DK1180020T4 - Poröse lægemiddelmatrixer og fremgangsmåder til fremstilling deraf - Google Patents

Poröse lægemiddelmatrixer og fremgangsmåder til fremstilling deraf

Info

Publication number
DK1180020T4
DK1180020T4 DK00939365T DK00939365T DK1180020T4 DK 1180020 T4 DK1180020 T4 DK 1180020T4 DK 00939365 T DK00939365 T DK 00939365T DK 00939365 T DK00939365 T DK 00939365T DK 1180020 T4 DK1180020 T4 DK 1180020T4
Authority
DK
Denmark
Prior art keywords
drug
porous matrix
forming agent
pore forming
volatile
Prior art date
Application number
DK00939365T
Other languages
English (en)
Other versions
DK1180020T3 (da
Inventor
Julie Straub
Howard Bernstein
Donald E Chickering Iii
Sarwat Khatak
Greg Randall
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27495210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1180020(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/433,486 external-priority patent/US6395300B1/en
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of DK1180020T3 publication Critical patent/DK1180020T3/da
Application granted granted Critical
Publication of DK1180020T4 publication Critical patent/DK1180020T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
DK00939365T 1999-05-27 2000-05-25 Poröse lægemiddelmatrixer og fremgangsmåder til fremstilling deraf DK1180020T4 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13632399P 1999-05-27 1999-05-27
US15865999P 1999-10-08 1999-10-08
US09/433,486 US6395300B1 (en) 1999-05-27 1999-11-04 Porous drug matrices and methods of manufacture thereof
US18631000P 2000-03-02 2000-03-02
PCT/US2000/014578 WO2000072827A2 (en) 1999-05-27 2000-05-25 Porous drug matrices and methods of manufacture thereof

Publications (2)

Publication Number Publication Date
DK1180020T3 DK1180020T3 (da) 2006-03-27
DK1180020T4 true DK1180020T4 (da) 2009-10-05

Family

ID=27495210

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00939365T DK1180020T4 (da) 1999-05-27 2000-05-25 Poröse lægemiddelmatrixer og fremgangsmåder til fremstilling deraf

Country Status (18)

