ZA200900031B - Improvements relating to nanodispersions - Google Patents

Improvements relating to nanodispersions

Info

Publication number
ZA200900031B
ZA200900031B ZA200900031A ZA200900031A ZA200900031B ZA 200900031 B ZA200900031 B ZA 200900031B ZA 200900031 A ZA200900031 A ZA 200900031A ZA 200900031 A ZA200900031 A ZA 200900031A ZA 200900031 B ZA200900031 B ZA 200900031B
Authority
ZA
South Africa
Prior art keywords
nanodispersions
improvements relating
relating
Prior art date
Application number
ZA200900031A
Other languages
English (en)
Inventor
Doris Angus
David John Duncalf
Andrew James Elphick
Alison Jayne Foster
James Long
Steven Paul Rannard
Dong Wang
Original Assignee
Unilever Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc filed Critical Unilever Plc
Publication of ZA200900031B publication Critical patent/ZA200900031B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
ZA200900031A 2006-07-13 2007-06-29 Improvements relating to nanodispersions ZA200900031B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0613925.7A GB0613925D0 (en) 2006-07-13 2006-07-13 Improvements relating to nanodispersions

Publications (1)

Publication Number Publication Date
ZA200900031B true ZA200900031B (en) 2010-04-28

Family

ID=36955583

Family Applications (7)

Application Number Title Priority Date Filing Date
ZA200900031A ZA200900031B (en) 2006-07-13 2007-06-29 Improvements relating to nanodispersions
ZA200900027A ZA200900027B (en) 2006-07-13 2007-06-29 Improvements relating to anti-parasitic compositions
ZA200900030A ZA200900030B (en) 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions
ZA200900028A ZA200900028B (en) 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions
ZA200900029A ZA200900029B (en) 2006-07-13 2007-06-29 Improvements relating to biocidal compositions
ZA200900345A ZA200900345B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical formulations
ZA200900347A ZA200900347B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical compositions

Family Applications After (6)

Application Number Title Priority Date Filing Date
ZA200900027A ZA200900027B (en) 2006-07-13 2007-06-29 Improvements relating to anti-parasitic compositions
ZA200900030A ZA200900030B (en) 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions
ZA200900028A ZA200900028B (en) 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions
ZA200900029A ZA200900029B (en) 2006-07-13 2007-06-29 Improvements relating to biocidal compositions
ZA200900345A ZA200900345B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical formulations
ZA200900347A ZA200900347B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical compositions

Country Status (17)

Country Link
US (10) US20090239749A1 (fr)
EP (8) EP2387992A1 (fr)
JP (9) JP2009542761A (fr)
CN (11) CN101489534A (fr)
AP (1) AP2008004713A0 (fr)
AR (4) AR061990A1 (fr)
AU (9) AU2007271830B2 (fr)
BR (8) BRPI0714230A2 (fr)
CA (8) CA2656223A1 (fr)
CL (4) CL2007002032A1 (fr)
ES (2) ES2741124T3 (fr)
GB (1) GB0613925D0 (fr)
IL (2) IL195911A0 (fr)
MX (2) MX2009000307A (fr)
TW (1) TW200812694A (fr)
WO (8) WO2008006715A2 (fr)
ZA (7) ZA200900031B (fr)

