08-21

Similar Documents

Publication Publication Date Title
ZA951372B (en) Antibody purification
GR3034332T3 (en) Protein purification.
EP1712623A3 (en) Selection of proteins using RNA-protein fusions
DE69430016D1 (de) Proteinreinigung
AU631681B2 (en) Radiolabeled anticoagulant peptides
TW273514B (xx)
ITRM920658A0 (it) Procedimento per la purificazione della proteina endotelina
WO1999028465A3 (en) Pias molecules that recognize and bind stat proteins and uses thereof
ZA97276B (en) Isolation of fibrinogen by affinity chromatography.
DK0858465T3 (da) Protein med antitumorvirkning.
KR970001106U (ko) 자동차용 헤드램프의 결합구조
GB9008404D0 (en) Protein purification by multiphase chromatography
KR970032585U (ko) 자동차의 헤드램프 어셈블리
KR970006421U (ko) 자동차의 헤드 램프 어셈블리
KR970001108U (ko) 자동차용 헤드램프의 결합구조
KR970038185U (ko) 자동차 센터플로워 멤버의 보강구조