Country Link
EP (1) EP1180020B2 (da)
JP (1) JP4722295B2 (da)
KR (2) KR100752000B1 (da)
CN (1) CN1240373C (da)
AT (1) ATE312601T1 (da)
AU (1) AU768022B2 (da)
BR (1) BR0010984A (da)
CA (1) CA2371836C (da)
DE (1) DE60024811T3 (da)
DK (1) DK1180020T4 (da)
ES (1) ES2250141T5 (da)
HK (2) HK1048956B (da)
IL (2) IL146659A0 (da)
MX (1) MXPA01012106A (da)
NO (1) NO323761B1 (da)
NZ (1) NZ516083A (da)
TW (1) TWI274589B (da)
WO (1) WO2000072827A2 (da)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342533B1 (en) 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
US8771740B2 (en) * 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
MY120279A (en) * 2000-05-26 2005-09-30 Pharmacia Corp Use of a celecoxib composition for fast pain relief
US6589557B2 (en) * 2000-06-15 2003-07-08 Acusphere, Inc. Porous celecoxib matrices and methods of manufacture thereof
US6613308B2 (en) * 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6514482B1 (en) 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
DE10059020A1 (de) * 2000-11-28 2002-05-29 Gruenenthal Gmbh Parenteral applizierbare Darreichungsformen
EP1343372A2 (en) 2000-12-21 2003-09-17 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
CA2434641A1 (en) * 2001-01-18 2002-08-22 Pharmacia And Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
KR100875610B1 (ko) † 2001-02-12 2008-12-26 와이어쓰 Ｏ-데스메틸-벤라팍신의 신규한 석시네이트 염
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US6805853B2 (en) 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
WO2002094231A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of analgesics through an inhalation route
WO2003007968A1 (en) * 2001-07-17 2003-01-30 Sun Pharmaceutical Industries Ltd. A cardiotonic composition
US7005138B2 (en) * 2001-12-21 2006-02-28 Duramed Pharmaceuticals, Inc. Method of systematically delivering SSRIs
SI2630954T1 (sl) * 2002-03-20 2017-02-28 Civitas Therapeutics, Inc. Pulmonalno dovajanje za levodopo
JP4452970B2 (ja) * 2002-03-27 2010-04-21 日本臓器製薬株式会社 ジクロフェナクナトリウム経口製剤
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8980870B2 (en) 2002-09-24 2015-03-17 Boehringer Ingelheim International Gmbh Solid telmisartan pharmaceutical formulations
WO2004030659A1 (en) * 2002-09-30 2004-04-15 Acusphere, Inc. Sustained release porous microparticles for inhalation
NZ542548A (en) 2003-03-31 2009-04-30 Titan Pharmaceuticals Inc Implantable polymeric device for sustained release of dopamine agonist
ATE510174T1 (de) 2003-05-21 2011-06-15 Alexza Pharmaceuticals Inc Schlag gezündete unabhängige heizeinheit
GB0401947D0 (en) 2004-01-28 2004-03-03 Unilever Plc Porous bodies and method of production thereof
KR100681660B1 (ko) * 2004-03-17 2007-02-09 주식회사종근당 방출제어 펠릿의 약제학적 조성물
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
EP1681056A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Process for preparing lansoprazole
US20080200533A1 (en) * 2005-07-04 2008-08-21 Ramu Krishnan Drug or Pharmaceutical Compounds and a Preparation Thereof
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
GB0523638D0 (en) 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
AR054215A1 (es) * 2006-01-20 2007-06-13 Eriochem Sa Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
US20100226990A1 (en) * 2006-01-27 2010-09-09 The Provost, Fellows And Scholars Of The College O Method of Producing Porous Microparticles
KR100917809B1 (ko) 2006-05-22 2009-09-18 에스케이케미칼주식회사 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물
GB0613925D0 (en) 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
EP2139533A2 (en) 2007-04-27 2010-01-06 Endo Pharmaceuticals Solutions Inc. Implant device release agents and methods of using same
PT103743B (pt) * 2007-05-16 2013-01-15 Hovione Farmaciencia S A Processo para preparar derivados de 21-disódio fosfato de pregnanos.
KR101544498B1 (ko) 2007-08-24 2015-08-17 스티칭 허트 네덜란드 칸커 인스티튜트 종양성 질환의 치료를 위한 조성물
GB0716591D0 (en) * 2007-08-24 2007-10-03 Vereniging Het Nl Kanker I Composition