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AU2007274040A1 (en) 2008-01-17
WO2008006715A3 (fr) 2008-05-08
EP2040680A2 (fr) 2009-04-01
MX2009000307A (es) 2009-01-26
CN101516342A (zh) 2009-08-26
US8945626B2 (en) 2015-02-03
GB0613925D0 (en) 2006-08-23
EP2040681B1 (fr) 2017-08-09
US20090304806A1 (en) 2009-12-10
CA2656233A1 (fr) 2008-01-17
TW200812694A (en) 2008-03-16
CL2010000516A1 (es) 2010-10-15
WO2008007151A3 (fr) 2008-03-06
IL195911A0 (en) 2009-09-01
US20100015233A1 (en) 2010-01-21
ZA200900029B (en) 2010-04-28
BRPI0714177A2 (pt) 2011-05-03
CA2659666A1 (fr) 2008-01-17
BRPI0714352A2 (pt) 2013-03-19
AU2007274041A1 (en) 2008-01-17
ZA200900345B (en) 2010-05-26
JP2009542794A (ja) 2009-12-03
EP2269581A1 (fr) 2011-01-05
CL2007002030A1 (es) 2008-01-18
US20090325995A1 (en) 2009-12-31
AU2010201900A1 (en) 2010-06-03
CA2656229A1 (fr) 2008-01-17
ZA200900347B (en) 2010-04-28
AU2007271829B2 (en) 2011-10-27
IL195933A (en) 2013-06-27
BRPI0714351A2 (pt) 2013-03-19
JP2009542761A (ja) 2009-12-03
US20100068282A1 (en) 2010-03-18
CN102671585A (zh) 2012-09-19
AR061991A1 (es) 2008-08-10
CA2656229C (fr) 2014-05-27
JP2009542764A (ja) 2009-12-03
JP2009542760A (ja) 2009-12-03
US7691873B2 (en) 2010-04-06
WO2008006713A2 (fr) 2008-01-17
AU2007271831B2 (en) 2010-11-18
JP2009542795A (ja) 2009-12-03
CN101516340A (zh) 2009-08-26
WO2008006716A3 (fr) 2008-03-13
EP2040677A2 (fr) 2009-04-01
CA2657586A1 (fr) 2008-01-17
US9060937B2 (en) 2015-06-23
CA2657582A1 (fr) 2008-01-17
ES2752460T3 (es) 2020-04-06
ZA200900030B (en) 2010-04-28
EP2040679A2 (fr) 2009-04-01
AU2007274039A1 (en) 2008-01-17
BRPI0714176A2 (pt) 2012-12-25
BRPI0714179A2 (pt) 2012-12-25
US20120134940A1 (en) 2012-05-31
AR077195A2 (es) 2011-08-10
CN101489531A (zh) 2009-07-22
BRPI0722376A2 (pt) 2012-05-22
WO2008007150A1 (fr) 2008-01-17
WO2008007152A3 (fr) 2008-03-06
EP2040680B1 (fr) 2019-08-07
AU2007271829A1 (en) 2008-01-17
BRPI0714230A2 (pt) 2013-01-15
US8821932B2 (en) 2014-09-02
AU2007271828B2 (en) 2010-12-02
CN101489535A (zh) 2009-07-22
EP2040678A2 (fr) 2009-04-01
US20100008995A1 (en) 2010-01-14
WO2008006715A2 (fr) 2008-01-17
WO2008006714A3 (fr) 2008-02-21
US20090239749A1 (en) 2009-09-24
WO2008006714A2 (fr) 2008-01-17
AP2008004713A0 (en) 2008-12-31
JP2010202665A (ja) 2010-09-16
WO2008007152A2 (fr) 2008-01-17
JP2009542763A (ja) 2009-12-03
AU2007271827A1 (en) 2008-01-17
AU2007271830A1 (en) 2008-01-17
JP2009542793A (ja) 2009-12-03
CN102631874A (zh) 2012-08-15
CN101489533A (zh) 2009-07-22
EP2040677B1 (fr) 2019-05-08
AR061990A1 (es) 2008-08-10
MX2009000309A (es) 2009-01-26
AU2007271828A1 (en) 2008-01-17
CN101489532A (zh) 2009-07-22
CN101516341A (zh) 2009-08-26
CL2007002031A1 (es) 2008-01-18
EP2386292A1 (fr) 2011-11-16
WO2008006716A2 (fr) 2008-01-17
CN101489534A (zh) 2009-07-22
CA2656223A1 (fr) 2008-01-17
ZA200900027B (en) 2010-04-28
BRPI0714353A2 (pt) 2013-05-07
US20120135058A1 (en) 2012-05-31
AU2007271831A1 (en) 2008-01-17
WO2008006712A2 (fr) 2008-01-17
WO2008007151A2 (fr) 2008-01-17
CL2007002032A1 (es) 2008-01-18
WO2008006713A3 (fr) 2008-07-31
CA2656217A1 (fr) 2008-01-17
CN101849911A (zh) 2010-10-06
JP2009542762A (ja) 2009-12-03

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