EP2197416A1 (en) * 2007-10-09 2010-06-23 Novartis Ag Pharmaceutical formulation of valsartan
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
CN102105427A (zh) * 2008-07-25 2011-06-22 阿尔法制药有限公司 粒度直径范围(D90)为大于3μm至约10μm的阿托伐醌
JP2012500788A (ja) * 2008-08-22 2012-01-12 スティヒティング ヘット ネーデルランド カンケル インスティテュート 組成物
WO2010102065A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
EP2411137B1 (en) 2009-03-27 2016-09-07 Bend Research, Inc. Spray-drying process
US9084976B2 (en) 2010-09-03 2015-07-21 Bend Research, Inc. Spray-drying apparatus and methods of using the same
WO2012031133A2 (en) 2010-09-03 2012-03-08 Bench Research, Inc. Spray-drying apparatus and methods of using the same
US9248584B2 (en) 2010-09-24 2016-02-02 Bend Research, Inc. High-temperature spray drying process and apparatus
CA2827336C (en) 2011-02-23 2016-01-26 Coeruleus Ltd. Flumazenil complexes, compositions comprising same and uses thereof
US9060938B2 (en) 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
CN103301095B (zh) * 2012-03-13 2016-04-13 中国科学院上海药物研究所 一种用于提高普罗布考口服吸收的多孔复合载药组合物及其制备方法
EP2863893A4 (en) * 2012-06-22 2015-07-01 Univ Queensland METHOD AND COMPOSITION FOR DELIVERING COMPOUND THROUGH A BIOLOGICAL BARRIER
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
JP6636952B2 (ja) * 2014-06-11 2020-01-29 スペックジーエックス エルエルシー 異なる溶解プロファイルを有する噴霧乾燥組成物及びその調製方法
CA2962719A1 (en) 2014-10-31 2016-05-06 Bend Research Inc. Process for forming active domains dispersed in a matrix
WO2016100949A2 (en) * 2014-12-18 2016-06-23 Windgap Medical, Inc. Method and compositions for dissolving or solubilizing therapeutic agents
US10751319B2 (en) 2015-06-04 2020-08-25 Crititech, Inc. Collection device and methods for use
CA2998483C (en) 2015-09-16 2022-09-06 Dfb Soria, Llc Delivery of drug nanoparticles and methods of use thereof
WO2017176628A1 (en) 2016-04-04 2017-10-12 Crititech, Inc. Methods for solid tumor treatment
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
KR101965708B1 (ko) * 2016-08-30 2019-04-04 이화여자대학교 산학협력단 스폰지 유사 구조를 갖는 고분자 미립자 및 이의 제조방법
ES2955884T3 (es) 2017-03-15 2023-12-07 Dfb Soria Llc Terapia tópica para el tratamiento de malignidades de la piel con nanoparticulas de taxanos
RU2019134145A (ru) 2017-06-09 2021-07-09 Крититек, Инк. Лечение эпителиальных кист путем внутрикистозной инъекции противоопухолевых частиц
KR20210118468A (ko) 2017-06-14 2021-09-30 크리티테크, 인크. 폐 장애의 치료 방법
EP3691631A1 (en) 2017-10-03 2020-08-12 Crititech, Inc. Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
BR112020013750A8 (pt) 2018-01-05 2022-10-18 Impel Neuropharma Inc Dispensação intranasal de olanzapina por dispositivo olfativo de precisão
JP7372252B2 (ja) 2018-03-16 2023-10-31 ディーエフビー ソリア リミテッド ライアビリティ カンパニー タキサンのナノ粒子を用いる子宮頸部上皮内腫瘍（ｃｉｎ）および子宮頸癌の処置のための局所療法
WO2020159676A1 (en) * 2019-01-29 2020-08-06 Bayer Healthcare Llc Topical gel compositions of naproxen
JP2022533055A (ja) * 2019-05-10 2022-07-21 アノメラ インコーポレイテッド 多孔質セルロース微小粒子およびそれらの製造方法
JP2023553202A (ja) 2020-12-08 2023-12-20 ルミナント バイオテク コーポレーション リミテッド 動物に物質を送達するための装置および方法の改善
CN113081971A (zh) * 2021-05-14 2021-07-09 江西中医药大学 一种中药多孔核壳型复合粒子粉体及其制备方法和应用
CN117538462B (zh) * 2024-01-10 2024-03-26 地奥集团成都药业股份有限公司 一种氨氯地平贝那普利胶囊有关物质的检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1265615A (da) * 1970-09-10 1972-03-01
NL7313626A (nl) † 1973-10-04 1975-04-08 Philips Nv Gecombineerde inrichting voor het produceren en sselen van warmte met een warmte ver- ende inrichting.
GB8322007D0 (en) † 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
IL82245A (en) * 1986-04-25 1990-07-26 Basf Ag Preparation of spray-dried granules of active ingredients
EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
PT954282E (pt) * 1997-01-16 2005-06-30 Massachusetts Inst Technology Preparacao de particulas para inalacao
EP1019021B2 (en) * 1997-09-29 2012-12-26 Novartis AG Stabilized preparations for use in metered dose inhalers
JP4758525B2 (ja) * 1998-03-20 2011-08-31 武田薬品工業株式会社 生理活性ポリペプチドの徐放性製剤およびその製造法
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery

Also Published As

Publication number Publication date
JP4722295B2 (ja) 2011-07-13
NO20015753L (no) 2002-01-28
ES2250141T5 (es) 2009-11-05
DK1180020T3 (da) 2006-03-27
CA2371836C (en) 2006-01-31
JP2003500438A (ja) 2003-01-07
NO323761B1 (no) 2007-07-02
NO20015753D0 (no) 2001-11-26
KR20070069219A (ko) 2007-07-02
IL146659A0 (en) 2002-07-25
DE60024811D1 (de) 2006-01-19
DE60024811T3 (de) 2010-01-07
EP1180020A2 (en) 2002-02-20
KR100752000B1 (ko) 2007-08-28
AU5445900A (en) 2000-12-18
BR0010984A (pt) 2002-04-30
MXPA01012106A (es) 2003-06-30
CN1365274A (zh) 2002-08-21
HK1094775A1 (en) 2007-04-13
IL146659A (en) 2010-05-31
DE60024811T2 (de) 2006-09-14
ATE312601T1 (de) 2005-12-15
NZ516083A (en) 2003-08-29
AU768022B2 (en) 2003-11-27
EP1180020B2 (en) 2009-06-24
KR20020011992A (ko) 2002-02-09
HK1048956A1 (en) 2003-04-25
CA2371836A1 (en) 2000-12-07
TWI274589B (en) 2007-03-01
KR100883477B1 (ko) 2009-02-16
WO2000072827A3 (en) 2001-01-25
WO2000072827A2 (en) 2000-12-07
HK1048956B (zh) 2006-07-28
WO2000072827A9 (en) 2002-01-31
ES2250141T3 (es) 2006-04-16
EP1180020B1 (en) 2005-12-14
CN1240373C (zh) 2006-02-08

Similar Documents

Publication Publication Date Title
DK1180020T4 (da) Poröse lægemiddelmatrixer og fremgangsmåder til fremstilling deraf
RU2420290C2 (ru) Твердые, пригодные для орального употребления фармацевтические формы применения, содержащие ривароксабан с модифицированным высвобождением
Gao et al. Enhanced oral bioavailability of a poorly water soluble drug PNU‐91325 by supersaturatable formulations
DE69812690D1 (de) Arzneistoffverabreichungssystem auf basis von flüssigkristall-strukturen
WO2001095877A3 (en) Porous celecoxib matrices and methods of manufacture thereof
CO5261593A1 (es) Formulaciones de entecavir de dosis bajas y uso
EA200000154A1 (ru) Способ солюбилизации фармацевтически активных ингредиентов в воде и в водных носителях
JPS58116414A (ja) ニカルジピン持続性製剤用球形顆粒およびその製造法
EP0560822A1 (en) METHOD FOR PRODUCING A SOLID DOSING UNIT FOR DELAYED RELEASE.
CN101541324B (zh) 医药组合物
JP2000256195A (ja) ニフェジピン小丸薬およびニフェジピン小丸薬の調製方法
AU2003235156B9 (en) Solid dispersion composition
ES2310550T3 (es) Preparacion liquida acuosa de pranoprofeno.
Minocha et al. SOlubility enhancement of poorly water soluble drugs by various techniques
TH78112B (th) เนื้อสารยารูพรุน และวิธีการของการผลิตของสิ่งเหล่านั้น
TH78112A (th) เนื้อสารยารูพรุน และวิธีการของการผลิตของสิ่งเหล่านั้น
Szaniawska Strategies in poorly soluble drug delivery systems
KR100981750B1 (ko) 분무-건조 과립 및 그의 제조방법
OGiso et al. ABSORPTION AND BIOAVAILABILITY OF CALCIUM AND MAGNESIUM SALTS OF INDOMETHACIN FROM RECTAL SUPPOSITO-RIES
JP5691142B2 (ja) ベンズイミダゾール系注射剤
EP0323762A1 (fr) Nouvelles compositions anti-tussives et leur procédé d'obtention
Mircia et al. Study of pentoxifylline chemical stability from modified release tablets with hydrophilic mould
JPH07291863A (ja) 腎保護作用剤
KR20040105182A (ko) 난용성 약물의 서방형 정제
CN105520912A (zh) 一种异银杏双黄酮微丸及其制备方法